Search Results - "Steklov, Mikhail"

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination by Baietti, Maria Francesca, Simicek, Michal, Abbasi Asbagh, Layka, Radaelli, Enrico, Lievens, Sam, Crowther, Jonathan, Steklov, Mikhail, Aushev, Vasily N, Martínez García, David, Tavernier, Jan, Sablina, Anna A

“…Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that…”
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Efficient shRNA-based knockdown of multiple target genes for cell therapy using a chimeric miRNA cluster platform by Rossi, Matteo, Steklov, Mikhail, Huberty, Fanny, Nguyen, Thuy, Marijsse, Jérôme, Jacques-Hespel, Céline, Najm, Paul, Lonez, Caroline, Breman, Eytan

“…Genome engineering technologies are powerful tools in cell-based immunotherapy to optimize or fine-tune cell functionalities. However, their use for multiple…”
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375 Enhanced anti-tumor activity and T-cell fitness of 2nd-generation MAGE-A1 TCR T-cells incorporating distinct CD8 co-receptor designs by Najm, Paul, Kemna, Josephine, Knipping, Friederike, Loenen, Marleen van, Sotiropoulou, Panagiota A, Steklov, Mikhail

“…BackgroundGeneration of dual CD4/CD8 TCR-T products by redirecting CD4+ T-cells to peptide-MHC class I complexes through incorporation of a CD8 co-receptor…”
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368 Counteracting TCR-T cell dysfunction in solid tumors through combination of FAS-based switch receptors and CD8-coreceptor by Knipping, Friederike, Najm, Paul, Kemna, Josephine, Loenen, Marleen van, Sotiropoulou, Panagiota A, Steklov, Mikhail

“…BackgroundThe immunosuppressive tumor microenvironment (TME) impedes solid tumor treatment by adoptive T cell therapies. Tumor-resident cells express multiple…”
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Targeted STAT1 therapy for LZTR1‐driven peripheral nerve sheath tumor by Ivanisevic, Tonci, Steklov, Mikhail, Lechat, Benoit, Cawthorne, Christopher, Gsell, Willy, Velde, Greetje Vande, Deroose, Christophe, Van Laere, Koen, Himmelreich, Uwe, Sewduth, Raj N, Sablina, Anna A

“…[...]those who undergo surgery may experience neurological deficits. [...]the management of schwannomas can be problematic due to their unpredictable growth…”
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394 High-affinity PRAME TCRs synergize with tailored CD8 co-receptor and switch receptors to generate potential best-in-class PRAME-targeting TCR-T therapy by Walcher, Lia, Knackstedt, Lorenz, Knipping, Friederike, Najm, Paul, Zschimmer, Paul, Sotiropoulou, Panagiota A, Kieback, Elisa, Loenen, Marleen van, Steklov, Mikhail, Poncette, Lucia

“…BackgroundPRAME is a promising target for immunotherapy due to high prevalence and high expression in multiple tumor indications with high unmet medical need…”
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146 Evolving Mutliplexed shRNA to generate tailored CAR T cell therapy by Steklov, Mikhail, Lecalve, Benjamin, Marijse, Jerome, Huberty, Fanny, Ramelot, Nancy, Jacques-Hespel, Celine, Iserentant, Hannes, Breman, Eytan, Gilham, David

“…BackgroundManipulating protein expression to generate cells with a specific desired phenotype is one of the central goals of engineered cell therapy. Short…”
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Structural basis for cytokinin receptor signaling: an evolutionary approach by Steklov, Mikhail Yu, Lomin, Sergey N, Osolodkin, Dmitry I, Romanov, Georgy A

“…Cytokinins are ubiquitous plant hormones; their signal is perceived by sensor histidine kinases—cytokinin receptors. This review focuses on recent advances on…”
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K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins by Magits, Wout, Steklov, Mikhail, Jang, Hyunbum, Sewduth, Raj N, Florentin, Amir, Lechat, Benoit, Sheryazdanova, Aidana, Zhang, Mingzhen, Simicek, Michal, Prag, Gali, Nussinov, Ruth, Sablina, Anna

“…The RAS pathway is among the most frequently activated signaling nodes in cancer. However, the mechanisms that alter RAS activity in human pathologies are not…”
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Plant membrane assays with cytokinin receptors underpin the unique role of free cytokinin bases as biologically active ligands by Lomin, Sergey N., Krivosheev, Dmitry M., Steklov, Mikhail Yu, Arkhipov, Dmitry V., Osolodkin, Dmitry I., Schmülling, Thomas, Romanov, Georgy A.

“…Cytokinin receptors play a key role in cytokinin-dependent processes regulating plant growth, development, and adaptation; therefore, the functional properties…”
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Single vector multiplexed shRNA provides a non-gene edited strategy to concurrently knockdown the expression of multiple genes in CAR T cells by Gilham, David Edward, Bornschein, Simon, Springuel, Lorraine, Michaux, Alexandre, Steklov, Mikhail, Breman, Eytan, Sotiropoulou, Panagiota A

“…Abstract only 3103 Background: Engineered T cells expressing chimeric antigen receptors (CAR) are now delivering clinically relevant results in patients with…”
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Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development by Najm, Paul, Zhao, Peihua, Steklov, Mikhail, Sewduth, Raj Nayan, Baietti, Maria Francesca, Pandolfi, Silvia, Criem, Nathan, Lechat, Benoit, Maia, Teresa Mendes, Van Haver, Delphi, Corthout, Nikky, Eyckerman, Sven, Impens, Francis, Sablina, Anna A

“…Meningiomas are the most common benign brain tumors. Mutations of the E3 ubiquitin ligase TRAF7 occur in 25% of meningiomas and commonly cooccur with mutations…”
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Abstract PR04: A bimodal mechanism of RAS inactivation by monoubiquitination by Magits, Wout, Steklov, Mikhail, Lechat, Benoit, Nussinov, Ruth, Sablina, Anna

“…Abstract The RAS pathway is the most frequently activated signaling node in human cancer. Nevertheless, the mechanisms leading to the hyperactivation of…”
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The Noonan Syndrome Gene Lztr1 Controls Cardiovascular Function by Regulating Vesicular Trafficking by Sewduth, Raj Nayan, Pandolfi, Silvia, Steklov, Mikhail, Sheryazdanova, Aidana, Zhao, Peihua, Criem, Nathan, Baietti, Maria F., Lechat, Benoit, Quarck, Rozeen, Impens, Francis, Sablina, Anna A.

“…Noonan syndrome (NS) is one of the most frequent genetic disorders. Bleeding problems are among the most common, yet poorly defined complications associated…”
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Co-regulation of the antagonistic RepoMan:Aurora-B pair in proliferating cells by Manzione, Maria Giulia, Rombouts, Jan, Steklov, Mikhail, Pasquali, Lorenzo, Sablina, Anna, Gelens, Lendert, Qian, Junbin, Bollen, Mathieu

“…Chromosome segregation during mitosis is antagonistically regulated by the Aurora-B kinase and RepoMan (recruits PP1 onto mitotic chromatin at…”
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Abstract A14: Mutations in the ubiquitin ligase adaptor LZTR1 drive human disease by dysregulating RAS ubiquitination and signaling by Steklov, Mikhail, Pandolfi, Silvia, Baietti, Maria Francesca, Carai, Paolo, Zhang, Mingzhen, Jang, Hyunbum, Cai, Yanyan, Legius, Eric, Tavernier, Jan, Gevaert, Kris, Impens, Francis, Heymans, Stephane, Messiaen, Ludwine, Nussimov, Ruth, Eyckerman, Sven, Sablina, Anna

“…Abstract Genetic evidence explicitly points out a role for LZTR1, an adaptor for cullin 3 (CUL3) ubiquitin ligase complex, in human disease. Mutations in LZTR1…”
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The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling by Asbagh, Layka Abbasi, Vazquez, Iria, Vecchione, Loredana, Budinska, Eva, De Vriendt, Veerle, Baietti, Maria Francesca, Steklov, Mikhail, Jacobs, Bart, Hoe, Nicholas, Singh, Sharat, Imjeti, Naga-Sailaja, Zimmermann, Pascale, Sablina, Anna, Tejpar, Sabine

“…Inappropriate activation of epidermal growth factor receptor (EGFR) plays a causal role in many cancers including colon cancer. The activation of EGFR by…”
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OTUB 1 triggers lung cancer development by inhibiting RAS monoubiquitination by Baietti, Maria Francesca, Simicek, Michal, Abbasi Asbagh, Layka, Radaelli, Enrico, Lievens, Sam, Crowther, Jonathan, Steklov, Mikhail, Aushev, Vasily N, Martínez García, David, Tavernier, Jan, Sablina, Anna A

“…Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that…”
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Facile Synthesis of 8-Azido-6-Benzylaminopurine by Steklov, Mikhail Yu, Tararov, Vitali I., Romanov, Georgy A., Mikhailov, Sergey N.

“…Bromination of 6-benzylaminopurine (1) with Br 2 in AcOH in the presence of AcONa afforded 6-benzylamino-8-bromopurine (2) in 59% yield. The position of…”
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