Search Results - "Steinmann, Gerhard G"

Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients by Hinrichsen, Holger, Benhamou, Yves, Wedemeyer, Heiner, Reiser, Markus, Sentjens, Roel E., Calleja, José L., Forns, Xavier, Erhardt, Andreas, Crönlein, Jens, Chaves, Ricardo L., Yong, Chan-Loi, Nehmiz, Gerhard, Steinmann, Gerhard G.

“…Background & Aims: Novel, potent, and well-tolerated hepatitis C virus (HCV) drugs are needed. BILN 2061 is a potent and specific inhibitor of HCV serine…”
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Faldaprevir combined with pegylated interferon alfa‐2a and ribavirin in treatment‐naïve patients with chronic genotype1 HCV: SILEN‐C1 trial by Sulkowski, Mark S., Asselah, Tarik, Lalezari, Jacob, Ferenci, Peter, Fainboim, Hugo, Leggett, Barbara, Bessone, Fernando, Mauss, Stefan, Heo, Jeong, Datsenko, Yakov, Stern, Jerry O., Kukolj, George, Scherer, Joseph, Nehmiz, Gerhard, Steinmann, Gerhard G., Böcher, Wulf O.

“…Faldaprevir (BI 201335) is a potent, hepatitis C virus (HCV) NS3/4A protease inhibitor with pharmacokinetic properties supportive of once‐daily (QD) dosing…”
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Faldaprevir combined with peginterferon alfa‐2a and ribavirin in chronic hepatitis C virus genotype‐1 patients with prior nonresponse: SILEN‐C2 trial by Sulkowski, Mark S., Bourlière, Marc, Bronowicki, Jean‐Pierre, Asselah, Tarik, Pawlotsky, Jean‐Michel, Shafran, Stephen D., Pol, Stanislas, Mauss, Stefan, Larrey, Dominique, Datsenko, Yakov, Stern, Jerry O., Kukolj, George, Scherer, Joseph, Nehmiz, Gerhard, Steinmann, Gerhard G., Böcher, Wulf O.

“…Faldaprevir (BI 201335) is a potent, hepatitis C virus (HCV) NS3/4A protease inhibitor. In all, 290 noncirrhotic HCV genotype (GT)‐1 patients with prior null…”
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Mechanisms underlying benign and reversible unconjugated hyperbilirubinemia observed with faldaprevir administration in hepatitis C virus patients by Sane, Rucha S, Steinmann, Gerhard G, Huang, Qihong, Li, Yongmei, Podila, Lalitha, Mease, Kirsten, Olson, Stephen, Taub, Mitchell E, Stern, Jerry O, Nehmiz, Gerhard, Böcher, Wulf O, Asselah, Tarik, Tweedie, Donald

“…Faldaprevir, an investigational agent for hepatitis C virus treatment, is well tolerated but associated with rapidly reversible, dose-dependent, clinically…”
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Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C by REISER, Markus, HINRICHSEN, Holger, BENHAMOU, Yves, REESINK, Henk W, WEDEMEYER, Heiner, AVENDANO, Cristina, RIBA, Neus, YONG, Chan-Loi, NEHMIZ, Gerhard, STEINMANN, Gerhard G

“…BILN-2061, a specific and potent peptidomimetic inhibitor of the HCV NS3 protease, has recently been shown to markedly lower serum hepatitis C virus (HCV)-RNA…”
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Su1025 Interferon-Stimulated Gene Expression Is Associated With Treatment Response to Faldaprevir Plus Pegylated Interferon α-2A and Ribavirin in Patients With Chronic HCV Genotype-1 Infection by Datsenko, Yakov, Baum, Patrick, Schirmbeck, Reinhold, Stern, Jerry O, Sha, Nanshi, Steinmann, Gerhard G

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Viral kinetics in patients with chronic hepatitis C treated with the serine protease inhibitor BILN 2061 by HERRMANN, Eva, ZEUZEM, Stefan, STEINMANN, Gerhard G, NEHMIZ, Gerhard, SARRAZIN, Christoph, HINRICHSEN, Holger, BENHAMOU, Yves, MANNS, Michael P, REISER, Markus, REESINK, Henk, CALLEJA, José L, FORNS, Xavier

“…We analysed viral kinetics from a 2-day treatment with BILN 2061, a serine protease inhibitor of hepatitis C virus, in patients chronically infected with…”
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Interferon-gamma in the prevention of severe burn-related infections: A European phase III multicenter trial by Wasserman, Daniel, Ioannovich, John D, Hinzmann, Ralf D, Deichsel, Guntram, Steinmann, Gerhard G

“…OBJECTIVESTo determine the efficacy and tolerance of interferon-gamma-1b (IFN-gamma) for the prevention of death related to infection in patients with burn…”
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Admission criteria for immunogerontological studies in man: the SENIEUR protocol by Ligthart, G J, Corberand, J X, Fournier, C, Galanaud, P, Hijmans, W, Kennes, B, Müller-Hermelink, H K, Steinmann, G G

“…Immunogerontological studies in man have often led to conflicting results. One of the main reasons is the selection of the subjects to be studied. Admission…”
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Faldaprevir combined with pegylated interferon alfa-2a and ribavirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial by Sulkowski, Mark S, Asselah, Tarik, Lalezari, Jacob, Ferenci, Peter, Fainboim, Hugo, Leggett, Barbara, Bessone, Fernando, Mauss, Stefan, Heo, Jeong, Datsenko, Yakov, Stern, Jerry O, Kukolj, George, Scherer, Joseph, Nehmiz, Gerhard, Steinmann, Gerhard G, Böcher, Wulf O

“…Faldaprevir (BI 201335) is a potent, hepatitis C virus (HCV) NS3/4A protease inhibitor with pharmacokinetic properties supportive of once-daily (QD) dosing…”
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Clinical experiences with interferon-alpha and interferon-gamma by Steinmann, G G, Rosenkaimer, F, Leitz, G

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Immunohistochemical characterization of the thymic microenvironment: a light-microscopic and ultrastructural immunocytochemical study by VON GAUDECKER, B, STEINMANN, G. G, HANSMANN, M.-L, HARPPRECHT, J, MILICEVIC, N. M, MÜLLER-HERMELINK, H.-K

“…The epithelial framework of the human thymus has been studied in parallel by immunohistochemical methods at the light- and electron-microscopic levels…”
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A rapid in vitro method for the evaluation of potential antitumor drugs requiring metabolic activation by hepatic S9 enzymes by Lebsanft, J, McMahon, J B, Steinmann, G G, Shoemaker, R H

“…Metabolic activation is a prerequisite for the antitumor activity of certain drugs such as cyclophosphamide. In vitro assays require systems for metabolic…”
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Immunopharmacological in vitro effects of Eleutherococcus senticosus extracts by STEINMANN, Gerhard G, ESPERESTER, Anke, JOLLER, Peter

“…The objective of these investigations was to further elucidate the immunopharmacological profile of fluid extracts of Eleutherococcus senticosus and to…”
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