Search Results - "Steinhauser, L"

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells by Hosios, Aaron M., Hecht, Vivian C., Danai, Laura V., Johnson, Marc O., Rathmell, Jeffrey C., Steinhauser, Matthew L., Manalis, Scott R., Vander Heiden, Matthew G.

“…Cells must duplicate their mass in order to proliferate. Glucose and glutamine are the major nutrients consumed by proliferating mammalian cells, but the…”
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Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair by Loffredo, Francesco S., Steinhauser, Matthew L., Gannon, Joseph, Lee, Richard T.

“…Cell therapy can improve cardiac function in animals and humans after injury, but the mechanism is unclear. We performed cell therapy experiments in…”
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Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment by Klattenhoff, Carla A., Scheuermann, Johanna C., Surface, Lauren E., Bradley, Robert K., Fields, Paul A., Steinhauser, Matthew L., Ding, Huiming, Butty, Vincent L., Torrey, Lillian, Haas, Simon, Abo, Ryan, Tabebordbar, Mohammadsharif, Lee, Richard T., Burge, Christopher B., Boyer, Laurie A.

“…Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner, yet little is known about their roles in lineage commitment. Here,…”
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Mammalian heart renewal by pre-existing cardiomyocytes by Senyo, Samuel E., Steinhauser, Matthew L., Pizzimenti, Christie L., Yang, Vicky K., Cai, Lei, Wang, Mei, Wu, Ting-Di, Guerquin-Kern, Jean-Luc, Lechene, Claude P., Lee, Richard T.

“…During normal ageing a low rate of division of pre-existing cardiomyocytes, rather than progenitor cells, is responsible for cardiomyocyte genesis; this…”
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FGF21 and the late adaptive response to starvation in humans by Fazeli, Pouneh K, Lun, Mingyue, Kim, Soo M, Bredella, Miriam A, Wright, Spenser, Zhang, Yang, Lee, Hang, Catana, Ciprian, Klibanski, Anne, Patwari, Parth, Steinhauser, Matthew L

“…In mice, FGF21 is rapidly induced by fasting, mediates critical aspects of the adaptive starvation response, and displays a number of positive metabolic…”
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Loss of White Adipose Hyperplastic Potential Is Associated with Enhanced Susceptibility to Insulin Resistance by Kim, Soo M., Lun, Mingyue, Wang, Mei, Senyo, Samuel E., Guillermier, Christelle, Patwari, Parth, Steinhauser, Matthew L.

“…Fat mass expansion occurs by adipocyte hypertrophy or recruitment of differentiating adipocyte progenitors, the relative balance of which may impact systemic…”
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Exercise induces new cardiomyocyte generation in the adult mammalian heart by Vujic, Ana, Lerchenmüller, Carolin, Wu, Ting-Di, Guillermier, Christelle, Rabolli, Charles P., Gonzalez, Emilia, Senyo, Samuel E., Liu, Xiaojun, Guerquin-Kern, Jean-Luc, Steinhauser, Matthew L., Lee, Richard T., Rosenzweig, Anthony

“…Loss of cardiomyocytes is a major cause of heart failure, and while the adult heart has a limited capacity for cardiomyogenesis, little is known about what…”
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Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism by Steinhauser, Matthew L., Bailey, Andrew P., Senyo, Samuel E., Guillermier, Christelle, Perlstein, Todd S., Gould, Alex P., Lee, Richard T., Lechene, Claude P.

“…Multi-isotope imaging mass spectrometry is used to investigate the ‘immortal strand hypothesis’, Drosophila lipid metabolism and human lymphopoiesis…”
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Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy by Loffredo, Francesco S., Steinhauser, Matthew L., Jay, Steven M., Gannon, Joseph, Pancoast, James R., Yalamanchi, Pratyusha, Sinha, Manisha, Dall’Osso, Claudia, Khong, Danika, Shadrach, Jennifer L., Miller, Christine M., Singer, Britta S., Stewart, Alex, Psychogios, Nikolaos, Gerszten, Robert E., Hartigan, Adam J., Kim, Mi-Jeong, Serwold, Thomas, Wagers, Amy J., Lee, Richard T.

“…The most common form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy in the elderly. To clarify the biological…”
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Regeneration of the heart by Steinhauser, Matthew L., Lee, Richard T.

“…The death of cardiac myocytes diminishes the heart's pump function and is a major cause of heart failure, one of the dominant causes of death worldwide. Other…”
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Aging Is a Powerful Risk Factor for Type 2 Diabetes Mellitus Independent of Body Mass Index by Fazeli, Pouneh K, Lee, Hang, Steinhauser, Matthew L

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Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling by Seki, Kenjiro, Sanada, Shoji, Kudinova, Anastacia Y, Steinhauser, Matthew L, Handa, Vandna, Gannon, Joseph, Lee, Richard T

“…ST2 is an interleukin (IL)-1 receptor family member with membrane-bound (ST2L) and soluble (sST2) isoforms, and sST2 is a biomarker for poor outcome in…”
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Prolonged fasting drives a program of metabolic inflammation in human adipose tissue by Fazeli, Pouneh K., Zhang, Yang, O'Keefe, John, Pesaresi, Tristan, Lun, Mingyue, Lawney, Brian, Steinhauser, Matthew L.

“…The human adaptive fasting response enables survival during periods of caloric deprivation. A crucial component of the fasting response is the shift from…”
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The circulating metabolome of human starvation by Steinhauser, Matthew L, Olenchock, Benjamin A, O'Keefe, John, Lun, Mingyue, Pierce, Kerry A, Lee, Hang, Pantano, Lorena, Klibanski, Anne, Shulman, Gerald I, Clish, Clary B, Fazeli, Pouneh K

“…The human adaptive starvation response allows for survival during long-term caloric deprivation. Whether the physiology of starvation is adaptive or…”
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Elimination of 15N-thymidine after oral administration in human infants by Ammanamanchi, Niyatie, Yester, Jessie, Bargaje, Anita P, Thomas, Dawn, Little, Kathryn C, Janzef, Shannon, Francis, Kimberly, Weinberg, Jacqueline, Johnson, Jennifer, Seery, Thomas, Harris, Tyler Hutchinson, Funari, Bryan J, Rose-Felker, Kirsten, Zinn, Matthew, Miller, Susan A, West, Shawn C, Feingold, Brian, Zhou, Hairu, Steinhauser, Matthew L, Csernica, Timothy, Michener, Robert, Kühn, Bernhard

“…We have developed a new clinical research approach for the quantification of cellular proliferation in human infants to address unanswered questions about…”
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Cadmium concentration in cattle tissues in the Czech Republic by Drapal, J, Steinhauser, L, Stastny, K, Faldyna, M

“…The aim of this paper was to evaluate the cadmium concentrations in the muscles, liver, and kidney of three age categories (≤ 8 months; ≤ 2 years; ≥ 2 years)…”
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Unhealthy visceral fat is associated with improved efficacy of immunotherapy in endometrial cancer by Steinhauser, Matthew L

“…Obesity is a known driver of endometrial cancer. In this issue of the JCI, Gómez-Banoy and colleagues investigated a cohort of patients with advanced…”
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Zinc-Induced Polymerization of Killer-Cell Ig-like Receptor into Filaments Promotes Its Inhibitory Function at Cytotoxic Immunological Synapses by Kumar, Santosh, Rajagopalan, Sumati, Sarkar, Pabak, Dorward, David W., Peterson, Mary E., Liao, Hsien-Shun, Guillermier, Christelle, Steinhauser, Matthew L., Vogel, Steven S., Long, Eric O.

“…The inhibitory function of killer cell immunoglobulin-like receptors (KIR) that bind HLA-C and block activation of human natural killer (NK) cells is dependent…”
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Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity by Zhang, Yang, Guillermier, Christelle, De Raedt, Thomas, Cox, Andrew G., Maertens, Ophelia, Yimlamai, Dean, Lun, Mingyue, Whitney, Adam, Maas, Richard L., Goessling, Wolfram, Cichowski, Karen, Steinhauser, Matthew L.

“…Malignant tumors exhibit high degrees of genomic heterogeneity at the cellular level, leading to the view that subpopulations of tumor cells drive growth and…”
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Pericyte Progenitors at the Crossroads Between Fibrosis and Regeneration by Steinhauser, Matthew L, Lee, Richard T

“…Tissue repair after injury is generally inversely related to the extent of scarring, suggesting the possibility that regeneration could be promoted by…”
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