Search Results - "Steinhardt, Maximilian Johannes"

High-dose carfilzomib achieves superior anti-tumor activity over low-dose and recaptures response in relapsed/refractory multiple myeloma resistant to lowdose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex by Zhou, Xiang, Besse, Andrej, Peter, Jessica, Steinhardt, Maximilian Johannes, Vogt, Cornelia, Nerreter, Silvia, Teufel, Eva, Stanojkovska, Emilia, Xiao, Xianghui, Hornburger, Hannah, Haertle, Larissa, Lopez, Max Mendez, Munawar, Umair, Riedel, Angela, Han, Seungbin, Maurits, Elmer, Overkleeft, Herman S, Florea, Bogdan, Einsele, Hermann, Kortüm, K Martin, Driessen, Christoph, Besse, Lenka, Rasche, Leo

“…Optimal carfilzomib dosing is a matter of debate. We analyzed the inhibition profiles of proteolytic proteasome subunits β5, β2 and β1 after low-dose (20/27…”
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P890: COMBINING SKY92 GENE EXPRESSION PROFILING WITH CYTOGENETICS ACCORDING TO R2‐ISS FOR MULTIPLE MYELOMA RISK CLASSIFICATION: THE FIRST PROSPECTIVE EVIDENCE by Zhou, Xiang, Engel, Benedict, Hofmann, Annika, Vogt, Cornelia, Nerreter, Silvia, Teufel, Eva, Stanojkovska, Emilia, Truger, Marietta, Weis, Philipp, Xiao, Xianghui, Eisele, Florian, Riedhammer, Christine, Johannes Steinhardt, Maximilian, Munawar, Umair, Han, Seungbin, Haertle, Larissa, Haferlach, Claudia, Einsele, Hermann, Martin Kortum, K, Rasche, Leo

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Liver stiffness as a prognostic parameter and tool for risk stratification in advanced cardiac transthyretin amyloidosis by Ihne-Schubert, Sandra Michaela, Morbach, Caroline, Goetze, Oliver, Cejka, Vladimir, Steinhardt, Maximilian Johannes, Frantz, Stefan, Einsele, Hermann, Sommer, Claudia, Störk, Stefan, Schubert, Torben, Geier, Andreas

“…In light of increasing therapeutic options, risk stratification of advanced cardiac transthyretin amyloidosis (ATTR-CA) is gaining clinical importance to avoid…”
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Spatial transcriptomics reveals profound subclonal heterogeneity and T-cell dysfunction in extramedullary myeloma by John, Mara, Helal, Moutaz, Duell, Johannes, Mattavelli, Greta, Stanojkovska, Emilia, Afrin, Nazia, Leipold, Alexander M., Steinhardt, Maximilian J., Zhou, Xiang, Žihala, David, Anilkumar Sithara, Anjana, Mersi, Julia, Waldschmidt, Johannes M., Riedhammer, Christine, Kadel, Sofie-Katrin, Truger, Marietta, Werner, Rudolf A., Haferlach, Claudia, Einsele, Hermann, Kretzschmar, Kai, Jelínek, Tomáš, Rosenwald, Andreas, Kortüm, K. Martin, Riedel, Angela, Rasche, Leo

“…•EMD mimics the architectural complexity of solid tumors, marked by diverse microenvironments, multiclonality, and TNFRSF17 and GPRC5D levels.•EMD shows…”
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Changes in T‐cell subsets, preexisting cytopenias and hyperferritinaemia correlate with cytopenias after BCMA targeted CAR T‐cell therapy in relapsed/refractory multiple myeloma: Results from a prospective comprehensive biomarker study by Zhou, Xiang, Wagner, Vivien, Scheller, Lukas, Stanojkovska, Emilia, Riedhammer, Christine, Xiao, Xianghui, Steinhardt, Maximilian Johannes, Vogt, Cornelia, Nerreter, Silvia, Eisele, Florian, John, Mara, Munawar, Umair, Kadel, Sofie‐Katrin, Mersi, Julia, Ruckdeschel, Anna, Schimanski, Sven, Haertle, Larissa, Waldschmidt, Johannes Moritz, Han, Seungbin, Topp, Max, Duell, Johannes, Einsele, Hermann, Riedel, Angela, Kortüm, K. Martin, Rasche, Leo

“…Summary Biomarkers for cytopenias following CAR T‐cell treatment in relapsed/refractory (RR) multiple myeloma (MM) are not completely defined. We prospectively…”
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Incremental prognostic utility of congestion markers in cardiac transthyretin amyloidosis by Ihne-Schubert, Sandra Michaela, Morbach, Caroline, Cejka, Vladimir, Steinhardt, Maximilian Johannes, Papagianni, Aikaterini, Frantz, Stefan, Einsele, Hermann, Wehler, Thomas, Kortüm, Klaus Martin, Sommer, Claudia, Störk, Stefan, Schubert, Torben, Geier, Andreas

“…Congestion is prognostically relevant in cardiac transthyretin amyloidosis (ATTR-CA), but whether congestion has an incremental prognostic value beyond the…”
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High-dose carfilzomib achieves superior anti-tumor activity over low-dose and recaptures response in relapsed/refractory multiple myeloma resistant to low-dose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex by Zhou, Xiang, Besse, Andrej, Peter, Jessica, Steinhardt, Maximilian Johannes, Vogt, Cornelia, Nerreter, Silvia, Teufel, Eva, Stanojkovska, Emilia, Xiao, Xianghui, Hornburger, Hannah, Haertle, Larissa, Mendez-Lopez, Max, Munawar, Umair, Riedel, Angela, Han, Seungbin, Maurits, Elmer, Overkleeft, Herman S., Florea, Bogdan, Einsele, Hermann, Kortüm, K. Martin, Driessen, Christoph, Besse, Lenka, Rasche, Leo

“…Optimal carfilzomib dosing is a matter of debate. We analyzed the inhibition profiles of proteolytic proteasome subunits β5, β2 and β1 after low-dose (20/27…”
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Carfilzomib Based Treatment Strategies in the Management of Relapsed/Refractory Multiple Myeloma with Extramedullary Disease by Zhou, Xiang, Flüchter, Patricia, Nickel, Katharina, Meckel, Katharina, Messerschmidt, Janin, Böckle, David, Knorz, Sebastian, Steinhardt, Maximilian Johannes, Krummenast, Franziska, Danhof, Sophia, Einsele, Hermann, Kortüm, K Martin, Rasche, Leo

“…Published experience with carfilzomib in patients with relapsed/refractory multiple myeloma (RRMM) and extramedullary disease (EMD) is still limited. The…”
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Real-World Experience with Minimal Residual Disease Testing with Next Generation Flow Cytometry and Functional Imaging in Multiple Myeloma by Böckle, David, Tabares Gaviria, Paula, Zhou, Xiang, Messerschmidt, Janin, Scheller, Lukas, Steinhardt, Maximilian Johannes, Seebacher, Elena, Ulbrich, Maria, Heidemeier, Anke, Buck, Andreas, Einsele, Hermann, Beilhack, Andreas, Kortuem, Martin, Rasche, Leo

“…Background: Minimal residual disease (MRD) diagnostics in multiple myeloma (MM) are gaining increasing importance to determine response depth beyond complete…”
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Salvage therapy with “Dara‐KDT‐P(A)CE” in heavily pretreated, high‐risk, proliferative, relapsed/refractory multiple myeloma by Zhou, Xiang, Ruckdeschel, Anna, Peter, Jessica, Böckle, David, Hornburger, Hannah, Danhof, Sophia, Steinhardt, Maximilian Johannes, Heimeshoff, Larissa, Einsele, Hermann, Kortüm, Klaus Martin, Rasche, Leo

“…The multi‐agent therapy “VDT‐PACE” represents an established regimen in relapsed/refractory multiple myeloma (RRMM). Here, we report on our experience with a…”
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Hierarchy of mono- and biallelic TP53 alterations in multiple myeloma cell fitness by Munawar, Umair, Rasche, Leo, Müller, Nicole, Vogt, Cornelia, Da-Via, Matteo, Haertle, Larissa, Arampatzi, Panagiota, Dietrich, Sascha, Roth, Markus, Garitano-Trojaola, Andoni, Steinhardt, Maximilian Johannes, Strifler, Susanne, Gallardo, Miguel, Martinez-Lopez, Joaquin, Bargou, Ralf C., Heckel, Tobias, Einsele, Hermann, Stühmer, Thorsten, Kortüm, K. Martin, Barrio, Santiago

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Obinutuzumab and venetoclax induced complete remission in a patient with ibrutinib‐resistant non‐nodal leukemic mantle cell lymphoma by Zhou, Xiang, Steinhardt, Maximilian Johannes, Düll, Johannes, Krummenast, Franziska, Danhof, Sophia, Meckel, Katharina, Nickel, Katharina, Grathwohl, Denise, Leicht, Hans‐Benno, Rosenwald, Andreas, Einsele, Hermann, Rasche, Leo, Kortüm, Martin

“…We herein report the case of a 73‐year‐old male patient who was diagnosed with leukemic non‐nodal MCL. This patient had received six cycles of bendamustine,…”
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AmyKoS—a German real-world prospective cohort study of patients with suspected and proven amyloidosis by Ihne-Schubert, Sandra Michaela, Morbach, Caroline, Papagianni, Aikaterini, Cejka, Vladimir, Steinhardt, Maximilian Johannes, Held, Melissa, Zeller, Daniel, Frantz, Stefan, Geier, Andreas, Knop, Stefan, Sommer, Claudia, Störk, Stefan, Einsele, Hermann

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Sequential CD38 monoclonal antibody retreatment leads to deep remission in a patient with relapsed/refractory multiple myeloma by Steinhardt, Maximilian Johannes, Zhou, Xiang, Krummenast, Franziska, Meckel, Katharina, Nickel, Katharina, Böckle, David, Messerschmidt, Janin, Knorz, Sebastian, Dierks, Alexander, Heidemeier, Anke, Lapa, Constantin, Einsele, Hermann, Rasche, Leo, Kortüm, Klaus Martin

“…We report on a currently 76-year-old female patient with relapsed/refractory (RR) multiple myeloma (MM) treated at our institution. This patient had received…”
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Sequential CD38 monoclonal antibody retreatment leads to deep remission in a patient with relapsed/refractory multiple myeloma by Steinhardt, Maximilian Johannes, Zhou, Xiang, Krummenast, Franziska, Meckel, Katharina, Nickel, Katharina, Böckle, David, Messerschmidt, Janin, Knorz, Sebastian, Dierks, Alexander, Heidemeier, Anke, Lapa, Constantin, Einsele, Hermann, Rasche, Leo, Kortüm, Klaus Martin

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