Search Results - "Steingrimsson, Eiríkur"

An eye on microphthalmia by Fock, Valerie, Steingrímsson, Eiríkur

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Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease by Travnickova, Jana, Wojciechowska, Sonia, Khamseh, Ava, Gautier, Philippe, Brown, Daniel V, Lefevre, Thomas, Brombin, Alessandro, Ewing, Ailith, Capper, Amy, Spitzer, Michaela, Dilshat, Ramile, Semple, Colin A, Mathers, Marie E, Lister, James A, Steingrimsson, Eiríkur, Voet, Thierry, Ponting, Chris P, Patton, E Elizabeth

“…The melanocyte-inducing transcription factor (MITF)-low melanoma transcriptional signature is predictive of poor outcomes for patients, but little is known…”
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The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye function by García-Llorca, Andrea, Aspelund, Snaefridur Gudmundsdottir, Ogmundsdottir, Margret Helga, Steingrimsson, Eiríkur, Eysteinsson, Thor

“…Mutations in the microphthalmia-associated transcription factor ( Mitf ) gene can cause retinal pigment epithelium (RPE) and retinal dysfunction and…”
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Hedgehog signalling in bone and osteoarthritis: the role of Smoothened and cholesterol by Smith, Abbi Elise, Sigurbjörnsdóttir, Elín Sóley, Steingrímsson, Eiríkur, Sigurbjörnsdóttir, Sara

“…Hedgehog signalling is essential for development, crucial for normal anatomical arrangement and activated during tissue damage repair. Dysregulation of…”
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Proton-pump inhibitors among adults: a nationwide drug-utilization study by Hálfdánarson, Óskar Ö., Pottegård, Anton, Björnsson, Einar S., Lund, Sigrún H., Ogmundsdottir, Margret H., Steingrímsson, Eiríkur, Ogmundsdottir, Helga M., Zoega, Helga

“…Background: The use of proton-pump inhibitors (PPIs) has grown worldwide, and there are concerns about increased unsubstantiated long-term use. The aim of the…”
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MITF has a central role in regulating starvation-induced autophagy in melanoma by Möller, Katrin, Sigurbjornsdottir, Sara, Arnthorsson, Asgeir O., Pogenberg, Vivian, Dilshat, Ramile, Fock, Valerie, Brynjolfsdottir, Solveig H., Bindesboll, Christian, Bessadottir, Margret, Ogmundsdottir, Helga M., Simonsen, Anne, Larue, Lionel, Wilmanns, Matthias, Thorsson, Vesteinn, Steingrimsson, Eirikur, Ogmundsdottir, Margret H.

“…The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB…”
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Reduction in the olfactory ability in aging Mitf mutant mice without evidence of neurodegeneration by Mechmet, Fatich, Steingrímsson, Eiríkur, Petersen, Petur Henry

“…Age-related decline occurs in most brain structures and sensory systems. An illustrative case is olfaction. The olfactory bulb (OB) undergoes deterioration…”
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User guide to MiT‐TFE isoforms and post‐translational modifications by Vu, Hong Nhung, Dilshat, Ramile, Fock, Valerie, Steingrímsson, Eiríkur

“…The microphthalmia‐associated transcription factor (MITF) is at the core of melanocyte and melanoma fate specification. The related factors TFEB and TFE3 have…”
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Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution by Louphrasitthiphol, Pakavarin, Siddaway, Robert, Loffreda, Alessia, Pogenberg, Vivian, Friedrichsen, Hans, Schepsky, Alexander, Zeng, Zhiqiang, Lu, Min, Strub, Thomas, Freter, Rasmus, Lisle, Richard, Suer, Eda, Thomas, Benjamin, Schuster-Böckler, Benjamin, Filippakopoulos, Panagis, Middleton, Mark, Lu, Xin, Patton, E. Elizabeth, Davidson, Irwin, Lambert, Jean-Philippe, Wilmanns, Matthias, Steingrímsson, Eiríkur, Mazza, Davide, Goding, Colin R.

“…It is widely assumed that decreasing transcription factor DNA-binding affinity reduces transcription initiation by diminishing occupancy of sequence-specific…”
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Acetylation reprograms MITF target selectivity and residence time by Louphrasitthiphol, Pakavarin, Loffreda, Alessia, Pogenberg, Vivian, Picaud, Sarah, Schepsky, Alexander, Friedrichsen, Hans, Zeng, Zhiqiang, Lashgari, Anahita, Thomas, Benjamin, Patton, E. Elizabeth, Wilmanns, Matthias, Filippakopoulos, Panagis, Lambert, Jean-Philippe, Steingrímsson, Eiríkur, Mazza, Davide, Goding, Colin R.

“…The ability of transcription factors to discriminate between different classes of binding sites associated with specific biological functions underpins…”
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Epigenetic regulation during melanocyte development and homeostasis by Dilshat, Ramile, Vu, Hong Nhung, Steingrímsson, Eiríkur

“…Melanocytes originate in the neural crest as precursor cells which then migrate and proliferate to reach their destination where they differentiate into…”
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MITF and TFEB cross-regulation in melanoma cells by Ballesteros-Álvarez, Josué, Dilshat, Ramile, Fock, Valerie, Möller, Katrín, Karl, Ludwig, Larue, Lionel, Ögmundsdóttir, Margrét Helga, Steingrímsson, Eiríkur

“…The MITF, TFEB, TFE3 and TFEC (MiT-TFE) proteins belong to the basic helix-loop-helix family of leucine zipper transcription factors. MITF is crucial for…”
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Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF by Pogenberg, Vivian, Ogmundsdóttir, Margrét H, Bergsteinsdóttir, Kristín, Schepsky, Alexander, Phung, Bengt, Deineko, Viktor, Milewski, Morlin, Steingrímsson, Eiríkur, Wilmanns, Matthias

“…Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte development and an important oncogene in melanoma. MITF heterodimeric…”
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Distribution of mast cells within the mouse heart and its dependency on Mitf by Ingason, Arnar Bragi, Mechmet, Fatich, Atacho, Diahann Alexandra Maria, Steingrímsson, Eiríkur, Petersen, Pétur Henry

“…•The distribution of cardiac mast cells in mice differs from humans and dogs.•This is important since mice are the most widely used genetic model for human…”
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MITF reprograms the extracellular matrix and focal adhesion in melanoma by Dilshat, Ramile, Fock, Valerie, Kenny, Colin, Gerritsen, Ilse, Lasseur, Romain Maurice Jacques, Travnickova, Jana, Eichhoff, Ossia M, Cerny, Philipp, Möller, Katrin, Sigurbjörnsdóttir, Sara, Kirty, Kritika, Einarsdottir, Berglind Ósk, Cheng, Phil F, Levesque, Mitchell, Cornell, Robert A, Patton, E Elizabeth, Larue, Lionel, de Tayrac, Marie, Magnúsdóttir, Erna, Ögmundsdóttir, Margrét Helga, Steingrimsson, Eirikur

“…The microphthalmia-associated transcription factor (MITF) is a critical regulator of melanocyte development and differentiation. It also plays an important…”
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Sun-induced freckling: ephelides and solar lentigines by Praetorius, Christian, Sturm, Richard A., Steingrimsson, Eirikur

“…Summary Freckles, the lay term for ephelides and lentigines, are important pigmentation characteristics observed in humans. Both are affected by sunlight;…”
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BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export by Ngeow, Kao Chin, Friedrichsen, Hans J., Li, Linxin, Zeng, Zhiqiang, Andrews, Sarah, Volpon, Laurent, Brunsdon, Hannah, Berridge, Georgina, Picaud, Sarah, Fischer, Roman, Lisle, Richard, Knapp, Stefan, Filippakopoulos, Panagis, Knowles, Helen, Steingrímsson, Eiríkur, Borden, Katherine L. B., Patton, E. Elizabeth, Goding, Colin R.

“…The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial…”
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miR-148 regulates Mitf in melanoma cells by Haflidadóttir, Benedikta S, Bergsteinsdóttir, Kristín, Praetorius, Christian, Steingrímsson, Eiríkur

“…The Microphthalmia associated transcription factor (Mitf) is an important regulator in melanocyte development and has been shown to be involved in melanoma…”
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Interpretation of complex phenotypes: lessons from the Mitf gene by Steingrimsson, Eirikur

“…Summary Mutations provide important structure–function relationships by allowing the correlation of phenotypes to the underlying genotypes. Knockout mutations…”
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Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif by Pogenberg, Vivian, Ballesteros-Álvarez, Josué, Schober, Romana, Sigvaldadóttir, Ingibjörg, Obarska-Kosinska, Agnieszka, Milewski, Morlin, Schindl, Rainer, Ögmundsdóttir, Margrét Helga, Steingrímsson, Eiríkur, Wilmanns, Matthias

“…Abstract Interrupted dimeric coiled coil segments are found in a broad range of proteins and generally confer selective functional properties such as binding…”
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