Search Results - "Steinfeldt, Tobias"

A non‐death function of the mitochondrial apoptosis apparatus in immunity by Brokatzky, Dominik, Dörflinger, Benedikt, Haimovici, Aladin, Weber, Arnim, Kirschnek, Susanne, Vier, Juliane, Metz, Arlena, Henschel, Julia, Steinfeldt, Tobias, Gentle, Ian E, Häcker, Georg

“…Apoptosis is a frequent form of programmed cell death, but the apoptotic signaling pathway can also be engaged at a low level, in the absence of cell death. We…”
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ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence by Singh, Shishir, Murillo-León, Mateo, Endres, Niklas Sebastian, Arenas Soto, Ailan Farid, Gómez-Marín, Jorge Enrique, Melbert, Florence, Kanneganti, Thirumala-Devi, Yamamoto, Masahiro, Campos, Claudia, Howard, Jonathan Charles, Taylor, Gregory Alan, Steinfeldt, Tobias

“…Toxoplasma gondii (T. gondii) is a zoonotic apicomplexan parasite that is an important cause of clinical disability in humans. On a global scale, one third of…”
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In vitro maturation of Toxoplasma gondii bradyzoites in human myotubes and their metabolomic characterization by Christiansen, Céline, Maus, Deborah, Hoppenz, Ellen, Murillo-León, Mateo, Hoffmann, Tobias, Scholz, Jana, Melerowicz, Florian, Steinfeldt, Tobias, Seeber, Frank, Blume, Martin

“…The apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections. However, current in vitro…”
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The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii by Howard, Jonathan C, Hunn, Julia P, Steinfeldt, Tobias

“…Highlights ► Up to 18 IRG proteins defend mice against Toxoplasma gondii and two Chlamydia species, but not against several other organisms. ► IRG proteins…”
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Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse by Lilue, Jingtao, Müller, Urs Benedikt, Steinfeldt, Tobias, Howard, Jonathan C

“…Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary…”
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Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice by Murillo-León, Mateo, Müller, Urs B., Zimmermann, Ines, Singh, Shishir, Widdershooven, Pia, Campos, Cláudia, Alvarez, Catalina, Könen-Waisman, Stephanie, Lukes, Nahleen, Ruzsics, Zsolt, Howard, Jonathan C., Schwemmle, Martin, Steinfeldt, Tobias

“…Some strains of the protozoan parasite Toxoplasma gondii (such as RH) are virulent in laboratory mice because they are not restricted by the Immunity-Related…”
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A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins by Fleckenstein, Martin C, Reese, Michael L, Könen-Waisman, Stephanie, Boothroyd, John C, Howard, Jonathan C, Steinfeldt, Tobias

“…The ability of mice to resist infection with the protozoan parasite, Toxoplasma gondii, depends in large part on the function of members of a complex family of…”
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Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii by Steinfeldt, Tobias, Könen-Waisman, Stephanie, Tong, Lan, Pawlowski, Nikolaus, Lamkemeyer, Tobias, Sibley, L David, Hunn, Julia P, Howard, Jonathan C

“…Virulence of complex pathogens in mammals is generally determined by multiple components of the pathogen interacting with the functional complexity and…”
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Author Correction: Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice by Murillo-León, Mateo, Müller, Urs B., Zimmermann, Ines, Singh, Shishir, Widdershoven, Pia, Campos, Claudia, Alvarez, Catalina, Könen-Waisman, Stephanie, Lukes, Nahleen, Ruzsics, Zsolt, Howard, Jonathan C., Schwemmle, Martin, Steinfeldt, Tobias

“…The original version of this Article contained an error in the Acknowledgements, which incorrectly omitted the following: ‘C.C., C.A., and J.C.H. were…”
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Demonstration of Nicking/Joining Activity at the Origin of DNA Replication Associated with the Rep and Rep′ Proteins of Porcine Circovirus Type 1 by STEINFELDT, Tobias, FINSTERBUSCH, Tim, MANKERTZ, Annette

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Functional Analysis of cis- and trans-Acting Replication Factors of Porcine Circovirus Type 1 by STEINFELDT, Tobias, FINSTERBUSCH, Tim, MANKERTZ, Annette

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Correction: Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii by Steinfeldt, Tobias, Könen-Waisman, Stephanie, Tong, Lan, Pawlowski, Nikolaus, Lamkemeyer, Tobias, Sibley, L David, Hunn, Julia P, Howard, Jonathan C

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New Reporter Gene-Based Replication Assay Reveals Exchangeability of Replication Factors of Porcine Circovirus Types 1 and 2 by Mankertz, Annette, Mueller, Bettina, Steinfeldt, Tobias, Schmitt, Cornelia, Finsterbusch, Tim

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Decoding Toxoplasma gondii virulence: the mechanisms of IRG protein inactivation by Murillo-Léon, Mateo, Bastidas-Quintero, Aura María, Steinfeldt, Tobias

“…IFN-γ-inducible immunity-related GTPases (IRG proteins) and guanylate binding proteins (GBP proteins) confer resistance against T. gondii by accumulating at…”
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Toxo XVII in the heart of Germany by Seeber, Frank, Blume, Martin, Dunay, Ildiko Rita, Lüder, Carsten, Meissner, Markus, Pernas, Lena, Schares, Gereon, Steinfeldt, Tobias

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The Toxoplasma gondii rhoptry protein ROP18 is an Irga6‐specific kinase and regulated by the dense granule protein GRA7 by Hermanns, Thomas, Müller, Urs B., Könen‐Waisman, Stephanie, Howard, Jonathan C., Steinfeldt, Tobias

“…Summary In mice, avirulent strains (e.g. types II and III) of the protozoan parasite Toxoplasma gondii are restricted by the immunity‐related GTPase (IRG)…”
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The arginine‐rich N‐terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii by Fentress, Sarah J., Steinfeldt, Tobias, Howard, Jonathan C., Sibley, L. David

“…Summary Toxoplasma gondii uses specialized secretory organelles called rhoptries to deliver virulence determinants into the host cell during parasite invasion…”
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Interaction of the replication proteins and the capsid protein of porcine circovirus type 1 and 2 with host proteins by Finsterbusch, Tim, Steinfeldt, Tobias, Doberstein, Kai, Rödner, Claudia, Mankertz, Annette

“…Abstract Porcine circovirus type 2 (PCV2) is an important pathogen in swine, whereas porcine circovirus type 1 (PCV1) is apathogenic. To analyze the…”
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Molecular biology of Porcine circovirus: analyses of gene expression and viral replication by Mankertz, Annette, Çaliskan, Rifat, Hattermann, Kim, Hillenbrand, Bernd, Kurzendoerfer, Petra, Mueller, Bettina, Schmitt, Cornelia, Steinfeldt, Tobias, Finsterbusch, Tim

“…The rep gene of Porcine circovirus type 1 directs the synthesis of two proteins. The full-length protein Rep is 312 amino acids in size, the spliced variant…”
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The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii: Acute virulence controlled by effector targeting by Fentress, Sarah J., Steinfeldt, Tobias, Howard, Jonathan C., Sibley, L. David

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