Search Results - "Steinfelder, Svenja"

Recent advances in understanding apicomplexan parasites by Seeber, Frank, Steinfelder, Svenja

“…Intracellular single-celled parasites belonging to the large phylum Apicomplexa are amongst the most prevalent and morbidity-causing pathogens worldwide. In…”
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Differential immunomodulation in human monocytes versus macrophages by filarial cystatin by Venugopal, Gopinath, Mueller, Marion, Hartmann, Susanne, Steinfelder, Svenja

“…Parasitic nematodes have evolved powerful immunomodulatory molecules to enable their survival in immunocompetent hosts by subverting immune responses and…”
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The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1) by Steinfelder, Svenja, Andersen, John F, Cannons, Jennifer L, Feng, Carl G, Joshi, Manju, Dwyer, Dennis, Caspar, Pat, Schwartzberg, Pamela L, Sher, Alan, Jankovic, Dragana

“…Schistosoma mansoni eggs contain factors that trigger potent Th2 responses in vivo and condition mouse dendritic cells (DCs) to promote Th2 lymphocyte…”
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Diplomatic Assistance: Can Helminth-Modulated Macrophages Act as Treatment for Inflammatory Disease? by Steinfelder, Svenja, O'Regan, Noëlle Louise, Hartmann, Susanne

“…Helminths have evolved numerous pathways to prevent their expulsion or elimination from the host to ensure long-term survival. During infection, they target…”
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The Host Peritoneal Cavity Harbors Prominent Memory Th2 and Early Recall Responses to an Intestinal Nematode by Yordanova, Ivet A, Jürchott, Karsten, Steinfelder, Svenja, Vogt, Katrin, Krüger, Ulrike, Kühl, Anja A, Sawitzki, Birgit, Hartmann, Susanne

“…Intestinal parasitic nematodes affect a quarter of the world's population, typically eliciting prominent effector Th2-driven host immune responses. As not all…”
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Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response by Ahmed, Norus, French, Timothy, Rausch, Sebastian, Kühl, Anja, Hemminger, Katrin, Dunay, Ildiko R, Steinfelder, Svenja, Hartmann, Susanne

“…Nematode infections, in particular gastrointestinal nematodes, are widespread and co-infections with other parasites and pathogens are frequently encountered…”
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The Worm-Specific Immune Response in Multiple Sclerosis Patients Receiving Controlled Trichuris suis Ova Immunotherapy by Yordanova, Ivet A, Ebner, Friederike, Schulz, Axel Ronald, Steinfelder, Svenja, Rosche, Berit, Bolze, Anna, Paul, Friedemann, Mei, Henrik E, Hartmann, Susanne

“…Considering their potent immunomodulatory properties, therapeutic applications of ova (TSO) are studied as potential alternative treatment of autoimmune…”
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Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses by O'Regan, Noëlle Louise, Steinfelder, Svenja, Venugopal, Gopinath, Rao, Gopala B, Lucius, Richard, Srikantam, Aparna, Hartmann, Susanne

“…Monocytes and macrophages contribute to the dysfunction of immune responses in human filariasis. During patent infection monocytes encounter microfilariae in…”
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A Novel Non-invasive Method to Detect RELM Beta Transcript in Gut Barrier Related Changes During a Gastrointestinal Nematode Infection by Ahmed, Norus, Heitlinger, Emanuel, Affinass, Nicole, Kühl, Anja A, Xenophontos, Natasa, Jarquin, Victor Hugo, Jost, Jenny, Steinfelder, Svenja, Hartmann, Susanne

“…Currently, methods for monitoring changes of gut barrier integrity and the associated immune response via non-invasive means are limited. Therefore, we aimed…”
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Pathogen-Reactive T Helper Cell Analysis in the Pig by Ebner, Friederike, Schwiertz, Patrycja, Steinfelder, Svenja, Pieper, Robert, Zentek, Jürgen, Schütze, Nicole, Baums, Christoph G, Alber, Gottfried, Geldhof, Peter, Hartmann, Susanne

“…There is growing interest in studying host-pathogen interactions in human-relevant large animal models such as the pig. Despite the progress in developing…”
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Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses by Nizzoli, Giulia, Krietsch, Jana, Weick, Anja, Steinfelder, Svenja, Facciotti, Federica, Gruarin, Paola, Bianco, Annalisa, Steckel, Bodo, Moro, Monica, Crosti, Mariacristina, Romagnani, Chiara, Stölzel, Katharina, Torretta, Sara, Pignataro, Lorenzo, Scheibenbogen, Carmen, Neddermann, Petra, De Francesco, Raffaele, Abrignani, Sergio, Geginat, Jens

“…Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8α+DC are specialized to cross-prime CD8+ T cells and produce…”
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A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation by Ziegler, Thomas, Rausch, Sebastian, Steinfelder, Svenja, Klotz, Christian, Hepworth, Matthew R, Kühl, Anja A, Burda, Paul-Christian, Lucius, Richard, Hartmann, Susanne

“…Immunomodulation is a common feature of chronic helminth infections and mainly attributed to the secretion of bioactive molecules, which target and modify host…”
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Intestinal helminth infection induces highly functional resident memory CD4+ T cells in mice by Steinfelder, Svenja, Rausch, Sebastian, Michael, Dörte, Kühl, Anja A., Hartmann, Susanne

“…Immunity to intestinal nematodes requires CD4⁺ Th2‐cell responses, including IL‐4 and IL‐13 production. Chronic infection with intestinal nematodes leads to…”
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Intestinal helminth infection induces highly functional resident memory CD4 super(+) T cells in mice by Steinfelder, Svenja, Rausch, Sebastian, Michael, Dorte, Kuehl, Anja A, Hartmann, Susanne

“…Immunity to intestinal nematodes requires CD4 Th2-cell responses, including IL-4 and IL-13 production. Chronic infection with intestinal nematodes leads to…”
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Association of a PD-L2 Gene Polymorphism with Chronic Lymphatic Filariasis in a South Indian Cohort by Venugopal, Gopinath, O'Regan, Noëlle L, Babu, Subash, Schumann, Ralf R, Srikantam, Aparna, Merle, Roswitha, Hartmann, Susanne, Steinfelder, Svenja

“…Lymphatic filariasis (LF) is a parasitic infection, caused by three closely related nematodes, namely , , and . Previously, we have shown that lysate from…”
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IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells by Kastirr, Ilko, Maglie, Stefano, Paroni, Moira, Alfen, Johanna Sophie, Nizzoli, Giulia, Sugliano, Elisa, Crosti, Maria-Cristina, Moro, Monica, Steckel, Bodo, Steinfelder, Svenja, Stölzel, Katharina, Romagnani, Chiara, Botti, Fiorenzo, Caprioli, Flavio, Pagani, Massimilliano, Abrignani, Sergio, Geginat, Jens

“…IL-21 promotes Th17 differentiation, and Th17 cells that upregulate T-bet, IFN-γ, and GM-CSF drive experimental autoimmune diseases in mice. Anti-IL-21…”
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A nematode immunomodulator suppresses grass pollen-specific allergic responses by controlling excessive Th2 inflammation by Daniłowicz-Luebert, Emilia, Steinfelder, Svenja, Kühl, Anja A., Drozdenko, Gennadiy, Lucius, Richard, Worm, Margitta, Hamelmann, Eckard, Hartmann, Susanne

“…[Display omitted] ► An animal model of allergic asthma using the clinically relevant allergen Phl p 5b was established. ► Filarial cystatin (AvCystatin) showed…”
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Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells by Steinfelder, Svenja, Floess, Stefan, Engelbert, Dirk, Haeringer, Barbara, Baron, Udo, Rivino, Laura, Steckel, Bodo, Gruetzkau, Andreas, Olek, Sven, Geginat, Jens, Huehn, Jochen, Hamann, Alf

“…CCR6 is a chemokine receptor expressed on Th17 cells and regulatory T cells that is induced by T-cell priming with certain cytokines, but how its expression…”
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CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function by Rivino, Laura, Gruarin, Paola, Häringer, Barbara, Steinfelder, Svenja, Lozza, Laura, Steckel, Bodo, Weick, Anja, Sugliano, Elisa, Jarrossay, David, Kühl, Anja A, Loddenkemper, Christoph, Abrignani, Sergio, Sallusto, Federica, Lanzavecchia, Antonio, Geginat, Jens

“…Interleukin (IL)-10 produced by regulatory T cell subsets is important for the prevention of autoimmunity and immunopathology, but little is known about the…”
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Modulation of Specific and Allergy-Related Immune Responses by Helminths by Daniłowicz-Luebert, Emilia, O'Regan, Noëlle L., Steinfelder, Svenja, Hartmann, Susanne

“…Helminths are master regulators of host immune responses utilising complex mechanisms to dampen host protective Th2-type responses and favour long-term…”
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