Search Results - "Steiner, Alexander"

Characterization of a rhabdomyosarcoma reveals a critical role for SMG7 in cancer cell viability and tumor growth by Steiner, Alexander J., Zheng, Yang, Tang, Yi

“…Soft-tissue sarcomas (STSs) are a rare and diverse group of mesenchymal cancers plagued with aggression, poor response to systemic therapy, and high rates of…”
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Microscale to manufacturing scale-up of cell-free cytokine production-a new approach for shortening protein production development timelines by Zawada, James F., Yin, Gang, Steiner, Alexander R., Yang, Junhao, Naresh, Alpana, Roy, Sushmita M., Gold, Daniel S., Heinsohn, Henry G., Murray, Christopher J.

“…Engineering robust protein production and purification of correctly folded biotherapeutic proteins in cell‐based systems is often challenging due to the…”
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Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System by Zimmerman, Erik S, Heibeck, Tyler H, Gill, Avinash, Li, Xiaofan, Murray, Christopher J, Madlansacay, Mary Rose, Tran, Cuong, Uter, Nathan T, Yin, Gang, Rivers, Patrick J, Yam, Alice Y, Wang, Willie D, Steiner, Alexander R, Bajad, Sunil U, Penta, Kalyani, Yang, Wenjin, Hallam, Trevor J, Thanos, Christopher D, Sato, Aaron K

“…Antibody–drug conjugates (ADCs) are a targeted chemotherapeutic currently at the cutting edge of oncology medicine. These hybrid molecules consist of a tumor…”
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Multisubunit tethering complexes in higher plants by Ravikumar, Raksha, Steiner, Alexander, Assaad, Farhah F

“…•Multisubunit tethering complexes (MTCs) can exist in a variety of modular forms.•Plant MTCs interact with small GTPases, SNAREs and Sec1/Munc18…”
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Patient-Reported Outcomes of Quality of Life, Functioning, and GI/Psychiatric Symptom Severity in Patients with Inflammatory Bowel Disease (IBD) by IsHak, Waguih W, Pan, Dana, Steiner, Alexander J, Feldman, Edward, Mann, Amy, Mirocha, James, Danovitch, Itai, Melmed, Gil Y

“…Patients with inflammatory bowel disease (IBD) are at risk for psychiatric disorders that impact symptom experience and health-related quality of life (HRQOL)…”
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Methods to Make Homogenous Antibody Drug Conjugates by Kline, Toni, Steiner, Alexander R., Penta, Kalyani, Sato, Aaron K., Hallam, Trevor J., Yin, Gang

“…Antibody drug conjugates (ADCs) have progressed from hypothesis to approved therapeutics in less than 30 years, and the technologies available to modify both…”
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Identification and characterization of a set of monocot BAHD monolignol transferases by Smith, Rebecca A, Beebe, Emily T, Bingman, Craig A, Vander Meulen, Kirk, Eugene, Alexis, Steiner, Alexander J, Karlen, Steven D, Ralph, John, Fox, Brian G

“…Plant BAHD acyltransferases perform a wide range of enzymatic tasks in primary and secondary metabolism. Acyl-CoA monolignol transferases, which couple a CoA…”
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Modular and predictable assembly of porous organic molecular crystals by Jones, James T. A., Hasell, Tom, Wu, Xiaofeng, Bacsa, John, Jelfs, Kim E., Schmidtmann, Marc, Chong, Samantha Y., Adams, Dave J., Trewin, Abbie, Schiffman, Florian, Cora, Furio, Slater, Ben, Steiner, Alexander, Day, Graeme M., Cooper, Andrew I.

“…Porous crystals made to order Controlling and predicting the structural properties of porous molecular crystals would have important implications in gas…”
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Ferroelectric Behavior of an Octahedral Metal‐Ligand Cage and Its 2D‐Connected Cage Framework by Prajesh, Neetu, Yadav, Ashok, Gourkhede, Rani, Praveenkumar, Balu, Steiner, Alexander, Boomishankar, Ramamoorthy

“…Supramolecular systems hold great potential as ferroelectric materials because they are easy to prepare and do not require toxic and environmentally damaging…”
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Plant Cytokinesis Is Orchestrated by the Sequential Action of the TRAPPII and Exocyst Tethering Complexes by Rybak, Katarzyna, Steiner, Alexander, Synek, Lukas, Klaeger, Susan, Kulich, Ivan, Facher, Eva, Wanner, Gerhard, Kuster, Bernhard, Zarsky, Viktor, Persson, Staffan, Assaad, Farhah F.

“…Plant cytokinesis is initiated in a transient membrane compartment, the cell plate, and completed by a process of maturation during which the cell plate…”
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Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain by Shcherbatko, Anatoly, Rossi, Andrea, Foletti, Davide, Zhu, Guoyun, Bogin, Oren, Galindo Casas, Meritxell, Rickert, Mathias, Hasa-Moreno, Adela, Bartsevich, Victor, Crameri, Andreas, Steiner, Alexander R., Henningsen, Robert, Gill, Avinash, Pons, Jaume, Shelton, David L., Rajpal, Arvind, Strop, Pavel

“…The prominent role of voltage-gated sodium channel 1.7 (Nav1.7) in nociception was revealed by remarkable human clinical and genetic evidence. Development of…”
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Malaria Derived Glycosylphosphatidylinositol Anchor Enhances Anti-Pfs25 Functional Antibodies That Block Malaria Transmission by Kapoor, Neeraj, Vanjak, Ivana, Rozzelle, James, Berges, Aym, Chan, Wei, Yin, Gang, Tran, Cuong, Sato, Aaron K, Steiner, Alexander R, Pham, Thao P, Birkett, Ashley J, Long, Carole A, Fairman, Jeff, Miura, Kazutoyo

“…Malaria, one of the most common vector borne human diseases, is a major world health issue. In 2015 alone, more than 200 million people were infected with…”
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Industry 4.0 In-Line AI Quality Control of Plastic Injection Molded Parts by Aminabadi, Saeid Saeidi, Tabatabai, Paul, Steiner, Alexander, Gruber, Dieter Paul, Friesenbichler, Walter, Habersohn, Christoph, Berger-Weber, Gerald

“…Automatic in-line process quality control plays a crucial role to enhance production efficiency in the injection molding industry. Industry 4.0 is leading the…”
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A simplified and robust protocol for immunoglobulin expression in Escherichia coli cell-free protein synthesis systems by Cai, Qi, Hanson, Jeffrey A., Steiner, Alexander R., Tran, Cuong, Masikat, Mary Rose, Chen, Rishard, Zawada, James F., Sato, Aaron K., Hallam, Trevor J., Yin, Gang

“…Cell‐free protein synthesis (CFPS) systems allow for robust protein expression with easy manipulation of conditions to improve protein yield and folding…”
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Interactions between Transport Protein Particle (TRAPP) complexes and Rab GTPases in Arabidopsis by Kalde, Monika, Elliott, Liam, Ravikumar, Raksha, Rybak, Katarzyna, Altmann, Melina, Klaeger, Susan, Wiese, Christian, Abele, Miriam, Al, Benjamin, Kalbfuß, Nils, Qi, Xingyun, Steiner, Alexander, Meng, Chen, Zheng, Huanquan, Kuster, Bernhard, Falter‐Braun, Pascal, Ludwig, Christina, Moore, Ian, Assaad, Farhah F.

“…Summary Transport Protein Particle II (TRAPPII) is essential for exocytosis, endocytosis, protein sorting and cytokinesis. In spite of a considerable…”
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Implementing Hydrogen Atom Transfer (HAT) Catalysis for Rapid and Selective Reductive Photoredox Transformations in Continuous Flow by Steiner, Alexander, Williams, Jason D., Rincón, Juan A, de Frutos, Oscar, Mateos, Carlos, Kappe, C. Oliver

“…The reductive transformation of aryl halides and carbonyl compounds is a key step in many photoredox transformations. By combining a highly reducing organic…”
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On-Off Porosity Switching in a Molecular Organic Solid by Jones, James T.A, Holden, Daniel, Mitra, Tamoghna, Hasell, Tom, Adams, Dave J, Jelfs, Kim E, Trewin, Abbie, Willock, David J, Day, Graeme M, Bacsa, John, Steiner, Alexander, Cooper, Andrew I

“…Pulling the old switcheroo: Microporosity can be switched “on” and “off” in a crystalline molecular organic solid composed of cage molecules (see scheme). The…”
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Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis by Ravikumar, Raksha, Kalbfuß, Nils, Gendre, Delphine, Steiner, Alexander, Altmann, Melina, Altmann, Stefan, Rybak, Katarzyna, Edelmann, Holger, Stephan, Friederike, Lampe, Marko, Facher, Eva, Wanner, Gerhard, Falter-Braun, Pascal, Bhalerao, Rishikesh P, Assaad, Farhah F

“…The trans-Golgi-network (TGN) has essential housekeeping functions in secretion, endocytosis and protein sorting, but also more specialized functions in plant…”
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Trazodone for Insomnia: A Systematic Review by Jaffer, Karim Yahia, Chang, Tiffany, Vanle, Brigitte, Dang, Jonathan, Steiner, Alexander J, Loera, Natalie, Abdelmesseh, Marina, Danovitch, Itai, Ishak, Waguih William

“…While trazodone is approved for the treatment of depression, the off-label use of this medication for insomnia has surpassed its usage as an antidepressant. In…”
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Aglycosylated antibodies and antibody fragments produced in a scalable in vitro transcription-translation system by Yin, Gang, Garces, Eudean D., Yang, Junhao, Zhang, Juan, Tran, Cuong, Steiner, Alexander R, Roos, Christine, Bajad, Sunil, Hudak, Susan, Penta, Kalyani, Zawada, James, Pollitt, Sonia, Murray, Christopher J.

“…We describe protein synthesis, folding and assembly of antibody fragments and full-length aglycosylated antibodies using an Escherichia coli-based open…”
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