Search Results - "Steindl, Theodora"

Parallel Screening:  A Novel Concept in Pharmacophore Modeling and Virtual Screening by Steindl, Theodora M, Schuster, Daniela, Laggner, Christian, Langer, Thierry

“…Parallel screening comprises a novel in silico method to predict the potential biological activities of a compound by screening it with a multitude of…”
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Pharmacophore Modeling and in Silico Screening for New P450 19 (Aromatase) Inhibitors by Schuster, Daniela, Laggner, Christian, Steindl, Theodora M, Palusczak, Anja, Hartmann, Rolf W, Langer, Thierry

“…Cytochrome P450 19 (P450 19, aromatase) constitutes a successful target for the treatment of breast cancer. This study analyzes chemical features common to…”
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Structure-Based Virtual Screening for the Discovery of Natural Inhibitors for Human Rhinovirus Coat Protein by Rollinger, Judith M, Steindl, Theodora M, Schuster, Daniela, Kirchmair, Johannes, Anrain, Kathrin, Ellmerer, Ernst P, Langer, Thierry, Stuppner, Hermann, Wutzler, Peter, Schmidtke, Michaela

“…Inhibitors of the human rhinovirus (HRV) coat protein are promising candidates to treat and prevent a number of upper respiratory diseases. The aim of this…”
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High-throughput structure-based pharmacophore modelling as a basis for successful parallel virtual screening by Steindl, Theodora M, Schuster, Daniela, Wolber, Gerhard, Laggner, Christian, Langer, Thierry

“…In order to assess bioactivity profiles for small organic molecules we propose to use parallel pharmacophore-based virtual screening. Our aim is to provide a…”
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Predicting drug metabolism induction in silico by Schuster, Daniela, Steindl, Theodora M, Langer, Thierry

“…The inducibility of drug-metabolizing enzymes and transporters by numerous xenobiotics has become a vital issue to be considered in the drug development…”
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Parallel Screening and Activity Profiling with HIV Protease Inhibitor Pharmacophore Models by Steindl, Theodora M, Schuster, Daniela, Laggner, Christian, Chuang, Karen, Hoffmann, Rémy D, Langer, Thierry

“…Parallel Screening has been introduced as an in silico method to predict the potential biological activities of compounds by screening them with a multitude of…”
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Evaluation of in vitro aldose redutase inhibitory activity of 5-arylidene-2,4-thiazolidinediones by Maccari, Rosanna, Ottanà, Rosaria, Ciurleo, Rosella, Vigorita, Maria Gabriella, Rakowitz, Dietmar, Steindl, Theodora, Langer, Thierry

“…A number of 5-arylidene-2,4-thiazolidinediones containing a hydroxy or a carboxymethoxy group in their 5-benzylidene moiety have been synthesised and evaluated…”
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Development and validation of an in silico P450 profiler based on pharmacophore models by Schuster, Daniela, Laggner, Christian, Steindl, Theodora M, Langer, Thierry

“…In today's drug discovery process, the very early consideration of ADME properties is aimed at a reduction of drug candidate drop out rate in later development…”
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Pharmacophore Modeling, Docking, and Principal Component Analysis Based Clustering:  Combined Computer-Assisted Approaches To Identify New Inhibitors of the Human Rhinovirus Coat Protein by Steindl, Theodora M, Crump, Carolyn E, Hayden, Frederick G, Langer, Thierry

“…The development and application of a sophisticated virtual screening and selection protocol to identify potential, novel inhibitors of the human rhinovirus…”
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Cleaning validation for blister packaging machines in an Austrian pharmacy by Steindl-Schönhuber, Theodora Maria, Trzaskowski, Adam, Gittler, Gunda

“…ObjectivesOur pharmacy works in accordance with the Good Manufacturing Practice in the area of multidose individual blister repackaging. This required…”
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5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases by Maccari, Rosanna, Paoli, Paolo, Ottanà, Rosaria, Jacomelli, Michela, Ciurleo, Rosella, Manao, Giampaolo, Steindl, Theodora, Langer, Thierry, Vigorita, Maria Gabriella, Camici, Guido

“…4-(5-Arylidene-2,4-dioxothiazolidin-3-yl)methylbenzoic acids ( 2) were synthesized and evaluated in vitro as inhibitors of PTP1B and LMW-PTP, two protein…”
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Influenza Virus Neuraminidase Inhibitors:  Generation and Comparison of Structure-Based and Common Feature Pharmacophore Hypotheses and Their Application in Virtual Screening by Steindl, Theodora, Langer, Thierry

“…X-ray crystallographic data of the influenza virus neuraminidase in complex with different inhibitors were used to generate chemical feature-based…”
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Structure–activity relationships and molecular modelling of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors by Maccari, Rosanna, Ottanà, Rosaria, Curinga, Carmela, Vigorita, Maria Gabriella, Rakowitz, Dietmar, Steindl, Theodora, Langer, Thierry

“…[Display omitted] The structure–activity relationships (SARs) of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors (ARIs) were extended…”
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Human Rhinovirus 3C Protease:  Generation of Pharmacophore Models for Peptidic and Nonpeptidic Inhibitors and Their Application in Virtual Screening by Steindl, Theodora, Laggner, Christian, Langer, Thierry

“…Three-dimensional pharmacophore models for peptidic and small organic nonpeptidic inhibitors of the human rhinovirus 3C protease were generated in a…”
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Parallel Screening: A Novel Concept in Pharmacophore Modeling and Virtual Screeningt by Steindl, Theodora M, Schuster, Daniela, Laggner, Christian, Langer, Thierry

“…Parallel screening comprises a novel in silico method to predict the potential biological activities of a compound by screening it with a multitude of…”
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TRICIN: A Phase II Trial on the Efficacy of Topical TRIchloroacetic Acid in Patients with Cervical Intraepithelial Neoplasia by Schwameis, Richard, Ganhoer-Schimboeck, Julia, Hadjari, Victoria Laudia, Hefler, Lukas, Bergmeister, Birgit, Küssel, Tatjana, Gittler, Gunda, Steindl-Schoenhuber, Theodora, Grimm, Christoph

“…Data on non-surgical treatment approaching persistent cervical intraepithelial neoplasia (CIN) are scarce. Retrospective analysis suggest high efficacy of…”
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Docking Versus Pharmacophore Model Generation: A Comparison of High-Throughput Virtual Screening Strategies for the Search of Human Rhinovirus Coat Protein Inhibitors by Steindl, Theodora, Langer, Thierry

“…Inhibition of the human rhinovirus coat protein is an intensively studied approach towards finding a therapy for common cold. We present the results of a…”
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DockingVersus Pharmacophore Model Generation: A Comparison of High-Throughput Virtual Screening Strategies for the Search of Human Rhinovirus Coat Protein Inhibitors by Steindl, Theodora, Langer, Thierry

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