Search Results - "Steinbusch, Harry"

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients by Chouliaras, Leonidas, Mastroeni, Diego, Delvaux, Elaine, Grover, Andrew, Kenis, Gunter, Hof, Patrick R, Steinbusch, Harry W.M, Coleman, Paul D, Rutten, Bart P.F, van den Hove, Daniel L.A

“…Abstract Epigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimer's disease (AD). Recent studies…”
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Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function by Njie, eMalick G, Boelen, Ellen, Stassen, Frank R, Steinbusch, Harry W.M, Borchelt, David R, Streit, Wolfgang J

“…Abstract To understand how microglial cell function may change with aging, various protocols have been developed to isolate microglia from the young and aged…”
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Developmental exposure to SSRIs, in addition to maternal stress, has long-term sex-dependent effects on hippocampal plasticity by Rayen, Ine, Gemmel, Mary, Pauley, Grace, Steinbusch, Harry W. M., Pawluski, Jodi L.

“…Rationale During pregnancy and postpartum period, 20 % of women are affected by depression, which is a growing health concern. Selective serotonin reuptake…”
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Neuronal Serotonin Release Triggers the Heat Shock Response in C. elegans in the Absence of Temperature Increase by Tatum, Marcus C., Ooi, Felicia K., Chikka, Madhusudana Rao, Chauve, Laetitia, Martinez-Velazquez, Luis A., Steinbusch, Harry W.M., Morimoto, Richard I., Prahlad, Veena

“…Cellular mechanisms aimed at repairing protein damage and maintaining homeostasis, widely understood to be triggered by the damage itself, have recently been…”
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Developmental fluoxetine exposure and prenatal stress alter sexual differentiation of the brain and reproductive behavior in male rat offspring by Rayen, Ine, Steinbusch, Harry W.M, Charlier, Thierry D, Pawluski, Jodi L

“…Summary Depression during pregnancy and postpartum is a significant health problem and affects up to 20% of women. While selective serotonin reuptake inhibitor…”
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Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson’s Disease? by Herrera, Andrea, Muñoz, Patricia, Steinbusch, Harry W. M, Segura-Aguilar, Juan

“…In 1967, L-dopa was introduced as part of the pharmacological therapy of Parkinson’s disease (PD) and, in spite of extensive research, no additional effective…”
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Nucleus accumbens and impulsivity by Basar, Koray, Sesia, Thibaut, Groenewegen, Henk, Steinbusch, Harry W M, Visser-Vandewalle, Veerle, Temel, Yasin

“…The multifaceted concept of impulsivity implies that different impulsivity aspects, mediated by different neural processes, influence behavior at different…”
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Measuring behavior in mice with chronic stress depression paradigm by Strekalova, Tatyana, Steinbusch, Harry W.M.

“…Many studies with chronic stress, a common depression paradigm, lead to inconsistent behavioral results. We are introducing a new model of stress-induced…”
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The epigenetics of aging and neurodegeneration by Lardenoije, Roy, Iatrou, Artemis, Kenis, Gunter, Kompotis, Konstantinos, Steinbusch, Harry W M, Mastroeni, Diego, Coleman, Paul, Lemere, Cynthia A, Hof, Patrick R, van den Hove, Daniel L A, Rutten, Bart P F

“…Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype. Epigenetics is of…”
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Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia by Soares, Lígia Mendes, De Vry, Jochen, Steinbusch, Harry W.M, Milani, Humberto, Prickaerts, Jos, Weffort de Oliveira, Rúbia M

“…Highlights • Rolipram improves cognition, reduces anxiety- and despair-like behaviors after BCCAO. • Rolipram decreases hippocampal neurodegeneration induced…”
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Delivery of peptide and protein drugs over the blood-brain barrier by Brasnjevic, Ivona, Steinbusch, Harry W M, Schmitz, Christoph, Martinez-Martinez, Pilar

“…Peptide and protein (P/P) drugs have been identified as showing great promises for the treatment of various neurodegenerative diseases. A major challenge in…”
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Selective phosphodiesterase inhibitors: a promising target for cognition enhancement by Reneerkens, Olga A. H., Rutten, Kris, Steinbusch, Harry W. M., Blokland, Arjan, Prickaerts, Jos

“…Rationale One of the major complaints most people face during aging is an impairment in cognitive functioning. This has a negative impact on the quality of…”
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Developmental fluoxetine exposure increases behavioral despair and alters epigenetic regulation of the hippocampal BDNF gene in adult female offspring by Boulle, Fabien, Pawluski, Jodi L., Homberg, Judith R., Machiels, Barbie, Kroeze, Yvet, Kumar, Neha, Steinbusch, Harry W.M., Kenis, Gunter, van den Hove, Daniel L.A.

“…A growing number of infants are exposed to selective serotonin reuptake inhibitor (SSRI) medications during the perinatal period. Perinatal exposure to SSRI…”
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Developmental fluoxetine exposure facilitates sexual behavior in female offspring by Rayen, Ine, Steinbusch, Harry W. M., Charlier, Thierry D., Pawluski, Jodi L.

“…Rationale A growing number of infants are being exposed to selective serotonin reuptake inhibitor (SSRI) medications during the perinatal period. SSRIs target…”
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5-HTT independent effects of fluoxetine on neuroplasticity by Levy, Marion J. F., Boulle, Fabien, Emerit, Michel Boris, Poilbout, Corinne, Steinbusch, Harry W. M., Van den Hove, Daniel L. A., Kenis, Gunter, Lanfumey, Laurence

“…Selective serotonin reuptake inhibitors are among the most prescribed antidepressants. Fluoxetine is the lead molecule which exerts its therapeutic effects, at…”
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Object recognition testing: Statistical considerations by Akkerman, Sven, Prickaerts, Jos, Steinbusch, Harry W.M., Blokland, Arjan

“…► Relative discrimination measure and investigation ratio are statistically identical. ► Absolute discrimination measures are more vulnerable to exploratory…”
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Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression by Levy, Marion J. F., Boulle, Fabien, Steinbusch, Harry W., van den Hove, Daniël L. A., Kenis, Gunter, Lanfumey, Laurence

“…Depression is a major health problem with a high prevalence and a heavy socioeconomic burden in western societies. It is associated with atrophy and impaired…”
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Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia by Koizumi, Takashi, Kerkhofs, Danielle, Mizuno, Toshiki, Steinbusch, Harry W M, Foulquier, Sébastien

“…Cerebral small vessels feed and protect the brain parenchyma thanks to the unique features of the blood-brain barrier. Cerebrovascular dysfunction is therefore…”
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Object recognition testing: Methodological considerations on exploration and discrimination measures by Akkerman, Sven, Blokland, Arjan, Reneerkens, Olga, van Goethem, Nick P., Bollen, Eva, Gijselaers, Hieronymus J.M., Lieben, Cindy K.J., Steinbusch, Harry W.M., Prickaerts, Jos

“…► Pre-experimental training prevents stress and habituation biases. ► No relation was found between sample trial exploration and memory performance. ► Test…”
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The Role of Vitamins in Neurodegenerative Disease: An Update by Rai, Sachchida Nand, Singh, Payal, Steinbusch, Harry W.M., Vamanu, Emanuel, Ashraf, Ghulam, Singh, Mohan Prasad

“…Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeostatic balance in humans and other animals. A deficiency in or…”
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