Search Results - "Steinbach, William J."

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium by Donnelly, J Peter, Chen, Sharon C, Kauffman, Carol A, Steinbach, William J, Baddley, John W, Verweij, Paul E, Clancy, Cornelius J, Wingard, John R, Lockhart, Shawn R, Groll, Andreas H, Sorrell, Tania C, Bassetti, Matteo, Akan, Hamdi, Alexander, Barbara D, Andes, David, Azoulay, Elie, Bialek, Ralf, Bradsher, Robert W, Bretagne, Stephane, Calandra, Thierry, Caliendo, Angela M, Castagnola, Elio, Cruciani, Mario, Cuenca-Estrella, Manuel, Decker, Catherine F, Desai, Sujal R, Fisher, Brian, Harrison, Thomas, Heussel, Claus Peter, Jensen, Henrik E, Kibbler, Christopher C, Kontoyiannis, Dimitrios P, Kullberg, Bart-Jan, Lagrou, Katrien, Lamoth, Frédéric, Lehrnbecher, Thomas, Loeffler, Jurgen, Lortholary, Olivier, Maertens, Johan, Marchetti, Oscar, Marr, Kieren A, Masur, Henry, Meis, Jacques F, Morrisey, C Orla, Nucci, Marcio, Ostrosky-Zeichner, Luis, Pagano, Livio, Patterson, Thomas F, Perfect, John R, Racil, Zdenek, Roilides, Emmanuel, Ruhnke, Marcus, Prokop, Cornelia Schaefer, Shoham, Shmuel, Slavin, Monica A, Stevens, David A, Thompson, George R, Vazquez, Jose A, Viscoli, Claudio, Walsh, Thomas J, Warris, Adilia, Wheat, L Joseph, White, P Lewis, Zaoutis, Theoklis E, Pappas, Peter G

“…Abstract Background Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases…”
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Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America by Patterson, Thomas F, Thompson, 3rd, George R, Denning, David W, Fishman, Jay A, Hadley, Susan, Herbrecht, Raoul, Kontoyiannis, Dimitrios P, Marr, Kieren A, Morrison, Vicki A, Nguyen, M Hong, Segal, Brahm H, Steinbach, William J, Stevens, David A, Walsh, Thomas J, Wingard, John R, Young, Jo-Anne H, Bennett, John E

“…It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment…”
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Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach by Juvvadi, Praveen R., Lee, Soo Chan, Heitman, Joseph, Steinbach, William J.

“…Increases in the incidence and mortality due to the major invasive fungal infections such as aspergillosis, candidiasis and cryptococcosis caused by the…”
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Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America by Patterson, Thomas F, Thompson, 3rd, George R, Denning, David W, Fishman, Jay A, Hadley, Susan, Herbrecht, Raoul, Kontoyiannis, Dimitrios P, Marr, Kieren A, Morrison, Vicki A, Nguyen, M Hong, Segal, Brahm H, Steinbach, William J, Stevens, David A, Walsh, Thomas J, Wingard, John R, Young, Jo-Anne H, Bennett, John E

“…It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment…”
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Epidemiology and Outcomes of Candidemia in 2019 Patients: Data from the Prospective Antifungal Therapy Alliance Registry by Horn, David L., Neofytos, Dionissios, Anaissie, Elias J., Fishman, Jay A., Steinbach, William J., Olyaei, Ali J., Marr, Kieren A., Pfaller, Michael A., Chang, Chi-Hsing, Webster, Karen M.

“…Background. Candidemia remains a major cause of morbidity and mortality in the health care setting, and the epidemiology of Candida infection is changing…”
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Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance by Cowen, Leah E, Steinbach, William J

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Guideline for the Management of Fever and Neutropenia in Children With Cancer and/or Undergoing Hematopoietic Stem-Cell Transplantation by LEHRNBECHER, Thomas, PHILLIPS, Robert, LEE DUPUIS, L, GIBSON, Faith, GROLL, Andreas H, GAUR, Aditya, GUPTA, Ajay, KEBUDI, Rejin, PETRILLI, Sérgio, STEINBACH, William J, VILLARROEL, Milena, ZAOUTIS, Theoklis, ALEXANDER, Sarah, LILLIAN SUNG, ALVARO, Frank, CARLESSE, Fabianne, FISHER, Brian, HAKIM, Hana, SANTOLAYA, Maria, CASTAGNOLA, Elio, DAVIS, Bonnie L

“…To develop an evidence-based guideline for the empiric management of pediatric fever and neutropenia (FN). The International Pediatric Fever and Neutropenia…”
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Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America by Walsh, Thomas J., Anaissie, Elias J., Denning, David W., Herbrecht, Raoul, Kontoyiannis, Dimitrios P., Marr, Kieren A., Morrison, Vicki A., Segal, Brahm H, Steinbach, William J., Stevens, David A., van Burik, Jo-Anne, Wingard, John R., Patterson, Thomas F.

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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents by Juvvadi, Praveen R., Fox, David, Bobay, Benjamin G., Hoy, Michael J., Gobeil, Sophie M. C., Venters, Ronald A., Chang, Zanetta, Lin, Jackie J., Averette, Anna Floyd, Cole, D. Christopher, Barrington, Blake C., Wheaton, Joshua D., Ciofani, Maria, Trzoss, Michael, Li, Xiaoming, Lee, Soo Chan, Chen, Ying-Lien, Mutz, Mitchell, Spicer, Leonard D., Schumacher, Maria A., Heitman, Joseph, Steinbach, William J.

“…Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive…”
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Heat Shock Protein 90 Is Required for Conidiation and Cell Wall Integrity in Aspergillus fumigatus by Lamoth, Frédéric, Juvvadi, Praveen R, Fortwendel, Jarrod R, Steinbach, William J

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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In Vitro Activity of Calcineurin and Heat Shock Protein 90 Inhibitors against Aspergillus fumigatus Azole- and Echinocandin-Resistant Strains by LAMOTH, Frederic, JUVVADI, Praveen R, GEHRKE, Christopher, STEINBACH, William J

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Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis by Lamoth, Frédéric, Juvvadi, Praveen R, Steinbach, William J

“…Invasive aspergillosis (IA) is a life-threatening infection due to Aspergillus fumigatus and other Aspergillus spp. Drugs targeting the fungal cell membrane…”
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Pediatric Invasive Aspergillosis: A Multicenter Retrospective Analysis of 139 Contemporary Cases by Burgos, Ana, Zaoutis, Theoklis E, Dvorak, Christopher C, Hoffman, Jill A, Knapp, Katherine M, Nania, Joseph J, Prasad, Priya, Steinbach, William J

“…Invasive aspergillosis is a major cause of morbidity and mortality in immunocompromised children. Invasive aspergillosis has been well characterized in adults;…”
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Transcriptional Activation of Heat Shock Protein 90 Mediated Via a Proximal Promoter Region as Trigger of Caspofungin Resistance in Aspergillus fumigatus by Lamoth, Frédéric, Juvvadi, Praveen R., Gehrke, Christopher, Asfaw, Yohannes G., Steinbach, William J.

“…Invasive aspergillosis is a deadly infection for which new antifungal therapies are needed. Heat shock protein 90 (Hsp90) is an essential chaperone in…”
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Are we there yet? Recent progress in the molecular diagnosis and novel antifungal targeting of Aspergillus fumigatus and invasive aspergillosis by Steinbach, William J

“…  First reported in 2008 [3], it is an immunochromotographic assay based on a mouse Mab that binds to a yet-unknown protein epitope present on an extracellular…”
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Transcriptional Regulation of Chitin Synthases by Calcineurin Controls Paradoxical Growth of Aspergillus fumigatus in Response to Caspofungin by FORTWENDEL, Jarrod R, JUWADI, Praveen R, PERFECT, B. Zachary, ROGG, Luise E, PERFECT, John R, STEINBACH, William J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Review of Newer Antifungal and Immunomodulatory Strategies for Invasive Aspergillosis by Steinbach, William J., Stevens, David A.

“…The incidence of invasive aspergillosis is markedly increasing, and mortality remains dismal. Previously there were only 2 antifungals with activity against…”
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Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22-modified FK520 analog against C. neoformans by Rivera, Angela, Young Lim, Won, Park, Eunchong, Dome, Patrick A, Hoy, Michael J, Spasojevic, Ivan, Sun, Sheng, Averette, Anna Floyd, Pina-Oviedo, Sergio, Juvvadi, Praveen R, Steinbach, William J, Ciofani, Maria, Hong, Jiyong, Heitman, Joseph

“…Fungal infections cause significant morbidity and mortality globally. The therapeutic armamentarium against these infections is limited, and the development of…”
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Combination and Sequential Antifungal Therapy for Invasive Aspergillosis: Review of Published In Vitro and In Vivo Interactions and 6281 Clinical Cases from 1966 to 2001 by Steinbach, William J., Stevens, David A., Denning, David W.

“…The development of newer antifungal drugs is creating new potential combination therapies to combat the dismal mortality rate associated with invasive…”
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Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs by Gobeil, Sophie M-C, Bobay, Benjamin G, Juvvadi, Praveen R, Cole, D Christopher, Heitman, Joseph, Steinbach, William J, Venters, Ronald A, Spicer, Leonard D

“…Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically…”
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