Search Results - "Stein, Jens"

Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality by Novkovic, Mario, Onder, Lucas, Cupovic, Jovana, Abe, Jun, Bomze, David, Cremasco, Viviana, Scandella, Elke, Stein, Jens V, Bocharov, Gennady, Turley, Shannon J, Ludewig, Burkhard

“…Fibroblastic reticular cells (FRCs) form the cellular scaffold of lymph nodes (LNs) and establish distinct microenvironmental niches to provide key molecules…”
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Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity by Chai, Qian, Onder, Lucas, Scandella, Elke, Gil-Cruz, Cristina, Perez-Shibayama, Christian, Cupovic, Jovana, Danuser, Renzo, Sparwasser, Tim, Luther, Sanjiv A., Thiel, Volker, Rülicke, Thomas, Stein, Jens V., Hehlgans, Thomas, Ludewig, Burkhard

“…The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR)…”
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How chemokines invite leukocytes to dance by Thelen, Marcus, Stein, Jens V

“…A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here we summarize recent findings on the initial steps in chemokine…”
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The outer mucus layer hosts a distinct intestinal microbial niche by Li, Hai, Limenitakis, Julien P., Fuhrer, Tobias, Geuking, Markus B., Lawson, Melissa A., Wyss, Madeleine, Brugiroux, Sandrine, Keller, Irene, Macpherson, Jamie A., Rupp, Sandra, Stolp, Bettina, Stein, Jens V., Stecher, Bärbel, Sauer, Uwe, McCoy, Kathy D., Macpherson, Andrew J.

“…The overall composition of the mammalian intestinal microbiota varies between individuals: within each individual there are differences along the length of the…”
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Organ-Specific Surveillance and Long-Term Residency Strategies Adapted by Tissue-Resident Memory CD8 + T Cells by Stein, Jens V, Ruef, Nora, Wissmann, Stefanie

“…Tissue-resident CD8 T cells (CD8 T ) populate lymphoid and non-lymphoid tissues after infections as first line of defense against re-emerging pathogens. To…”
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The Dual Role of High Endothelial Venules in Cancer Progression versus Immunity by Milutinovic, Stefan, Abe, Jun, Godkin, Andrew, Stein, Jens V, Gallimore, Awen

“…Secondary lymphoid organs (SLOs) are important initiators and regulators of immunity. To carry out this function, the blood vasculature must deliver oxygen and…”
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Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells by Hons, Miroslav, Kopf, Aglaja, Hauschild, Robert, Leithner, Alexander, Gaertner, Florian, Abe, Jun, Renkawitz, Jörg, Stein, Jens V., Sixt, Michael

“…Although much is known about the physiological framework of T cell motility, and numerous rate-limiting molecules have been identified through loss-of-function…”
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Multitier mechanics control stromal adaptations in the swelling lymph node by Assen, Frank P., Abe, Jun, Hons, Miroslav, Hauschild, Robert, Shamipour, Shayan, Kaufmann, Walter A., Costanzo, Tommaso, Krens, Gabriel, Brown, Markus, Ludewig, Burkhard, Hippenmeyer, Simon, Heisenberg, Carl-Philipp, Weninger, Wolfgang, Hannezo, Edouard, Luther, Sanjiv A., Stein, Jens V., Sixt, Michael

“…Lymph nodes (LNs) comprise two main structural elements: fibroblastic reticular cells that form dedicated niches for immune cell interaction and capsular…”
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DOCK2 and phosphoinositide-3 kinase δ mediate two complementary signaling pathways for CXCR5-dependent B cell migration by Wissmann, Stefanie, Stolp, Bettina, Jímenez, Ana Marcos, Stein, Jens V

“…Naive B cells use the chemokine receptor CXCR5 to enter B cell follicles, where they scan CXCL13-expressing ICAM-1 VCAM-1 follicular dendritic cells (FDCs) for…”
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Regulation of global CD8+ T‐cell positioning by the actomyosin cytoskeleton by Stein, Jens V., Ruef, Nora

“…Summary CD8+ T cells have evolved as one of the most motile mammalian cell types, designed to continuously scan peptide–major histocompatibility complexes…”
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Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse by Leithner, Alexander, Altenburger, Lukas M, Hauschild, Robert, Assen, Frank P, Rottner, Klemens, Stradal, Theresia E B, Diz-Muñoz, Alba, Stein, Jens V, Sixt, Michael

“…Dendritic cells (DCs) are crucial for the priming of naive T cells and the initiation of adaptive immunity. Priming is initiated at a heterologous cell-cell…”
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Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation by Onder, Lucas, Danuser, Renzo, Scandella, Elke, Firner, Sonja, Chai, Qian, Hehlgans, Thomas, Stein, Jens V, Ludewig, Burkhard

“…The development of lymph nodes (LNs) and formation of LN stromal cell microenvironments is dependent on lymphotoxin-β receptor (LTβR) signaling. In particular,…”
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CD169 + macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling by Camara, Abdouramane, Lavanant, Alice C, Abe, Jun, Desforges, Henri Lee, Alexandre, Yannick O, Girardi, Erika, Igamberdieva, Zinaida, Asano, Kenichi, Tanaka, Masato, Hehlgans, Thomas, Pfeffer, Klaus, Pfeffer, Sébastien, Mueller, Scott N, Stein, Jens V, Mueller, Christopher G

“…CD169 macrophages reside in lymph node (LN) and spleen and play an important role in the immune defense against pathogens. As resident macrophages, they are…”
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The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis by Thelen, Flavian, Wissmann, Stefanie, Ruef, Nora, Stein, Jens V

“…Naïve T cells (T ) constitutively recirculate through secondary lymphatic organs (SLOs), where they scan dendritic cells (DCs) for cognate peptide-loaded major…”
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pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion by Ozga, Aleksandra J, Moalli, Federica, Abe, Jun, Swoger, Jim, Sharpe, James, Zehn, Dietmar, Kreutzfeldt, Mario, Merkler, Doron, Ripoll, Jorge, Stein, Jens V

“…During adaptive immune responses, CD8 T cells with low TCR affinities are released early into the circulation before high-affinity clones become dominant at…”
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3D imaging of undissected optically cleared Anopheles stephensi mosquitoes and midguts infected with Plasmodium parasites by De Niz, Mariana, Kehrer, Jessica, Brancucci, Nicolas M B, Moalli, Federica, Reynaud, Emmanuel G, Stein, Jens V, Frischknecht, Friedrich

“…Malaria is a life-threatening disease, caused by Apicomplexan parasites of the Plasmodium genus. The Anopheles mosquito is necessary for the sexual replication…”
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B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice by Hayward, Darryl A, Vanes, Lesley, Wissmann, Stefanie, Sivapatham, Sujana, Hartweger, Harald, O'May, Joshua Biggs, de Boer, Leonard L, Mitter, Richard, Köchl, Robert, Stein, Jens V, Tybulewicz, Victor L J

“…Migration and adhesion play critical roles in B cells, regulating recirculation between lymphoid organs, migration within lymphoid tissue, and interaction with…”
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Dynamic spherical harmonics approach for shape classification of migrating cells by Medyukhina, Anna, Blickensdorf, Marco, Cseresnyés, Zoltán, Ruef, Nora, Stein, Jens V., Figge, Marc Thilo

“…Cell migration involves dynamic changes in cell shape. Intricate patterns of cell shape can be analyzed and classified using advanced shape descriptors,…”
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DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses by Harada, Yosuke, Tanaka, Yoshihiko, Terasawa, Masao, Pieczyk, Markus, Habiro, Katsuyoshi, Katakai, Tomoya, Hanawa-Suetsugu, Kyoko, Kukimoto-Niino, Mutsuko, Nishizaki, Tomoko, Shirouzu, Mikako, Duan, Xuefeng, Uruno, Takehito, Nishikimi, Akihiko, Sanematsu, Fumiyuki, Yokoyama, Shigeyuki, Stein, Jens V., Kinashi, Tatsuo, Fukui, Yoshinori

“…To migrate efficiently through the interstitium, dendritic cells (DCs) constantly adapt their shape to the given structure of the extracellular matrix and…”
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Dopamine, sleep, and neuronal excitability modulate amyloid-β-mediated forgetting in Drosophila by Kaldun, Jenifer C, Lone, Shahnaz R, Humbert Camps, Ana M, Fritsch, Cornelia, Widmer, Yves F, Stein, Jens V, Tomchik, Seth M, Sprecher, Simon G

“…Alzheimer disease (AD) is one of the main causes of age-related dementia and neurodegeneration. However, the onset of the disease and the mechanisms causing…”
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