Search Results - "Stein, Ilan"

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma by Finkin, Shlomi, Yuan, Detian, Stein, Ilan, Taniguchi, Koji, Weber, Achim, Unger, Kristian, Browning, Jeffrey L, Goossens, Nicolas, Nakagawa, Shigeki, Gunasekaran, Ganesh, Schwartz, Myron E, Kobayashi, Masahiro, Kumada, Hiromitsu, Berger, Michael, Pappo, Orit, Rajewsky, Klaus, Hoshida, Yujin, Karin, Michael, Heikenwalder, Mathias, Ben-Neriah, Yinon, Pikarsky, Eli

“…Ectopic lymphoid structures develop at sites of chronic inflammation and are generally thought to be beneficial in the control of cancer. Pikarsky and…”
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Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development by Shilo, Asaf, Ben Hur, Vered, Denichenko, Polina, Stein, Ilan, Pikarsky, Eli, Rauch, Jens, Kolch, Walter, Zender, Lars, Karni, Rotem

“…In recent years, it has become clear that splicing factors play a direct role in cancer development. We showed previously that splicing factors SRSF1, SRSF6,…”
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Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment by Horwitz, Elad, Stein, Ilan, Andreozzi, Mariacarla, Nemeth, Julia, Shoham, Avivit, Pappo, Orit, Schweitzer, Nora, Tornillo, Luigi, Kanarek, Naama, Quagliata, Luca, Zreik, Farid, Porat, Rinnat M, Finkelstein, Rutie, Reuter, Hendrik, Koschny, Ronald, Ganten, Tom, Mogler, Carolin, Shibolet, Oren, Hess, Jochen, Breuhahn, Kai, Grunewald, Myriam, Schirmacher, Peter, Vogel, Arndt, Terracciano, Luigi, Angel, Peter, Ben-Neriah, Yinon, Pikarsky, Eli

“…Death rates from hepatocellular carcinoma (HCC) are steadily increasing, yet therapeutic options for advanced HCC are limited. We identify a subset of mouse…”
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PI3K/AKT/mTOR‐dependent stabilization of oncogenic far‐upstream element binding proteins in hepatocellular carcinoma cells by Samarin, Jana, Laketa, Vibor, Malz, Mona, Roessler, Stephanie, Stein, Ilan, Horwitz, Elad, Singer, Stephan, Dimou, Eleni, Cigliano, Antonio, Bissinger, Michaela, Falk, Christine Susanne, Chen, Xin, Dooley, Steven, Pikarsky, Eli, Calvisi, Diego Francesco, Schultz, Carsten, Schirmacher, Peter, Breuhahn, Kai

“…Transcription factors of the far‐upstream element‐binding protein (FBP) family represent cellular pathway hubs, and their overexpression in liver cancer…”
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Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation‐associated liver carcinogenesis in mice by Pusterla, Tobias, Nèmeth, Julia, Stein, Ilan, Wiechert, Lars, Knigin, David, Marhenke, Silke, Longerich, Thomas, Kumar, Varun, Arnold, Bernd, Vogel, Arndt, Bierhaus, Angelika, Pikarsky, Eli, Hess, Jochen, Angel, Peter

“…The receptor for advanced glycation endproducts (RAGE) is a multiligand receptor and member of the immunoglobulin superfamily. RAGE is mainly involved in…”
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Extensive elimination of acinar cells during normal postnatal pancreas growth by Stolovich-Rain, Miri, Fridlich, Ori, Azulai, Shira, Klochendler, Agnes, Anzi, Shira, Magenheim, Judith, Stein, Ilan, Mushasha, Fatima, Glaser, Benjamin, Pikarsky, Eli, Ben-Zvi, Danny, Dor, Yuval

“…While programmed cell death plays important roles during morphogenetic stages of development, post-differentiation organ growth is considered an efficient…”
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S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis by Németh, Julia, Stein, Ilan, Haag, Daniel, Riehl, Astrid, Longerich, Thomas, Horwitz, Elad, Breuhahn, Kai, Gebhardt, Christoffer, Schirmacher, Peter, Hahn, Meinhard, Ben‐Neriah, Yinon, Pikarsky, Eli, Angel, Peter, Hess, Jochen

“…The nuclear factor‐kappaB (NF‐κB) signaling pathway has been recently shown to participate in inflammation‐induced cancer progression. Here, we describe a…”
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Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation by Hefetz-Sela, Simona, Stein, Ilan, Klieger, Yair, Porat, Rinnat, Sade-Feldman, Moshe, Zreik, Farid, Nagler, Arnon, Pappo, Orit, Quagliata, Luca, Dazert, Eva, Eferl, Robert, Terracciano, Luigi, Wagner, Erwin F., Ben-Neriah, Yinon, Baniyash, Michal, Pikarsky, Eli

“…The inflamed tumor microenvironment plays a critical role in tumorigenesis. However, the mechanisms through which immune cells, particularly macrophages,…”
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Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome by Zaaroor-Regev, Daphna, de Bie, Prim, Scheffner, Martin, Noy, Tahel, Shemer, Ruth, Heled, Maya, Stein, Ilan, Pikarsky, Eli, Ciechanover, Aaron

“…The polycomb repressive complex (PRC) 1 protein Ring1B is an ubiquitin ligase that modifies nucleosomal histone H2A, a modification which plays a critical role…”
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Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation by Maimon, Avraham, Mogilevsky, Maxim, Shilo, Asaf, Golan-Gerstl, Regina, Obiedat, Akram, Ben-Hur, Vered, Lebenthal-Loinger, Ilana, Stein, Ilan, Reich, Reuven, Beenstock, Jonah, Zehorai, Eldar, Andersen, Claus L., Thorsen, Kasper, Ørntoft, Torben F., Davis, Roger J., Davidson, Ben, Mu, David, Karni, Rotem

“…The kinase Mnk2 is a substrate of the MAPK pathway and phosphorylates the translation initiation factor eIF4E. In humans, MKNK2, the gene encoding for Mnk2, is…”
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High SEPT9_i1 protein expression is associated with high-grade prostate cancers by Gilad, Roni, Meir, Karen, Stein, Ilan, German, Larissa, Pikarsky, Eli, Mabjeesh, Nicola J

“…Septins are a family of GTP-binding cytoskeleton proteins expressed in many solid tumors. Septin 9 (SEPT9) in particular was found overexpressed in diverse…”
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The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers by Darash-Yahana, Merav, Gillespie, John W, Hewitt, Stephen M, Chen, Yun-Yun K, Maeda, Shin, Stein, Ilan, Singh, Satya P, Bedolla, Roble B, Peled, Amnon, Troyer, Dean A, Pikarsky, Eli, Karin, Michael, Farber, Joshua M

“…Clinical observations and mouse models have suggested that inflammation can be pro-tumorigenic. Since chemokines are critical in leukocyte trafficking, we…”
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Genome-wide analysis of androgen receptor targets reveals COUP-TF1 as a novel player in human prostate cancer by Perets, Ruth, Kaplan, Tommy, Stein, Ilan, Hidas, Guy, Tayeb, Shay, Avraham, Eti, Ben-Neriah, Yinon, Simon, Itamar, Pikarsky, Eli

“…Androgen activity plays a key role in prostate cancer progression. Androgen receptor (AR) is the main mediator of androgen activity in the prostate, through…”
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Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia by Stein, Ilan, Itin, Ahuva, Einat, Paz, Skaliter, Rami, Grossman, Zehava, Keshet, Eli

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2 by Malakar, Pushkar, Stein, Ilan, Saragovi, Amijai, Winkler, Roni, Stern-Ginossar, Noam, Berger, Michael, Pikarsky, Eli, Karni, Rotem

“…Reprogrammed glucose metabolism of enhanced aerobic glycolysis (or the Warburg effect) is known as a hallmark of cancer. The roles of long noncoding RNAs…”
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Sequence-based Design of Kinase Inhibitors Applicable for Therapeutics and Target Identification by Niv, Masha Y., Rubin, Hila, Cohen, Jacob, Tsirulnikov, Lilia, Licht, Tamar, Peretzman-Shemer, Adi, Cna'an, Einat, Tartakovsky, Alexander, Stein, Ilan, Albeck, Shira, Weinstein, Irina, Goldenberg-Furmanov, Mirela, Tobi, Dror, Cohen, Einat, Laster, Morris, Ben-Sasson, Shmuel A., Reuveni, Hadas

“…A platform for specifically modulating kinase-dependent signaling using peptides derived from the catalytic domain of the kinase is presented. This technology,…”
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miRNA-Guided Imaging and Photodynamic Therapy Treatment of Cancer Cells Using Zn(II)-Protoporphyrin IX-Loaded Metal–Organic Framework Nanoparticles by Zhang, Pu, Ouyang, Yu, Sohn, Yang Sung, Fadeev, Michael, Karmi, Ola, Nechushtai, Rachel, Stein, Ilan, Pikarsky, Eli, Willner, Itamar

“…An analytical platform for the selective miRNA-21-guided imaging of breast cancer cells and miRNA-221-guided imaging of ovarian cancer cells and the selective…”
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Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation by Malakar, Pushkar, Shilo, Asaf, Mogilevsky, Adi, Stein, Ilan, Pikarsky, Eli, Nevo, Yuval, Benyamini, Hadar, Elgavish, Sharona, Zong, Xinying, Prasanth, Kannanganattu V, Karni, Rotem

“…Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise contributions to oncogenesis are still emerging. Here we report that the lncRNA…”
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UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma by Wolf, Yochai, Bartok, Osnat, Patkar, Sushant, Eli, Gitit Bar, Cohen, Sapir, Litchfield, Kevin, Levy, Ronen, Jiménez-Sánchez, Alejandro, Trabish, Sophie, Lee, Joo Sang, Karathia, Hiren, Barnea, Eilon, Day, Chi-Ping, Cinnamon, Einat, Stein, Ilan, Solomon, Adam, Bitton, Lital, Pérez-Guijarro, Eva, Dubovik, Tania, Shen-Orr, Shai S., Miller, Martin L., Merlino, Glenn, Levin, Yishai, Pikarsky, Eli, Eisenbach, Lea, Admon, Arie, Swanton, Charles, Ruppin, Eytan, Samuels, Yardena

“…Although clonal neo-antigen burden is associated with improved response to immune therapy, the functional basis for this remains unclear. Here we study this…”
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microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis by Roy, Sanchari, Hooiveld, Guido J., Seehawer, Marco, Caruso, Stefano, Heinzmann, Florian, Schneider, Anne T., Frank, Anna K., Cardenas, David Vargas, Sonntag, Roland, Luedde, Mark, Trautwein, Christian, Stein, Ilan, Pikarsky, Eli, Loosen, Sven, Tacke, Frank, Ringelhan, Marc, Avsaroglu, Seda Kilinc, Goga, Andrei, Buendia, Marie-Annick, Vucur, Mihael, Heikenwalder, Mathias, Zucman-Rossi, Jessica, Zender, Lars, Roderburg, Christoph, Luedde, Tom

“…We performed an integrated analysis to identify microRNAs (miRNAs) and messenger RNAs (mRNAs) with altered expression in liver tumors from 3 mouse models of…”
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