Search Results - "Steijaert, Marvin"

Large-scale comparison of machine learning methods for drug target prediction on ChEMBL by Mayr, Andreas, Klambauer, Günter, Unterthiner, Thomas, Steijaert, Marvin, Wegner, Jörg K, Ceulemans, Hugo, Clevert, Djork-Arné, Hochreiter, Sepp

“…Deep learning is currently the most successful machine learning technique in a wide range of application areas and has recently been applied successfully in…”
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Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery by Simm, Jaak, Klambauer, Günter, Arany, Adam, Steijaert, Marvin, Wegner, Jörg Kurt, Gustin, Emmanuel, Chupakhin, Vladimir, Chong, Yolanda T, Vialard, Jorge, Buijnsters, Peter, Velter, Ingrid, Vapirev, Alexander, Singh, Shantanu, Carpenter, Anne E, Wuyts, Roel, Hochreiter, Sepp, Moreau, Yves, Ceulemans, Hugo

“…In both academia and the pharmaceutical industry, large-scale assays for drug discovery are expensive and often impractical, particularly for the increasingly…”
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Synaptic transmission from horizontal cells to cones is impaired by loss of connexin hemichannels by Klaassen, Lauw J, Sun, Ziyi, Steijaert, Marvin N, Bolte, Petra, Fahrenfort, Iris, Sjoerdsma, Trijntje, Klooster, Jan, Claassen, Yvonne, Shields, Colleen R, Ten Eikelder, Huub M M, Janssen-Bienhold, Ulrike, Zoidl, Georg, McMahon, Douglas G, Kamermans, Maarten

“…In the vertebrate retina, horizontal cells generate the inhibitory surround of bipolar cells, an essential step in contrast enhancement. For the last decades,…”
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Decoding NMDA Receptor Signaling: Identification of Genomic Programs Specifying Neuronal Survival and Death by Zhang, Sheng-Jia, Steijaert, Marvin N., Lau, David, Schütz, Günther, Delucinge-Vivier, Celine, Descombes, Patrick, Bading, Hilmar

“…NMDA receptors promote neuronal survival but also cause cell degeneration and neuron loss. The mechanisms underlying these opposite effects on neuronal fate…”
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DARTpaths, an in silico platform to investigate molecular mechanisms of compounds by Bhalla, Diksha, Steijaert, Marvin N, Poppelaars, Eefje S, Teunis, Marc, van der Voet, Monique, Corradi, Marie, Dévière, Elisabeth, Noothout, Luke, Tomassen, Wilco, Rooseboom, Martijn, Currie, Richard A, Krul, Cyrille, Pieters, Raymond, van Noort, Vera, Wildwater, Marjolein

“…Abstract Summary Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating…”
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Hemichannel-mediated and pH-based feedback from horizontal cells to cones in the vertebrate retina by Fahrenfort, Iris, Steijaert, Marvin, Sjoerdsma, Trijntje, Vickers, Evan, Ripps, Harris, van Asselt, Jorrit, Endeman, Duco, Klooster, Jan, Numan, Robert, ten Eikelder, Huub, von Gersdorff, Henrique, Kamermans, Maarten

“…Recent studies designed to identify the mechanism by which retinal horizontal cells communicate with cones have implicated two processes. According to one…”
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Systems biology of resilience and optimal health: integrating Chinese and Western medicine perspectives by van Wietmarschen, Herman, Schro雗, Yan, Kallen, Victor, Steijaert, Marvin, A. de Graaf, Albert, van Ommena and Jan van der Greef, Ben

“…Western science has been strong in measuring details of biological systems such as gene expression levels and metabolite concentrations, and has generally…”
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Scaling machine learning for target prediction in drug discovery using Apache Spark by Harnie, Dries, Saey, Mathijs, Vapirev, Alexander E., Wegner, Jörg Kurt, Gedich, Andrey, Steijaert, Marvin, Ceulemans, Hugo, Wuyts, Roel, De Meuter, Wolfgang

“…In the context of drug discovery, a key problem is the identification of candidate molecules that affect proteins associated with diseases. Inside Janssen…”
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Large-scale comparison of machine learning methods for drug target prediction on ChEMBLElectronic supplementary information (ESI) available: Overview, Data Collection and Clustering, Methods, Results, Appendix. See DOI: 10.1039/c8sc00148k by Mayr, Andreas, Klambauer, Günter, Unterthiner, Thomas, Steijaert, Marvin, Wegner, Jörg K, Ceulemans, Hugo, Clevert, Djork-Arné, Hochreiter, Sepp

“…Deep learning is currently the most successful machine learning technique in a wide range of application areas and has recently been applied successfully in…”
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Large-scale comparison of machine learning methods for drug target prediction on ChEMBL† †Electronic supplementary information (ESI) available: Overview, Data Collection and Clustering, Methods, Results, Appendix. See DOI: 10.1039/c8sc00148k by Mayr, Andreas, Klambauer, Günter, Unterthiner, Thomas, Steijaert, Marvin, Wegner, Jörg K., Ceulemans, Hugo, Clevert, Djork-Arné, Hochreiter, Sepp

“…The to date largest comparative study of nine state-of-the-art drug target prediction methods finds that deep learning outperforms all other competitors. The…”
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Chloride currents in cones modify feedback from horizontal cells to cones in goldfish retina by Endeman, Duco, Fahrenfort, Iris, Sjoerdsma, Trijntje, Steijaert, Marvin, ten Eikelder, Huub, Kamermans, Maarten

“…Key points •  The GABAergic pathway modulates feedback between retinal horizontal cells (HCs) and cone photoreceptors, but is not mediating negative feedback,…”
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Systems biology of resilience and optimal health:integrating Chinese and Western medicine pesrspectives by Yan Schro?n, Victor Kallen, Marvin Steijaert, Albert A. de Graaf, Ben van Ommen, Jan van der Greef

“…Western science has been strong in measuring details of biological systems such as gene expression levels and metabolite concentrations, and has generally…”
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Scaling Machine Learning for Target Prediction in Drug Discovery using Apache Spark by Harnie, Dries, Vapirev, Alexander E., Wegner, Jorg Kurt, Gedich, Andrey, Steijaert, Marvin, Wuyts, Roel, De Meuter, Wolfgang

“…In the context of drug discovery, a key problem is the identification of candidate molecules that affect proteins associated with diseases. Inside Janssen…”
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