Search Results - "Steiger, Katja"

Structure-Preserving Color Normalization and Sparse Stain Separation for Histological Images by Vahadane, Abhishek, Tingying Peng, Sethi, Amit, Albarqouni, Shadi, Lichao Wang, Baust, Maximilian, Steiger, Katja, Schlitter, Anna Melissa, Esposito, Irene, Navab, Nassir

“…Staining and scanning of tissue samples for microscopic examination is fraught with undesirable color variations arising from differences in raw materials and…”
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Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia by Ecker, Veronika, Stumpf, Martina, Brandmeier, Lisa, Neumayer, Tanja, Pfeuffer, Lisa, Engleitner, Thomas, Ringshausen, Ingo, Nelson, Nina, Jücker, Manfred, Wanninger, Stefan, Zenz, Thorsten, Wendtner, Clemens, Manske, Katrin, Steiger, Katja, Rad, Roland, Müschen, Markus, Ruland, Jürgen, Buchner, Maike

“…Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the suppression of oncogenic kinase signaling. Here, we test the hypothesis that…”
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Exploring the Role of RGD-Recognizing Integrins in Cancer by Nieberler, Markus, Reuning, Ute, Reichart, Florian, Notni, Johannes, Wester, Hans-Jürgen, Schwaiger, Markus, Weinmüller, Michael, Räder, Andreas, Steiger, Katja, Kessler, Horst

“…Integrins are key regulators of communication between cells and with their microenvironment. Eight members of the integrin superfamily recognize the tripeptide…”
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Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes by Mueller, Sebastian, Engleitner, Thomas, Maresch, Roman, Zukowska, Magdalena, Lange, Sebastian, Kaltenbacher, Thorsten, Konukiewitz, Björn, Öllinger, Rupert, Zwiebel, Maximilian, Strong, Alex, Yen, Hsi-Yu, Banerjee, Ruby, Louzada, Sandra, Fu, Beiyuan, Seidler, Barbara, Götzfried, Juliana, Schuck, Kathleen, Hassan, Zonera, Arbeiter, Andreas, Schönhuber, Nina, Klein, Sabine, Veltkamp, Christian, Friedrich, Mathias, Rad, Lena, Barenboim, Maxim, Ziegenhain, Christoph, Hess, Julia, Dovey, Oliver M., Eser, Stefan, Parekh, Swati, Constantino-Casas, Fernando, de la Rosa, Jorge, Sierra, Marta I., Fraga, Mario, Mayerle, Julia, Klöppel, Günter, Cadiñanos, Juan, Liu, Pentao, Vassiliou, George, Weichert, Wilko, Steiger, Katja, Enard, Wolfgang, Schmid, Roland M., Yang, Fengtang, Unger, Kristian, Schneider, Günter, Varela, Ignacio, Bradley, Allan, Saur, Dieter, Rad, Roland

“…The poor correlation of mutational landscapes with phenotypes limits our understanding of the pathogenesis and metastasis of pancreatic ductal adenocarcinoma…”
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Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice by Michler, Thomas, Kosinska, Anna D., Festag, Julia, Bunse, Till, Su, Jinpeng, Ringelhan, Marc, Imhof, Hortenzia, Grimm, Dirk, Steiger, Katja, Mogler, Carolin, Heikenwalder, Mathias, Michel, Marie-Louise, Guzman, Carlos A., Milstein, Stuart, Sepp-Lorenzino, Laura, Knolle, Percy, Protzer, Ulrike

“…Hepatitis B virus (HBV) infection persists because the virus-specific immune response is dysfunctional. Therapeutic vaccines might be used to end immune…”
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MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically by Munkhbaatar, Enkhtsetseg, Dietzen, Michelle, Agrawal, Deepti, Anton, Martina, Jesinghaus, Moritz, Boxberg, Melanie, Pfarr, Nicole, Bidola, Pidassa, Uhrig, Sebastian, Höckendorf, Ulrike, Meinhardt, Anna-Lena, Wahida, Adam, Heid, Irina, Braren, Rickmer, Mishra, Ritu, Warth, Arne, Muley, Thomas, Poh, Patrina S. P., Wang, Xin, Fröhling, Stefan, Steiger, Katja, Slotta-Huspenina, Julia, van Griensven, Martijn, Pfeiffer, Franz, Lange, Sebastian, Rad, Roland, Spella, Magda, Stathopoulos, Georgios T., Ruland, Jürgen, Bassermann, Florian, Weichert, Wilko, Strasser, Andreas, Branca, Caterina, Heikenwalder, Mathias, Swanton, Charles, McGranahan, Nicholas, Jost, Philipp J.

“…Evasion of programmed cell death represents a critical form of oncogene addiction in cancer cells. Understanding the molecular mechanisms underpinning cancer…”
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CXCL9 inhibits tumour growth and drives anti-PD-L1 therapy in ovarian cancer by Seitz, Stefanie, Dreyer, Tobias F., Stange, Christoph, Steiger, Katja, Bräuer, Rosalinde, Scheutz, Leandra, Multhoff, Gabriele, Weichert, Wilko, Kiechle, Marion, Magdolen, Viktor, Bronger, Holger

“…Background Response to immune checkpoint blockade (ICB) in ovarian cancer remains disappointing. Several studies have identified the chemokine CXCL9 as a…”
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Composition and Clinical Impact of the Immunologic Tumor Microenvironment in Oral Squamous Cell Carcinoma by Boxberg, Melanie, Leising, Lena, Steiger, Katja, Jesinghaus, Moritz, Alkhamas, Aezlat, Mielke, Marion, Pfarr, Nicole, Götz, Carolin, Wolff, Klaus Dietrich, Weichert, Wilko, Kolk, Andreas

“…Immunotherapy shows promising results and revolutionizes treatment of oral squamous cell carcinoma (OSCC). The immunologic microenvironment might have…”
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Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid by Düwel, Stephan, Hundshammer, Christian, Gersch, Malte, Feuerecker, Benedikt, Steiger, Katja, Buck, Achim, Walch, Axel, Haase, Axel, Glaser, Steffen J., Schwaiger, Markus, Schilling, Franz

“…Natural pH regulatory mechanisms can be overruled during several pathologies such as cancer, inflammation and ischaemia, leading to local pH changes in the…”
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High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett’s Esophagus via Interleukin 8 and Alterations to the Gut Microbiome by Münch, Natasha Stephens, Fang, Hsin-Yu, Ingermann, Jonas, Maurer, H. Carlo, Anand, Akanksha, Kellner, Victoria, Sahm, Vincenz, Wiethaler, Maria, Baumeister, Theresa, Wein, Frederik, Einwächter, Henrik, Bolze, Florian, Klingenspor, Martin, Haller, Dirk, Kavanagh, Maria, Lysaght, Joanne, Friedman, Richard, Dannenberg, Andrew J., Pollak, Michael, Holt, Peter R., Muthupalani, Sureshkumar, Fox, James G., Whary, Mark T., Lee, Yoomi, Ren, Tony Y., Elliot, Rachael, Fitzgerald, Rebecca, Steiger, Katja, Schmid, Roland M., Wang, Timothy C., Quante, Michael

“…Barrett’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progression from BE to cancer is associated with obesity, possibly due to increased…”
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Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma by Schick, Markus, Zhang, Le, Maurer, Sabine, Maurer, Hans Carlo, Isaakaidis, Konstandina, Schneider, Lara, Patra, Upayan, Schunck, Kathrin, Rohleder, Elena, Hofstetter, Julia, Baluapuri, Apoorva, Scherger, Anna Katharina, Slotta-Huspenina, Julia, Hettler, Franziska, Weber, Julia, Engleitner, Thomas, Maresch, Roman, Slawska, Jolanta, Lewis, Richard, Istvanffy, Rouzanna, Habringer, Stefan, Steiger, Katja, Baiker, Armin, Oostendorp, Robert A. J., Miething, Cornelius, Lenhof, Hans-Peter, Bassermann, Florian, Chapuy, Björn, Wirth, Matthias, Wolf, Elmar, Rad, Roland, Müller, Stefan, Keller, Ulrich

“…SUMOylation is a post-translational modification of proteins that regulates these proteins’ localization, turnover or function. Aberrant SUMOylation is…”
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PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice by Weber, Julia, de la Rosa, Jorge, Grove, Carolyn S., Schick, Markus, Rad, Lena, Baranov, Olga, Strong, Alexander, Pfaus, Anja, Friedrich, Mathias J., Engleitner, Thomas, Lersch, Robert, Öllinger, Rupert, Grau, Michael, Menendez, Irene Gonzalez, Martella, Manuela, Kohlhofer, Ursula, Banerjee, Ruby, Turchaninova, Maria A., Scherger, Anna, Hoffman, Gary J., Hess, Julia, Kuhn, Laura B., Ammon, Tim, Kim, Johnny, Schneider, Günter, Unger, Kristian, Zimber-Strobl, Ursula, Heikenwälder, Mathias, Schmidt-Supprian, Marc, Yang, Fengtang, Saur, Dieter, Liu, Pentao, Steiger, Katja, Chudakov, Dmitriy M., Lenz, Georg, Quintanilla-Martinez, Leticia, Keller, Ulrich, Vassiliou, George S., Cadiñanos, Juan, Bradley, Allan, Rad, Roland

“…B-cell lymphoma (BCL) is the most common hematologic malignancy. While sequencing studies gave insights into BCL genetics, identification of non-mutated cancer…”
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Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology by Feldmann, Karin, Maurer, Carlo, Peschke, Katja, Teller, Steffen, Schuck, Kathleen, Steiger, Katja, Engleitner, Thomas, Öllinger, Rupert, Nomura, Alice, Wirges, Nils, Papargyriou, Aristeidis, Jahan Sarker, Rim Sabrina, Ranjan, Raphela Aranie, Dantes, Zahra, Weichert, Wilko, Rustgi, Anil K., Schmid, Roland M., Rad, Roland, Schneider, Günter, Saur, Dieter, Reichert, Maximilian

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibroblast-rich desmoplastic stroma. Cancer-associated fibroblasts (CAFs) have been shown to…”
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A machine learning algorithm predicts molecular subtypes in pancreatic ductal adenocarcinoma with differential response to gemcitabine-based versus FOLFIRINOX chemotherapy by Kaissis, Georgios, Ziegelmayer, Sebastian, Lohöfer, Fabian, Steiger, Katja, Algül, Hana, Muckenhuber, Alexander, Yen, Hsi-Yu, Rummeny, Ernst, Friess, Helmut, Schmid, Roland, Weichert, Wilko, Siveke, Jens T, Braren, Rickmer

“…Development of a supervised machine-learning model capable of predicting clinically relevant molecular subtypes of pancreatic ductal adenocarcinoma (PDAC) from…”
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ACVIM consensus statement on pancreatitis in cats by Forman, Marnin A., Steiner, Joerg M., Armstrong, P. Jane, Camus, Melinda S., Gaschen, Lorrie, Hill, Steve L., Mansfield, Caroline S., Steiger, Katja

“…Background Pancreatitis in cats, although commonly diagnosed, still presents many diagnostic and management challenges. Objective To summarize the current…”
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PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the “Cancer Integrin” αvβ6 with Ga-68-Trivehexin by Quigley, Neil Gerard, Steiger, Katja, Hoberück, Sebastian, Czech, Norbert, Zierke, Maximilian Alexander, Kossatz, Susanne, Pretze, Marc, Richter, Frauke, Weichert, Wilko, Pox, Christian, Kotzerke, Jörg, Notni, Johannes

“…Purpose To develop a new probe for the αvβ6-integrin and assess its potential for PET imaging of carcinomas. Methods Ga-68-Trivehexin was synthesized by…”
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Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation by Maisam Afzali, Ali, Stüve, Lasse, Pfaller, Monika, Aly, Lilian, Steiger, Katja, Knier, Benjamin, Korn, Thomas

“…Aquaporin-4 (AQP4) is the molecular target of the immune response in neuromyelitis optica (NMO) that leads to severe structural damage in the central nervous…”
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CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice by Weber, Julia, Öllinger, Rupert, Friedrich, Mathias, Ehmer, Ursula, Barenboim, Maxim, Steiger, Katja, Heid, Irina, Mueller, Sebastian, Maresch, Roman, Engleitner, Thomas, Gross, Nina, Geumann, Ulf, Fu, Beiyuan, Segler, Angela, Yuan, Detian, Lange, Sebastian, Strong, Alexander, de la Rosa, Jorge, Esposito, Irene, Liu, Pentao, Cadiñanos, Juan, Vassiliou, George S., Schmid, Roland M., Schneider, Günter, Unger, Kristian, Yang, Fengtang, Braren, Rickmer, Heikenwälder, Mathias, Varela, Ignacio, Saur, Dieter, Bradley, Allan, Rad, Roland

“…Here, we show CRISPR/Cas9-based targeted somatic multiplexmutagenesis and its application for high-throughput analysis of gene function in mice. Using hepatic…”
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CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma by Fang, Hsin-Yu, Münch, Natasha Stephens, Schottelius, Margret, Ingermann, Jonas, Liu, Haibo, Schauer, Michael, Stangl, Stefan, Multhoff, Gabriele, Steiger, Katja, Gerngroß, Carlos, Jesinghaus, Moritz, Weichert, Wilko, Kühl, Anja A, Sepulveda, Antonia R, Wester, Hans-Jürgen, Wang, Timothy C, Quante, Michael

“…Barrett's esophagus represents an early stage in carcinogenesis leading to esophageal adenocarcinoma. Considerable evidence supports a major role for chronic…”
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Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice by Maresch, Roman, Mueller, Sebastian, Veltkamp, Christian, Öllinger, Rupert, Friedrich, Mathias, Heid, Irina, Steiger, Katja, Weber, Julia, Engleitner, Thomas, Barenboim, Maxim, Klein, Sabine, Louzada, Sandra, Banerjee, Ruby, Strong, Alexander, Stauber, Teresa, Gross, Nina, Geumann, Ulf, Lange, Sebastian, Ringelhan, Marc, Varela, Ignacio, Unger, Kristian, Yang, Fengtang, Schmid, Roland M., Vassiliou, George S., Braren, Rickmer, Schneider, Günter, Heikenwalder, Mathias, Bradley, Allan, Saur, Dieter, Rad, Roland

“…Mouse transgenesis has provided fundamental insights into pancreatic cancer, but is limited by the long duration of allele/model generation. Here we show…”
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