Search Results - "Steidler, L"

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis by Vandenbroucke, K, de Haard, H, Beirnaert, E, Dreier, T, Lauwereys, M, Huyck, L, Van Huysse, J, Demetter, P, Steidler, L, Remaut, E, Cuvelier, C, Rottiers, P

“…Inflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal disorder. Systemic treatment of IBD patients with anti-tumor necrosis factor…”
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Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10 by Steidler, Lothar, Hans, Wolfgang, Schotte, Lieven, Neirynck, Sabine, Obermeier, Florian, Falk, Werner, Fiers, Walter, Remaut, Erik

“…The cytokine interleukin-10 (IL-10) has shown promise in clinical trials for treatment of inflammatory bowel disease (IBD). Using two mouse models, we show…”
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Scoring of MYC protein expression in diffuse large B-cell lymphomas: concordance rate among hematopathologists by Mahmoud, Amer Z, George, Tracy I, Czuchlewski, David R, Zhang, Qian-Yun, Wilson, Carla S, Sever, Cordelia E, Bakhirev, Alexei G, Zhang, Dahua, Steidler, Nichole L, Reichard, Kaaren K, Kang, Huining, Foucar, Kathryn, Vasef, Mohammad A

“…Recent studies have shown that immunohistochemical evaluation of MYC protein expression in diffuse large B-cell lymphoma is a useful prognostic tool with high…”
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Trimming of two major type 1 diabetes driving antigens, GAD65 and IA-2, allows for successful expression in Lactococcus lactis by Robert, S, Van Huynegem, K, Gysemans, C, Mathieu, C, Rottiers, P, Steidler, L

“…Type 1 diabetes (T1D) is a chronic autoimmune disease characterised by excessive immune reactions against auto-antigens of pancreatic β-cells. Restoring…”
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Secretion of biologically active murine interleukin-10 by Lactococcus lactis by Schotte, L., Steidler, L., Vandekerckhove, J., Remaut, E.

“…We investigated the ability of Lactococcus lactis to secrete biologically active, murine interleukin-10 (mIL-10). mIL-10 was synthesized as a fusion protein,…”
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CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn’s disease by Laukens, D, Peeters, H, Marichal, D, Vander Cruyssen, B, Mielants, H, Elewaut, D, Demetter, P, Cuvelier, C, Van Den Berghe, M, Rottiers, P, Veys, E M, Remaut, E, Steidler, L, De Keyser, F, De Vos, M

“…Background: The association between spondyloarthropathy and Crohn’s disease is well known. A risk for evolution to Crohn’s disease has already been shown in…”
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Altered gut transcriptome in spondyloarthropathy by Laukens, D, Peeters, H, Cruyssen, B V, Boonefaes, T, Elewaut, D, De Keyser, F, Mielants, H, Cuvelier, C, Veys, E M, Knecht, K, Van Hummelen, P, Remaut, E, Steidler, L, De Vos, M, Rottiers, P

“…Background: Intestinal inflammation is a common feature of spondyloarthropathy (SpA) and Crohn’s disease. Inflammation is manifested clinically in Crohn’s…”
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Overexpression of α1-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis by Hochepied, T, Wullaert, A, Berger, F G, Baumann, H, Brouckaert, P, Steidler, L, Libert, C

“…Background: α1-Acid glycoprotein (α1-AGP) is an acute phase protein in most mammalian species whose concentration rises 2–5-fold during an acute phase…”
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Development of an enteric-coated formulation containing freeze-dried, viable recombinant for the ileal mucosal delivery of human interleukin-10 by HUYGHEBAERT, N, VERMEIRE, A, NEIRYNCK, S, STEIDLER, L, REMAUT, E, REMON, J

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Secretion of biologically active murine interleukin-2 by Lactococcus lactis subsp. lactis by STEIDLER, L, WELLS, J. M, RAYEMAEKERS, A, VANDEKERCKHOVE, J, FIERS, W, REMAUT, E

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Lactococcus lactis, a tool for the delivery of therapeutic proteins treatment of IBD by Steidler, L

“…Inflammatory bowel disease (IBD) is a group of chronic intestinal inflammatory diseases that consists of ulcerative colitis (UC), an inflammation of the large…”
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CD34+ megakaryocytes (≥30%) are associated with megaloblastic anaemia and non-acute myeloid neoplasia by Insuasti-Beltran, Giovanni, Steidler, Nichole L, Kang, Huining, Reichard, Kaaren K

“…Insuasti‐Beltran G, Steidler N L, Kang H & Reichard K K 
(2012) Histopathology 61, 694–701 CD34+ megakaryocytes (≥30%) are associated with megaloblastic…”
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Genetically engineered probiotics by Steidler, Lothar

“…Probiotic micro-organisms have been used for many years. Originating as food supplements, they are now most often administered orally and offer an attractive…”
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Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10 by Steidler, Lothar, Neirynck, Sabine, Goddeeris, Bruno, Remaut, Erik, Remon, Jean Paul, Snoeck, Veerle, Vermeire, An, Huyghebaert, Nathalie, Cox, Eric

“…Genetically modified Lactococcus lactis secreting interleukin 10 provides a therapeutic approach for inflammatory bowel disease. However, the release of such…”
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Pap pili as a vector system for surface exposition of an immunoglobulin G-binding domain of protein A of Staphylococcus aureus in Escherichia coli by STEIDLER, L, REMAUT, E, FIERS, W

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Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice by Vandenbroucke, Klaas, Hans, Wolfgang, Van Huysse, Jacques, Neirynck, Sabine, Demetter, Pieter, Remaut, Erik, Rottiers, Pieter, Steidler, Lothar

“…Effective therapeutics for treating acute colitis, caused by disruption of the intestinal epithelial barrier, are scarce. Trefoil factors (TFF) are…”
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AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis by Caluwaerts, Silvia, Vandenbroucke, Klaas, Steidler, Lothar, Neirynck, Sabine, Vanhoenacker, Peter, Corveleyn, Sam, Watkins, Brynmor, Sonis, Stephen, Coulie, Bernard, Rottiers, Pieter

“…Summary Non-clinical studies, focusing on the pharmacodynamics (PD), pharmacokinetics (PK) and safety pharmacology of genetically modified Lactococcus lactis (…”
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Production of Soluble and Active Recombinant Murine Interleukin-2 in Escherichia coli: High Level Expression, Kil-Induced Release, and Purification by Robbens, J., Raeymaekers, A., Steidler, L., Fiers, W., Remaut, E.

“…We describe the production of soluble murine interleukin-2 (mIL2) and its purification following regulated release in the growth medium of Escherichia coli…”
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The expression of the Photinus pyralis luciferase gene in Staphylococcus aureus Cowan I allows the development of a live amplifiable tool for immunodetection by Steidler, L, Yu, W, Fiers, W, Remaut, E

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Screening and construction of probiotic strains with enhanced protective properties against intestinal disorders by Mercenier, A., Hols, P., Roussel, Y., Perez-Martinez, G., Buesa, J., Wilks, M., Pozzi, G., Remaut, E., Morelli, L., Grangette, C., Monedero, V., Palumbo, E., Foligne, B., Steidler, L., Nutten, S.

“…Within the scope of the DEPROHEALTH project, a range of wild-type strains of Lactobacillus were analysed for their ability to interact with the host immune…”
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