Search Results - "Stehouwer, CDA"

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression by Claringbould, Annique, Westra, Harm-Jan, Bonder, Marc Jan, Deelen, Patrick, Kirsten, Holger, Saha, Ashis, Yazar, Seyhan, Brugge, Harm, Oelen, Roy, de Vries, Dylan H., van der Wijst, Monique G. P., Kasela, Silva, Pervjakova, Natalia, Alves, Isabel, Favé, Marie-Julie, Agbessi, Mawussé, Christiansen, Mark W., Jansen, Rick, Seppälä, Ilkka, Tong, Lin, Teumer, Alexander, Schramm, Katharina, Hemani, Gibran, Verlouw, Joost, Yaghootkar, Hanieh, Sönmez Flitman, Reyhan, Brown, Andrew, Kukushkina, Viktorija, Kalnapenkis, Anette, Rüeger, Sina, Porcu, Eleonora, Kettunen, Johannes, Lee, Bernett, Zhang, Futao, Qi, Ting, Arindrarto, Wibowo, Beutner, Frank, Dmitrieva, Julia, Elansary, Mahmoud, Fairfax, Benjamin P., Georges, Michel, Heijmans, Bastiaan T., Hewitt, Alex W., Kähönen, Mika, Kim, Yungil, Knight, Julian C., Kovacs, Peter, Krohn, Knut, Li, Shuang, Loeffler, Markus, Marigorta, Urko M., Mei, Hailang, Momozawa, Yukihide, Müller-Nurasyid, Martina, Nauck, Matthias, Nivard, Michel G., Penninx, Brenda W. J. H., Pritchard, Jonathan K., Raitakari, Olli T., Rotzschke, Olaf, Slagboom, Eline P., Stehouwer, Coen D. A., Stumvoll, Michael, Sullivan, Patrick, ’t Hoen, Peter A. C., Thiery, Joachim, Tönjes, Anke, van Dongen, Jenny, van Iterson, Maarten, Veldink, Jan H., Völker, Uwe, Warmerdam, Robert, Wijmenga, Cisca, Swertz, Morris, Andiappan, Anand, Montgomery, Grant W., Ripatti, Samuli, Perola, Markus, Kutalik, Zoltan, Dermitzakis, Emmanouil, Bergmann, Sven, van Meurs, Joyce, Prokisch, Holger, Ahsan, Habibul, Pierce, Brandon L., Lehtimäki, Terho, Psaty, Bruce M., Gharib, Sina A., Awadalla, Philip, Milani, Lili, Ouwehand, Willem H., Downes, Kate, Stegle, Oliver, Battle, Alexis, Visscher, Peter M., Yang, Jian, Powell, Joseph, Gibson, Greg, Esko, Tõnu, Franke, Lude

“…Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene…”
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Effects of transdermal and oral postmenopausal hormone therapy on vascular function: a randomized, placebo-controlled study in healthy postmenopausal women by Hemelaar, Majoie, van der Mooren, Marius J, van Baal, W Marchien, Schalkwijk, Casper G, Kenemans, Peter, Stehouwer, Coen D A

“…To compare the effect of transdermal and oral estrogen therapy, the latter with or without the addition of gestodene, on plasma concentrations of markers of…”
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Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100 667 Patients by Willeit, Peter, Tschiderer, Lena, Allara, Elias, Reuber, Kathrin, Seekircher, Lisa, Gao, Lu, Liao, Ximing, Lonn, Eva, Gerstein, Hertzel C., Yusuf, Salim, Brouwers, Frank P., Asselbergs, Folkert W., van Gilst, Wiek, Anderssen, Sigmund A., Grobbee, Diederick E., Kastelein, John J.P., Visseren, Frank L.J., Ntaios, George, Hatzitolios, Apostolos I., Savopoulos, Christos, Nieuwkerk, Pythia T., Stroes, Erik, Walters, Matthew, Higgins, Peter, Dawson, Jesse, Gresele, Paolo, Guglielmini, Giuseppe, Migliacci, Rino, Ezhov, Marat, Safarova, Maya, Balakhonova, Tatyana, Sato, Eiichi, Amaha, Mayuko, Nakamura, Tsukasa, Kapellas, Kostas, Jamieson, Lisa M., Skilton, Michael, Blumenthal, James A., Hinderliter, Alan, Sherwood, Andrew, Smith, Patrick J., van Agtmael, Michiel A., Reiss, Peter, van Vonderen, Marit G.A., Kiechl, Stefan, Klingenschmid, Gerhard, Sitzer, Matthias, Stehouwer, Coen D.A., Uthoff, Heiko, Zou, Zhi-Yong, Cunha, Ana R., Neves, Mario F., Witham, Miles D., Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Bernal, Enrique, Wachtell, Kristian, Kjeldsen, Sverre E., Olsen, Michael H., Preiss, David, Sattar, Naveed, Beishuizen, Edith, Huisman, Menno V., Espeland, Mark A., Schmidt, Caroline, Agewall, Stefan, Ok, Ercan, Aşçi, Gülay, de Groot, Eric, Grooteman, Muriel P.C., Blankestijn, Peter J., Bots, Michiel L., Sweeting, Michael J., Thompson, Simon G., Lorenz, Matthias W.

“…BACKGROUND:To quantify the association between effects of interventions on carotid intima-media thickness (cIMT) progression and their effects on…”
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The obesogenic environment and incident cardiovascular disease in The Maastricht Study by Chan, J A, Bosma, H, Schram, M T, Stehouwer, CDA, Lakerveld, J, Koster, A

“…Abstract Background The built environment has been identified as an upstream determinant of cardiovascular disease (CVD) in which neighborhood walkability and…”
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A randomized placebo-controlled study of the effect of transdermal vs. oral estradiol with or without gestodene on homocysteine levels by Smolders, R G V, van der Mooren, M J, Teerlink, T, Merkus, J M W M, Kroeks, M V A M, Franke, H R, Stehouwer, C D A, Kenemans, P

“…To assess the effect of transdermal vs. oral administration of E2 on plasma homocysteine levels and to evaluate the impact of adding a progestogen to these…”
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Medication adherence among patients with gout: A systematic review and meta-analysis by Scheepers, Lieke E.J.M., van Onna, Marloes, Stehouwer, Coen D.A., Singh, Jasvinder A., Arts, Ilja C.W., Boonen, Annelies

“…In the management of chronic gout, a large proportion of patients need long-term management with urate lowering therapy (ULT). This study reviews medication…”
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Different effects of low-dose transdermal and oral oestrogen therapy on procarboxy-peptidase U, an inhibitor of fibrinolysis, in healthy postmenopausal women: a randomised, placebo-controlled study by Post, Marinka S, Leurs, Judith R, van der Mooren, Marius J, van Baal, W Marchien, Hendriks, Dirk F, Stehouwer, Coen D A, Kenemans, Peter

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Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits by Porcu, Eleonora, Rüeger, Sina, Lepik, Kaido, Santoni, Federico A., Reymond, Alexandre, Kutalik, Zoltán

“…Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, but their biological interpretation often remains…”
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C-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction by Kaptoge, Stephen, Di Angelantonio, Emanuele, Pennells, Lisa, Wood, Angela M, White, Ian R, Gao, Pei, Walker, Matthew, Thompson, Alexander, Sarwar, Nadeem, Caslake, Muriel, Butterworth, Adam S, Amouyel, Philippe, Assmann, Gerd, Bakker, Stephan J L, Barr, Elizabeth L M, Barrett-Connor, Elizabeth, Benjamin, Emelia J, Björkelund, Cecilia, Brenner, Hermann, Brunner, Eric, Clarke, Robert, Cooper, Jackie A, Cremer, Peter, Cushman, Mary, Dagenais, Gilles R, D'Agostino, Sr, Ralph B, Dankner, Rachel, Davey-Smith, George, Deeg, Dorly, Dekker, Jacqueline M, Engström, Gunnar, Folsom, Aaron R, Fowkes, F Gerry R, Gallacher, John, Gaziano, J Michael, Giampaoli, Simona, Gillum, Richard F, Hofman, Albert, Howard, Barbara V, Ingelsson, Erik, Iso, Hiroyasu, Jørgensen, Torben, Kiechl, Stefan, Kitamura, Akihiko, Kiyohara, Yutaka, Koenig, Wolfgang, Kromhout, Daan, Kuller, Lewis H, Lawlor, Debbie A, Meade, Tom W, Nissinen, Aulikki, Nordestgaard, Børge G, Onat, Altan, Panagiotakos, Demosthenes B, Psaty, Bruce M, Rodriguez, Beatriz, Rosengren, Annika, Salomaa, Veikko, Kauhanen, Jussi, Salonen, Jukka T, Shaffer, Jonathan A, Shea, Steven, Ford, Ian, Stehouwer, Coen D A, Strandberg, Timo E, Tipping, Robert W, Tosetto, Alberto, Wassertheil-Smoller, Sylvia, Wennberg, Patrik, Westendorp, Rudi G, Whincup, Peter H, Wilhelmsen, Lars, Woodward, Mark, Lowe, Gordon D O, Wareham, Nicholas J, Khaw, Kay-Tee, Sattar, Naveed, Packard, Chris J, Gudnason, Vilmundur, Ridker, Paul M, Pepys, Mark B, Thompson, Simon G, Danesh, John

“…In a pooled analysis of data from nearly 250,000 people from 52 studies, the authors estimated the incremental value of C-reactive protein or fibrinogen level…”
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Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies by Sarwar, N, Gao, P, Seshasai, S R Kondapally, Gobin, R, Kaptoge, S, Di Angelantonio, E, Ingelsson, E, Lawlor, D A, Selvin, E, Stampfer, M, Stehouwer, C D A, Lewington, S, Pennells, L, Thompson, A, Sattar, N, White, I R, Ray, K K, Danesh, J

“…Summary Background Uncertainties persist about the magnitude of associations of diabetes mellitus and fasting glucose concentration with risk of coronary heart…”
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Socioeconomic inequalities in health-related functioning among people with Type 2 Diabetes by Meisters, R, Albers, J, Sezer, B, de Galan, B E, Eussen, SJPM, Stehouwer, CDA, Schram, M T, van Greevenbroek, MMJ, Koster, A, Bosma, H

“…Abstract Background Type 2 Diabetes mellitus (T2DM) is a common chronic disease which disproportionally affects disadvantaged groups. People with a low…”
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Socioeconomic inequalities in type 2 diabetes and job demands/control/support - The Maastricht Study by Sezer, B, Koster, A, Albers, J, Meisters, R, Schram, M, Eussen, S, Dukers, N, de Rijk, A, Stehouwer, CDA, Bosma, H

“…Abstract Background Low socioeconomic position (SEP) is an important determinant of Type 2 Diabetes Mellitus (T2DM). Adverse environments in the exposome might…”
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Health inequalities in type 2 diabetes: contributions of exposures in the residential environment by Albers, J D, Koster, A, Sezer, B, Meisters, R, Schram, M T, Eussen, SJPM, Dukers, NHTM, Stehouwer, CDA, Lakerveld, J, Bosma, H

“…Abstract Background People with lower socioeconomic position (SEP) have higher risk of type 2 diabetes (T2D). Besides genetic predisposition, the exposome…”
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Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3 year trial by Out, Mattijs, Kooy, Adriaan, Lehert, Philippe, Schalkwijk, Casper A., Stehouwer, Coen D.A.

“…AimsMetformin treatment is associated with a decrease of serum vitamin B12, but whether this reflects tissue B12 deficiency is controversial. We studied the…”
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Heritability estimates for 361 blood metabolites across 40 genome-wide association studies by Hagenbeek, Fiona A., Pool, René, van Dongen, Jenny, Draisma, Harmen H. M., Jan Hottenga, Jouke, Willemsen, Gonneke, Abdellaoui, Abdel, Fedko, Iryna O., den Braber, Anouk, Visser, Pieter Jelle, de Geus, Eco J. C. N., Willems van Dijk, Ko, Verhoeven, Aswin, Suchiman, H. Eka, Beekman, Marian, Slagboom, P. Eline, van Duijn, Cornelia M., Harms, Amy C., Hankemeier, Thomas, Bartels, Meike, Nivard, Michel G., Boomsma, Dorret I.

“…Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to…”
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Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies by Sarwar, Nadeem, Sandhu, Manjinder S, Ricketts, Sally L, Butterworth, Adam S, Di Angelantonio, Emanuele, Boekholdt, S Matthijs, Ouwehand, Willem, Watkins, Hugh, Samani, Nilesh J, Saleheen, Danish, Lawlor, Debbie, Reilly, Muredach P, Hingorani, Aroon D, Talmud, Philippa J, Danesh, John

“…Summary Background Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that…”
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“Vasocrine” signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease by Yudkin, John S, Eringa, Etto, Stehouwer, Coen DA

“…Adipose tissue expresses cytokines that inhibit insulin signalling pathways in liver and muscle. Obesity also results in impairment of endothelium-dependent…”
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Vascular complications in diabetes mellitus: the role of endothelial dysfunction by Schalkwijk, Casper G, Stehouwer, Coen D A

“…The endothelium is a complex organ with a multitude of properties essential for control of vascular functions. Dysfunction of the vascular endothelium is…”
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Metabolic syndrome and 10-year cardiovascular disease risk in the hoorn study by DEKKER, Jacqueline M, GIRMAN, Cynthia, RHODES, Thomas, NIJPELS, Giel, STEHOUWER, Coen D. A, BOUTER, Lex M, HEINE, Robert J

“…Different definitions of the metabolic syndrome have been proposed. Their value in a clinical setting to assess cardiovascular disease (CVD) risk is still…”
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Electrocardiographic characteristics of patients with coronavirus disease 2019 (COVID-2019) related pneumonia at first presentation by Nguyen, U, Strik, M, Abu-Arib, S, Bruekers, A, Nguyen, T, Massud, A, Willems, R, Dekker, S, Spaetgens, B, Engels, E, Crijns, HGJM, Koopmans, R, Henry, R, Stehouwer, CDA

“…Abstract Funding Acknowledgements Type of funding sources: None. Purpose To evaluate electrocardiographic (ECG) characteristics at first presentation in…”
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