Search Results - "Stehling, Oliver"

N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization by Freibert, Sven-A., Boniecki, Michal T., Stümpfig, Claudia, Schulz, Vinzent, Krapoth, Nils, Winge, Dennis R., Mühlenhoff, Ulrich, Stehling, Oliver, Cygler, Miroslaw, Lill, Roland

“…Synthesis of iron-sulfur (Fe/S) clusters in living cells requires scaffold proteins for both facile synthesis and subsequent transfer of clusters to target…”
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The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism by Lill, Roland, Hoffmann, Bastian, Molik, Sabine, Pierik, Antonio J., Rietzschel, Nicole, Stehling, Oliver, Uzarska, Marta A., Webert, Holger, Wilbrecht, Claudia, Mühlenhoff, Ulrich

“…Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–sulfur (Fe/S) proteins, and participate in cellular iron…”
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Maturation of cytosolic and nuclear iron–sulfur proteins by Netz, Daili J.A, Mascarenhas, Judita, Stehling, Oliver, Pierik, Antonio J, Lill, Roland

“…Highlights • Biogenesis of cytosolic and nuclear Fe/S proteins is essential and conserved. • The process involves the function of mitochondria and the CIA…”
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MMS19 Assembles Iron-Sulfur Proteins Required for DNA Metabolism and Genomic Integrity by Stehling, Oliver, Vashisht, Ajay A., Mascarenhas, Judita, Jonsson, Zophonias O., Sharma, Tanu, Netz, Daili J. A., Pierik, Antonio J., Wohlschlegel, James A., Lill, Roland

“…Instability of the nuclear genome is a hallmark of cancer and aging. MMS19 protein has been linked to maintenance of genomic integrity, but the molecular basis…”
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Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis by Sheftel, Alex D., Stehling, Oliver, Pierik, Antonio J., Elsässer, Hans-Peter, Mühlenhoff, Ulrich, Webert, Holger, Hobler, Anna, Hannemann, Frank, Bernhardt, Rita, Lill, Roland, Merchant, Sabeeha

“…Mammalian adrenodoxin (ferredoxin 1; Fdx1) is essential for the synthesis of various steroid hormones in adrenal glands. As a member of the [2Fe-2S]…”
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The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron–sulfur proteins by Lill, Roland, Dutkiewicz, Rafal, Freibert, Sven A., Heidenreich, Torsten, Mascarenhas, Judita, Netz, Daili J., Paul, Viktoria D., Pierik, Antonio J., Richter, Nadine, Stümpfig, Martin, Srinivasan, Vasundara, Stehling, Oliver, Mühlenhoff, Ulrich

“…Mitochondria have been derived from alpha-bacterial endosymbionts during the evolution of eukaryotes. Numerous bacterial functions have been maintained inside…”
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The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation by Sheftel, Alex D, Wilbrecht, Claudia, Stehling, Oliver, Niggemeyer, Brigitte, Elsässer, Hans-Peter, Mühlenhoff, Ulrich, Lill, Roland

“…Members of the bacterial and mitochondrial iron-sulfur cluster (ISC) assembly machinery include the so-called A-type ISC proteins, which support the assembly…”
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Compartmentalization of iron between mitochondria and the cytosol and its regulation by Mühlenhoff, Ulrich, Hoffmann, Bastian, Richter, Nadine, Rietzschel, Nicole, Spantgar, Farah, Stehling, Oliver, Uzarska, Marta A., Lill, Roland

“…Iron is essential for life. Its coordinated distribution between intracellular compartments and the adaptation of iron uptake to intracellular demands are…”
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Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins by Stehling, Oliver, Mascarenhas, Judita, Vashisht, Ajay A., Sheftel, Alex D., Niggemeyer, Brigitte, Rösser, Ralf, Pierik, Antonio J., Wohlschlegel, James A., Lill, Roland

“…Numerous cytosolic and nuclear proteins involved in metabolism, DNA maintenance, protein translation, or iron homeostasis depend on iron-sulfur (Fe/S)…”
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Haptoglobin buffers lipopolysaccharides to delay activation of NFκB by Zein, Laura, Grossmann, Josina, Swoboda, Helena, Borgel, Christina, Wilke, Bernhard, Awe, Stephan, Nist, Andrea, Stiewe, Thorsten, Stehling, Oliver, Freibert, Sven-Andreas, Adhikary, Till, Chung, Ho-Ryun

“…It has remained yet unclear which soluble factors regulate the anti-inflammatory macrophage phenotype observed in both homeostasis and tumourigenesis. We show…”
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Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation by Haunhorst, Petra, Hanschmann, Eva-Maria, Bräutigam, Lars, Stehling, Oliver, Hoffmann, Bastian, Mühlenhoff, Ulrich, Lill, Roland, Berndt, Carsten, Lillig, Christopher Horst

“…The mechanisms by which eukaryotic cells handle and distribute the essential micronutrient iron within the cytosol and other cellular compartments are only…”
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Human Ind1, an Iron-Sulfur Cluster Assembly Factor for Respiratory Complex I by Sheftel, Alex D., Stehling, Oliver, Pierik, Antonio J., Netz, Daili J. A., Kerscher, Stefan, Elsässer, Hans-Peter, Wittig, Ilka, Balk, Janneke, Brandt, Ulrich, Lill, Roland

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A novel IBA57 variant is associated with mitochondrial iron–sulfur protein deficiency and necrotizing myelopathy in dogs by Mandigers, Paul J. J., Stehling, Oliver, Vos-Loohuis, Manon, Van Steenbeek, Frank G., Lill, Roland, Leegwater, Peter A.

“…Introduction: Hereditary necrotizing myelopathy (HNM) in young Kooiker dogs is characterized by progressive ataxia and paralysis with autosomal recessive…”
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Mechanisms of FeS protein biogenesis and related diseases by Lill, Roland, Stehling, Oliver

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Role of Human Mitochondrial Nfs1 in Cytosolic Iron-Sulfur Protein Biogenesis and Iron Regulation by Biederbick, Annette, Stehling, Oliver, Rösser, Ralf, Niggemeyer, Brigitte, Nakai, Yumi, Elsässer, Hans-Peter, Lill, Roland

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Human Nbp35 Is Essential for both Cytosolic Iron-Sulfur Protein Assembly and Iron Homeostasis by Stehling, Oliver, Netz, Daili J. A., Niggemeyer, Brigitte, Rösser, Ralf, Eisenstein, Richard S., Puccio, Helene, Pierik, Antonio J., Lill, Roland

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Mechanisms of iron–sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes by Lill, Roland, Dutkiewicz, Rafal, Elsässer, Hans-Peter, Hausmann, Anja, Netz, Daili J.A., Pierik, Antonio J., Stehling, Oliver, Urzica, Eugen, Mühlenhoff, Ulrich

“…Iron–sulfur (Fe/S) clusters are important cofactors of numerous proteins involved in electron transfer, metabolic and regulatory processes. In eukaryotic…”
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Mitochondrial iron-sulfur protein biogenesis and human disease by Stehling, Oliver, Wilbrecht, Claudia, Lill, Roland

“…Work during the past 14 years has shown that mitochondria are the primary site for the biosynthesis of iron-sulfur (Fe/S) clusters. In fact, it is this process…”
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Investigation of iron-sulfur protein maturation in eukaryotes by Stehling, Oliver, Smith, Paul M, Biederbick, Annette, Balk, Janneke, Lill, Roland, Mühlenhoff, Ulrich

“…Iron-sulfur (Fe-S) clusters are cofactors of many proteins that are involved in central biochemical pathways, such as oxidative phosphorylation,…”
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Iron–sulfur proteins in health and disease by Sheftel, Alex, Stehling, Oliver, Lill, Roland

“…Iron–sulfur (Fe/S) proteins are a class of ubiquitous components that assist in vital and diverse biochemical tasks in virtually every living cell. These tasks…”
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