Search Results - "Stegmuller, Judith"

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging by Oberdoerffer, Philipp, Michan, Shaday, McVay, Michael, Mostoslavsky, Raul, Vann, James, Park, Sang-Kyu, Hartlerode, Andrea, Stegmuller, Judith, Hafner, Angela, Loerch, Patrick, Wright, Sarah M., Mills, Kevin D., Bonni, Azad, Yankner, Bruce A., Scully, Ralph, Prolla, Tomas A., Alt, Frederick W., Sinclair, David A.

“…Genomic instability and alterations in gene expression are hallmarks of eukaryotic aging. The yeast histone deacetylase Sir2 silences transcription and…”
Get full text

Calcium-Regulated MEF2 Sumoylation Switch Controls Postsynaptic Differentiation by Shalizi, Aryaman, Gaudillière, Brice, Yuan, Zengqiang, Stegmůller, Judith, Shirogane, Takahiro, Ge, Qingyuan, Tan, Yi, Schulman, Brenda, Harper, J. Wade, Bonni, Azad

“…Postsynaptic differentiation of dendrites is an essential step in synapse formation. We report here a requirement for the transcription factor myocyte enhancer…”
Get full text

Cdh1-APC Controls Axonal Growth and Patterning in the Mammalian Brain by Konishi, Yoshiyuki, Stegmüller, Judith, Matsuda, Takahiko, Bonni, Shirin, Bonni, Azad

“…The anaphase-promoting complex (APC) is highly expressed in postmitotic neurons, but its function in the nervous system was previously unknown. We report that…”
Get full text

Mechanistic contributions of FBXO7 to Parkinson disease by Joseph, Sabitha, Schulz, Jörg Bernhard, Stegmüller, Judith

“…Parkinson disease (PD) is, without doubt, a burden on modern society as the prevalence increases significantly with age. Owing to this growing number of PD…”
Get full text

Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice by Vingill, Siv, Brockelt, David, Lancelin, Camille, Tatenhorst, Lars, Dontcheva, Guergana, Preisinger, Christian, Schwedhelm-Domeyer, Nicola, Joseph, Sabitha, Mitkovski, Miso, Goebbels, Sandra, Nave, Klaus-Armin, Schulz, Jörg B, Marquardt, Till, Lingor, Paul, Stegmüller, Judith

“…Mutations in the FBXO7 ( PARK15 ) gene have been implicated in a juvenile form of parkinsonism termed parkinsonian pyramidal syndrome (PPS), characterized by…”
Get full text

New transgenic ALS/FTD models on the rat‐walk by Stegmüller, Judith, Synofzik, Matthis

“…This Editorial highlights a study by Huang and colleagues in the current issue of Journal of Neurochemistry. The authors introduce a novel ALS‐FTD (amyotrophic…”
Get full text

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth by Iavarone, Antonio, Lasorella, Anna, Stegmüller, Judith, Guardavaccaro, Daniele, Liu, Guangchao, Carro, Maria S, Rothschild, Gerson, de la Torre-Ubieta, Luis, Pagano, Michele, Bonni, Azad

“…In the developing nervous system, Id2 (inhibitor of DNA binding 2, also known as inhibitor of differentiation 2) enhances cell proliferation, promotes tumour…”
Get full text

Cell-Intrinsic Regulation of Axonal Morphogenesis by the Cdh1-APC Target SnoN by Stegmüller, Judith, Konishi, Yoshiyuki, Huynh, Mai Anh, Yuan, Zengqiang, DiBacco, Sara, Bonni, Azad

“…Axonal growth is fundamental to the establishment of neuronal connectivity in the brain. However, the cell-intrinsic mechanisms that govern axonal…”
Get full text

The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal morphogenesis and migration by Vadhvani, Mayur, Schwedhelm-Domeyer, Nicola, Mukherjee, Chaitali, Stegmüller, Judith

“…Neuronal development requires proper migration, polarization and establishment of axons and dendrites. Growing evidence identifies the ubiquitin proteasome…”
Get full text

TGFβ-Smad2 Signaling Regulates the Cdh1-APC/SnoN Pathway of Axonal Morphogenesis by Stegmüller, Judith, Huynh, Mai Anh, Yuan, Zengqiang, Konishi, Yoshiyuki, Bonni, Azad

“…Axon growth is critical to the establishment of neuronal connectivity. The E3 ubiquitin ligase Cdh1-anaphase-promoting complex (Cdh1-APC) and its substrate the…”
Get full text

A SnoN-Ccd1 Pathway Promotes Axonal Morphogenesis in the Mammalian Brain by Ikeuchi, Yoshiho, Stegmuller, Judith, Netherton, Stuart, Huynh, Mai Anh, Masu, Masayuki, Frank, David, Bonni, Shirin, Bonni, Azad

“…The transcriptional corepressor SnoN is a critical regulator of axonal morphogenesis, but how SnoN drives axonal growth is unknown. Here, we report that…”
Get full text

The E3 ligase Cdh1-anaphase promoting complex operates upstream of the E3 ligase Smurf1 in the control of axon growth by Kannan, Madhuvanthi, Lee, Shih-Ju, Schwedhelm-Domeyer, Nicola, Stegmüller, Judith

“…Axon growth is an essential event during brain development and is extremely limited due to extrinsic and intrinsic inhibition in the adult brain. The E3…”
Get full text

A FOXO-Pak1 transcriptional pathway controls neuronal polarity by de la Torre-Ubieta, Luis, Gaudillière, Brice, Yang, Yue, Ikeuchi, Yoshiho, Yamada, Tomoko, DiBacco, Sara, Stegmüller, Judith, Schüller, Ulrich, Salih, Dervis A, Rowitch, David, Brunet, Anne, Bonni, Azad

“…Neuronal polarity is essential for normal brain development and function. However, cell-intrinsic mechanisms that govern the establishment of neuronal polarity…”
Get full text

Regulation of Cdh1-APC Function in Axon Growth by Cdh1 Phosphorylation by Huynh, Mai Anh, Stegmuller, Judith, Litterman, Nadia, Bonni, Azad

“…The ubiquitin ligase Cdh1-anaphase promoting complex (Cdh1-APC) plays a key role in the control of axonal morphogenesis in the mammalian brain, but the…”
Get full text

The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2 by Maus, Frank, Sakry, Dominik, Binamé, Fabien, Karram, Khalad, Rajalingam, Krishnaraj, Watts, Colin, Heywood, Richard, Krüger, Rejko, Stegmüller, Judith, Werner, Hauke B, Nave, Klaus-Armin, Krämer-Albers, Eva-Maria, Trotter, Jacqueline

“…The NG2 proteoglycan is characteristically expressed by oligodendrocyte progenitor cells (OPC) and also by aggressive brain tumours highly resistant to chemo-…”
Get full text

Gallyas Silver Impregnation of Myelinated Nerve Fibers by Joseph, Sabitha, Werner, Hauke B, Stegmüller, Judith

“…In the nervous system of vertebrates, nerve impulse propagation is accelerated by the ensheathment of neuronal axons with myelin. Myelin sheaths are…”
Get full text

PIASx Is a MEF2 SUMO E3 Ligase That Promotes Postsynaptic Dendritic Morphogenesis by Shalizi, Aryaman, Bilimoria, Parizad M, Stegmuller, Judith, Gaudilliere, Brice, Yang, Yue, Shuai, Ke, Bonni, Azad

“…Postsynaptic morphogenesis of dendrites is essential for the establishment of neural connectivity in the brain, but the mechanisms that govern postsynaptic…”
Get full text

p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation by Kannan, Madhuvanthi, Lee, Shih-Ju, Schwedhelm-Domeyer, Nicola, Nakazawa, Takanobu, Stegmüller, Judith

“…Axon growth is an essential process during brain development. The E3 ubiquitin ligase Cdh1-APC has emerged as a critical regulator of intrinsic axon growth…”
Get full text

Erythropoietin Dampens Injury-Induced Microglial Motility by Mitkovski, Miso, Dahm, Liane, Heinrich, Ralf, Monnheimer, Mathieu, Gerhart, Simone, Stegmüller, Judith, Hanisch, Uwe-Karsten, Nave, Klaus-Armin, Ehrenreich, Hannelore

“…Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these…”
Get full text

An Isoform-Specific SnoN1-FOXO1 Repressor Complex Controls Neuronal Morphogenesis and Positioning in the Mammalian Brain by Huynh, Mai Anh, Ikeuchi, Yoshiho, Netherton, Stuart, de la Torre-Ubieta, Luis, Kanadia, Rahul, Stegmüller, Judith, Cepko, Constance, Bonni, Shirin, Bonni, Azad

“…Control of neuronal positioning is fundamental to normal brain development. However, the cell-intrinsic mechanisms that govern neuronal positioning remain to…”
Get full text