Search Results - "Steflik, Jeremy"

Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines by France, Scott P., Aleku, Godwin A., Sharma, Mahima, Mangas‐Sanchez, Juan, Howard, Roger M., Steflik, Jeremy, Kumar, Rajesh, Adams, Ralph W., Slabu, Iustina, Crook, Robert, Grogan, Gideon, Wallace, Timothy W., Turner, Nicholas J.

“…Biocatalytic retrosynthetic analysis of dibenz[c,e]azepines has highlighted the use of imine reductase (IRED) and ω‐transaminase (ω‐TA) biocatalysts to…”
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Biocatalytic reductive amination from discovery to commercial manufacturing applied to abrocitinib JAK1 inhibitor by Kumar, Rajesh, Karmilowicz, Michael J., Burke, Dylan, Burns, Michael P., Clark, Leslie A., Connor, Christina G., Cordi, Eric, Do, Nga M., Doyle, Kevin M., Hoagland, Steve, Lewis, Chad A., Mangan, David, Martinez, Carlos A., McInturff, Emma L., Meldrum, Kevin, Pearson, Robert, Steflik, Jeremy, Rane, Anil, Weaver, John

“…Enzymatic reductive amination, being a direct, selective and green methodology, has attracted significant interest in a short period of time and is emerging as…”
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Excitatory Monocyte Chemoattractant Protein-1 Signaling Is Up-Regulated in Sensory Neurons after Chronic Compression of the Dorsal Root Ganglion by White, Fletcher A., Sun, Jihu, Waters, Stephen M., Ma, Chao, Ren, Dongjun, Ripsch, Matthew, Steflik, Jeremy, Cortright, Daniel N., LaMotte, Robert H., Miller, Richard J., Snyder, Solomon H.

“…Neuronal hyperexcitability in both injured and adjacent uninjured neurons is associated with states of chronic injury and pain and is likely subject to…”
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Molecular Characterization of the Gerbil C5a Receptor and Identification of a Transmembrane Domain V Amino Acid That Is Crucial for Small Molecule Antagonist Interaction by Waters, Stephen M., Brodbeck, Robbin M., Steflik, Jeremy, Yu, Jianying, Baltazar, Carolyn, Peck, Amy E., Severance, Daniel, Zhang, Lu Yan, Currie, Kevin, Chenard, Bertrand L., Hutchison, Alan J., Maynard, George, Krause, James E.

“…Anaphylatoxin C5a is a potent inflammatory mediator associated with pathogenesis and progression of several inflammation-associated disorders. Small molecule…”
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Engineering of a Reductive Aminase to Enable the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor by Steflik, Jeremy, Gilio, Amelia, Burns, Michael, Grogan, Gideon, Kumar, Rajesh, Lewis, Russell, Martinez, Carlos

“…Biocatalytic reductive amination reactions with reductive aminases (RedAms) are emerging transformations with a high potential value for pharmaceutical…”
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Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination by France, Scott P., Howard, Roger M., Steflik, Jeremy, Weise, Nicholas J., Mangas‐Sanchez, Juan, Montgomery, Sarah L., Crook, Robert, Kumar, Rajesh, Turner, Nicholas J.

“…Reductive amination of carbonyl compounds constitutes one of the most efficient ways to rapidly construct chiral and achiral amine frameworks. Imine reductase…”
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Chemoenzymatic Asymmetric Synthesis of Pregabalin Precursors via Asymmetric Bioreduction of β‑Cyanoacrylate Esters Using Ene-Reductases by Winkler, Christoph K, Clay, Dorina, Davies, Simon, O’Neill, Pat, McDaid, Paul, Debarge, Sebastien, Steflik, Jeremy, Karmilowicz, Mike, Wong, John W, Faber, Kurt

“…The asymmetric bioreduction of a library of β-cyanoacrylate esters using ene-reductases was studied with the aim to provide a biocatalytic route to precursors…”
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Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor by Duan, Shengquan, Widlicka, Daniel W, Burns, Michael P, Kumar, Rajesh, Hotham, Ian, Desrosiers, Jean-Nicolas, Bowles, Paul, Jones, Kris N, Nicholson, Lindsay D, Buetti-Weekly, Michele T, Han, Lu, Steflik, Jeremy, Hansen, Eric, Hayward, Cheryl M, Strohmeyer, Holly, Monfette, Sébastien, Sutton, Scott C, Morris, Christopher

“…Biocatalytic reductive amination catalyzed by engineered imine reductase (RedAms) is a new and powerful tool for the synthesis of substituted chiral amines…”
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Development of the Synthetic Route to PF-06878031 Part 2: Amide Reduction Route by Brown, Maria S., Buck, Julia, Critcher, Douglas J., Derrick, Andrew M., Fenton, Harriet, Fussell, Steven J., Gymer, Adam E. S., Hawksworth, Michael, Ingram, Heather, Johnson, Rebecca A., Kumar, Rajesh, Laity, Daniel A., Lewis, Russell D., Mathew, Jinu S., McGivern, Laura, Moses, Ian B., Palaia, Andrew T., Patel, Miheal J., Rellegue, James, Rose, Emily K., Scott, Adam, Steflik, Jeremy, Twiddle, Steven J. R.

“…The target compound PF-06878031 is a key structural fragment of a range of oral late-stage glucagon-like peptide-1 receptor agonists (GLP-1-RA) under…”
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Nitrile as Activating Group in the Asymmetric Bioreduction of β-Cyanoacrylic Acids Catalyzed by Ene-Reductases by Winkler, Christoph K., Clay, Dorina, Turrini, Nikolaus G., Lechner, Horst, Kroutil, Wolfgang, Davies, Simon, Debarge, Sebastien, O'Neill, Pat, Steflik, Jeremy, Karmilowicz, Mike, Wong, John W., Faber, Kurt

“…Asymmetric bioreduction of an (E)‐β‐cyano‐2,4‐dienoic acid derivative by ene‐reductases allowed a shortened access to a precursor of pregabalin…”
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Evaluation of Several Routes to Advanced Pregabalin Intermediates: Synthesis and Enantioselective Enzymatic Reduction Using Ene-Reductases by Debarge, Sébastien, McDaid, Paul, O’Neill, Pat, Frahill, James, Wong, John W, Carr, Donncha, Burrell, Adam, Davies, Simon, Karmilowicz, Mike, Steflik, Jeremy

“…This publication describes the evaluation of four synthetic routes to the advanced pregabalin (Lyrica) intermediate 7. Asymmetric reduction of (E)-7 with an…”
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Nitrile as Activating Group in the Asymmetric Bioreduction of [beta]-Cyanoacrylic Acids Catalyzed by Ene-Reductases by Winkler, Christoph K, Clay, Dorina, Turrini, Nikolaus G, Lechner, Horst, Kroutil, Wolfgang, Davies, Simon, Debarge, Sebastien, O'Neill, Pat, Steflik, Jeremy, Karmilowicz, Mike, Wong, John W, Faber, Kurt

“…Asymmetric bioreduction of an (E)-[beta]-cyano-2,4-dienoic acid derivative by ene-reductases allowed a shortened access to a precursor of pregabalin…”
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Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines by France, Scott P., Aleku, Godwin A., Sharma, Mahima, Mangas‐Sanchez, Juan, Howard, Roger M., Steflik, Jeremy, Kumar, Rajesh, Adams, Ralph W., Slabu, Iustina, Crook, Robert, Grogan, Gideon, Wallace, Timothy W., Turner, Nicholas J.

“…Biocatalytic retrosynthetic analysis of dibenz[c,e]azepines has highlighted the use of imine reductase (IRED) and ω‐transaminase (ω‐TA) biocatalysts to…”
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Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction. VOLUME 280 (2005) PAGES 40617-40623 by Waters, Stephen M., Brodbeck, Robbin M., Steflik, Jeremy, Yu, Jianying, Baltazar, Carolyn, Peck, Amy E., Severance, Daniel, Zhang, Lu Yan, Currie, Kevin, Chenard, Bertrand L., Hutchison, Alan J., Maynard, George, Krause, James E.

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