Search Results - "Steffes, M"

PEGylation of Paclitaxel-Loaded Cationic Liposomes Drives Steric Stabilization of Bicelles and Vesicles thereby Enhancing Delivery and Cytotoxicity to Human Cancer Cells by Steffes, Victoria M, Zhang, Zhening, MacDonald, Scott, Crowe, John, Ewert, Kai K, Carragher, Bridget, Potter, Clinton S, Safinya, Cyrus R

“…Poly­(ethylene glycol) (PEG) is a polymer used widely in drug delivery to create “stealth” nanoparticles (NPs); PEG coatings suppress NP detection and…”
Get full text

Cationic Liposomes as Vectors for Nucleic Acid and Hydrophobic Drug Therapeutics by Ewert, Kai K, Scodeller, Pablo, Simón-Gracia, Lorena, Steffes, Victoria M, Wonder, Emily A, Teesalu, Tambet, Safinya, Cyrus R

“…Cationic liposomes (CLs) are effective carriers of a variety of therapeutics. Their applications as vectors of nucleic acids (NAs), from long DNA and mRNA to…”
Get full text

Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002 by Lee, D.-H, Lee, I.-K, Porta, M, Steffes, M, Jacobs, D. R. Jr

“…Aims/hypothesis We recently reported associations of some persistent organic pollutants (POPs) with both prevalence of type 2 diabetes and insulin resistance…”
Get full text

Paclitaxel loading in cationic liposome vectors is enhanced by replacement of oleoyl with linoleoyl tails with distinct lipid shapes by Zhen, Yuhong, Ewert, Kai K., Fisher, William S., Steffes, Victoria M., Li, Youli, Safinya, Cyrus R.

“…Lipid carriers of hydrophobic paclitaxel (PTX) are used in clinical trials for cancer chemotherapy. Improving their loading capacity requires enhanced PTX…”
Get full text

Association between asthma and serum adiponectin concentration in women by Sood, A, Cui, X, Qualls, C, Beckett, W S, Gross, M D, Steffes, M W, Smith, L J, Jacobs, Jr, D R

“…The association of murine asthma with adiposity may be mediated by adiponectin, an anti-inflammatory adipokine with reduced serum concentrations in obese…”
Get more information

Synthesis of linear and cyclic peptide–PEG–lipids for stabilization and targeting of cationic liposome–DNA complexes by Ewert, Kai K., Kotamraju, Venkata Ramana, Majzoub, Ramsey N., Steffes, Victoria M., Wonder, Emily A., Teesalu, Tambet, Ruoslahti, Erkki, Safinya, Cyrus R.

“…[Display omitted] Because nucleic acids (NAs) have immense potential value as therapeutics, the development of safe and effective synthetic NA vectors…”
Get full text

Can persistent organic pollutants explain the association between serum γ-glutamyltransferase and type 2 diabetes by Lee, D.-H, Steffes, M. W, Jacobs, D. R. Jr

“…The results of several epidemiological studies of serum γ-glutamyltransferase (GGT) led us to hypothesise that associations of GGT within its normal range with…”
Get full text

Insulin secretion measured by stimulated C-peptide in long-established Type 1 diabetes in the Diabetes Control and Complications Trial (DCCT)/ Epidemiology of Diabetes Interventions and Complications (EDIC) cohort: a pilot study by McGee, P., Steffes, M., Nowicki, M., Bayless, M., Gubitosi-Klug, R., Cleary, P., Lachin, J., Palmer, J.

“…Aims To evaluate whether clinically relevant concentrations of stimulated C‐peptide in response to a mixed‐meal tolerance test can be detected after almost…”
Get full text

HbA1c measurements across- different platforms: exercising caution when making decisions regarding diagnosis by Cao, J., Li, D., Steffes, M., Bellin, M. D.

Get full text

HbA 1c measurements across- different platforms: exercising caution when making decisions regarding diagnosis by Cao, J, Li, D, Steffes, M, Bellin, M D

Get full text

Reversal of Lesions of Diabetic Nephropathy after Pancreas Transplantation by Fioretto, Paola, Steffes, Michael W, Sutherland, David E.R, Goetz, Frederick C, Mauer, Michael

“…Diabetic nephropathy is the single most important cause of end-stage renal disease. 1 It results from the gradual accumulation of extracellular matrix in…”
Get full text

Hemoglobin A1c Measurements over Nearly Two Decades: Sustaining Comparable Values throughout the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications Study by Steffes, Michael, Cleary, Patricia, Goldstein, David, Little, Randie, Wiedmeyer, Hsiao-Mei, Rohlfing, Curt, England, Jack, Bucksa, Jean, Nowicki, Maren, DCCT/EDIC Research Group

“…Clinical trials require assays that provide consistent results during the course of a study. The hemoglobin A1c (HbA1c) assay, a measure of chronic glycemia,…”
Get full text

Effects of Insulin in Relatives of Patients with Type 1 Diabetes Mellitus

“…Persons who are at high risk for type 1 diabetes may be identified on the basis of islet-cell antibody levels, insulin antibody levels, and genetic studies…”
Get full text

Stability of haemoglobin A1c (HbA1c) measurements from frozen whole blood samples stored for over a decade by Selvin, E., Coresh, J., Jordahl, J., Boland, L., Steffes, M. W.

“…Objective  Haemoglobin A1c (HbA1c), a measure of long‐term glycaemic control, is at the centre of the clinical management of diabetes mellitus. However, the…”
Get full text

Gamma-glutamyltransferase and diabetes: a 4 year follow-up study by LEE, D.-H, HA, M.-H, KIM, J.-H, CHRISTIANI, D. C, GROSS, M. D, STEFFES, M, BLOMHOFF, R, JACOBS, D. R

“…Gamma-glutamyltransferase (GGT) is located on the external surface of most cells and mediates the uptake of gluthathione, an important component of…”
Get full text

Association of inflammation with worsening HOMA-insulin resistance by Park, K, Steffes, M, Lee, D.-H, Himes, J. H, Jacobs, D. R. Jr

“…Aims/hypothesis We examined the cross-sectional and longitudinal relationships between C-reactive protein (CRP), a marker of low-grade inflammation, and…”
Get full text

Renal function and rate of hip bone loss in older men: the Osteoporotic Fractures in Men Study by Ishani, A., Paudel, M., Taylor, B. C., Barrett-Connor, E., Jamal, S., Canales, M., Steffes, M., Fink, H. A., Orwoll, E., Cummings, S. R., Ensrud, K. E.

“…Summary Older men with reduced renal function are at increased risk of hip bone loss. Given the robustness of this association across different measures and a…”
Get full text

Ovarian reserve in women with Type 1 diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study by Kim, C., Dunn, R. L., Braffett, B., Cleary, P. A., Arends, V., Steffes, M., Lanham, M. S. M., Randolph, J. F., Wessells, H., Wellons, M. F., Sarma, A. V.

“…Markers of ovarian reserve such as anti-Müllerian hormone (AMH) are used in the management of fertility and prediction of menopause. Although women with type 1…”
Get full text

Glycohemoglobin: A Primary Predictor of the Development or Reversal of Complications of Diabetes Mellitus by Krishnamurti, Uma, Steffes, Michael W

“…Diabetes mellitus is a major health problem worldwide with long-term micro- and macrovascular complications responsible for a majority of its morbidity and…”
Get full text

Prevention of diabetic renal disease with special reference to microalbuminuria by Mogensen, C E, Keane, W F, Bennett, P H, Jerums, G, Parving, H H, Passa, P, Steffes, M W, Striker, G E, Viberti, G C

Get more information