Search Results - "Steffen, D."

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain by Dawicki-McKenna, Jennine M., Langelier, Marie-France, DeNizio, Jamie E., Riccio, Amanda A., Cao, Connie D., Karch, Kelly R., McCauley, Michael, Steffen, Jamin D., Black, Ben E., Pascal, John M.

“…Poly(ADP-ribose) polymerase-1 (PARP-1) creates the posttranslational modification PAR from substrate NAD+ to regulate multiple cellular processes. DNA breaks…”
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STED imaging of endogenously tagged ARF GTPases reveals their distinct nanoscale localizations by Wong-Dilworth, Luis, Rodilla-Ramirez, Carmen, Fox, Eleanor, Restel, Steffen D, Stockhammer, Alexander, Adarska, Petia, Bottanelli, Francesca

“…ADP-ribosylation factor (ARF) GTPases are major regulators of cellular membrane homeostasis. High sequence similarity and multiple, possibly redundant…”
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Structural basis for allosteric PARP-1 retention on DNA breaks by Zandarashvili, Levani, Langelier, Marie-France, Velagapudi, Uday Kiran, Hancock, Mark A, Steffen, Jamin D, Billur, Ramya, Hannan, Zain M, Wicks, Andrew J, Krastev, Dragomir B, Pettitt, Stephen J, Lord, Christopher J, Talele, Tanaji T, Pascal, John M, Black, Ben E

“…The success of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors (PARPi) to treat cancer relates to their ability to trap PARP-1 at the site of a DNA break…”
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Amplified seasonal cycle in hydroclimate over the Amazon river basin and its plume region by Liang, Yu-Chiao, Lo, Min-Hui, Lan, Chia-Wei, Seo, Hyodae, Ummenhofer, Caroline C., Yeager, Stephen, Wu, Ren-Jie, Steffen, John D.

“…The Amazon river basin receives ~2000 mm of precipitation annually and contributes ~17% of global river freshwater input to the oceans; its hydroclimatic…”
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N-terminal pro–B-type natriuretic peptide for monitoring after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension by Kriechbaum, Steffen D., Wiedenroth, Christoph B., Wolter, Jan Sebastian, Hütz, Regula, Haas, Moritz, Breithecker, Andreas, Roller, Fritz C., Keller, Till, Guth, Stefan, Rolf, Andreas, Hamm, Christian W., Mayer, Eckhard, Liebetrau, Christoph

“…Balloon pulmonary angioplasty (BPA) is an emerging interventional treatment option for chronic thromboembolic pulmonary hypertension (CTEPH). The non-invasive…”
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Riociguat and balloon pulmonary angioplasty improve prognosis in patients with inoperable chronic thromboembolic pulmonary Hypertension by Wiedenroth, Christoph B., Rolf, Andreas, Steinhaus, Kristin, Adameit, Miriam S.D., Kriechbaum, Steffen D., Haas, Moritz, Roller, Fritz, Hamm, Christian W., Ghofrani, H. Ardeschir, Mayer, Eckhard, Breithecker, Andreas, Guth, Stefan, Liebetrau, Christoph

“…The combination of riociguat and interventional balloon pulmonary angioplasty (BPA) is currently used to treat patients with inoperable chronic thromboembolic…”
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CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages by De, Ishani, Steffen, Megan D, Clark, Paul A, Patros, Clayton J, Sokn, Emily, Bishop, Stephanie M, Litscher, Suzanne, Maklakova, Vilena I, Kuo, John S, Rodriguez, Fausto J, Collier, Lara S

“…Current therapies for high-grade gliomas extend survival only modestly. The glioma microenvironment, including glioma-associated microglia/macrophages (GAM),…”
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Complications of balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension: Impact on the outcome by Wiedenroth, Christoph B., Deissner, Henrike, Adameit, Miriam S.D., Kriechbaum, Steffen D., Ghofrani, H.-Ardeschir, Breithecker, Andreas, Haas, Moritz, Roller, Fritz, Rolf, Andreas, Hamm, Christian W., Mayer, Eckhard, Guth, Stefan, Liebetrau, Christoph

“…Balloon pulmonary angioplasty (BPA) is an emerging interventional treatment for inoperable chronic thromboembolic pulmonary hypertension (CTEPH) that targets…”
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Sensitivity, Specificity, and Sex Differences in Symptoms Reported on the 13‐Item Acute Coronary Syndrome Checklist by DeVon, Holli A., Rosenfeld, Anne, Steffen, Alana D., Daya, Mohamud

“…Background Clinical symptoms are part of the risk stratification approaches used in the emergency department (ED) to evaluate patients with suspected acute…”
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Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts by Steffen, Fabio D., Khier, Mokrane, Kowerko, Danny, Cunha, Richard A., Börner, Richard, Sigel, Roland K. O.

“…The fidelity of group II intron self-splicing and retrohoming relies on long-range tertiary interactions between the intron and its flanking exons. By…”
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Dynamics of high-sensitivity cardiac troponin T during therapy with balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension by Kriechbaum, Steffen D, Wiedenroth, Christoph B, Keller, Till, Wolter, Jan Sebastian, Ajnwojner, Ruth, Peters, Karina, Haas, Moritz A, Roller, Fritz C, Breithecker, Andreas, Rieth, Andreas J, Guth, Stefan, Rolf, Andreas, Bandorski, Dirk, Hamm, Christian W, Mayer, Eckhard, Liebetrau, Christoph

“…Balloon pulmonary angioplasty (BPA) is an interventional treatment modality for inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Therapy…”
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Structural Implications for Selective Targeting of PARPs by Steffen, Jamin D, Brody, Jonathan R, Armen, Roger S, Pascal, John M

“…Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that use NAD(+) as a substrate to synthesize polymers of ADP-ribose (PAR) as post-translational…”
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Pregnancy-associated plasma protein A – a new indicator of pulmonary vascular remodeling in chronic thromboembolic pulmonary hypertension? by Kriechbaum, Steffen D, Rudolph, Felix, Wiedenroth, Christoph B, Mielzarek, Lisa, Haas, Moritz, Guth, Stefan, Hamm, Christian W, Mayer, Eckhard, Liebetrau, Christoph, Keller, Till

“…Abstract Background In chronic thromboembolic pulmonary hypertension (CTEPH) impaired pulmonary hemodynamics lead to right heart failure. Natriuretic peptides…”
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B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow by Barz, Malwine J, Behrmann, Lena, Capron, Danaëlle, Zuchtriegel, Gabriele, Steffen, Fabio D, Kunz, Leo, Zhang, Yang, Vermeerbergen, Iria Jimenez, Marovca, Blerim, Kirschmann, Moritz, Zech, Antonia, Nombela-Arrieta, César, Ziegler, Urs, Schroeder, Timm, Bornhauser, Beat, Bourquin, Jean-Pierre

“…Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). The bone marrow…”
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Comparison between filter- and optimization-based motion cueing algorithms for driving simulation by Cleij, D., Venrooij, J., Pretto, P., Katliar, M., Bülthoff, H.H., Steffen, D., Hoffmeyer, F.W., Schöner, H.-P.

“…•Optimization-based cueing algorithms show improvements w.r.t. filter-based cueing.•Continuous and overall rating result in similar perceived motion mismatch…”
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Does Age Matter? Pulmonary Endarterectomy in the Elderly Patient with CTEPH by Wiedenroth, Christoph B, Bandorski, Dirk, Ariobi, Kanischka, Ghofrani, H-Ardeschir, Lankeit, Mareike, Liebetrau, Christoph, Pruefer, Diethard, Mayer, Eckhard, Kriechbaum, Steffen D, Guth, Stefan

“…The gold standard treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) is pulmonary endarterectomy (PEA). Little is known about the…”
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Inheritance of a mutation causing neuropathy with splayed forelimbs in Jersey cattle by Al-Khudhair, A., Null, D.J., Cole, J.B., Wolfe, C.W., Steffen, D.J., VanRaden, P.M.

“…A new undesirable genetic factor, neuropathy with splayed forelimbs (JNS), has been identified recently in the Jersey breed. Calves affected with JNS are…”
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Randomized controlled pilot of a group antenatal care model and the sociodemographic factors associated with pregnancy-related empowerment in sub-Saharan Africa by Patil, Crystal L, Klima, Carrie S, Leshabari, Sebalda C, Steffen, Alana D, Pauls, Heather, McGown, Molly, Norr, Kathleen F

“…The links between empowerment and a number of health-related outcomes in sub-Saharan Africa have been documented, but empowerment related to pregnancy is…”
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Womb to womb: Maternal litter size and birth weight but not adult characteristics predict early neonatal death of offspring in the common marmoset monkey by Rutherford, Julienne N, Ross, Corinna N, Ziegler, Toni, Burke, Larisa A, Steffen, Alana D, Sills, Aubrey, Layne Colon, Donna, deMartelly, Victoria A, Narapareddy, Laren R, Tardif, Suzette D

“…A singular focus on maternal health at the time of a pregnancy leaves much about perinatal mortality unexplained, especially when there is growing evidence for…”
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Galectin-3, GDF-15, and sST2 for the assessment of disease severity and therapy response in patients suffering from inoperable chronic thromboembolic pulmonary hypertension by Kriechbaum, Steffen D., Wiedenroth, Christoph B., Peters, Karina, Barde, Marta A., Ajnwojner, Ruth, Wolter, Jan-Sebastian, Haas, Moritz, Roller, Fritz C., Guth, Stefan, Rieth, Andreas J., Rolf, Andreas, Hamm, Christian W., Mayer, Eckhard, Keller, Till, Liebetrau, Christoph

“…This study examined sST2, GDF-15, and galectin-3 as indicators of disease severity and therapy response in chronic thromboembolic pulmonary hypertension…”
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