Search Results - "Steffan, D."

Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study by Ramos, Yolande F M, den Hollander, Wouter, Bovée, Judith V M G, Bomer, Nils, van der Breggen, Ruud, Lakenberg, Nico, Keurentjes, J Christiaan, Goeman, Jelle J, Slagboom, P Eline, Nelissen, Rob G H H, Bos, Steffan D, Meulenbelt, Ingrid

“…Identify gene expression profiles associated with OA processes in articular cartilage and determine pathways changing during the disease process. Genome wide…”
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Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis by Bos, Steffan D, Page, Christian M, Andreassen, Bettina K, Elboudwarej, Emon, Gustavsen, Marte W, Briggs, Farren, Quach, Hong, Leikfoss, Ingvild S, Bjølgerud, Anja, Berge, Tone, Harbo, Hanne F, Barcellos, Lisa F

“…Determine whether MS-specific DNA methylation profiles can be identified in whole blood or purified immune cells from untreated MS patients. Whole blood, CD4+…”
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Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients by Rhead, Brooke, Brorson, Ina S, Berge, Tone, Adams, Cameron, Quach, Hong, Moen, Stine Marit, Berg-Hansen, Pål, Celius, Elisabeth Gulowsen, Sangurdekar, Dipen P, Bronson, Paola G, Lea, Rodney A, Burnard, Sean, Maltby, Vicki E, Scott, Rodney J, Lechner-Scott, Jeannette, Harbo, Hanne F, Bos, Steffan D, Barcellos, Lisa F

“…DNA methylation is an epigenetic mark that is influenced by environmental factors and is associated with changes to gene expression and phenotypes. It may link…”
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Genes expressed in blood link osteoarthritis with apoptotic pathways by Ramos, Yolande F M, Bos, Steffan D, Lakenberg, Nico, Böhringer, Stefan, den Hollander, Wouter J, Kloppenburg, Margreet, Slagboom, P Eline, Meulenbelt, Ingrid

“…To identify novel gene expression networks in blood of osteoarthritis patients compared to controls. A comprehensive exploration of gene expression in…”
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Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array by Slieker, Roderick C, Bos, Steffan D, Goeman, Jelle J, Bovée, Judith Vmg, Talens, Rudolf P, van der Breggen, Ruud, Suchiman, H Eka D, Lameijer, Eric-Wubbo, Putter, Hein, van den Akker, Erik B, Zhang, Yanju, Jukema, J Wouter, Slagboom, P Eline, Meulenbelt, Ingrid, Heijmans, Bastiaan T

“…DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated…”
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Discovery of Ruthenium(II) Metallocompound and Olaparib Synergy for Cancer Combination Therapy by Yusoh, Nur Aininie, Tiley, Paul R., James, Steffan D., Harun, Siti Norain, Thomas, Jim A., Saad, Norazalina, Hii, Ling-Wei, Chia, Suet Lin, Gill, Martin R., Ahmad, Haslina

“…Synergistic drug combinations can extend the use of poly­(ADP-ribose) polymerase inhibitors (PARPi) such as Olaparib to BRCA-proficient tumors and overcome…”
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Transcriptional Associations of Osteoarthritis‐Mediated Loss of Epigenetic Control in Articular Cartilage by den Hollander, Wouter, Ramos, Yolande F. M., Bomer, Nils, Elzinga, Stefan, van der Breggen, Ruud, Lakenberg, Nico, de Dijcker, Wesley J., Suchiman, H. Eka D., Duijnisveld, Bouke J., Houwing‐Duistermaat, Jeanine J., Slagboom, P. Eline, Bos, Steffan D., Nelissen, Rob G. H. H., Meulenbelt, Ingrid

“…Objective To identify osteoarthritis (OA) progression–modulating pathways in articular cartilage and their respective regulatory epigenetic and genetic…”
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Are white matter hyperintensities associated with neuroborreliosis? The answer is twofold by Lindland, Elisabeth S, Røvang, Martin S, Solheim, Anne Marit, Andreassen, Silje, Skarstein, Ingerid, Dareez, Nazeer, MacIntosh, Bradley J, Eikeland, Randi, Ljøstad, Unn, Mygland, Åse, Bos, Steffan D, Ulvestad, Elling, Reiso, Harald, Lorentzen, Åslaug R, Harbo, Hanne F, Bjørnerud, Atle, Beyer, Mona K

“…Many consider white matter hyperintensities (WMHs) to be important imaging findings in neuroborreliosis. However, evidence regarding association with WMHs is…”
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Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis by Bomer, Nils, den Hollander, Wouter, Ramos, Yolande F M, Bos, Steffan D, van der Breggen, Ruud, Lakenberg, Nico, Pepers, Barry A, van Eeden, Annelies E, Darvishan, Arash, Tobi, Elmar W, Duijnisveld, Bouke J, van den Akker, Erik B, Heijmans, Bastiaan T, van Roon-Mom, Willeke Mc, Verbeek, Fons J, van Osch, Gerjo J V M, Nelissen, Rob G H H, Slagboom, P Eline, Meulenbelt, Ingrid

“…To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the…”
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Predicting disease severity in multiple sclerosis using multimodal data and machine learning by Andorra, Magi, Freire, Ana, Zubizarreta, Irati, de Rosbo, Nicole Kerlero, Bos, Steffan D., Rinas, Melanie, Høgestøl, Einar A., de Rodez Benavent, Sigrid A., Berge, Tone, Brune-Ingebretse, Synne, Ivaldi, Federico, Cellerino, Maria, Pardini, Matteo, Vila, Gemma, Pulido-Valdeolivas, Irene, Martinez-Lapiscina, Elena H., Llufriu, Sara, Saiz, Albert, Blanco, Yolanda, Martinez-Heras, Eloy, Solana, Elisabeth, Bäcker-Koduah, Priscilla, Behrens, Janina, Kuchling, Joseph, Asseyer, Susanna, Scheel, Michael, Chien, Claudia, Zimmermann, Hanna, Motamedi, Seyedamirhosein, Kauer-Bonin, Josef, Brandt, Alex, Saez-Rodriguez, Julio, Alexopoulos, Leonidas G., Paul, Friedemann, Harbo, Hanne F., Shams, Hengameh, Oksenberg, Jorge, Uccelli, Antonio, Baeza-Yates, Ricardo, Villoslada, Pablo

“…Background Multiple sclerosis patients would benefit from machine learning algorithms that integrates clinical, imaging and multimodal biomarkers to define the…”
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Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis by Brune, Synne, Høgestøl, Einar A, de Rodez Benavent, Sigrid A, Berg-Hansen, Pål, Beyer, Mona K, Leikfoss, Ingvild Sørum, Bos, Steffan D, Sowa, Piotr, Brunborg, Cathrine, Andorra, Magi, Pulido Valdeolivas, Irene, Asseyer, Susanna, Brandt, Alexander, Chien, Claudia, Scheel, Michael, Blennow, Kaj, Zetterberg, Henrik, Kerlero de Rosbo, Nicole, Paul, Friedemann, Uccelli, Antonio, Villoslada, Pablo, Berge, Tone, Harbo, Hanne F

“…Background: Serum neurofilament light (sNfL) chain is a promising biomarker reflecting neuro-axonal injury in multiple sclerosis (MS). However, the ability of…”
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Multiscale networks in multiple sclerosis by Kennedy, Keith E, Kerlero de Rosbo, Nicole, Uccelli, Antonio, Cellerino, Maria, Ivaldi, Federico, Contini, Paola, De Palma, Raffaele, Harbo, Hanne F, Berge, Tone, Bos, Steffan D, Høgestøl, Einar A, Brune-Ingebretsen, Synne, de Rodez Benavent, Sigrid A, Paul, Friedemann, Brandt, Alexander U, Bäcker-Koduah, Priscilla, Behrens, Janina, Kuchling, Joseph, Asseyer, Susanna, Scheel, Michael, Chien, Claudia, Zimmermann, Hanna, Motamedi, Seyedamirhosein, Kauer-Bonin, Josef, Saez-Rodriguez, Julio, Rinas, Melanie, Alexopoulos, Leonidas G, Andorra, Magi, Llufriu, Sara, Saiz, Albert, Blanco, Yolanda, Martinez-Heras, Eloy, Solana, Elisabeth, Pulido-Valdeolivas, Irene, Martinez-Lapiscina, Elena H, Garcia-Ojalvo, Jordi, Villoslada, Pablo

“…Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full…”
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GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors by Leijten, Jeroen C H, Bos, Steffan D, Landman, Ellie B M, Georgi, Nicole, Jahr, Holger, Meulenbelt, Ingrid, Post, Janine N, van Blitterswijk, Clemens A, Karperien, Marcel

“…Osteoarthritis is, at least in a subset of patients, associated with hypertrophic differentiation of articular chondrocytes. Recently, we identified the bone…”
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A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis by Ramos, Yolande F M, Bos, Steffan D, van der Breggen, Ruud, Kloppenburg, Margreet, Ye, Kai, Lameijer, Eric-Wubbo E M W, Nelissen, Rob G H H, Slagboom, P Eline, Meulenbelt, Ingrid

“…To identify pathogenic mutations that reveal underlying biological mechanisms driving osteoarthritis (OA). Exome sequencing was applied to two distant family…”
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Incidence of gastrointestinal stromal tumours is underestimated: Results of a nation-wide study by Goettsch, Wim G., Bos, Steffan D., Breekveldt-Postma, Nancy, Casparie, Mariel, Herings, Ron M.C., Hogendoorn, Pancras C.W.

“…Gastrointestinal stromal tumours (GIST) are identified by their specific morphology added with immunohistochemical staining with anti-CD117, the phenotypic…”
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Brain disconnectome mapping derived from white matter lesions and serum neurofilament light levels in multiple sclerosis: A longitudinal multicenter study by Rise, Henning H., Brune, Synne, Chien, Claudia, Berge, Tone, Bos, Steffan D., Andorrà, Magí, Valdeolivas, Irene Pulido, Beyer, Mona K., Sowa, Piotr, Scheel, Michael, Brandt, Alexander U., Asseyer, Susanna, Blennow, Kaj, Pedersen, Mads L., Zetterberg, Henrik, de Schotten, Michel Thiebaut, Cellerino, Maria, Uccelli, Antonio, Paul, Friedemann, Villoslada, Pablo, Harbo, Hanne F., Westlye, Lars T., Høgestøl, Einar A.

“…•Individual disconnectome maps generated using a template of 7T MRI data.•Disconnectome maps conceptualize distal brain network aberrations.•Using lesions maps…”
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Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells by Leikfoss, Ingvild S, Keshari, Pankaj K, Gustavsen, Marte W, Bjølgerud, Anja, Brorson, Ina S, Celius, Elisabeth G, Spurkland, Anne, Bos, Steffan D, Harbo, Hanne F, Berge, Tone

“…For multiple sclerosis, genome wide association studies and follow up studies have identified susceptibility single nucleotide polymorphisms located in or near…”
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Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells by Eriksson, Anna M., Leikfoss, Ingvild Sørum, Abrahamsen, Greger, Sundvold, Vibeke, Isom, Martine Mesel, Keshari, Pankaj K., Rognes, Torbjørn, Landsverk, Ole J. B., Bos, Steffan D., Harbo, Hanne F., Spurkland, Anne, Berge, Tone

“…C‐type lectin‐like domain family 16 member A (CLEC16A) is associated with autoimmune disorders, including multiple sclerosis (MS), but its functional relevance…”
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Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors by Wang, Yunpeng, Bos, Steffan D, Harbo, Hanne F, Thompson, Wesley K, Schork, Andrew J, Bettella, Francesco, Witoelar, Aree, Lie, Benedicte A, Li, Wen, McEvoy, Linda K, Djurovic, Srdjan, Desikan, Rahul S, Dale, Anders M, Andreassen, Ole A

“…Background: Epidemiological findings suggest a relationship between multiple sclerosis (MS) and cardiovascular disease (CVD) risk factors, although the nature…”
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Genetic variants are major determinants of CSF antibody levels in multiple sclerosis by Goris, An, Pauwels, Ine, Gustavsen, Marte W, van Son, Brechtje, Hilven, Kelly, Bos, Steffan D, Celius, Elisabeth Gulowsen, Berg-Hansen, Pål, Aarseth, Jan, Myhr, Kjell-Morten, D'Alfonso, Sandra, Barizzone, Nadia, Leone, Maurizio A, Martinelli Boneschi, Filippo, Sorosina, Melissa, Liberatore, Giuseppe, Kockum, Ingrid, Olsson, Tomas, Hillert, Jan, Alfredsson, Lars, Bedri, Sahl Khalid, Hemmer, Bernhard, Buck, Dorothea, Berthele, Achim, Knier, Benjamin, Biberacher, Viola, van Pesch, Vincent, Sindic, Christian, Bang Oturai, Annette, Søndergaard, Helle Bach, Sellebjerg, Finn, Jensen, Poul Erik H, Comabella, Manuel, Montalban, Xavier, Pérez-Boza, Jennifer, Malhotra, Sunny, Lechner-Scott, Jeannette, Broadley, Simon, Slee, Mark, Taylor, Bruce, Kermode, Allan G, Gourraud, Pierre-Antoine, Sawcer, Stephen J, Andreassen, Bettina Kullle, Dubois, Bénédicte, Harbo, Hanne F

“…Immunological hallmarks of multiple sclerosis include the production of antibodies in the central nervous system, expressed as presence of oligoclonal bands…”
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