Search Results - "Stefela, Alzbeta"

Atorvastatin Modulates Bile Acid Homeostasis in Mice with Diet-Induced Nonalcoholic Steatohepatitis by Lastuvkova, Hana, Faradonbeh, Fatemeh Alaei, Schreiberova, Jolana, Hroch, Milos, Mokry, Jaroslav, Faistova, Hana, Nova, Zuzana, Hyspler, Radomír, Igreja Sa, Ivone Cristina, Nachtigal, Petr, Stefela, Alzbeta, Pavek, Petr, Micuda, Stanislav

“…Bile acids (BA) play a significant role in the pathophysiology of nonalcoholic steatohepatitis (NASH). The present study evaluates the modulation of bile acid…”
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(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells by Stefela, Alzbeta, Kaspar, Miroslav, Drastik, Martin, Kronenberger, Thales, Micuda, Stanislav, Dracinsky, Martin, Klepetarova, Blanka, Kudova, Eva, Pavek, Petr

“…Bile acids (BAs) are key signaling steroidal molecules that regulate glucose, lipid, and energy homeostasis via interactions with the farnesoid X receptor…”
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PLGA Based Nanospheres as a Potent Macrophage-Specific Drug Delivery System by Boltnarova, Barbora, Kubackova, Jana, Skoda, Josef, Stefela, Alzbeta, Smekalova, Monika, Svacinova, Petra, Pavkova, Ivona, Dittrich, Milan, Scherman, Daniel, Zbytovska, Jarmila, Pavek, Petr, Holas, Ondrej

“…Macrophages possess an innate ability to scavenge heterogenous objects from the systemic circulation and to regulate inflammatory diseases in various organs…”
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Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain by Skoda, Josef, Dusek, Jan, Drastik, Martin, Stefela, Alzbeta, Dohnalova, Klara, Chalupsky, Karel, Smutny, Tomas, Micuda, Stanislav, Gerbal-Chaloin, Sabine, Pavek, Petr

“…The constitutive androstane receptor (CAR) is the essential regulator of genes involved both in xenobiotic and endobiotic metabolism. Diazepam has been shown…”
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Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2‑a]pyridine Structure by Mejdrová, Ivana, Dušek, Jan, Škach, Kryštof, Stefela, Alžbeta, Skoda, Josef, Chalupský, Karel, Dohnalová, Klára, Pavkova, Ivona, Kronenberger, Thales, Rashidian, Azam, Smutná, Lucie, Duchoslav, Vojtěch, Smutny, Tomas, Pávek, Petr, Nencka, Radim

“…The nuclear constitutive androstane receptor (CAR, NR1I3) plays significant roles in many hepatic functions, such as fatty acid oxidation, biotransformation,…”
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Carvedilol impairs bile acid homeostasis in mice: implication for nonalcoholic steatohepatitis by Lastuvkova, Hana, Nova, Zuzana, Hroch, Milos, Alaei Faradonbeh, Fatemeh, Schreiberova, Jolana, Mokry, Jaroslav, Faistova, Hana, Stefela, Alzbeta, Dusek, Jan, Kucera, Otto, Hyspler, Radomír, Dohnalkova, Ester, Bayer, Rachel L, Hirsova, Petra, Pavek, Petr, Micuda, Stanislav

“…Abstract Carvedilol is a widely used beta-adrenoreceptor antagonist for multiple cardiovascular indications; however, it may induce cholestasis in patients,…”
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Front Cover: When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists (ChemMedChem 4/2023) by Díaz‐Holguín, Alejandro, Rashidian, Azam, Pijnenburg, Dirk, Monteiro Ferreira, Glaucio, Stefela, Alzbeta, Kaspar, Miroslav, Kudova, Eva, Poso, Antti, Beuningen, Rinie, Pavek, Petr, Kronenberger, Thales

“…The Front Cover features the farnesoid X receptor (FXR) which is a nuclear receptor with a role in regulating bile acid synthesis and cholesterol homeostasis…”
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3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism by Stefela, Alzbeta, Kaspar, Miroslav, Drastik, Martin, Holas, Ondrej, Hroch, Milos, Smutny, Tomas, Skoda, Josef, Hutníková, Miriama, Pandey, Amit V., Micuda, Stanislav, Kudova, Eva, Pavek, Petr

“…[Display omitted] •3β-IsoOCA is an efficient FXR activator due to epimerization to OCA in the hepatic cells.•3,7-DehydroOCA is a novel potent GPBAR1…”
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When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists by Díaz‐Holguín, Alejandro, Rashidian, Azam, Pijnenburg, Dirk, Monteiro Ferreira, Glaucio, Stefela, Alzbeta, Kaspar, Miroslav, Kudova, Eva, Poso, Antti, Beuningen, Rinie, Pavek, Petr, Kronenberger, Thales

“…Farnesoid X receptor (FXR) is a nuclear receptor with an essential role in regulating bile acid synthesis and cholesterol homeostasis. FXR activation by…”
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