Search Results - "Stefansson, M."

EZH2 Expression Is Associated With High Proliferation Rate and Aggressive Tumor Subgroups in Cutaneous Melanoma and Cancers of the Endometrium, Prostate, and Breast by BACHMANN, Ingeborg M, HALVORSEN, Ole J, COLLETT, Karin, STEFANSSON, Ingunn M, STRAUME, Oddbjørn, HAUKAAS, Svein A, SALVESEN, Helga B, OTTE, Arie P, AKSLEN, Lars A

“…EZH2 is a member of the polycomb group of genes and important in cell cycle regulation. Increased expression of EZH2 has been associated previously with…”
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Elevated expression of Aurora-A/AURKA in breast cancer associates with younger age and aggressive features by Ingebriktsen, L M, Humlevik, R O C, Svanøe, A A, Sæle, A K M, Winge, I, Toska, K, Kalvenes, M B, Davidsen, B, Heie, A, Knutsvik, G, Askeland, C, Stefansson, I M, Hoivik, E A, Akslen, L A, Wik, E

“…Aurora kinase A (AURKA) is reported to be overexpressed in breast cancer. In addition to its role in regulating cell cycle and mitosis, studies have reported…”
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Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial by Trovik, Jone, Wik, Elisabeth, Werner, Henrica M.J, Krakstad, Camilla, Helland, Harald, Vandenput, Ingrid, Njolstad, Tormund S, Stefansson, Ingunn M, Marcickiewicz, Janusz, Tingulstad, Solveig, Staff, Anne C, Amant, Frederic, Akslen, Lars A, Salvesen, Helga B

“…Abstract Background Preoperative histologic examination of tumour tissue is essential when deciding if endometrial cancer surgery should include lymph node…”
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Baseline microvessel density predicts response to neoadjuvant bevacizumab treatment of locally advanced breast cancer by Krüger, Kristi, Silwal-Pandit, Laxmi, Wik, Elisabeth, Straume, Oddbjørn, Stefansson, Ingunn M., Borgen, Elin, Garred, Øystein, Naume, Bjørn, Engebraaten, Olav, Akslen, Lars A.

“…A subset of breast cancer patients benefits from preoperative bevacizumab and chemotherapy, but validated predictive biomarkers are lacking. Here, we aimed to…”
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Evaluation of Ki67 expression across distinct categories of breast cancer specimens: a population-based study of matched surgical specimens, core needle biopsies and tissue microarrays by Knutsvik, Gøril, Stefansson, Ingunn M, Aziz, Sura, Arnes, Jarle, Eide, Johan, Collett, Karin, Akslen, Lars A

“…Tumor cell proliferation in breast cancer is strongly prognostic and may also predict response to chemotherapy. However, there is no consensus on counting…”
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Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer by COLLETT, Karin, EIDE, Geir E, ARNES, Jarle, STEFANSSON, Ingunn M, EIDE, Johan, BRAATEN, Audun, AAS, Turid, OTTE, Ariel P, AKSLEN, Lars A

“…The polycomb group protein enhancer of zeste homologue 2 (EZH2) has been linked to invasive properties of aggressive breast cancer. In this report, tissue…”
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Drug-Sensitive FGFR2 Mutations in Endometrial Carcinoma by Dutt, Amit, Salvesen, Helga B., Chen, Tzu-Hsiu, Ramos, Alex H., Onofrio, Robert C., Hatton, Charlie, Nicoletti, Richard, Winckler, Wendy, Grewal, Rupinder, Hanna, Megan, Wyhs, Nicolas, Ziaugra, Liuda, Richter, Daniel J., Trovik, Jone, Engelsen, Ingeborg B., Stefansson, Ingunn M., Fennell, Tim, Cibulskis, Kristian, Zody, Michael C., Akslen, Lars A., Gabriel, Stacey, Wong, Kwok-Kin, Sellers, William R., Meyerson, Matthew, Greulich, Heidi

“…Oncogenic activation of tyrosine kinases is a common mechanism of carcinogenesis and, given the druggable nature of these enzymes, an attractive target for…”
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Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer by Foulkes, William D., Stefansson, Ingunn M., Chappuis, Pierre O., Bégin, Louis R., Goffin, John R., Wong, Nora, Trudel, Michel, Akslen, Lars A.

“…A basal epithelial phenotype is found in not more than 15% of all invasive breast cancers. Microarray studies have shown that this phenotype is associated with…”
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Stathmin Overexpression Identifies High-Risk Patients and Lymph Node Metastasis in Endometrial Cancer by TROVIK, Jone, WIK, Elisabeth, SALVESEN, Helga B, STEFANSSON, Ingunn M, MARCICKIEWICZ, Janusz, TINGULSTAD, Solveig, STAFF, Anne C, NJOLSTAD, Tormund S, VANDENPUT, Ingrid, AMANT, Frederic, AKSLEN, Lars A

“…Overexpression of the oncogen Stathmin has been linked to aggressive endometrial carcinoma and a potential for PI3Kinase inhibitors in this disease. We wanted…”
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Integrated Genomic Profiling of Endometrial Carcinoma Associates Aggressive Tumors with Indicators of PI3 Kinase Activation by Salvesen, H. B., Carter, S. L., Mannelqvist, M., Dutt, A., Getz, G., Stefansson, I. M., Raeder, M. B., Sos, M. L., Engelsen, I. B., Trovik, J., Wik, E., Greulich, H., Bø, T. H., Jonassen, I., Thomas, R. K., Zander, T., Garraway, L. A., Øyan, A. M., Sellers, W. R., Kalland, K. H., Meyerson, M., Akslen, L. A., Beroukhim, R., Gray, Joe W.

“…Although 75% of endometrial cancers are treated at an early stage, 15% to 20% of these recur. We performed an integrated analysis of genome-wide expression and…”
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Vascular proliferation is important for clinical progress of endometrial cancer by STEFANSSON, Ingunn M, SALVESEN, Helga B, AKSLEN, Lars A

“…Angiogenesis is essential for tumor growth, invasion, and metastatic spread. Whereas microvessel density (MVD) has been widely used as a measure of…”
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Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer by Krüger, Kristi, Wik, Elisabeth, Knutsvik, Gøril, Nalwoga, Hawa, Klingen, Tor A., Arnes, Jarle B., Chen, Ying, Mannelqvist, Monica, Dimitrakopoulou, Konstantina, Stefansson, Ingunn M., Birkeland, Even, Aas, Turid, Tobin, Nicholas P., Jonassen, Inge, Bergh, Jonas, Foulkes, William D., Akslen, Lars A.

“…We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive…”
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Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers by Raeder, Maria B, Birkeland, Even, Trovik, Jone, Krakstad, Camilla, Shehata, Shyemaa, Schumacher, Steven, Zack, Travis I, Krohn, Antje, Werner, Henrica Mj, Moody, Susan E, Wik, Elisabeth, Stefansson, Ingunn M, Holst, Frederik, Oyan, Anne M, Tamayo, Pablo, Mesirov, Jill P, Kalland, Karl H, Akslen, Lars A, Simon, Ronald, Beroukhim, Rameen, Salvesen, Helga B

“…Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target…”
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Preoperative tumor size at MRI predicts deep myometrial invasion, lymph node metastases, and patient outcome in endometrial carcinomas by Ytre-Hauge, Sigmund, Husby, Jenny A, Magnussen, Inger J, Werner, Henrica M J, Salvesen, Øyvind O, Bjørge, Line, Trovik, Jone, Stefansson, Ingunn M, Salvesen, Helga B, Haldorsen, Ingfrid S

“…The aim of this study was to explore the relation between preoperative tumor size based on magnetic resonance imaging (MRI) and the surgical pathologic staging…”
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Prognostic Impact of Alterations in P-Cadherin Expression and Related Cell Adhesion Markers in Endometrial Cancer by STEFANSSON, Ingunn M, SALVESEN, Helga B, AKSLEN, Lars A

“…Reduced tumor cell adhesion is associated with invasive growth and unfavorable prognosis. In endometrial carcinoma, the prognostic impact of adhesion markers…”
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The prognostic implication of the basal-like (cyclin Ehigh/p27low/p53+/ glomeruloid-microvascular-proliferation+) phenotype of BRCA1-related breast cancer by FOULKES, William D, BRUNET, Jean-Sébastien, KAPUSTA, Linda, PORTER, Peggy, AKSLEN, Lars A, STEFANSSON, Ingunn M, STRAUME, Oddbjørn, CHAPPUIS, Pierre O, BEGIN, Louis R, HAMEL, Nancy, GOFFIN, John R, WONG, Nora, TRUDEL, Michel

“…Previous studies have shown that BRCA1-related breast cancers are often high-grade tumors that do not express estrogen receptors, HER2, p27(Kip1), or cyclin…”
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An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer by Mannelqvist, Monica, Wik, Elisabeth, Stefansson, Ingunn M, Akslen, Lars A

“…Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature…”
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A Basal Epithelial Phenotype Is More Frequent in Interval Breast Cancers Compared with Screen Detected Tumors by COLLETT, Karin, STEFANSSON, Ingunn M, EIDE, Johan, BRAATEN, Audun, HEGE WANG, EIDE, Geir Egil, THORESEN, Steinar Ø, FOULKES, William D, AKSLEN, Lars A

“…Interval breast cancer reduce the effectiveness of mammography screening programs. We studied 95 interval cancers, diagnosed during 1996 to 2001 as part of the…”
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Pleistocene genetic legacy suggests incipient species of Sebastes mentella in the Irminger Sea by Stefánsson, M O, Sigurdsson, T, Pampoulie, C, Daníelsdóttir, A K, Thorgilsson, B, Ragnarsdóttir, A, Gíslason, D, Coughlan, J, Cross, T F, Bernatchez, L

“…To investigate a possible speciation event within the redfish (Sebastes mentella) complex in the Irminger Sea, we examined genetics, traditional morphology,…”
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The genetic spectrum of a population-based sample of familial hemiplegic migraine by Thomsen, L. L., Kirchmann, M., Bjornsson, A., Stefansson, H., Jensen, R. M., Fasquel, A. C., Petursson, H., Stefansson, M., Frigge, M. L., Kong, A., Gulcher, J., Stefansson, K., Olesen, J.

“…Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura and transient hemiplegia. FHM mutations are known in three genes, the CACNA1A (FHM1)…”
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