Search Results - "Stefanski, Casey D"

Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic Response by Stefanski, Casey D, Prosperi, Jenifer R

“…Resistance to chemotherapy occurs through mechanisms within the epithelial tumor cells or through interactions with components of the tumor microenvironment…”
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APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells by Stefanski, Casey D., Keffler, Kaitlyn, McClintock, Stephanie, Milac, Lauren, Prosperi, Jenifer R.

“…Chemoresistance is one of the leading causes of cancer-related deaths in the United States. Triple negative breast cancer (TNBC), a subtype lacking the known…”
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APC Loss Prevents Doxorubicin-Induced Cell Death by Increasing Drug Efflux and a Chemoresistant Cell Population in Breast Cancer by Stefanski, Casey D, Arnason, Anne, Maloney, Sara, Kotsen, Janna, Powers, Elizabeth, Zhang, Jian-Ting, Prosperi, Jenifer R

“…Chemoresistance is a major health concern affecting cancer patients. Resistance is multifactorial, with one mechanism being the increased expression of ABC…”
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Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine by Strubberg, Ashlee M, Liu, Jinghua, Walker, Nancy M, Stefanski, Casey D, MacLeod, R. John, Magness, Scott T, Clarke, Lane L

“…Background & Aims Cystic fibrosis (CF) patients and CF mouse models have increased risk for gastrointestinal tumors. CF mice show augmented intestinal…”
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SOX10 Loss Sensitizes Melanoma Cells to Cytokine-Mediated Inflammatory Cell Death by Rosenbaum, Sheera R, Caksa, Signe, Stefanski, Casey D, Trachtenberg, Isabella V, Wilson, Haley P, Wilski, Nicole A, Ott, Connor A, Purwin, Timothy J, Haj, Jelan I, Pomante, Danielle, Kotas, Daniel, Chervoneva, Inna, Capparelli, Claudia, Aplin, Andrew E

“…The transcription factor, SOX10, plays an important role in the differentiation of neural crest precursors to the melanocytic lineage. Malignant transformation…”
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Combating CHK1 resistance in triple negative breast cancer: EGFR inhibition as potential combinational therapy by Stefanski, Casey D, Prosperi, Jenifer R

“…Triple negative breast cancer (TNBC) is marked by a lack of expression of the Estrogen Receptor, Progesterone Receptor, and human epidermal growth factor…”
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Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium by Walker, Nancy M, Liu, Jinghua, Stein, Sydney R, Stefanski, Casey D, Strubberg, Ashlee M, Clarke, Lane L

“…Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), an anion channel providing a major pathway for Cl(-) and HCO3…”
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APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation by VanKlompenberg, Monica K, Leyden, Emily, Arnason, Anne H, Zhang, Jian-Ting, Stefanski, Casey D, Prosperi, Jenifer R

“…Resistance to chemotherapy is one of the leading causes of death from breast cancer. We recently established that loss of (APC) in the Mouse Mammary Tumor…”
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Abstract 1404: Loss of adenomatous polyposis coli induces DOX resistance through upregulation of ABC transporters by Stefanski, Casey D., Prosperi, Jenifer R., Milac, Lauren

“…Chemoresistance is a leading cause of breast cancer related deaths. Therefore, understanding the molecular basis for chemoresistance is essential for novel…”
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Abstract 4463: Loss of APC mediates doxorubicin resistance in breast cancer cells by Stefanski, Casey D., Keffler, Kaitlyn, McClintock, Stephanie, Prosperi, Jenifer R.

“…Resistance to chemotherapy is one of the leading causes of breast cancer related deaths. Understanding the molecular basis for chemoresistance is essential for…”
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Abstract 3246: APC loss prevents doxorubicin-induced cell death by effluxing drug and increasing a chemoresistant cell population by Stefanski, Casey D., Kotsen, Janna, Bernard, Amy, Prosperi, Jenifer

“…Chemoresistance is a leading cause of breast cancer related deaths. Therefore, understanding the molecular basis for chemoresistance is essential for novel…”
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Adenomatous Polyposis Coli Regulates ABC Transporters and DNA Repair Mechanisms to Cause Doxorubicin Resistance by Stefanski, Casey D

“…Chemoresistance is a leading cause of breast cancer related deaths. Therefore, understanding the molecular basis for chemoresistance is essential for novel…”
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Abstract A023: Arachidonic acid metabolism promoting cross resistance in melanoma cells by Stefanski, Casey D., Erkes, Daniel A., Purwin, Timothy J., Mersky, Glenn L., Kitterman, Erica L., Mustafa, Manal, Haj, Jelan, Melissaratos, Diana, Aplin, Andrew E.

“…Melanoma patients initially respond well to first line immunotherapy. However, cross resistance to immunotherapy and BRAF/MEK inhibitor is a clinical challenge…”
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Abstract 6942: Single cell resolution of intrapatient drug resistance mechanisms in metastatic melanoma by Wilson, Haley P., Mersky, Glenn L., Haj, Jelan I., Teh, Jessica, Cheng, Phil F., Caksa, Signe, Stefanski, Casey D., Chua, Vivian, Capparelli, Claudia, Levesque, Mitch P., Dummer, Reinhard, Purwin, Timothy J., Aplin, Andrew E.

“…Intrapatient heterogeneity among different metastatic sites contributes to immunotherapy (ICi) and targeted therapy resistance. Determining the evolution of…”
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Abstract C048: Intrapatient heterogeneity and targeting microenvironment protection mechanisms in melanoma metastasis by Wilson, Haley P., Mersky, Glenn L., Haj, Jelan I., Teh, Jessica L.F., Cheng, Phil F., Caksa, Signe, Mustafa, Manal, Trachtenberg, Isabella, Waltrich, Francis J., Stefanski, Casey D., Chua, Vivian, Erkes, Dan A., Levesque, Mitchell P., Dummer, Reinhard, Purwin, Timothy J., Capparelli, Claudia, Aplin, Andrew E.

“…Intrapatient tumor heterogeneity contributes to immunotherapy and targeted therapy resistance in cutaneous metastatic melanoma patients. More than 50% of…”
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