Microcirculatory changes in the skin after postmastectomy radiotherapy in women with breast cancer

Postmastectomy radiotherapy (PMRT) increases the risk for complications after breast reconstruction. The pathophysiological mechanism underlying this increased risk is not completely understood. The aim of this study was to examine if there is a relationship between PMRT and microvascular perfusion...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; p. 4149
Main Authors:	Elawa, Sherif, Mirdell, Robin, Stefanis, Aristotelis, Tesselaar, Erik, Farnebo, Simon
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20-02-2024 Nature Publishing Group Nature Portfolio
Subjects:	631/67/1347 639/624/1107 Blood flow Breast cancer Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Chest Female Humanities and Social Sciences Humans Mastectomy - adverse effects Mastectomy - methods Microcirculation Microvasculature multidisciplinary Perfusion Radiation therapy Radiotherapy, Adjuvant - adverse effects Reconstructive surgery Retrospective Studies Science Science (multidisciplinary) Skin Treatment Outcome
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Summary:	Postmastectomy radiotherapy (PMRT) increases the risk for complications after breast reconstruction. The pathophysiological mechanism underlying this increased risk is not completely understood. The aim of this study was to examine if there is a relationship between PMRT and microvascular perfusion in the skin directly after, and at 2 and 6 months after PMRT and to assess if there is impaired responsiveness to a topically applied vasodilator (Methyl nicotinate—MN) after PMRT. Skin microvascular responses after PMRT were measured on two sites in the irradiated chest wall of 22 women before, immediately after, and at 2 and 6 months after unilateral PMRT with the contralateral breast as a control. A significant increase in basal skin perfusion was observed in the irradiated chest wall immediately after RT ( p < 0.0001). At 2 and 6 months after RT, there was no longer a difference in basal skin perfusion compared to the contralateral breast and compared to baseline. Similarly, the blood flow response in the skin after application of MN was stronger immediately after RT compared to before RT ( p < 0.0001), but there was no difference at later time points. These results indicate that the increased risk for complications after surgical procedures are not directly related to changes in skin perfusion and microvascular responsiveness observed after postmastectomy RT.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-024-54650-4