Search Results - "Stefanik, Michael T"

Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior by Stefanik, Michael T., Kupchik, Yonatan M., Kalivas, Peter W.

“…Animal models of relapse reveal that the motivation to seek drug is regulated by enduring morphological and physiological changes in the nucleus accumbens, as…”
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Optogenetic dissection of basolateral amygdala projections during cue-induced reinstatement of cocaine seeking by Stefanik, Michael T, Kalivas, Peter W

“…Stimuli previously associated with drugs of abuse can become triggers that elicit craving and lead to drug-seeking behavior. The basolateral amygdala (BLA) is…”
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Protein Translation in the Nucleus Accumbens Is Dysregulated during Cocaine Withdrawal and Required for Expression of Incubation of Cocaine Craving by Werner, Craig T, Stefanik, Michael T, Milovanovic, Mike, Caccamise, Aaron, Wolf, Marina E

“…Exposure to drug-associated cues can induce drug craving and relapse in abstinent addicts. Cue-induced craving that progressively intensifies ("incubates")…”
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Optogenetic inhibition of cocaine seeking in rats by Stefanik, Michael T., Moussawi, Khaled, Kupchik, Yonatan M., Smith, Kyle C., Miller, Rachel L., Huff, Mary L., Deisseroth, Karl, Kalivas, Peter W., LaLumiere, Ryan T.

“…Inhibitory optogenetics was used to examine the roles of the prelimbic cortex (PL), the nucleus accumbens core (NAcore) and the PL projections to the NAcore in…”
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Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking by Stefanik, Michael T, Kupchik, Yonatan M, Brown, Robyn M, Kalivas, Peter W

“…The core subcompartment of the nucleus accumbens (NAcore) contributes significantly to behavioral responses following motivationally relevant stimuli,…”
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GluA2‐lacking AMPA receptors in the nucleus accumbens core and shell contribute to the incubation of oxycodone craving in male rats by Wong, Benjamin, Zimbelman, Alexa R., Milovanovic, Mike, Wolf, Marina E., Stefanik, Michael T.

“…One of the most challenging issues in the treatment of substance use disorder, including misuse of opioids such as oxycodone, is persistent vulnerability to…”
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AMPA Receptor Plasticity in Accumbens Core Contributes to Incubation of Methamphetamine Craving by Scheyer, Andrew F, Loweth, Jessica A, Christian, Daniel T, Uejima, Jamie, Rabei, Rana, Le, Tuan, Dolubizno, Hubert, Stefanik, Michael T, Murray, Conor H, Sakas, Courtney, Wolf, Marina E

“…Abstract Background The incubation of cue-induced drug craving in rodents provides a model of persistent vulnerability to craving and relapse in human addicts…”
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Ionotropic and metabotropic glutamate receptors regulate protein translation in co-cultured nucleus accumbens and prefrontal cortex neurons by Stefanik, Michael T., Sakas, Courtney, Lee, Dennis, Wolf, Marina E.

“…The regulation of protein translation by glutamate receptors and its role in plasticity have been extensively studied in the hippocampus. In contrast, very…”
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AMPA receptor and metabotropic glutamate receptor 1 adaptations in the nucleus accumbens core during incubation of methamphetamine craving by Murray, Conor H, Loweth, Jessica A, Milovanovic, Mike, Stefanik, Michael T, Caccamise, Aaron J, Dolubizno, Hubert, Funke, Jonathan R, Foster Olive, M, Wolf, Marina E

“…Cue-induced drug craving progressively intensifies after withdrawal from self-administration of cocaine, methamphetamine, and other drugs of abuse, a…”
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Cascades of Homeostatic Dysregulation Promote Incubation of Cocaine Craving by Wang, Junshi, Ishikawa, Masago, Yang, Yue, Otaka, Mami, Kim, James Y, Gardner, George R, Stefanik, Michael T, Milovanovic, Mike, Huang, Yanhua H, Hell, Johannes W, Wolf, Marina E, Schlüter, Oliver M, Dong, Yan

“…In human drug users, cue-induced drug craving progressively intensifies after drug abstinence, promoting drug relapse. This time-dependent progression of drug…”
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Withdrawal From Cocaine Self-administration Alters the Regulation of Protein Translation in the Nucleus Accumbens by Stefanik, Michael T., Milovanovic, Mike, Werner, Craig T., Spainhour, John C.G., Wolf, Marina E.

“…Cue-induced cocaine craving incubates during abstinence from cocaine self-administration. Expression of incubation ultimately depends on elevation of homomeric…”
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GluN3-Containing NMDA Receptors in the Rat Nucleus Accumbens Core Contribute to Incubation of Cocaine Craving by Christian, Daniel T, Stefanik, Michael T, Bean, Linda A, Loweth, Jessica A, Wunsch, Amanda M, Funke, Jonathan R, Briggs, Clark A, Lyons, Joseph, Neal, Demetria, Milovanovic, Mike, D'Souza, Gary X, Stutzmann, Grace E, Nicholson, Daniel A, Tseng, Kuei Y, Wolf, Marina E

“…Cue-induced cocaine craving progressively intensifies (incubates) after withdrawal from cocaine self-administration in rats and humans. In rats, the expression…”
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mGlu1 tonically regulates levels of calcium‐permeable AMPA receptors in cultured nucleus accumbens neurons through retinoic acid signaling and protein translation by Loweth, Jessica A., Reimers, Jeremy M., Caccamise, Aaron, Stefanik, Michael T., Woo, Kenneth Kin Yan, Chauhan, Nirav M., Werner, Craig T., Wolf, Marina E.

“…In several brain regions, ongoing metabotropic glutamate receptor 1 (mGlu1) transmission has been shown to tonically suppress synaptic levels of Ca2+‐permeable…”
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Effects of optogenetic inhibition on relapse and associated dendritic plasticity by Stefanik, Michael T

“…Relapse to cocaine seeking can occur after long periods of abstinence and is often preceded by exposure to craving-inducing drug-associated cues. The enduring…”
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