Search Results - "Stefani, Mariane M.A."

Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development by Sampaio, Lucas H, Stefani, Mariane Ma, Oliveira, Regiane M, Sousa, Ana Lm, Ireton, Greg C, Reed, Steven G, Duthie, Malcolm S

“…Leprosy is a chronic infectious disease caused by Mycobacterium leprae that can manifest a wide variety of immunological and clinical outcomes ranging from…”
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Development and pre-clinical assessment of a 73kD chimeric fusion protein as a defined sub-unit vaccine for leprosy by Duthie, Malcolm S., Sampaio, Lucas H., Oliveira, Regiane M., Raman, Vanitha S., O’Donnell, Joanne, Bailor, H. Remy, Ireton, Greg C., Sousa, Ana Lucia M., Stefani, Mariane M.A., Reed, Steven G.

“…► We produce a chimeric fusion protein incorporating selected Mycobacterium leprae antigens. ► We demonstrate protein recognition by IgG in MB leprosy patient…”
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Molecular screening shows extensive HIV-1 genetic diversity in Central West Brazil by Stefani, Mariane M.A, Pereira, Gisner A.S, Lins, Janaina A.B, Alcantara, Keila C, Silveira, Alexsander A, Viegas, Angela A, Maya, Nadia C, Mussi, Aparecida Hg

“…Abstract Background Information is limited about HIV-1 subtypes circulating in less populated Brazilian areas where the AIDS epidemic is expanding, such as in…”
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Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae by Benjak, Andrej, Avanzi, Charlotte, Singh, Pushpendra, Loiseau, Chloé, Girma, Selfu, Busso, Philippe, Fontes, Amanda N. Brum, Miyamoto, Yuji, Namisato, Masako, Bobosha, Kidist, Salgado, Claudio G., da Silva, Moisés B., Bouth, Raquel C., Frade, Marco A. C., Filho, Fred Bernardes, Barreto, Josafá G., Nery, José A. C., Bührer-Sékula, Samira, Lupien, Andréanne, Al-Samie, Abdul R., Al-Qubati, Yasin, Alkubati, Abdul S., Bretzel, Gisela, Vera-Cabrera, Lucio, Sakho, Fatoumata, Johnson, Christian R., Kodio, Mamoudou, Fomba, Abdoulaye, Sow, Samba O., Gado, Moussa, Konaté, Ousmane, Stefani, Mariane M. A., Penna, Gerson O., Suffys, Philip N., Sarno, Euzenir Nunes, Moraes, Milton O., Rosa, Patricia S., Baptista, Ida M. F. Dias, Spencer, John S., Aseffa, Abraham, Matsuoka, Masanori, Kai, Masanori, Cole, Stewart T.

“…Leprosy is a chronic human disease caused by the yet-uncultured pathogen Mycobacterium leprae . Although readily curable with multidrug therapy (MDT), over…”
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Human Genetic Susceptibility of Leprosy Recurrence by Uaska Sartori, Priscila Verchai, Penna, Gerson O., Bührer-Sékula, Samira, Pontes, Maria A. A., Gonçalves, Heitor S., Cruz, Rossilene, Virmond, Marcos C. L., Dias-Baptista, Ida M. F., Rosa, Patricia S., Penna, Maria L. F., Medeiros Fava, Vinicius, Stefani, Mariane M. A., Távora Mira, Marcelo

“…Host genetic susceptibility to leprosy has been intensively investigated over the last decades; however, there are no studies on the role of genetic variants…”
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Risk factors for leprosy reactions in three endemic countries by Scollard, David M, Martelli, Celina M T, Stefani, Mariane M A, Maroja, Maria de Fatima, Villahermosa, Laarni, Pardillo, Fe, Tamang, Krishna B

“…The objective of this study was to ascertain risk factors for complications (reactions or neuritis) in leprosy patients at the time of diagnosis in three…”
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A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts by Gama, Rafael Silva, Souza, Márcio Luís Moreira de, Sarno, Euzenir Nunes, Moraes, Milton Ozório de, Gonçalves, Aline, Stefani, Mariane M A, Garcia, Raúl Marcel González, Fraga, Lucia Alves de Oliveira

“…Early detection of Mycobacterium leprae is a key strategy for disrupting the transmission chain of leprosy and preventing the potential onset of physical…”
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High Prevalence and Onward Transmission of Non-Pandemic HIV-1 Subtype B Clades in Northern and Northeastern Brazilian Regions by Divino, Flavia, de Lima Guerra Corado, Andre, Gomes Naveca, Felipe, Stefani, Mariane M A, Bello, Gonzalo

“…The Human immunodeficiency virus type-1 (HIV-1) epidemic in Brazil is mainly driven by the subtype B pandemic lineage (BPANDEMIC), while Caribbean non-pandemic…”
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Detection of Mansonella ozzardi among blood donors from highly endemic interior cities of Amazonas state, northern Brazil by Abrahim, Claudia M. M., Py‐Daniel, Victor, Luz, Sergio L. B., Fraiji, Nelson A., Stefani, Mariane M. A.

“…BACKGROUND In the Brazilian Amazon, the filarial nematode Mansonella ozzardi co‐exists with malaria parasites and thick blood smear microscopy is considered…”
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High rate of seromarkers for HIV, HBV and syphilis among blood donors using confidential unit exclusion, before and after HIV‐NAT implementation at a major public blood bank in the Brazilian Amazon by Souza, Janaina C., Crispim, Myuki A. E., Abrahim, Claudia, Fraiji, Nelson A., Kiesslich, Dagmar, Stefani, Mariane M. A.

“…BACKGROUND Confidential unit exclusion (CUE) was introduced in the 1980's as an additional layer to blood safety, before highly specific and sensitive nucleic…”
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In situ T regulatory cells and Th17 cytokines in paired samples of leprosy type 1 and type 2 reactions by Costa, Maurício Barcelos, Hungria, Emerith Mayra, Freitas, Aline Araújo, Sousa, Ana Lúcia O M, Jampietro, Juliano, Soares, Fernando A, Stefani, Mariane M A

“…Leprosy is a complex chronic, infectious dermato-neurological disease that affects the skin and peripheral nerves especially during immuno-inflammatory…”
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Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases by Stefani, Mariane M A, Avanzi, Charlotte, Bührer-Sékula, Samira, Benjak, Andrej, Loiseau, Chloé, Singh, Pushpendra, Pontes, Maria A A, Gonçalves, Heitor S, Hungria, Emerith M, Busso, Philippe, Piton, Jérémie, Silveira, Maria I S, Cruz, Rossilene, Schetinni, Antônio, Costa, Maurício B, Virmond, Marcos C L, Diorio, Suzana M, Dias-Baptista, Ida M F, Rosa, Patricia S, Matsuoka, Masanori, Penna, Maria L F, Cole, Stewart T, Penna, Gerson O

“…Since leprosy is both treated and controlled by multidrug therapy (MDT) it is important to monitor recurrent cases for drug resistance and to distinguish…”
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A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy by Fava, Vinicius M, Manry, Jeremy, Cobat, Aurélie, Orlova, Marianna, Van Thuc, Nguyen, Moraes, Milton O, Sales-Marques, Carolinne, Stefani, Mariane M A, Latini, Ana Carla P, Belone, Andrea F, Thai, Vu Hong, Abel, Laurent, Alcaïs, Alexandre, Schurr, Erwin

“…Leprosy Type-1 Reactions (T1Rs) are pathological inflammatory responses that afflict a sub-group of leprosy patients and result in peripheral nerve damage…”
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Genetic and Immunological Evidence Implicates Interleukin 6 as a Susceptibility Gene for Leprosy Type 2 Reaction by Sousa, Ana Lucia M., Fava, Vinicius M., Sampaio, Lucas H., Martelli, Celina Maria T., Costa, Mauricio B., Mira, Marcelo T., Stefani, Mariane M. A.

“…In leprosy, type 1 reaction (T1R) and type 2 reaction (T2R) are major causes of nerve injury and permanent disabilities. A previous study on plasma levels of…”
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Identification of New HIV-1 Circulating Recombinant Forms CRF81_cpx and CRF99_BF1 in Central Western Brazil and of Unique BF1 Recombinant Forms by Reis, Mônica N G, Guimarães, Monick L, Bello, Gonzalo, Stefani, Mariane M A

“…Intersubtype recombinants classified as circulating recombinant forms (CRFs) or unique recombinant forms (URFs) have been shown to play an important role in…”
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Association of TNFSF8 Regulatory Variants With Excessive Inflammatory Responses but not Leprosy Per Se by Fava, Vinicius M., Cobat, Aurélie, Van Thuc, Nguyen, Latini, Ana Carla P., Stefani, Mariane M. A., Belone, Andrea F., Ba, Nguyen Ngoc, Orlova, Marianna, Manry, Jérémy, Mira, Marcelo T., Thai, Vu Hong, Abel, Laurent, Alcaïs, Alexandra, Schurr, Erwin

“…Background. Type 1 reactions (TIR) affect a considerable proportion of patients with leprosy. In those with TIR, the host immune response pathologically…”
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Mast cell heterogeneity and anti-inflammatory annexin A1 expression in leprosy skin lesions by Costa, Maurício B., Mimura, Kallyne K.O., Freitas, Aline A., Hungria, Emerith M., Sousa, Ana Lúcia O.M., Oliani, Sonia M., Stefani, Mariane M.A.

“…Mast cells (MCs) have important immunoregulatory roles in skin inflammation. Annexin A1 (ANXA1) is an endogenous anti-inflammatory protein that can be…”
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Mycobacterium leprae -Specific Antibodies in Multibacillary Leprosy Patients Decrease During and After Treatment With Either the Regular 12 Doses Multidrug Therapy (MDT) or the Uniform 6 Doses MDT by Hungria, Emerith M, Bührer-Sékula, Samira, Oliveira, Regiane M, Aderaldo, Lúcio C, Pontes, Maria Araci A, Cruz, Rossilene, de Gonçalves, Heitor S, Penna, Maria L F, Penna, Gerson O, Stefani, Mariane M A

“…Leprosy serology reflects the bacillary load of patients and multidrug therapy (MDT) reduces -specific antibody titers of multibacillary (MB) patients. The ( )…”
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Use of Protein Antigens for Early Serological Diagnosis of Leprosy by Duthie, Malcolm S, Goto, Wakako, Ireton, Greg C, Reece, Stephen T, Cardoso, Ludimila P V, Martelli, Celina M T, Stefani, Mariane M A, Nakatani, Maria, de Jesus, Robson Crusue, Netto, Eduardo M, Balagon, Ma V F, Tan, Esterlina, Gelber, Robert H, Maeda, Yumi, Makino, Masahiko, Hoft, Dan, Reed, Steven G

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Development and pre-clinical assessment of a 73 kD chimeric fusion protein as a defined sub-unit vaccine for leprosy by Duthie, Malcolm S, Sampaio, Lucas H, Oliveira, Regiane M, Raman, Vanitha S, O’Donnell, Joanne, Bailor, H. Remy, Ireton, Greg C, Sousa, Ana Lucia M, Stefani, Mariane M.A, Reed, Steven G

“…Highlights ► We produce a chimeric fusion protein incorporating selected Mycobacterium leprae antigens. ► We demonstrate protein recognition by IgG in MB…”
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