Search Results - "Stefan, Tammy"

Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression by Stetson, L. C., Balasubramanian, Dheepa, Ribeiro, Susan Pereira, Stefan, Tammy, Gupta, Kalpana, Xu, Xuan, Fourati, Slim, Roe, Anne, Jackson, Zachary, Schauner, Robert, Sharma, Ashish, Tamilselvan, Banumathi, Li, Samuel, de Lima, Marcos, Hwang, Tae Hyun, Balderas, Robert, Saunthararajah, Yogen, Maciejewski, Jaroslaw, LaFramboise, Thomas, Barnholtz-Sloan, Jill S., Sekaly, Rafick-Pierre, Wald, David N.

“…The prognosis of most patients with AML is poor due to frequent disease relapse. The cause of relapse is thought to be from the persistence of leukemia…”
Get full text

GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation by Gupta, Kalpana, Stefan, Tammy, Ignatz-Hoover, James, Moreton, Stephen, Parizher, Gary, Saunthararajah, Yogen, Wald, David N

“…1,25-dihydroxyvitamin D3 (1,25D), the biologically active form of vitamin D, is widely considered a promising therapy for acute myeloid leukemia (AML) based on…”
Get full text

Phase I Trial of Lithium and Tretinoin for Treatment of Relapsed and Refractory Non-promyelocytic Acute Myeloid Leukemia by Ueda, Masumi, Stefan, Tammy, Stetson, Lindsay, Ignatz-Hoover, James J, Tomlinson, Benjamin, Creger, Richard J, Cooper, Brenda, Lazarus, Hillard M, de Lima, Marcos, Wald, David N, Caimi, Paolo F

“…Glycogen synthase kinase-3 (GSK3) inhibitors induce differentiation and growth inhibition of acute myeloid leukemia (AML) cells. Our pre-clinical studies…”
Get full text

Dynamic epitope expression from static cytometry data: principles and reproducibility by Jacobberger, James W, Avva, Jayant, Sreenath, Sree N, Weis, Michael C, Stefan, Tammy

“…An imprecise quantitative sense for the oscillating levels of proteins and their modifications, interactions, and translocations as a function of the cell…”
Get full text

Cyclin B1 is rate limiting but not essential for mitotic entry and progression in mammalian somatic cells by Soni, Deena V., Sramkoski, R. Michael, Lam, Minh, Stefan, Tammy, Jacobberger, James W.

“…Cyclin B1 should have some rate limiting function for cell cycle progression. To test this, we measured the effect of siRNA-mediated depletion of cyclin B1 on…”
Get full text

Cabazitaxel-induced stabilization of microtubules enhances radiosensitivity in ovarian cancer cells by Kunos, Charles A, Stefan, Tammy, Jacobberger, James W

“…Up to 40% of women with ovarian cancer have short disease-free intervals due to molecular mechanisms of chemotherapy resistance. New therapeutic strategies are…”
Get full text

Analysis of the multiparametric cell cycle data by Jacobberger, James W, Sramkoski, R Michael, Stefan, Tammy, Bray, Chris, Bagwell, C Bruce

“…This chapter was originally written in 2011. The idea was to give some history of cell cycle analysis before and after flow cytometry became widely accessible;…”
Get full text

Abstract 3295: Combining GSK3 inhibition and Vitamin D as a differentiation strategy for AML by Gupta, Kalpana, Stefan, Tammy, Wald, David N.

“…Vitamin D has widely been considered a promising therapy for cancer, particularly Acute Myeloid Leukemia (AML), due to its ability to terminally differentiate…”
Get full text

Multiparameter Cell Cycle Analysis by Jacobberger, James W, Sramkoski, R Michael, Stefan, Tammy, Woost, Philip G

“…Cell cycle cytometry and analysis are essential tools for studying cells of model organisms and natural populations (e.g., bone marrow). Methods have not…”
Get more information

Flow cytometry of DNMT1 as a biomarker of hypomethylating therapies by Woost, Philip G., William, Basem M., Cooper, Brenda W., Ueda Oshima, Masumi, Otegbeye, Folashade, De Lima, Marcos J., Wald, David, Mahfouz, Reda Z., Saunthararajah, Yogen, Stefan, Tammy, Jacobberger, James W.

“…The 5‐azacytidine (AZA) and decitabine (DEC) are noncytotoxic, differentiation‐inducing therapies approved for treatment of myelodysplastic syndrome, acute…”
Get full text

Ribonucleotide Reductase Inhibition Enhances Chemoradiosensitivity of Human Cervical Cancers by Kunos, Charles A., Radivoyevitch, Tomas, Pink, John, Chiu, Song-Mao, Stefan, Tammy, Jacobberger, James, Kinsella, Timothy J.

“…For repair of damaged DNA, cells increase de novo synthesis of deoxyribonucleotide triphosphates through the rate-limiting, p53-regulated ribonucleotide…”
Get full text

Glycogen Synthase Kinase-3 (GSK3) Inhibition with Lithium in Combination with Tretinoin Induces Differentiation in Non-Promyelocytic Acute Myeloid Leukemia (AML) by Ueda, Masumi, Caimi, Paolo F., Stefan, Tammy, Lazarus, Hillard M., Cooper, Brenda, de Lima, Marcos, Gerson, Stanton L., Wald, David N.

“…Lithium (Li) is a GSK3 inhibitor that induces differentiation and anti-proliferation of AML cells in vitro. Pre-clinical studies demonstrated GSK3 inhibition…”
Get full text

Multiparameter cell cycle analysis by Jacobberger, James W, Sramkoski, R Michael, Stefan, Tammy

“…Cell cycle-related cytometry and analysis is an essential experimental paradigm for the cell biology of yeast, mammalian, and drosophila cells. Methods have…”
Get more information

All-Trans-Retinoic Acid (ATRA) Combined with Lithium As Treatment of Relapsed Non-Progranulocytic AML: Therapeutic Targeting Inhibition of the Glycogen Synthase Kinase 3-Beta (GSK3) Enzyme by Caimi, Paolo, Gupta, Kalpana, Stefan, Tammy, Cooper, Brenda, William, Basem M., Campagnaro, Erica L, Creger, Richard J., Kane, Donna, Gerson, Stanton L., Lazarus, Hillard M., de Lima, Marcos, Wald, David N.

“…Introduction: Targeting the maturation arrest in acute myeloid leukemia (AML) to induce differentiation instead of killing rapidly dividing cells can lead to…”
Get full text

Laser Scanning Cytometry of Mitosis: State and Stage Analysis by Stefan, Tammy, Jacobberger, James W.

“…Here we use a concept of cell state, which can be defined as the conjunction of expression levels of an arbitrary number of biomolecules or modifications…”
Get full text

Cell Cycle Arrest by Kynurenine in Lens Epithelial Cells by Mailankot, Maneesh, Smith, Dawn, Howell, Scott, Wang, Benlian, Jacobberger, James W, Stefan, Tammy, Nagaraj, Ram H

“…Indolemine 2,3-dioxygenase (IDO)-mediated oxidation of tryptophan produces kynurenines (KYNs), which may play a role in cataract formation. The molecular…”
Get full text

Phase I trial of the combination of flavopiridol and imatinib mesylate in patients with Bcr-Abl+ hematological malignancies by Bose, Prithviraj, Perkins, Edward B., Honeycut, Connie, Wellons, Martha D., Stefan, Tammy, Jacobberger, James W., Kontopodis, Emmanouil, Beumer, Jan H., Egorin, Merrill J., Imamura, Chiyo K., Douglas Figg, W., Karp, Judith E., Koc, Omer N., Cooper, Brenda W., Luger, Selina M., Colevas, A. Dimitrios, Roberts, John D., Grant, Steven

“…Purpose Imatinib is an inhibitor of the Bcr-Abl tyrosine kinase; however, resistance is common. Flavopiridol, a cyclin-dependent kinase (CDK) inhibitor,…”
Get full text

A new biomarker for mitotic cells by Jacobberger, James W., Frisa, Phyllis S., Sramkoski, R. Michael, Stefan, Tammy, Shults, Keith E., Soni, Deena V.

“…Many epitopes are phosphorylated during mitosis. These epitopes are useful biomarkers for mitotic cells. The most commonly used are MPM‐2 and serine 10 of…”
Get full text

Phase I trial of the combination of flavopiridol and imatinib mesylate in patients with Bcr-Abl^sup +^ hematological malignancies by Bose, Prithviraj, Perkins, Edward B, Honeycut, Connie, Wellons, Martha D, Stefan, Tammy, Jacobberger, James W, Kontopodis, Emmanouil, Beumer, Jan H, Egorin, Merrill J, Imamura, Chiyo K, Douglas Figg, W, Karp, Judith E, Koc, Omer N, Cooper, Brenda W, Luger, Selina M, Colevas, A Dimitrios, Roberts, John D, Grant, Steven

“…Imatinib is an inhibitor of the Bcr-Abl tyrosine kinase; however, resistance is common. Flavopiridol, a cyclin-dependent kinase (CDK) inhibitor, down-regulates…”
Get full text

Determination of O 6-benzylguanine in human plasma by reversed-phase high-performance liquid chromatography by Stefan, Tammy L., Ingalls, Stephen T., Gerson, Stanton L., Willson, James K.V., Hoppel, Charles L.

“…A high-performance liquid chromatographic assay for O 6-benzylguanine utilizing liquid-liquid extraction and reversed-phase chromatography has been developed…”
Get full text