Search Results - "Steeves, Meredith A"

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications by Hardbower, Dana M., Asim, Mohammad, Luis, Paula B., Singh, Kshipra, Barry, Daniel P., Yang, Chunying, Steeves, Meredith A., Cleveland, John L., Schneider, Claus, Piazuelo, M. Blanca, Gobert, Alain P., Wilson, Keith T.

“…Macrophage activation is a critical step in host responses during bacterial infections. Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine…”
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Tristetraprolin Impairs Myc-Induced Lymphoma and Abolishes the Malignant State by Rounbehler, Robert J., Fallahi, Mohammad, Yang, Chunying, Steeves, Meredith A., Li, Weimin, Doherty, Joanne R., Schaub, Franz X., Sanduja, Sandhya, Dixon, Dan A., Blackshear, Perry J., Cleveland, John L.

“…Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover…”
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Hsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy by Joo, Joung Hyuck, Dorsey, Frank C., Joshi, Aashish, Hennessy-Walters, Kristin M., Rose, Kristie L., McCastlain, Kelly, Zhang, Ji, Iyengar, Rekha, Jung, Chang Hwa, Suen, Der-Fen, Steeves, Meredith A., Yang, Chia-Ying, Prater, Stephanie M., Kim, Do-Hyung, Thompson, Craig B., Youle, Richard J., Ney, Paul A., Cleveland, John L., Kundu, Mondira

“…Autophagy, the primary recycling pathway of cells, plays a critical role in mitochondrial quality control under normal growth conditions and in the response to…”
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Identification of antibodies cross-reactive with woodchuck immune cells and activation of virus-specific and global cytotoxic T cell responses by anti-PD-1 and anti-PD-L1 in experimental chronic hepatitis B and persistent occult hepadnaviral infection by Corkum, Christopher P, Wiede, Louisa L, Ruble, Cara L-A, Qiu, Jiabin, Mulrooney-Cousins, Patricia M, Steeves, Meredith A, Watson, David E, Michalak, Tomasz I

“…Woodchuck infected with woodchuck hepatitis virus (WHV) is the most pathogenically compatible naturally occurring model of human hepatitis B virus (HBV)…”
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Targeting the autophagy pathway for cancer chemoprevention by Steeves, Meredith A, Dorsey, Frank C, Cleveland, John L

“…Autophagy is crucial for maintaining cellular homeostasis, coping with metabolic stress, and limiting oxidative damage. Several autophagy-deficient or knockout…”
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Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy by Fernandez, Mario R, Schaub, Franz X, Yang, Chunying, Li, Weimin, Yun, Seongseok, Schaub, Stephanie K, Dorsey, Frank C, Liu, Min, Steeves, Meredith A, Ballabio, Andrea, Tzankov, Alexandar, Chen, Zhihua, Koomen, John M, Berglund, Anders E, Cleveland, John L

“…MYC family oncoproteins are regulators of metabolic reprogramming that sustains cancer cell anabolism. Normal cells adapt to nutrient-limiting conditions by…”
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Current nonclinical approaches for immune assessments of immuno-oncology biotherapeutics by Grimaldi, Christine, Ibraghimov, Alex, Kiessling, Andrea, Rattel, Benno, Ji, Changhua, Fuller, Claudette L., Brennan, Frank R., Regenass-Lechner, Franziska, Shenton, Jacintha, Price, Karen D., Piché, Marie-Soleil, Steeves, Meredith A., Prell, Rodney, Dudal, Sherri, Kronenberg, Sven, Freebern, Wendy, Blanset, Diann

“…•Cancer immunotherapy is associated with immune-related adverse events.•Current nonclinical approaches for assessment of these adverse events are reviewed in…”
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Affinity maturation and autoimmunity to DNA by Marion, Tony N, Krishnan, Meera R, Steeves, Meredith A, Desai, Dharmesh D

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Monitoring the autophagy pathway in cancer by Dorsey, Frank C, Steeves, Meredith A, Prater, Stephanie M, Schröter, Thomas, Cleveland, John L

“…Autophagy is an ancient cell survival pathway that is induced by metabolic stress and that helps prevent bioenergetic failure. This pathway has emerged as a…”
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Analysis of regulatory and effector T cell repertoires during MOG-EAE (99.7) by Liu, Xin, Steeves, Meredith A, Nguyen, Phuong, Geiger, Terrence L

“…How the repertoires of conventional (Tconv) and Foxp3+ regulatory T-cells (Treg) compare in the context of active autoimmune disease is poorly understood. We…”
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Abstract 4027: Myc controls mRNA stability through the agency of AU-binding proteins to promote lymphomagenesis by Rounbehler, Robert J., Fallahi, Mohammad, Steeves, Meredith A., Li, Weimin, Yang, Chunying, Doherty, Joanne R., Cleveland, John L.

“…Myc oncoproteins regulate transcription by binding to target genes harboring E-boxes or Initiator elements, yet these responses explain only a fraction of the…”
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Tolerance to DNA in (NZB × NZW)F1 Mice That Inherit an Anti-DNA VH as a Conventional μ H Chain Transgene but Not as a VH Knock-in Transgene by Steeves, Meredith A., Marion, Tony N.

“…Lupus-prone (NZB × NZW)F1 (BWF1) mice were made transgenic (Tg) for an anti-DNA Ab inherited either as a conventional VH3H9-μ H chain Tg (3H9-μ) with or…”
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Tristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state by Rounbehler, Robert J., Fallahi, Mohammad, Yang, Chunying, Steeves, Meredith A., Li, Weimin, Doherty, Joanne R., Schaub, Franz X., Sanduja, Sandhya, Dixon, Dan A., Blackshear, Perry J., Cleveland, John L.

“…Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is…”
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Abstract 261: Emerging roles for the CREB regulated transcription coactivators (CRTCs) in oncogenesis by Amelio, Antonio L., Dorsey, Frank C., Steeves, Meredith A., Southern, Mark R., Young, Brandon M., Lawani, Mariam B., Prater, Stephanie M., Alperstein, Adam S., Cleveland, John L., Conkright, Michael D.

“…Oncogenesis is a complex, multi-factorial process of cellular transformation that leads to the development of many types of cancers. The factors that…”
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Tolerance to DNA in (NZB x NZW)F1 mice that inherit an anti-DNA V(H) as a conventional micro H chain transgene but not as a V(H) knock-in transgene by Steeves, Meredith A, Marion, Tony N

“…Lupus-prone (NZB x NZW)F(1) (BWF(1)) mice were made transgenic (Tg) for an anti-DNA Ab inherited either as a conventional V(H)3H9- micro H chain Tg (3H9- micro…”
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Tolerance to DNA in (NZB x NZW)F sub(1) Mice That Inherit an Anti-DNA V sub(H) as a Conventional mu H Chain Transgene but Not as a V sub(H) Knock-in Transgene by Steeves, Meredith A, Marion, Tony N

“…Lupus-prone (NZB x NZW)F sub(1) (BWF sub(1)) mice were made transgenic (Tg) for an anti-DNA Ab inherited either as a conventional V sub(H)3H9- mu H chain Tg…”
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Tolerance and autoimmunity in (NZB x NZW)F1 mice transgenic for anti-DNA antibody by Steeves, Meredith A

“…(NZB x NZW)F1 mice appear to control self-reactive anti-DNA B cells arising in the bone marrow with a combination of tolerogenic mechanisms, including…”
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Tolerance to DNA in (NZB x NZW)F1 Mice That Inherit an Anti-DNA VH as a Conventional {micro} H Chain Transgene but Not as a VH Knock-in Transgene by Steeves, Meredith A, Marion, Tony N

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