Search Results - "Steere, Boyd"

S806 Mirikizumab-Induced Transcriptome Changes in Patient Biopsies at Week 12 Are Maintained Through Week 52 in Patients With Ulcerative Colitis by Johnson, Travis, Steere, Boyd, Zhang, Pengyue, Zang, Yong, Higgs, Richard, Gottlieb, Klaus, Reinisch, Walter, Panés, Julian, Krishnan, Venkatesh

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Integrated analysis of global mRNA and protein expression data in HEK293 cells overexpressing PRL-1 by Dumaual, Carmen M, Steere, Boyd A, Walls, Chad D, Wang, Mu, Zhang, Zhong-Yin, Randall, Stephen K

“…The protein tyrosine phosphatase PRL-1 represents a putative oncogene with wide-ranging cellular effects. Overexpression of PRL-1 can promote cell…”
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The Formation of Amphotericin B Ion Channels in Lipid Bilayers by Fujii, Gary, Chang, Joan-En, Coley, Terry, Steere, Boyd

“…The ability of amphotericin B (AmB) to form ion-permeable channels in cholesterol containing lipid bilayers was studied by UV/visible absorbance, circular…”
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Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23 by Steere, Boyd, Beidler, Catherine, Martin, Andrea, Bright, Stu, Kikly, Kristy, Benschop, Robert J.

“…Interleukin (IL)-23 exists as a heterodimer consisting of p19 and p40 and is a key cytokine for promoting inflammatory responses in a variety of target organs…”
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569 A TRANSCRIPTOME-DEPENDENT PROGNOSTIC MODEL OF RESPONSE IN PATIENTS WITH ULCERATIVE COLITIS by Johnson, Travis S., Reinisch, Walter, Steere, Boyd, Milch, Catherine, Morris, Nathan, D'Haens, Geert, Huang, Kun, Krishnan, Venkatesh

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Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance by Aschenbrenner, Dominik, Quaranta, Maria, Banerjee, Soumya, Ilott, Nicholas, Jansen, Joanneke, Steere, Boyd, Chen, Yin-Huai, Ho, Stephen, Cox, Karen, Arancibia-Cárcamo, Carolina V, Coles, Mark, Gaffney, Eamonn, Travis, Simon Pl, Denson, Lee, Kugathasan, Subra, Schmitz, Jochen, Powrie, Fiona, Sansom, Stephen N, Uhlig, Holm H

“…Dysregulated immune responses are the cause of IBDs. Studies in mice and humans suggest a central role of interleukin (IL)-23-producing mononuclear phagocytes…”
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Tu1467: MIRIKIZUMAB-INDUCED UPREGULATION OF COLONIC TRANSCRIPTS CORRELATES WITH IMPROVEMENTS IN STOOL FREQUENCY IN A PHASE 2 STUDY OF PATIENTS WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS by Steere, Boyd, Powell, Nick, Higgs, Richard, Wang, Ying C., Milch, Catherine, Sandborn, William J., Sands, Bruce E., Reinisch, Walter, D'Haens, Geert, Krishnan, Venkatesh

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Sa1125 GENE EXPRESSION (GE) VALUES IN A PHASE 2 TRIAL OF MIRIKIZUMAB IN ULCERATIVE COLITIS (UC) CORRELATE BETTER WITH HISTOPATHOLOGY (HP) THAN ENDOSCOPY (EN) AND MAYO SCORES by Steere, Boyd, Gottlieb, Klaus, Schmitz, Jochen, Higgs, Richard, Jia, Bochao, Milch, Catherine, Tuttle, Jay, Krishnan, Venkatesh, Belin, Ruth, Reinisch, Walter

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Tu1854 MIRIKIZUMAB REGULATES GENES INVOLVED IN ANTI-TNF RESISTANCE AND ULCERATIVE COLITIS DISEASE ACTIVITY by Steere, Boyd, Schmitz, Jochen, Powell, Nicholas, Higgs, Richard, Gottlieb, Klaus, Liu, Yushi, Jia, Bochao, Tuttle, Jay, Sandborn, William J., Sands, Bruce E., Krishnan, Venkatesh

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Mirikizumab-Induced Transcriptome Changes in Ulcerative Colitis Patient Biopsies at Week 12 Are Maintained Through Week 52 by Johnson, Travis, Steere, Boyd, Zhang, Pengyue, Zang, Yong, Higgs, Richard, Milch, Catherine, Reinisch, Walter, Panés, Julian, Huang, Kun, D'Haens, Geert, Krishnan, Venkatesh

“…Mirikizumab, an anti-interleukin-23p19 monoclonal antibody, demonstrated efficacy in phase 2 and 3 randomized clinical trials of patients with…”
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Mirikizumab Regulates Genes Involved in Ulcerative Colitis Disease Activity and Anti-TNF Resistance: Results From a Phase 2 Study by Steere, Boyd, Schmitz, Jochen, Powell, Nick, Higgs, Richard, Gottlieb, Klaus, Liu, Yushi, Jia, Bochao, Tuttle, Jay L., Sandborn, William J., Sands, Bruce E., D'Haens, Geert, Reinisch, Walter, Krishnan, Venkatesh

“…Mirikizumab, a monoclonal antibody targeting the p19 subunit of interleukin (IL)-23, demonstrated efficacy and was well-tolerated in a phase 2 randomized…”
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Prediction of in vivo clearance and associated variability of CYP2C19 substrates by genotypes in populations utilizing a pharmacogenetics-based mechanistic model by Steere, Boyd, Baker, Jessica A Roseberry, Hall, Stephen D, Guo, Yingying

“…It is important to examine the cytochrome P450 2C19 (CYP2C19) genetic contribution to drug disposition and responses of CYP2C19 substrates during drug…”
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Mirikizumab regulates genes involved in ulcerative colitis disease activity and anti-TNF resistance: results from a phase 2 study by Steere, Boyd, Schmitz, Jochen, Powell, Nick, Higgs, Richard, Gottlieb, Klaus, Liu, Yushi, Jia, Bochao, Tuttle, Jay L, Sandborn, William J, Sands, Bruce E, D’Haens, Geert, Reinisch, Walter, Krishnan, Venkatesh

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Integrated Analysis of Global mRNA and Protein Expression Data in HEK293 Cells Overexpressing PRL-1: e72977 by Dumaual, Carmen M, Steere, Boyd A, Walls, Chad D, Wang, Mu, Zhang, Zhong-Yin, Randall, Stephen K

“…Background The protein tyrosine phosphatase PRL-1 represents a putative oncogene with wide-ranging cellular effects. Overexpression of PRL-1 can promote cell…”
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Characterization of High-Order Diphtheria Toxin Oligomers by Steere, Boyd, Eisenberg, David

“…In 3D domain swapping, a domain of a protein breaks its noncovalent bonds with the protein core and its place is taken by the identical domain of another…”
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Characterization of diphtheria toxin high-order oligomerization and energetics by Steere, Boyd Allen

“…Proteins, because of their great size and complexity, have a diversity of stable structures greater than most other classes of molecules and derive functional…”
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