Search Results - "Steen, V."

Changes in causes of death in systemic sclerosis, 1972–2002 by Steen, Virginia D, Medsger, Thomas A

“…Background: Survival of scleroderma has changed since the renal crisis treatment has become possible. Aims: To document the changes in survival and organ…”
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Genome-wide association studies establish that human intelligence is highly heritable and polygenic by Davies, G, Tenesa, A, Payton, A, Yang, J, Harris, S E, Liewald, D, Ke, X, Le Hellard, S, Christoforou, A, Luciano, M, McGhee, K, Lopez, L, Gow, A J, Corley, J, Redmond, P, Fox, H C, Haggarty, P, Whalley, L J, McNeill, G, Goddard, M E, Espeseth, T, Lundervold, A J, Reinvang, I, Pickles, A, Steen, V M, Ollier, W, Porteous, D J, Horan, M, Starr, J M, Pendleton, N, Visscher, P M, Deary, I J

“…General intelligence is an important human quantitative trait that accounts for much of the variation in diverse cognitive abilities. Individual differences in…”
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Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A by Kløverpris, Søren, Mikkelsen, Jakob H., Pedersen, Josefine H., Jepsen, Malene R., Laursen, Lisbeth S., Petersen, Steen V., Oxvig, Claus

“…Stanniocalcin-1 (STC1) is a disulfide-bound homodimeric glycoprotein, first identified as a hypocalcemic hormone important for maintaining calcium homeostasis…”
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Adding functionality to milk-based protein: Preparation, and physico-chemical characterization of β-lactoglobulin-phenolic conjugates by Abd El-Maksoud, Ahmed A., Abd El-Ghany, Ismail H., El-Beltagi, Hossam S., Anankanbil, Sampson, Banerjee, Chiranjib, Petersen, Steen V., Pérez, Bianca, Guo, Zheng

“…•β-Lactoglobulin-caffeic acid conjugate (βLg-CA) is prepared via one-pot reaction.•An optimal coupling of 8mol caffeic acid to 1mol βLg is obtained at pH…”
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Digital ulcers: overt vascular disease in systemic sclerosis by Steen, V., Denton, C. P., Pope, J. E., Matucci-Cerinic, M.

“…RP is an almost universal manifestation of SSc, with 95% of all patients being affected, and resulting in digital ulcers (DUs) in ∼30% of the patients each…”
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Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement by Mortensen, Sofia, Kidmose, Rune T, Petersen, Steen V, Szilágyi, Ágnes, Prohászka, Zoltan, Andersen, Gregers R

“…Complement component C4 is a central protein in the classical and lectin pathways within the complement system. During activation of complement, its major…”
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Functional amyloid in Pseudomonas by Dueholm, Morten S, Petersen, Steen V, Sønderkær, Mads, Larsen, Poul, Christiansen, Gunna, Hein, Kim L, Enghild, Jan J, Nielsen, Jeppe L, Nielsen, Kåre L, Nielsen, Per H, Otzen, Daniel E

“…Amyloids are highly abundant in many microbial biofilms and may play an important role in their architecture. Nevertheless, little is known of the amyloid…”
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Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT) by Lencz, T, Knowles, E, Davies, G, Guha, S, Liewald, D C, Starr, J M, Djurovic, S, Melle, I, Sundet, K, Christoforou, A, Reinvang, I, Mukherjee, S, DeRosse, Pamela, Lundervold, A, Steen, V M, John, M, Espeseth, T, Räikkönen, K, Widen, E, Palotie, A, Eriksson, J G, Giegling, I, Konte, B, Ikeda, M, Roussos, P, Giakoumaki, S, Burdick, K E, Payton, A, Ollier, W, Horan, M, Donohoe, G, Morris, D, Corvin, A, Gill, M, Pendleton, N, Iwata, N, Darvasi, A, Bitsios, P, Rujescu, D, Lahti, J, Hellard, S L, Keller, M C, Andreassen, O A, Deary, I J, Glahn, D C, Malhotra, A K

“…It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset…”
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Analogue Modeling of Plate Rotation Effects in Transform Margins and Rift‐Transform Intersections by Farangitakis, G.‐P., Sokoutis, D., McCaffrey, K. J. W., Willingshofer, E., Kalnins, L. M., Phethean, J. J. J., Hunen, J., Steen, V.

“…Transform margins are first‐order tectonic features that accommodate oceanic spreading. Uncertainties remain about their evolution, genetic relationship to…”
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Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System by Pedersen, Dennis V, Gadeberg, Trine A F, Thomas, Caroline, Wang, Yong, Joram, Nicolas, Jensen, Rasmus K, Mazarakis, Sofia M M, Revel, Margot, El Sissy, Carine, Petersen, Steen V, Lindorff-Larsen, Kresten, Thiel, Steffen, Laursen, Nick S, Fremeaux-Bacchi, Véronique, Andersen, Gregers R

“…Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative…”
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Predictors of end stage lung disease in systemic sclerosis by Steen, V

“…[...]in the first five years of disease patients should have pulmonary function tests (PFTs) monitored closely, every six months, until lung function…”
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The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response by Hu, Lili, Zachariae, Elias D, Larsen, Ulrike G, Vilhardt, Frederik, Petersen, Steen V

“…Superoxide dismutase 3 (SOD3) is an extracellular enzyme with the capacity to modulate extracellular redox conditions by catalyzing the dismutation of…”
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FAM20C phosphorylation of the RGDSVVYGLR motif in osteopontin inhibits interaction with the αvβ3 integrin by Schytte, Gitte N., Christensen, Brian, Bregenov, Ida, Kjøge, Katarzyna, Scavenius, Carsten, Petersen, Steen V., Enghild, Jan J., Sørensen, Esben S.

“…Osteopontin (OPN) is a ubiquitously expressed, multifunctional, and highly phosphorylated protein. OPN contains two neighboring integrin‐binding motifs, RGD…”
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Pulmonary complications: one of the most challenging complications of systemic sclerosis by Wells, A. U., Steen, V., Valentini, G.

“…Pulmonary manifestations of SSc are leading causes of disease-related morbidity and mortality. Key clinical issues relate to the early detection of fibrotic…”
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Redox Regulation of the Superoxide Dismutases SOD3 and SOD2 in the Pulmonary Circulation by Hernandez-Saavedra, Daniel, Swain, Kalin, Tuder, Rubin, Petersen, Steen V, Nozik-Grayck, Eva

“…When evaluating the role of redox-regulating signaling in pulmonary vascular diseases, it is intriguing to consider the modulation of key antioxidant enzymes…”
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An innate antiviral pathway acting before interferons at epithelial surfaces by Iversen, Marie B, Reinert, Line S, Thomsen, Martin K, Bagdonaite, Ieva, Nandakumar, Ramya, Cheshenko, Natalia, Prabakaran, Thaneas, Vakhrushev, Sergey Y, Krzyzowska, Malgosha, Kratholm, Sine K, Ruiz-Perez, Fernando, Petersen, Steen V, Goriely, Stanislas, Bibby, Bo Martin, Eriksson, Kristina, Ruland, Jürgen, Thomsen, Allan R, Herold, Betsy C, Wandall, Hans H, Frische, Sebastian, Holm, Christian K, Paludan, Søren R

“…Mucosal surfaces often represent the first point of entry for pathogens. Paludan and colleagues demonstrate that disruption of the mucus itself can initiate a…”
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Hydrogen peroxide induce modifications of human extracellular superoxide dismutase that results in enzyme inhibition by Gottfredsen, Randi H, Larsen, Ulrike G, Enghild, Jan J, Petersen, Steen V

“…Superoxide dismutase (EC-SOD) controls the level of superoxide in the extracellular space by catalyzing the dismutation of superoxide into hydrogen peroxide…”
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The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework by Nielsen, Lau D., Foged, Mads M., Albert, Anastasia, Bertelsen, Andreas B., Søltoft, Cecilie L., Robinson, Samuel D., Petersen, Steen V., Purcell, Anthony W., Olivera, Baldomero M., Norton, Raymond S., Vasskog, Terje, Safavi-Hemami, Helena, Teilum, Kaare, Ellgaard, Lars

“…Venomous marine cone snails produce peptide toxins (conotoxins) that bind ion channels and receptors with high specificity and therefore are important…”
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Bone Formation in Zebrafish: The Significance of DAF-FM DA Staining for Nitric Oxide Detection by Huysseune, Ann, Larsen, Ulrike G, Larionova, Daria, Matthiesen, Cecilie L, Petersen, Steen V, Muller, Marc, Witten, P Eckhard

“…DAF-FM DA is widely used as a live staining compound to show the presence of nitric oxide (NO) in cells. Applying this stain to live zebrafish embryos is known…”
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The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold by Hong, Zebin, Nowakowski, Michal, Spronk, Chris, Petersen, Steen V, Andreasen, Peter A, Koźmiński, Wiktor, Mulder, Frans A A, Jensen, Jan K

“…A decade ago, motif at N-terminus with eight-cysteines (MANEC) was defined as a new protein domain family. This domain is found exclusively at the N-terminus…”
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