Search Results - "Steen, V M"

Genome-wide association studies establish that human intelligence is highly heritable and polygenic by Davies, G, Tenesa, A, Payton, A, Yang, J, Harris, S E, Liewald, D, Ke, X, Le Hellard, S, Christoforou, A, Luciano, M, McGhee, K, Lopez, L, Gow, A J, Corley, J, Redmond, P, Fox, H C, Haggarty, P, Whalley, L J, McNeill, G, Goddard, M E, Espeseth, T, Lundervold, A J, Reinvang, I, Pickles, A, Steen, V M, Ollier, W, Porteous, D J, Horan, M, Starr, J M, Pendleton, N, Visscher, P M, Deary, I J

“…General intelligence is an important human quantitative trait that accounts for much of the variation in diverse cognitive abilities. Individual differences in…”
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Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT) by Lencz, T, Knowles, E, Davies, G, Guha, S, Liewald, D C, Starr, J M, Djurovic, S, Melle, I, Sundet, K, Christoforou, A, Reinvang, I, Mukherjee, S, DeRosse, Pamela, Lundervold, A, Steen, V M, John, M, Espeseth, T, Räikkönen, K, Widen, E, Palotie, A, Eriksson, J G, Giegling, I, Konte, B, Ikeda, M, Roussos, P, Giakoumaki, S, Burdick, K E, Payton, A, Ollier, W, Horan, M, Donohoe, G, Morris, D, Corvin, A, Gill, M, Pendleton, N, Iwata, N, Darvasi, A, Bitsios, P, Rujescu, D, Lahti, J, Hellard, S L, Keller, M C, Andreassen, O A, Deary, I J, Glahn, D C, Malhotra, A K

“…It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset…”
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Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism by Gjerde, J., Hauglid, M., Breilid, H., Lundgren, S., Varhaug, J. E., Kisanga, E. R., Mellgren, G., Steen, V. M., Lien, E. A.

“…Background: Tamoxifen is hydroxylated by cytochrome P450 (CYP) 2D6 to the potent metabolites 4-hydroxytamoxifen (4OHtam) and 4-hydroxy-N-demethyltamoxifen…”
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Association between the insulin-induced gene 2 ( ) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? by Le Hellard, S, Theisen, F M, Haberhausen, M, Raeder, M B, Fernø, J, Gebhardt, S, Hinney, A, Remschmidt, H, Krieg, J C, Mehler-Wex, C, Nöthen, M M, Hebebrand, J, Steen, V M

“…Atypical antipsychotics are nowadays the most widely used drugs to treat schizophrenia and other psychosis. Unfortunately, some of them can cause major…”
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Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1 by Brogger, J, Steen, V. M, Eiken, H. G, Gulsvik, A, Bakke, P

“…There is evidence of a hereditary component in chronic obstructive pulmonary disease (COPD). A number of genetic association studies have been performed to…”
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Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder by SJØHOLT, G, EBSTEIN, R. P, MURAD, I, MOLVEN, A, STEEN, V. M, LIE, R. T, BERLE, J. Ø, MALLET, J, DELEUZE, J. F, LEVINSON, D. F, LAURENT, C, MUIAHED, M, BANNOURA, I

“…Manic-depressive (bipolar) illness is a serious psychiatric disorder with a strong genetic predisposition. The disorder is likely to be multifactorial and…”
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Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: Induction of immunity-linked genes by Håvik, B, Røkke, H, Dagyte, G, Stavrum, A.-K, Bramham, C.R, Steen, V.M

“…Abstract Gene expression in adult neuronal circuits is dynamically modulated in response to synaptic activity. Persistent changes in synaptic strength, as seen…”
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Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? by Fernø, J, Raeder, M B, Vik-Mo, A O, Skrede, S, Glambek, M, Tronstad, K-J, Breilid, H, Løvlie, R, Berge, R K, Stansberg, C, Steen, V M

“…Several studies have reported on structural abnormalities, decreased myelination and oligodendrocyte dysfunction in post-mortem brains from schizophrenic…”
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A possible association between schizophrenia and GRIK3 polymorphisms in a multicenter sample of Scandinavian origin (SCOPE) by Djurovic, S, Kähler, A.K, Kulle, B, Jönsson, E.G, Agartz, I, Le Hellard, S, Hall, H, Jakobsen, K.D, Hansen, T, Melle, I, Werge, T, Steen, V.M, Andreassen, O.A

“…Abstract There is considerable evidence of altered glutamatergic signalling in schizophrenia and a polymorphic variant of the GRIK3 glutamate receptor gene on…”
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Dopamine D3-receptor gene variant and susceptibility to tardive dyskinesia in schizophrenic patients by Steen, V M, Løvlie, R, MacEwan, T, McCreadie, R G

“…Schizophrenia is a serious psychiatric illness with a life-time risk of approximately one percent. Many of the patients, but not all, benefit from treatment…”
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Some new hope but still no hype for academic psychiatry in Norway by Steen, V M

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Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders by Gohar, S. M., Dieset, I., Steen, N. E., Mørch, R. H., Vedal, T. S. J., Reponen, E. J., Steen, V. M., Andreassen, O. A., Melle, I.

“…Objective Associations between suicidality and lipid dysregulation are documented in mental illness, but the potential role of leptin remains unclear. We…”
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A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients by Sjøholt, G, Gulbrandsen, A K, Løvlie, R, Berle, J O, Molven, A, Steen, V M

“…For several decades, lithium has been the drug of choice in the long-term treatment of manic-depressive illness, but the molecular mechanism(s) mediating its…”
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Non-functional CYP2D6 alleles and risk for neuroleptic-induced movement disorders in schizophrenic patients by ANDREASSEN, O. A, MACEWAN, T, GULBRANDSEN, A.-K, MCCREADIE, R. G, STEEN, V. M

“…The use of classic anti-psychotic drugs in the long-term treatment of schizophrenia is associated with risk for extrapyramidal side-effects, such as akathisia,…”
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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium by Trampush, J W, Yang, M L Z, Yu, J, Knowles, E, Davies, G, Liewald, D C, Starr, J M, Djurovic, S, Melle, I, Sundet, K, Christoforou, A, Reinvang, I, DeRosse, P, Lundervold, A J, Steen, V M, Espeseth, T, Räikkönen, K, Widen, E, Palotie, A, Eriksson, J G, Giegling, I, Konte, B, Roussos, P, Giakoumaki, S, Burdick, K E, Payton, A, Ollier, W, Horan, M, Chiba-Falek, O, Attix, D K, Need, A C, Cirulli, E T, Voineskos, A N, Stefanis, N C, Avramopoulos, D, Hatzimanolis, A, Arking, D E, Smyrnis, N, Bilder, R M, Freimer, N A, Cannon, T D, London, E, Poldrack, R A, Sabb, F W, Congdon, E, Conley, E D, Scult, M A, Dickinson, D, Straub, R E, Donohoe, G, Morris, D, Corvin, A, Gill, M, Hariri, A R, Weinberger, D R, Pendleton, N, Bitsios, P, Rujescu, D, Lahti, J, Le Hellard, S, Keller, M C, Andreassen, O A, Deary, I J, Glahn, D C, Malhotra, A K, Lencz, T

“…This corrects the article DOI: 10.1038/mp.2016.244…”
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Olanzapine depot exposure in male rats: Dose-dependent lipogenic effects without concomitant weight gain by Fernø, J, Ersland, K.M, Duus, I.H, González-García, I, Fossan, K.O, Berge, R.K, Steen, V.M, Skrede, S

“…Abstract Treatment with second-generation antipsychotic agents such as olanzapine frequently results in metabolic adverse effects, e.g. hyperphagia, weight…”
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Genome-wide autozygosity is associated with lower general cognitive ability by Howrigan, D P, Simonson, M A, Davies, G, Harris, S E, Tenesa, A, Starr, J M, Liewald, D C, Deary, I J, McRae, A, Wright, M J, Montgomery, G W, Hansell, N, Martin, N G, Payton, A, Horan, M, Ollier, W E, Abdellaoui, A, Boomsma, D I, DeRosse, P, Knowles, E E M, Glahn, D C, Djurovic, S, Melle, I, Andreassen, O A, Christoforou, A, Steen, V M, Hellard, S L, Sundet, K, Reinvang, I, Espeseth, T, Lundervold, A J, Giegling, I, Konte, B, Hartmann, A M, Rujescu, D, Roussos, P, Giakoumaki, S, Burdick, K E, Bitsios, P, Donohoe, G, Corley, R P, Visscher, P M, Pendleton, N, Malhotra, A K, Neale, B M, Lencz, T, Keller, M C

“…Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical…”
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Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene by Løvlie, Roger, Daly, Ann K., Molven, Anders, Idle, Jeffrey R., Steen, Vidar M.

“…Up to 7% of Caucasians may demonstrate ultrarapid metabolism of debrisoquine due to inheritance of alleles with duplicated functional CYP2D6 genes. Here we…”
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Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples by Le Hellard, S, Mühleisen, T W, Djurovic, S, Fernø, J, Ouriaghi, Z, Mattheisen, M, Vasilescu, C, Raeder, M B, Hansen, T, Strohmaier, J, Georgi, A, Brockschmidt, F F, Melle, I, Nenadic, I, Sauer, H, Rietschel, M, Nöthen, M M, Werge, T, Andreassen, O A, Cichon, S, Steen, V M

“…Several studies have reported structural brain abnormalities, decreased myelination and oligodendrocyte dysfunction in schizophrenia. In the central nervous…”
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Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins by Hill, W D, Davies, G, van de Lagemaat, L N, Christoforou, A, Marioni, R E, Fernandes, C P D, Liewald, D C, Croning, M D R, Payton, A, Craig, L C A, Whalley, L J, Horan, M, Ollier, W, Hansell, N K, Wright, M J, Martin, N G, Montgomery, G W, Steen, V M, Le Hellard, S, Espeseth, T, Lundervold, A J, Reinvang, I, Starr, J M, Pendleton, N, Grant, S G N, Bates, T C, Deary, I J

“…Differences in general cognitive ability (intelligence) account for approximately half of the variation in any large battery of cognitive tests and are…”
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