Search Results - "Steen, Judith A"

Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics by Belin, Stephane, Nawabi, Homaira, Wang, Chen, Tang, Shaojun, Latremoliere, Alban, Warren, Peter, Schorle, Hubert, Uncu, Ceren, Woolf, Clifford J., He, Zhigang, Steen, Judith A.

“…Neurons differ in their responses to injury, but the underlying mechanisms remain poorly understood. Using quantitative proteomics, we characterized the…”
Get full text

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease by Mair, Waltraud, Muntel, Jan, Tepper, Katharina, Tang, Shaojun, Biernat, Jacek, Seeley, William W, Kosik, Kenneth S, Mandelkow, Eckhard, Steen, Hanno, Steen, Judith A

“…Tauopathies, including Alzheimer’s disease (AD), are associated with the aggregation of modified microtubule associated protein tau. This pathological state of…”
Get full text

Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma by Weeraratne, Shyamal Dilhan, Amani, Vladimir, Teider, Natalia, Pierre-Francois, Jessica, Winter, Dominic, Kye, Min Jeong, Sengupta, Soma, Archer, Tenley, Remke, Marc, Bai, Alfa H. C., Warren, Peter, Pfister, Stefan M., Steen, Judith A. J., Pomeroy, Scott L., Cho, Yoon-Jae

“…Medulloblastomas are the most common malignant brain tumors in children. Several large-scale genomic studies have detailed their heterogeneity, defining…”
Get full text

Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits by Akten, Bikem, Kye, Min Jeong, Hao, Le T, Wertz, Mary H, Singh, Sasha, Nie, Duyu, Huang, Jia, Merianda, Tanuja T, Twiss, Jeffery L, Beattie, Christine E, Steen, Judith A.J, Sahin, Mustafa

“…Spinal muscular atrophy (SMA), caused by the deletion of the SMN1 gene, is the leading genetic cause of infant mortality. SMN protein is present at high levels…”
Get full text

Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms by Nawabi, Homaira, Belin, Stephane, Cartoni, Romain, Williams, Philip R., Wang, Chen, Latremolière, Alban, Wang, Xuhua, Zhu, Junjie, Taub, Daniel G., Fu, Xiaoqin, Yu, Bin, Gu, Xiaosong, Woolf, Clifford J., Liu, Judy S., Gabel, Christopher V., Steen, Judith A., He, Zhigang

“…After axotomy, neuronal survival and growth cone re-formation are required for axon regeneration. We discovered that doublecortin-like kinases (DCLKs), members…”
Get full text

Cell-Type-Specific Profiling of Alternative Translation Identifies Regulated Protein Isoform Variation in the Mouse Brain by Sapkota, Darshan, Lake, Allison M., Yang, Wei, Yang, Chengran, Wesseling, Hendrik, Guise, Amanda, Uncu, Ceren, Dalal, Jasbir S., Kraft, Andrew W., Lee, Jin-Moo, Sands, Mark S., Steen, Judith A., Dougherty, Joseph D.

“…Alternative translation initiation and stop codon readthrough in a few well-studied cases have been shown to allow the same transcript to generate multiple…”
Get full text

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability by Silva, M. Catarina, Cheng, Chialin, Mair, Waltraud, Almeida, Sandra, Fong, Helen, Biswas, M. Helal U., Zhang, Zhijun, Huang, Yadong, Temple, Sally, Coppola, Giovanni, Geschwind, Daniel H., Karydas, Anna, Miller, Bruce L., Kosik, Kenneth S., Gao, Fen-Biao, Steen, Judith A., Haggarty, Stephen J.

“…Frontotemporal dementia (FTD) and other tauopathies characterized by focal brain neurodegeneration and pathological accumulation of proteins are commonly…”
Get full text

Common mouse models of tauopathy reflect early but not late human disease by Wenger, Kathrin, Viode, Arthur, Schlaffner, Christoph N, van Zalm, Patrick, Cheng, Long, Dellovade, Tammy, Langlois, Xavier, Bannon, Anthony, Chang, Rui, Connors, Theresa R, Oakley, Derek, Renard, Bernhard, Rappsilber, Juri, Hyman, Bradley, Steen, Hanno, Steen, Judith A

“…Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer's Disease (AD) and while several drugs…”
Get full text

Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability by Lalonde, Jasmin, Reis, Surya A., Sivakumaran, Sudhir, Holland, Carl S., Wesseling, Hendrik, Sauld, John F., Alural, Begum, Zhao, Wen-Ning, Steen, Judith A., Haggarty, Stephen J.

“…The role of Arc in synaptic plasticity and memory consolidation has been investigated for many years with recent evidence that defects in the expression or…”
Get full text

Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation by Zhou, Zhaolan, Hong, Elizabeth J., Cohen, Sonia, Zhao, Wen-ning, Ho, Hsin-yi Henry, Schmidt, Lauren, Chen, Wen G., Lin, Yingxi, Savner, Erin, Griffith, Eric C., Hu, Linda, Steen, Judith A.J., Weitz, Charles J., Greenberg, Michael E.

“…Mutations or duplications in MECP2 cause Rett and Rett-like syndromes, neurodevelopmental disorders characterized by mental retardation, motor dysfunction, and…”
Get full text

Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis by Özlü, Nurhan, Qureshi, Mohammad H, Toyoda, Yusuke, Renard, Bernhard Y, Mollaoglu, Gürkan, Özkan, Nazlı E, Bulbul, Selda, Poser, Ina, Timm, Wiebke, Hyman, Anthony A, Mitchison, Timothy J, Steen, Judith A

“…The cell surface is the cellular compartment responsible for communication with the environment. The interior of mammalian cells undergoes dramatic…”
Get full text

FLEXIQuant-LF to quantify protein modification extent in label-free proteomics data by Schlaffner, Christoph N, Kahnert, Konstantin, Muntel, Jan, Chauhan, Ruchi, Renard, Bernhard Y, Steen, Judith A, Steen, Hanno

“…Improvements in LC-MS/MS methods and technology have enabled the identification of thousands of modified peptides in a single experiment. However, protein…”
Get full text

NMDA mediated contextual conditioning changes miRNA expression by Kye, Min Jeong, Neveu, Pierre, Lee, Yong-Seok, Zhou, Miou, Steen, Judith A, Sahin, Mustafa, Kosik, Kenneth S, Silva, Alcino J

“…We measured the expression of 187 miRNAs using quantitative real time PCR in the hippocampal CA1 region of contextually conditioned mice and cultured embryonic…”
Get full text

Basal Activity of a PARP1-NuA4 Complex Varies Dramatically across Cancer Cell Lines by Krukenberg, Kristin A., Jiang, Ruomu, Steen, Judith A., Mitchison, Timothy J.

“…Poly(ADP-ribose) polymerases (PARPs) catalyze poly(ADP-ribose) addition onto proteins, an important posttranslational modification involved in transcription,…”
Get full text

A screen for regulators of survival of motor neuron protein levels by Makhortova, Nina R, Hayhurst, Monica, Cerqueira, Antonio, Sinor-Anderson, Amy D, Zhao, Wen-Ning, Heiser, Patrick W, Arvanites, Anthony C, Davidow, Lance S, Waldon, Zachary O, Steen, Judith A, Lam, Kelvin, Ngo, Hien D, Rubin, Lee L

“…Compounds identified from a high-content screen implicate RTK activation as well as GSK-3 inhibition in regulating SMN levels and point to a therapeutic…”
Get full text

When less can yield more - Computational preprocessing of MS/MS spectra for peptide identification by Renard, Bernhard Y, Kirchner, Marc, Monigatti, Flavio, Ivanov, Alexander R, Rappsilber, Juri, Winter, Dominic, Steen, Judith A.J, Hamprecht, Fred A, Steen, Hanno

“…The effectiveness of database search algorithms, such as Mascot, Sequest and ProteinPilot is limited by the quality of the input spectra: spurious peaks in…”
Get full text

FLEXIQinase, a mass spectrometry–based assay, to unveil multikinase mechanisms by Singh, Sasha A, Winter, Dominic, Bilimoria, Parizad M, Bonni, Azad, Steen, Hanno, Steen, Judith A

“…An in vitro kinase assay for quantification of site-specific substrate phosphorylation allows identification of kinase-kinase dependencies. We introduce a mass…”
Get full text

Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: A quantitative proteomic analysis by Steen, Judith A.J, Steen, Hanno, Georgi, Ann, Parker, Kenneth, Springer, Michael, Kirchner, Marc, Hamprecht, Fred, Kirschner, Marc W

“…The anaphase promoting complex (APC) controls the degradation of proteins during exit from mitosis and entry into S-phase. The activity of the APC is regulated…”
Get full text

NITPICK: peak identification for mass spectrometry data by Renard, Bernhard Y, Kirchner, Marc, Steen, Hanno, Steen, Judith A J, Hamprecht, Fred A

“…The reliable extraction of features from mass spectra is a fundamental step in the automated analysis of proteomic mass spectrometry (MS) experiments. This…”
Get full text

Deuteration distribution estimation with improved sequence coverage for HX/MS experiments by Lou, Xinghua, Kirchner, Marc, Renard, Bernhard Y., Köthe, Ullrich, Boppel, Sebastian, Graf, Christian, Lee, Chung-Tien, Steen, Judith A. J., Steen, Hanno, Mayer, Matthias P., Hamprecht, Fred A.

“…Motivation: Time-resolved hydrogen exchange (HX) followed by mass spectrometry (MS) is a key technology for studying protein structure, dynamics and…”
Get full text