Search Results - "Steen, Dirk M van der"

Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs by Bijen, Helena M., van der Steen, Dirk M., Hagedoorn, Renate S., Wouters, Anne K., Wooldridge, Linda, Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.

“…Adoptive transfer of T cells engineered with a cancer-specific T cell receptor (TCR) has demonstrated clinical benefit. However, the risk for off-target…”
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PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy by Luk, Sietse J, Steen, Dirk M van der, Hagedoorn, Renate S, Jordanova, Ekaterina S, Schilham, Marco W, Bovée, Judith VMG, Cleven, Arjen HG, Falkenburg, JH Frederik, Szuhai, Karoly, Heemskerk, Mirjam HM

“…Synovial sarcoma expresses multiple cancer testis antigens that could potentially be targeted by T-cell receptor (TCR) gene therapy. In this study we…”
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Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia by van der Lee, Dyantha I, Reijmers, Rogier M, Honders, Maria W, Hagedoorn, Renate S, de Jong, Rob Cm, Kester, Michel Gd, van der Steen, Dirk M, de Ru, Arnoud H, Kweekel, Christiaan, Bijen, Helena M, Jedema, Inge, Veelken, Hendrik, van Veelen, Peter A, Heemskerk, Mirjam Hm, Falkenburg, J H Frederik, Griffioen, Marieke

“…The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the nucleophosmin 1 (NPM1) gene. Mutated NPM1 (ΔNPM1) is an attractive…”
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PRAME and CTCFL-reactive TCRs for the treatment of ovarian cancer by van Amerongen, Rosa A, Tuit, Sander, Wouters, Anne K, van de Meent, Marian, Siekman, Sterre L, Meeuwsen, Miranda H, Wachsmann, Tassilo L A, Remst, Dennis F G, Hagedoorn, Renate S, van der Steen, Dirk M, de Ru, Arnoud H, Verdegaal, Els M E, van Veelen, Peter A, Falkenburg, J H Frederik, Heemskerk, Mirjam H M

“…Recurrent disease emerges in the majority of patients with ovarian cancer (OVCA). Adoptive T-cell therapies with T-cell receptors (TCRs) targeting…”
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Broadly applicable TCR-based therapy for multiple myeloma targeting the immunoglobulin J chain by Meeuwsen, Miranda H, Wouters, Anne K, Wachsmann, Tassilo L A, Hagedoorn, Renate S, Kester, Michel G D, Remst, Dennis F G, van der Steen, Dirk M, de Ru, Arnoud H, van Hees, Els P, Kremer, Martijn, Griffioen, Marieke, van Veelen, Peter A, Falkenburg, J H Frederik, Heemskerk, Mirjam H M

“…The immunoglobulin J chain (Jchain) is highly expressed in the majority of multiple myeloma (MM), and Jchain-derived peptides presented in HLA molecules may be…”
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WT1-specific TCRs directed against newly identified peptides install antitumor reactivity against acute myeloid leukemia and ovarian carcinoma by van Amerongen, Rosa A, Hagedoorn, Renate S, Remst, Dennis F G, Assendelft, Danique C, van der Steen, Dirk M, Wouters, Anne K, van de Meent, Marian, Kester, Michel G D, de Ru, Arnoud H, Griffioen, Marieke, van Veelen, Peter A, Falkenburg, J H Frederik, Heemskerk, Mirjam H M

“…BackgroundTranscription factor Wilms’ tumor gene 1 (WT1) is an ideal tumor target based on its expression in a wide range of tumors, low-level expression in…”
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A library of cancer testis specific T cell receptors for T cell receptor gene therapy by de Rooij, Marije A.J., Remst, Dennis F.G., van der Steen, Dirk M., Wouters, Anne K., Hagedoorn, Renate S., Kester, Michel G.D., Meeuwsen, Miranda H., Wachsmann, Tassilo L.A., de Ru, Arnoud H., van Veelen, Peter A., Verdegaal, Els M.E., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.

“…To increase the number of cancer patients that can be treated with T cell receptor (TCR) gene therapy, we aimed to identify a set of high-affinity…”
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HLA Monomers as a Tool to Monitor Indirect Allorecognition by Breman, Eytan, van Miert, Paula P, van der Steen, Dirk M, Heemskerk, Mirjam H, Doxiadis, Ilias I, Roelen, Dave, Claas, Frans H, van Kooten, Cees

“…BACKGROUNDRecognition of donor antigens can occur through two separate pathwaysthe direct pathway (non-self HLA on donor cells) and the indirect pathway…”
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Combined CD8+ and CD4+ adenovirus hexon-specific T cells associated with viral clearance after stem cell transplantation as treatment for adenovirus infection by ZANDVLIET, Maarten L, FREDERIK FALKENBURG, J. H, GUCHELAAR, Henk-Jan, SCHILHAM, Marco W, MEIJ, Pauline, VAN LIEMPT, Ellis, VELTROP-DUITS, Louise A, LANKESTER, Arjan C, KALPOE, Jayant S, KESTER, Michel G. D, VAN DER STEEN, Dirk M, VAN TOL, Maarten J, WILLEMZE, Roel

“…Human adenovirus can cause morbidity and mortality in immunocompromised patients after allogeneic stem cell transplantation. Reconstitution of…”
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Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens by de Waard, Antonius A., Verkerk, Tamara, Hoefakker, Kelly, van der Steen, Dirk M., Jongsma, Marlieke L.M., Melamed Kadosh, Dganit, Bliss, Sophie, de Ru, Arnoud H., Admon, Arie, van Veelen, Peter A., Griffioen, Marieke, Heemskerk, Mirjam H.M., Spaapen, Robbert M.

“…Tumors with an impaired transporter associated with antigen processing (TAP) present several endoplasmic reticulum-derived self-antigens on HLA class I (HLA-I)…”
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PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma by Gezgin, Gülçin, Luk, Sietse J, Cao, Jinfeng, Dogrusöz, Mehmet, van der Steen, Dirk M, Hagedoorn, Renate S, Krijgsman, Daniëlle, van der Velden, Pieter A, Field, Matthew G, Luyten, Gregorius P M, Szuhai, Karoly, Harbour, J William, Jordanova, Ekaterina S, Heemskerk, Mirjam H M, Jager, Martine J

“…Uveal melanoma (UM) is an intraocular primary malignant neoplasm that often gives rise to metastatic disease for which there are no effective therapies. A…”
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Identification of Varicella-Zoster Virus-Specific CD8 T Cells in Patients after T-Cell-Depleted Allogeneic Stem Cell Transplantation by VAN DER HEIDEN, Pim L. J, DE BOER, Renate, WILLEMZE, Roel, FALKENBURG, J. H. Frederik, HEEMSKERK, Mirjam H. M, VAN DER STEEN, Dirk M, KESTER, Michel G. D, VAN DER HOORN, Menno W. A. G, HAARMAN, Wilmy M. E, BARNBY-PORRITT, Helen E, FRY, Jeremy W, NAPPER, C. E, MARIJT, Erik W. A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1 by Jahn, Lorenz, Hombrink, Pleun, Hagedoorn, Renate S., Kester, Michel G.D., van der Steen, Dirk M., Rodriguez, Tania, Pentcheva-Hoang, Tsvetelina, de Ru, Arnoud H., Schoonakker, Marjolein P., Meeuwsen, Miranda H., Griffioen, Marieke, van Veelen, Peter A., Falkenburg, J.H.Frederik, Heemskerk, Mirjam H.M.

“…Immunotherapy for hematological malignancies or solid tumors by administration of monoclonal antibodies or T cells engineered to express chimeric antigen…”
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A broad and systematic approach to identify B cell malignancy-targeting TCRs for multi-antigen-based T cell therapy by Meeuwsen, Miranda H., Wouters, Anne K., Jahn, Lorenz, Hagedoorn, Renate S., Kester, Michel G.D., Remst, Dennis F.G., Morton, Laura T., van der Steen, Dirk M., Kweekel, Christiaan, de Ru, Arnoud H., Griffioen, Marieke, van Veelen, Peter A., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.

“…CAR T cell therapy has shown great promise for the treatment of B cell malignancies. However, antigen-negative escape variants often cause disease relapse,…”
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Cutting Edge: Unconventional CD8 + T Cell Recognition of a Naturally Occurring HLA-A02:01-Restricted 20mer Epitope by Meeuwsen, Miranda H, Wouters, Anne K, Hagedoorn, Renate S, Kester, Michel G D, Remst, Dennis F G, van der Steen, Dirk M, de Ru, Arnoud, van Veelen, Peter A, Rossjohn, Jamie, Gras, Stephanie, Falkenburg, J H Frederik, Heemskerk, Mirjam H M

“…Unconventional HLA class I-restricted CD8 T cell epitopes, longer than 10 aa, have been implicated to play a role in human immunity against viruses and cancer…”
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PRAME-Specific Allo-HLA―Restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-Cell Receptor Gene Transfer by AMIR, Avital L, VAN DER STEEN, Dirk M, JEDEMA, Inge, GRIFFIOEN, Marieke, VAN VEELEN, Peter A, FALKENBURG, J. H. Frederik, HEEMSKERK, Mirjam H. M, VAN LOENEN, Marleen M, HAGEDOORN, Renate S, DE BOER, Renate, KESTER, Michel D. G, DE RU, Arnoud H, LUGTHART, Gert-Jan, VAN KOOTEN, Cees, HIEMSTRA, Pieter S

“…In human leukocyte antigen (HLA)-matched stem cell transplantation (SCT), it has been shown that beneficial immune response mediating graft-versus-tumor (GVT)…”
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Natural killer cells facilitate PRAME-specific T-cell reactivity against neuroblastoma by Spel, Lotte, Boelens, Jaap-Jan, van der Steen, Dirk M, Blokland, Nina J G, van Noesel, Max M, Molenaar, Jan J, Heemskerk, Mirjam H M, Boes, Marianne, Nierkens, Stefan

“…Neuroblastoma is the most common solid tumor in children with an estimated 5-year progression free survival of 20-40% in stage 4 disease. Neuroblastoma…”
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Therapeutic targeting of the BCR-associated protein CD79b in a TCR-based approach is hampered by aberrant expression of CD79b by Jahn, Lorenz, Hombrink, Pleun, Hassan, Chopie, Kester, MichelG.D., van der Steen, Dirk M., Hagedoorn, Renate S., Falkenburg, J. H. Frederik, van Veelen, Peter A., Heemskerk, MirjamH.M.

“…Immunotherapy of B-cell malignancies using CD19-targeted chimeric antigen receptor–transduced T cells or CD20-targeted therapeutic monoclonal antibodies has…”
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Allo-HLA–reactive T cells inducing graft-versus-host disease are single peptide specific by Amir, Avital L., van der Steen, Dirk M., Hagedoorn, Renate S., Kester, Michel G.D., van Bergen, Cornelis A.M., Drijfhout, Jan W., de Ru, Arnoud H., Falkenburg, J. H. Frederik, van Veelen, Peter A., Heemskerk, Mirjam H.M.

“…T-cell alloreactivity directed against non–self-HLA molecules has been assumed to be less peptide specific than conventional T-cell reactivity. A large…”
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A library of cancer testis specific T cell receptors for T cell receptor gene therapy by de Rooij, Marije A.J., Remst, Dennis F.G., van der Steen, Dirk M., Wouters, Anne K., Hagedoorn, Renate S., Kester, Michel G.D., Meeuwsen, Miranda H., Wachsmann, Tassilo L.A., de Ru, Arnoud H., van Veelen, Peter A., Verdegaal, Els M.E., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.

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