Search Results - "Steele, D"

A new class of synthetic retinoid antibiotics effective against bacterial persisters by Kim, Wooseong, Zhu, Wenpeng, Hendricks, Gabriel Lambert, Van Tyne, Daria, Steele, Andrew D., Keohane, Colleen E., Fricke, Nico, Conery, Annie L., Shen, Steven, Pan, Wen, Lee, Kiho, Rajamuthiah, Rajmohan, Fuchs, Beth Burgwyn, Vlahovska, Petia M., Wuest, William M., Gilmore, Michael S., Gao, Huajian, Ausubel, Frederick M., Mylonakis, Eleftherios

“…Synthetic retinoid compounds can kill both growing and persister MRSA cells by disrupting the membrane lipid bilayer, and are effective in a mouse model of…”
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Signatures of copy number alterations in human cancer by Steele, Christopher D., Abbasi, Ammal, Islam, S. M. Ashiqul, Bowes, Amy L., Khandekar, Azhar, Haase, Kerstin, Hames-Fathi, Shadi, Ajayi, Dolapo, Verfaillie, Annelien, Dhami, Pawan, McLatchie, Alex, Lechner, Matt, Light, Nicholas, Shlien, Adam, Malkin, David, Feber, Andrew, Proszek, Paula, Lesluyes, Tom, Mertens, Fredrik, Flanagan, Adrienne M., Tarabichi, Maxime, Van Loo, Peter, Alexandrov, Ludmil B., Pillay, Nischalan

“…Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-related processes of replication stress, mitotic errors, spindle…”
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'Vancowax' for haemostasis and topical antibiotic post sternotomy by Steele, D, Walker, A

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Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors by Rakowski, S.K., Winterkorn, E.B., Paul, E., Steele, D.J.R., Halpern, E.F., Thiele, E.A.

“…Tuberous sclerosis complex is a genetic disorder characterized by hamartomatous lesions in multiple organs, frequently involving the kidney. We conducted a…”
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Vitamin D levels and early mortality among incident hemodialysis patients by Wolf, M., Shah, A., Gutierrez, O., Ankers, E., Monroy, M., Tamez, H., Steele, D., Chang, Y., Camargo, C.A., Tonelli, M., Thadhani, R.

“…Vitamin D deficiency is associated with cardiovascular disease, the most common cause of mortality in hemodialysis patients. To investigate the relation…”
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Axonal prion protein is required for peripheral myelin maintenance by Weis, Joachim, Tiberi, Cinzia, Steele, Andrew D, Aguzzi, Adriano, Toyka, Klaus V, Fischer, Heike, Schwarz, Petra, Wessig, Carsten, Nave, Klaus-Armin, Baumann, Frank, Bremer, Juliane

“…The signals ensuring maintenance of the myelin sheath on peripheral nerves are distinct from those instructing myelination and are largely unknown. Here, the…”
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Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways by Steele, Christopher D., Tarabichi, Maxime, Oukrif, Dahmane, Webster, Amy P., Ye, Hongtao, Fittall, Matthew, Lombard, Patrick, Martincorena, Iñigo, Tarpey, Patrick S., Collord, Grace, Haase, Kerstin, Strauss, Sandra J., Berisha, Fitim, Vaikkinen, Heli, Dhami, Pawan, Jansen, Marnix, Behjati, Sam, Amary, M. Fernanda, Tirabosco, Roberto, Feber, Andrew, Campbell, Peter J., Alexandrov, Ludmil B., Van Loo, Peter, Flanagan, Adrienne M., Pillay, Nischalan

“…Undifferentiated sarcomas (USARCs) of adults are diverse, rare, and aggressive soft tissue cancers. Recent sequencing efforts have confirmed that USARCs…”
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Increase in Activity During Calorie Restriction Requires Sirt1 by Chen, Danica, Steele, Andrew D, Lindquist, Susan, Guarente, Leonard

“…Sir2 (silent information regulator 2) is a nicotinamide adenine dinucletide-dependent deacetylase required for longevity due to calorie restriction in yeast…”
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BRCA1 dysfunction in sporadic basal-like breast cancer by TURNER, N. C, REIS-FILHO, J. S, TUTT, A. N, RUSSELL, A. M, SPRINGALL, R. J, RYDER, K, STEELE, D, SAVAGE, K, GILLETT, C. E, SCHMITT, F. C, ASHWORTH, A

“…Basal-like breast cancers form a distinct subtype of breast cancer characterized by the expression of markers expressed in normal basal/myoepithelial cells…”
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Type 1 dopamine receptor (D1R)-independent circadian food anticipatory activity in mice by Assali, Dina R, Sidikpramana, Michael, Villa, Andrew P, Falkenstein, Jeffrey, Steele, Andrew D

“…Circadian rhythms are entrained by light and influenced by non-photic stimuli, such as feeding. The activity preceding scheduled mealtimes, food anticipatory…”
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SIRT1 transgenic mice show phenotypes resembling calorie restriction by Bordone, Laura, Cohen, Dena, Robinson, Ashley, Motta, Maria Carla, Van Veen, Ed, Czopik, Agnieszka, Steele, Andrew D., Crowe, Hayley, Marmor, Stephen, Luo, Jianyuan, Gu, Wei, Guarente, Leonard

“…Summary We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that…”
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Surface hydrophilic modification of RO membranes by plasma polymerization for low organic fouling by Zou, L., Vidalis, I., Steele, D., Michelmore, A., Low, S.P., Verberk, J.Q.J.C.

“…[Display omitted] ▶ A hydrophilic polymer, triglyme, was deposited by plasma polymerization on the surface of commercial RO membrane. ▶ The permeation…”
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Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator by Khandekar, Azhar, Vangara, Raviteja, Barnes, Mark, Díaz-Gay, Marcos, Abbasi, Ammal, Bergstrom, Erik N, Steele, Christopher D, Pillay, Nischalan, Alexandrov, Ludmil B

“…All cancers harbor somatic mutations in their genomes. In principle, mutations affecting between one and fifty base pairs are generally classified as small…”
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Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcoma by Zoumpoulidou, Georgia, Alvarez-Mendoza, Carlos, Mancusi, Caterina, Ahmed, Ritika-Mahmuda, Denman, Milly, Steele, Christopher D., Tarabichi, Maxime, Roy, Errin, Davies, Lauren R., Manji, Jiten, Cristalli, Camilla, Scotlandi, Katia, Pillay, Nischalan, Strauss, Sandra J., Mittnacht, Sibylle

“…Loss-of-function mutations in the RB1 tumour suppressor are key drivers in cancer, including osteosarcoma. RB1 loss-of-function compromises genome-maintenance…”
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Abnormal temporal difference reward-learning signals in major depression by Kumar, P., Waiter, G., Ahearn, T., Milders, M., Reid, I., Steele, J. D.

“…Anhedonia is a core symptom of major depressive disorder (MDD), long thought to be associated with reduced dopaminergic function. However, most antidepressants…”
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Full restoration of specific infectivity and strain properties from pure mammalian prion protein by Burke, Cassandra M, Walsh, Daniel J, Steele, Alexander D, Agrimi, Umberto, Di Bari, Michele Angelo, Watts, Joel C, Supattapone, Surachai

“…The protein-only hypothesis predicts that infectious mammalian prions are composed solely of PrPSc, a misfolded conformer of the normal prion protein, PrPC…”
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Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase by Meng, Song, Steele, Andrew D., Yan, Wei, Pan, Guohui, Kalkreuter, Edward, Liu, Yu-Chen, Xu, Zhengren, Shen, Ben

“…Nature forms S-S bonds by oxidizing two sulfhydryl groups, and no enzyme installing an intact hydropersulfide (-SSH) group into a natural product has been…”
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Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy by Lechner, Matt, Schartinger, Volker H., Steele, Christopher D., Nei, Wen Long, Ooft, Marc Lucas, Schreiber, Liesa-Marie, Pipinikas, Christodoulos P., Chung, Grace Tin-Yun, Chan, Yuk Yu, Wu, Feng, To, Ka-Fai, Tsang, Chi Man, Pearce, Wayne, Morelli, Daniele, Philpott, Martin, Masterson, Liam, Nibhani, Reshma, Wells, Graham, Bell, Christopher G., Koller, Julia, Delecluse, Susanne, Yip, Yim Ling, Liu, Jacklyn, Forde, Cillian T., Forster, Martin D., Jay, Amrita, Dudás, József, Krapp, Annika, Wan, Simon, Uprimny, Christian, Sprung, Susanne, Haybaeck, Johannes, Fenton, Tim R., Chester, Kerry, Thirlwell, Christina, Royle, Gary, Marafioti, Teresa, Gupta, Rajeev, Indrasari, Sagung Rai, Herdini, Camelia, Slim, Mohd Afiq Mohd, Indrawati, I., Sutton, Liam, Fles, Renske, Tan, Bing, Yeong, Joe, Jain, Amit, Han, Shuting, Wang, Haitao, Loke, Kelvin S. H., He, Wan, Xu, Ruilian, Jin, Hongtao, Cheng, Zhiqiang, Howard, David, Hwang, Peter H., Le, Quynh-Thu, Tay, Joshua K., West, Robert B., Tsao, Sai Wah, Meyer, Tim, Riechelmann, Herbert, Oppermann, Udo, Delecluse, Henri-Jacques, Willems, Stefan M., Chua, Melvin L. K., Busson, Pierre, Lo, Kwok Wai, Wollmann, Guido, Pillay, Nischalan, Vanhaesebroeck, Bart, Lund, Valerie J.

“…Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year…”
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Blunted midbrain reward activation during smoking withdrawal: a preliminary study by Conti, A A, Tolomeo, S, Baldacchino, A, Steele, J D

“…Tobacco smoking is the leading preventable cause of death, causing more than six million deaths annually worldwide, mainly due to cardiovascular disease and…”
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1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence by Carr, L. K., Steele, D., Steele, S., Wagner, D., Pruchnic, R., Jankowski, R., Erickson, J., Huard, J., Chancellor, M. B.

“…We hereby report a 1-year follow-up on eight women in the first North America trial in which stress urinary incontinence (SUI) was treated with muscle-derived…”
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