Search Results - "Steckler, T. T."

Data quality in drug discovery and preclinical drug development by Steckler, T

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Very Low Band Gap Thiadiazoloquinoxaline Donor–Acceptor Polymers as Multi-tool Conjugated Polymers by Steckler, Timothy T, Henriksson, Patrik, Mollinger, Sonya, Lundin, Angelica, Salleo, Alberto, Andersson, Mats R

“…Here we report on the synthesis of two novel very low band gap (VLG) donor–acceptor polymers (E g ≤ 1 eV) and an oligomer based on the thia­diazolo­quinoxaline…”
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Relevance of the metabotropic glutamate receptor (mGluR5) in the regulation of NREM-REM sleep cycle and homeostasis: Evidence from mGluR5 (−/−) mice by Ahnaou, A., Raeymaekers, L., Steckler, T., Drinkenbrug, W.H.I.M.

“…•mGluR5 (−/−) mice showed reduced REM sleep during the light phase.•mGluR5 (−/−) mice had maintained reduction of NREM sleep-REM sleep state…”
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Developmental programing: impact of testosterone on placental differentiation by Beckett, E M, Astapova, O, Steckler, T L, Veiga-Lopez, A, Padmanabhan, V

“…Gestational testosterone treatment causes maternal hyperinsulinemia, intrauterine growth retardation (IUGR), low birth weight, and adult reproductive and…”
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GSK-3β dysregulation contributes to parkinson’s-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein by Credle, J J, George, J L, Wills, J, Duka, V, Shah, K, Lee, Y-C, Rodriguez, O, Simkins, T, Winter, M, Moechars, D, Steckler, T, Goudreau, J, Finkelstein, D I, Sidhu, A

“…Aberrant posttranslational modifications (PTMs) of proteins, namely phosphorylation, induce abnormalities in the biological properties of recipient proteins,…”
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A Spray-Processable, Low Bandgap, and Ambipolar Donor−Acceptor Conjugated Polymer by Steckler, Timothy T, Zhang, Xuan, Hwang, Jungseek, Honeyager, Ryan, Ohira, Shino, Zhang, Xiao-Hong, Grant, Adrian, Ellinger, Stefan, Odom, Susan A, Sweat, Daniel, Tanner, David B, Rinzler, Andrew G, Barlow, Stephen, Brédas, Jean-Luc, Kippelen, Bernard, Marder, Seth R, Reynolds, John R

“…Combining a strong donor, tris(dodecyloxy)phenyl)-dithieno[3,2-b:2′,3′-d]pyrrole, with a strong acceptor,…”
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Effect of electron-withdrawing side chain modifications on the optical properties of thiophene–quinoxaline acceptor based polymers by Kroon, Renee, Lundin, Angelica, Lindqvist, Camilla, Henriksson, Patrik, Steckler, Timothy T., Andersson, Mats R.

“…Four new thiophene–quinoxaline acceptor based polymers have been synthesized. The parent thiophene–quinoxaline acceptor based copolymer was modified by…”
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P.2.012 Glutamatergic manipulation in spatial search processes: advanced cognitive neurophysiological analysis in rats by Jacob, S, Tahon, K, Steckler, T, Drinkenburg, P

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Negative versus positive allosteric modulation of metabotropic glutamate receptors (mGluR5): indices for potential pro-cognitive drug properties based on EEG network oscillations and sleep-wake organization in rats by Ahnaou, A., Langlois, X., Steckler, T., Bartolome-Nebreda, J. M., Drinkenburg, W. H. I. M.

“…Rationale Evidence is emerging that positive and negative modulation of the metabotropic glutamate (mGluR5) receptors has the potential for treating cognitive…”
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P.1.j.037 Imaging neurophysiological dynamics underlying cognitive performance in a rat touch-screen reversal learning paradigm by Tahon, K, Talpos, J, Steckler, T, Drinkenburg, W

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Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei – potential implication for arousal and attention by Sauvage, M, Steckler, T

“…Corticotropin-releasing hormone (CRH) interacts with noradrenergic, dopaminergic and cholinergic systems of the brain, and these interactions are thought to be…”
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Subchronic memantine induced concurrent functional disconnectivity and altered ultra-structural tissue integrity in the rodent brain: revealed by multimodal MRI by Sekar, S., Jonckers, E., Verhoye, M., Willems, R., Veraart, J., Van Audekerke, J., Couto, J., Giugliano, M., Wuyts, K., Dedeurwaerdere, S., Sijbers, J., Mackie, C., Ver Donck, L., Steckler, T., Van der Linden, A.

“…Background An effective NMDA antagonist imaging model may find key utility in advancing schizophrenia drug discovery research. We investigated effects of…”
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Efficient red electroluminescence from diketopyrrolopyrrole copolymerised with a polyfluorene by Fenwick, O., Fusco, S., Baig, T. N., Di Stasio, F., Steckler, T. T., Henriksson, P., Fléchon, C., Andersson, M. R., Cacialli, F.

“…We report the synthesis, characterization, and device incorporation of copolymers based on a common green-emitting polyfluorene but containing a small…”
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N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement by Gregory, K J, Herman, E J, Ramsey, A J, Hammond, A S, Byun, N E, Stauffer, S R, Manka, J T, Jadhav, S, Bridges, T M, Weaver, C D, Niswender, C M, Steckler, T, Drinkenburg, W H, Ahnaou, A, Lavreysen, H, Macdonald, G J, Bartolomé, J M, Mackie, C, Hrupka, B J, Caron, M G, Daigle, T L, Lindsley, C W, Conn, P J, Jones, C K

“…Impaired transmission through glutamatergic circuits has been postulated to play a role in the underlying pathophysiology of schizophrenia. Furthermore,…”
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Using estrus detection patches to optimally time insemination improved pregnancy risk in suckled beef cows enrolled in a fixed-time artificial insemination program by Hill, S L, Grieger, D M, Olson, K C, Jaeger, J R, Dahlen, C R, Bridges, G A, Dantas, F, Larson, J E, Muth-Spurlock, A M, Ahola, J K, Fischer, M C, Perry, G A, Larimore, E L, Steckler, T L, Whittier, W D, Currin, J F, Stevenson, J S

“…A multilocation study examined pregnancy risk (PR) after delaying AI in suckled beef cows from 60 to 75 h when estrus had not been detected by 60 h in response…”
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Contribution of melanin-concentrating hormone (MCH1) receptor to thermoregulation and sleep stabilization: Evidence from MCH1 (−/−) mice by Ahnaou, A., Dautzenberg, F.M., Huysmans, H., Steckler, T., Drinkenburg, W.H.I.M.

“…▶ MCH1r (−/−) mice exhibited increases body temperature and reduced NREM sleep time. ▶ Reduced NREM sleep by shorter NREM sleep episodes may impact sleep…”
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Developmental programming: postnatal estradiol amplifies ovarian follicular defects induced by fetal exposure to excess testosterone and dihydrotestosterone in sheep by Veiga-Lopez, A, Wurst, A K, Steckler, T L, Ye, W, Padmanabhan, V

“…Excess of prenatal testosterone (T) induces reproductive defects including follicular persistence. Comparative studies with T and dihydrotestosterone (DHT)…”
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S.18.04 Animal models of neuropsychiatric disorders: ketamine and related drugs by Steckler, T, Bahn, S, Spedding, M, Tricklebank, M

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The molecular neurobiology of stress--evidence from genetic and epigenetic models by Steckler, T

“…Knowledge of the genetic and molecular events underlying the neuroendocrine and behavioural sequelae of the response to stress has advanced rapidly over recent…”
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Metabotropic glutamate receptor modulation, translational methods, and biomarkers: relationships with anxiety by Nordquist, R. E., Steckler, T., Wettstein, J. G., Mackie, C., Spooren, W.

“…Rationale The increasing awareness of the need to align clinical and preclinical research to facilitate rapid development of new drug therapies is reflected in…”
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