Search Results - "Steckel, Nina"

Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients by Elmaagacli, Ahmet H., Steckel, Nina K., Koldehoff, Michael, Hegerfeldt, Yael, Trenschel, Rudolf, Ditschkowski, Markus, Christoph, Sandra, Gromke, Tanja, Kordelas, Lambros, Ottinger, Hellmut D., Ross, Rudolf S., Horn, Peter A., Schnittger, Susanne, Beelen, Dietrich W.

“…The impact of early human cytomegalovirus (HCMV) replication on leukemic recurrence was evaluated in 266 consecutive adult (median age, 47 years; range, 18-73…”
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The Activating NKG2C Receptor Is Significantly Reduced in NK Cells after Allogeneic Stem Cell Transplantation in Patients with Severe Graft-versus-Host Disease by Kordelas, Lambros, Steckel, Nina-Kristin, Horn, Peter A, Beelen, Dietrich W, Rebmann, Vera

“…Natural killer (NK) cells play a central role in the innate immune system. In allogeneic stem cell transplantation (alloSCT), alloreactive NK cells derived by…”
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Adoptive transfer of cellular immunity against cytomegalovirus by virus-specific lymphocytes from a third-party family donor by Lindemann, Monika, Eiz-Vesper, Britta, Steckel, Nina K., Tischer, Sabine, Fiedler, Melanie, Heinold, Andreas, Klisanin, Vesna, Maecker-Kolhoff, Britta, Blasczyk, Rainer, Horn, Peter A., Beelen, Dietrich W., Koldehoff, Michael

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High‐dose melphalan‐based sequential conditioning chemotherapy followed by allogeneic haematopoietic stem cell transplantation in adult patients with relapsed or refractory acute myeloid leukaemia by Steckel, Nina K., Groth, Christoph, Mikesch, Jan‐Henrik, Trenschel, Rudolf, Ottinger, Hellmut, Kordelas, Lambros, Mueller‐Tidow, Carsten, Schliemann, Christoph, Reicherts, Christian, Albring, Joern C., Silling, Gerda, Schmidt, Eva, Berdel, Wolfgang E., Lenz, Georg, Ditschkowski, Markus, Beelen, Dietrich W., Stelljes, Matthias

“…Summary Considering the unsatisfactory results of salvage therapies for patients with relapsed/refractory acute myeloid leukaemia (R/R‐AML), their value before…”
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Dynamic International Prognostic Scoring System scores, pre-transplant therapy and chronic graft-versus-host disease determine outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis by DITSCHKOWSKI, Markus, ELMAAGACLI, Ahmet H, TRENSCHEL, Rudolf, GROMKE, Tanja, STECKEL, Nina K, KOLDEHOFF, Michael, BEELEN, Dietrich W

“…Myelofibrosis is a myeloproliferative stem cell disorder curable exclusively by allogeneic hematopoietic stem cell transplantation and is associated with…”
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Optimizing anti‐T‐lymphocyte globulin dosing to improve long‐term outcome after unrelated hematopoietic cell transplantation for hematologic malignancies by Turki, Amin T., Klisanin, Vesna, Bayraktar, Evren, Kordelas, Lambros, Trenschel, Rudolf, Ottinger, Hellmut, Steckel, Nina K., Tsachakis‐Mück, Nikolaos, Leserer, Saskia, Ditschkowski, Markus, Liebregts, Tobias, Koldehoff, Michael, Fleischhauer, Katharina, Beelen, Dietrich W.

“…Prophylaxis of graft‐versus‐host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HCT) remains challenging. Because prospective…”
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Long-Term Follow-Up after Adoptive Transfer of BK-Virus-Specific T Cells in Hematopoietic Stem Cell Transplant Recipients by Koldehoff, Michael, Eiz-Vesper, Britta, Maecker-Kolhoff, Britta, Steckel, Nina K, Dittmer, Ulf, Horn, Peter A, Lindemann, Monika

“…The BK virus (BKV) causes severe hemorrhagic cystitis in hematopoietic stem cell transplant (HSCT) recipients. To eliminate reactivated BKV, symptomatic…”
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Ileostomy for steroid-resistant acute graft-versus-host disease of the gastrointestinal tract by Turki, Amin T., Bayraktar, Evren, Basu, Oliver, Benkö, Tamas, Yi, Ji-Hee, Kehrmann, Jan, Tzalavras, Asterios, Liebregts, Tobias, Beelen, Dietrich W., Steckel, Nina K.

“…Steroid-resistant acute graft-versus-host disease (GVHD) of the gastrointestinal tract associates with important morbidity and mortality. While high-dose…”
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Endoscopic and Histological Findings Are Predicted by Fecal Calprotectin in Acute Intestinal Graft-Versus-Host-Disease by Adam, Birgit, Koldehoff, Michael, Ditschkowski, Markus, Gromke, Tanja, Hlinka, Michal, Trenschel, Rudolf, Kordeals, Lambros, Steckel, Nina K., Beelen, Dietrich W., Liebregts, Tobias

“…Background Gastrointestinal graft-versus-host-disease (GI-GVHD) is a major cause of nonrelapse mortality after hematopoietic stem cell transplantation (HSCT)…”
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Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation by ELMAAGACLI, Ahmet H, KOLDEHOFF, Michael, GROSSE-WILDE, Hans, BEELEN, Dietrich W, HINDAHL, Heidrun, STECKEL, Nina K, TRENSCHEL, Rudolf, PECENY, Rudolf, OTTINGER, Hellmut, RATH, Peter-Michael, ROSS, Rudolf Stefan, ROGGENDORF, Michael

“…NOD2 and TLR-4 genes belong to the innate immune system that detects invading pathogens through several pattern-recognition receptors. Here we analyzed 403…”
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Modulating impact of human chorionic gonadotropin hormone on the maturation and function of hematopoietic cells by Koldehoff, Michael, Katzorke, Thomas, Wisbrun, Natalie C., Propping, Dirk, Wohlers, Susanne, Bielfeld, Peter, Steckel, Nina K., Beelen, Dietrich W., Elmaagacli, Ahmet H.

“…hCG may be useful for the induction of immune tolerance in allogeneic transplantation. hCG hormone is a naturally occurring, immune‐modulating agent, which is…”
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Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors by Bonifacius, Agnes, Lamottke, Britta, Tischer-Zimmermann, Sabine, Schultze-Florey, Rebecca, Goudeva, Lilia, Heuft, Hans-Gert, Arseniev, Lubomir, Beier, Rita, Beutel, Gernot, Cario, Gunnar, Fröhlich, Birgit, Greil, Johann, Hansmann, Leo, Hasenkamp, Justin, Höfs, Michaela, Hundsdoerfer, Patrick, Jost, Edgar, Kafa, Kinan, Kriege, Oliver, Kröger, Nicolaus, Mathas, Stephan, Meisel, Roland, Nathrath, Michaela, Putkonen, Mervi, Ravens, Sarina, Reinhardt, Hans Christian, Sala, Elisa, Sauer, Martin G, Schmitt, Clemens, Schroers, Roland, Steckel, Nina Kristin, Trappe, Ralf Ulrich, Verbeek, Mareike, Wolff, Daniel, Blasczyk, Rainer, Eiz-Vesper, Britta, Maecker-Kolhoff, Britta

“…BACKGROUNDAdoptive transfer of EBV-specific T cells can restore specific immunity in immunocompromised patients with EBV-associated complications.METHODSWe…”
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Maternal molecular features and gene profiling of monocytes during first trimester pregnancy by Koldehoff, Michael, Cierna, Barbara, Steckel, Nina K, Beelen, Dietrich W, Elmaagacli, Ahmet H

“…Abstract We examined the molecular characteristics of monocytes of pregnant and non-pregnant women to investigate the molecular effects that are associated…”
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Quantitative analysis of chimerism after allogeneic stem cell transplantation by real‐time polymerase chain reaction with single nucleotide polymorphisms, standard tandem repeats,and Y‐chromosome‐specific sequences by Koldehoff, Michael, Steckel, Nina K., Hlinka, Michal, Beelen, Dietrich W., Elmaagacli, Ahmet H.

“…We compared the results of chimerism analyses with real‐time SNP‐PCR to those obtained by the classical STR‐PCR method in 135 hematopoietic stem cell…”
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Growth factor‐independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate by Elmaagacli, Ahmet H., Koldehoff, Michael, Zakrzewski, Johannes L., Steckel, Nina K., Ottinger, Hellmut, Beelen, Dietrich W.

“…Summary Growth factor‐independent 1B (GFI1B) is a transcription factor essential for the development and differentiation of erythroid and megakaryocytic…”
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Use of the activating gene mutation of the tyrosine kinase (VAL617Phe) JAK2 as a minimal residual disease marker in patients with myelofibrosis and myeloid metaplasia after allogeneic stem cell transplantation by STECKEL, Nina K, KOLDEHOFF, Michael, DITSCHKOWSKI, Markus, BEELEN, Dietrich W, ELMAAGACLI, Ahmet H

“…Here we report on the use of a new real-time polymerase chain reaction (PCR) method to detect and quantify the activating gene mutation of the tyrosine kinase…”
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Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital by Scharmann, Ulrike, Herbstreit, Frank, Steckel, Nina Kristin, Dedy, Jutta, Buer, Jan, Rath, Peter-Michael, Verhasselt, Hedda Luise

“…Due to Coronavirus disease (COVID-19) a new group of patients at risk emerged with COVID-19-associated mucormycosis (CAM). Systematic studies, evaluating the…”
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Microbiologic Diagnostic Workup of Acute Respiratory Failure with Pulmonary Infiltrates after Allogeneic Hematopoietic Stem Cell Transplantation: Findings in the Era of Molecular- and Biomarker-Based Assays by Wohlfarth, Philipp, Turki, Amin T., Steinmann, Joerg, Fiedler, Melanie, Steckel, Nina K., Beelen, Dietrich W., Liebregts, Tobias

“…•A broad molecular- and biomarker-based microbiologic workup identified causative pathogens in 70% of HSCT recipients with acute respiratory failure admitted…”
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Clinical Utility of Quantitative PCR for Chimerism and Engraftment Monitoring after Allogeneic Stem Cell Transplantation for Hematologic Malignancies by Ahci, Müberra, B.Sc, Stempelmann, Karin, Buttkereit, Ulrike, Ph.D, Crivello, Pietro, Ph.D, Trilling, Mirko, Ph.D, Heinold, Andreas, Ph.D, Steckel, Nina Kristin, M.D, Koldehoff, Michael, M.D, Horn, Peter A., M.D, Beelen, Dietrich W., M.D, Fleischhauer, Katharina, M.D

“…Highlights • Added sensitivity of qPCR compared to STR chimerism post-SCT has clinical utility • Engraftment kinetics are imprinted by CMV serostatus and…”
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Incidence of HLA Loss in a Global Multicentric Cohort of Post-Transplantation Relapses: Results from the Hlaloss Collaborative Study by Vago, Luca, Toffalori, Cristina, Ahci, Müberra, Lange, Vinzenz, Lang, Kathrin, Todaro, Sonia, Lorentino, Francesca, Stempelmann, Karin, Heinold, Andreas, Stoelzel, Friedrich, Waterhouse, Miguel, Claus, Rainer, Gendzekhadze, Ketevan, Onozawa, Masahiro, Devillier, Raynier, Tang, Ruoping, Ulman, Maayan, Kwon, Mi, Gojo, Ivana, Ruggeri, Loredana, Imovilli, Annalisa, Facchini, Luca, Lazarevic, Dejan, Lupo Stanghellini, Maria Teresa, Peccatori, Jacopo, Steckel, Nina Kristin, Horn, Peter A., Picardi, Alessandra, Manetta, Sara, Busca, Alessandro, Pinana, Jose Luis, Sanz, Jaime, Martínez-Laperche, Carolina, Ciurea, Stefan O., Luznik, Leo, Velardi, Andrea, Arcese, William, Sanz, Guillermo, Pini, Massimo, Bruno, Benedetto, Kobbe, Guido, Al Malki, Monzr, Teshima, Takanori, Kroeger, Nicolaus, Finke, Jürgen, Nagler, Arnon, Blaise, Didier, Mohty, Mohamad, Bornhäuser, Martin, Beelen, Dietrich W., Schmidt, Alexander H., Ciceri, Fabio, Fleischhauer, Katharina

“…Introduction. Genomic loss of an HLA haplotype encoding incompatible alleles (“HLA loss”) has been described in previous single-center studies as a mechanism…”
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