Search Results - "Stebbins, Christopher"

Nusinersen initiated in infants during the presymptomatic stage of spinal muscular atrophy: Interim efficacy and safety results from the Phase 2 NURTURE study by De Vivo, Darryl C., Bertini, Enrico, Swoboda, Kathryn J., Hwu, Wuh-Liang, Crawford, Thomas O., Finkel, Richard S., Kirschner, Janbernd, Kuntz, Nancy L., Parsons, Julie A., Ryan, Monique M., Butterfield, Russell J., Topaloglu, Haluk, Ben-Omran, Tawfeg, Sansone, Valeria A., Jong, Yuh-Jyh, Shu, Francy, Staropoli, John F., Kerr, Douglas, Sandrock, Alfred W., Stebbins, Christopher, Petrillo, Marco, Braley, Gabriel, Johnson, Kristina, Foster, Richard, Gheuens, Sarah, Bhan, Ishir, Reyna, Sandra P., Fradette, Stephanie, Farwell, Wildon

“…•NURTURE is an ongoing study of nusinersen started in a presymptomatic stage of SMA.•All infants were ≥25 months old, and alive without permanent…”
Get full text

Immunogenicity for antisense oligonucleotides: a risk-based assessment by Stebbins, Christopher C, Petrillo, Marco, Stevenson, Lauren F

“…The specificity and application of ASOs have been broadly demonstrated in both animal models and humans for various disease targets (9), resulting in the…”
Get full text

Neurofilament as a potential biomarker for spinal muscular atrophy by Darras, Basil T., Crawford, Thomas O., Finkel, Richard S., Mercuri, Eugenio, De Vivo, Darryl C., Oskoui, Maryam, Tizzano, Eduardo F., Ryan, Monique M., Muntoni, Francesco, Zhao, Guolin, Staropoli, John, McCampbell, Alexander, Petrillo, Marco, Stebbins, Christopher, Fradette, Stephanie, Farwell, Wildon, Sumner, Charlotte J.

“…Objective To evaluate plasma phosphorylated neurofilament heavy chain (pNF‐H) as a biomarker in spinal muscular atrophy (SMA). Methods Levels of pNF‐H were…”
Get full text

Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products by Koren, Eugen, Smith, Holly W., Shores, Elizabeth, Shankar, Gopi, Finco-Kent, Deborah, Rup, Bonita, Barrett, Yu-Chen, Devanarayan, Viswanath, Gorovits, Boris, Gupta, Shalini, Parish, Thomas, Quarmby, Valerie, Moxness, Michael, Swanson, Steven J., Taniguchi, Gary, Zuckerman, Linda A., Stebbins, Christopher C., Mire-Sluis, Anthony

“…The appropriate evaluation of the immunogenicity of biopharmaceuticals is of major importance for their successful development and licensure. Antibodies…”
Get full text

Vav1 Dephosphorylation by the Tyrosine Phosphatase SHP-1 as a Mechanism for Inhibition of Cellular Cytotoxicity by Stebbins, Christopher C., Watzl, Carsten, Billadeau, Daniel D., Leibson, Paul J., Burshtyn, Deborah N., Long, Eric O.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Essential Role of LAT in T Cell Development by Zhang, Weiguo, Sommers, Connie L, Burshtyn, Deborah N, Stebbins, Christopher C, DeJarnette, Jan B, Trible, Ronald P, Grinberg, Alexander, Tsay, Henry C, Jacobs, Helena M, Kessler, Craig M, Long, Eric O, Love, Paul E, Samelson, Lawrence E

“…The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement. Phosphorylated LAT binds many critical signaling molecules…”
Get full text

Cutting Edge: NK Cell Inhibitory Receptors Prevent Tyrosine Phosphorylation of the Activation Receptor 2B4 (CD244) by Watzl, Carsten, Stebbins, Christopher C, Long, Eric O

“…Abstract 2B4 is an NK cell activation receptor that can provide a costimulatory signal to other activation receptors and whose mode of signal transduction is…”
Get full text

Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158) by Long, Eric O., Barber, Domingo F., Burshtyn, Deborah N., Faure, Mathias, Peterson, Mary, Rajagopalan, Sumati, Renard, Valéry, Sandusky, Mina, Stebbins, Christopher C., Wagtmann, Nicolai, Watzl, Carsten

“…The killer cell immunoglobulin‐like receptor (KIR) family includes receptors that bind to HLA class I molecules on target cells and inhibit natural killer…”
Get full text

Randomized Phase IIa Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis by Raghu, Ganesh, Mouded, Majd, Prasse, Antje, Stebbins, Christopher, Zhao, Guolin, Song, Guochen, Arefayene, Million, Violette, Shelia M, Gallagher, Diana, Gibson, Kevin F

“…Patients with IPF typically tolerated the once-weekly subcutaneous treatment of BG00011 at doses less than 1.0 mg/kg well in this short phase lla research…”
Get full text

A Phase IIb Randomized Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis by Raghu, Ganesh, Mouded, Majd, Chambers, Daniel C, Martinez, Fernando J, Richeldi, Luca, Lancaster, Lisa H, Hamblin, Mark J, Gibson, Kevin F, Rosas, Ivan O, Prasse, Antje, Zhao, Guolin, Serenko, Michael, Novikov, Natasha, McCurley, Amy, Bansal, Prashant, Stebbins, Christopher, Arefayene, Million, Ibebunjo, Stella, Violette, Shelia M, Gallagher, Diana, Behr, Jürgen

“…Idiopathic pulmonary fibrosis (IPF) has few available treatments. The results do not support the further clinical development of BG00011, a monoclonal…”
Get full text

Randomized Phase IIa Clinical Study of an Anti-α v β 6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis by Raghu, Ganesh, Mouded, Majd, Prasse, Antje, Stebbins, Christopher, Zhao, Guolin, Song, Guochen, Arefayene, Million, Violette, Shelia M, Gallagher, Diana, Gibson, Kevin F

Get full text

A Phase IIb Randomized Clinical Study of an Anti-α v β 6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis by Raghu, Ganesh, Mouded, Majd, Chambers, Daniel C, Martinez, Fernando J, Richeldi, Luca, Lancaster, Lisa H, Hamblin, Mark J, Gibson, Kevin F, Rosas, Ivan O, Prasse, Antje, Zhao, Guolin, Serenko, Michael, Novikov, Natasha, McCurley, Amy, Bansal, Prashant, Stebbins, Christopher, Arefayene, Million, Ibebunjo, Stella, Violette, Shelia M, Gallagher, Diana, Behr, Jürgen

“…Treatment options for idiopathic pulmonary fibrosis (IPF) are limited. To evaluate the efficacy and safety of BG00011, an anti-α β IgG1 monoclonal antibody, in…”
Get full text

Association of Phosphorylated Neurofilament Heavy Chain (pNF-H) Levels With Motor Function Achievement in Individuals With Spinal Muscular Atrophy (SMA) Treated With Nusinersen (S27.009) by Sumner, Charlotte J., Darras, Basil T., Muntoni, Francesco, Crawford, Thomas O., Finkel, Richard S., Mercuri, Eugenio, De Vivo, Darryl C., Oskoui, Maryam, Tizzano, Eduardo, Ryan, Monique M., Zhao, Guolin, Petrillo, Marco, Stebbins, Christopher, Fradette, Stephanie, Farwell, Wildon

“…Abstract only…”
Get full text

Adapting dried blood spot sampling for an anti-therapeutic antibody immunogenicity assay by Xiang, Yuhong, Welch, Mackenzie, Amaravadi, Lakshmi, Stebbins, Christopher

“…Dried blood spot sampling is a microvolume sampling technique with many potential advantages. It allows for easier handling and less expensive shipment and…”
Get full text

2018 White Paper on Recent Issues in Bioanalysis: focus on flow cytometry, gene therapy, cut points and key clarifications on BAV (Part 3 - LBA/cell-based assays: immunogenicity, biomarkers and PK assays) by Stevenson, Lauren, Richards, Susan, Pillutla, Renuka, Torri, Albert, Kamerud, John, Mehta, Devangi, Keller, Stephen, Purushothama, Shobha, Gorovits, Boris, Litwin, Virginia, Stebbins, Christopher, Marini, Joseph, Beaver, Chris, Sperinde, Gizette, Siguenza, Patricia, Staack, Roland F, Qiu, Yongchang, Amaravadi, Lakshmi, Amur, Shashi, Fleener, Catherine Aversa, Baltrukonis, Daniel, Catlett, Ian, Cherry, Elana, Chung, Shan, Cludts, Isabelle, Donato, Lorella Di, Fischer, Saloumeh, Fraser, Stephanie, Garofolo, Fabio, Green, Cherie, Gunn, George, Haidar, Sam, Haulenbeek, Jonathan, Henderson, Neil, Hopper, Shirley, Ishii-Watabe, Akiko, Islam, Rafiq, Janelsins, Brian, Jawa, Vibha, Kakkanaiah, Vellalore, Kamondi, Szilard, Kolaitis, Gerry, Kubiak, Robert J, Kumar, Seema, Kurki, Pekka, Liang, Meina, Liu, Patrick, Maxfield, Kimberly, Myler, Heather, Palackal, Nisha, Palmer, Rachel, Pedras-Vasconcelos, João, Piccoli, Steven, Rhyne, Paul, Saito, Yoshiro, Savoie, Natasha, Schick, Eginhard, Schweighardt, Becky, Shih, Judy, Song, An, Sriraman, Priya, Staelens, Ludovicus, Sumner, Giane, Sun, Yongliang, Ullmann, Martin, Verthelyi, Daniela, Wadhwa, Meenu, Wang, Yow-Ming, Xu, Yuanxin, Yan, Haoheng, Yang, Tong-yuan, Zeng, Rong

“…The 2018 12 Workshop on Recent Issues in Bioanalysis took place in Philadelphia, PA, USA on April 9-13, 2018 with an attendance of over 900 representatives…”
Get full text

2018 White Paper on Recent Issues in Bioanalysis: 'A global bioanalytical community perspective on last decade of incurred samples reanalysis (ISR)' (Part 1 - small molecule regulated bioanalysis, small molecule biomarkers, peptides & oligonucleotide bioanalysis) by Welink, Jan, Xu, Yuanxin, Yang, Eric, Wilson, Amanda, Henderson, Neil, Luo, Lina, Fraser, Stephanie, Kavita, Uma, Musuku, Adrien, James, Christopher, Fraier, Daniela, Zhang, Yan, Goykhman, Dina, Summerfield, Scott, Woolf, Eric, Verhaeghe, Tom, Hughes, Nicola, Behling, Alexander, Brown, Kirk, Bulychev, Alex, Buonarati, Michael, Cherry, Elana, Cho, Seongeun Julia, Cludts, Isabelle, Dillen, Lieve, Dodge, Robert, Edmison, Anna, Garofolo, Fabio, Green, Rachel, Haidar, Sam, Hottenstein, Charles, Ishii-Watabe, Akiko, Jang, Hyun Gyung, Ji, Allena, Jones, Barry, Kassim, Sean, Ma, Mark, Lima Santos, Gustavo Mendes, Norris, Daniel A, Owen, Tate, Piccoli, Steven, Ramanathan, Ragu, Röhl, Ingo, Rosenbaum, Anton I, Saito, Yoshiro, Sangster, Timothy, Savoie, Natasha, Stebbins, Christopher, Sydor, Jens, de Merbel, Nico van, Verthelyi, Daniela, Vinter, Stephen, Whale, Emma

“…The 2018 12 Workshop on Recent Issues in Bioanalysis (12th WRIB) took place in Philadelphia, PA, USA on April 9-13, 2018 with an attendance of over 900…”
Get full text

Natural Killer Cells and Mast Cells from gp49B Null Mutant Mice Are Functional by Rojo, Susana, Stebbins, Christopher C., Peterson, Mary E., Dombrowicz, David, Wagtmann, Nicolai, Long, Eric O.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

2018 White Paper on Recent Issues in Bioanalysis by Welink, Jan, Xu, Yuanxin, Yang, Eric, Wilson, Amanda, Henderson, Neil, Luo, Lina, Fraser, Stephanie, Kavita, Uma, Musuku, Adrien, James, Christopher, Fraier, Daniela, Zhang, Yan, Goykhman, Dina, Summerfield, Scott, Woolf, Eric, Verhaeghe, Tom, Hughes, Nicola, Behling, Alexander, Brown, Kirk, Bulychev, Alex, Buonarati, Michael, Cherry, Elana, Cho, Seongeun (Julia), Cludts, Isabelle, Dillen, Lieve, Dodge, Robert, Edmison, Anna, Garofolo, Fabio, Green, Rachel, Haidar, Sam, Hottenstein, Charles, Ishii-Watabe, Akiko, Jang, Hyun Gyung, Ji, Allena, Jones, Barry, Kassim, Sean, Ma, Mark, Lima Santos, Gustavo Mendes, Norris, Daniel A, Owen, Tate, Piccoli, Steven, Ramanathan, Ragu, Röhl, Ingo, Rosenbaum, Anton I, Saito, Yoshiro, Sangster, Timothy, Savoie, Natasha, Stebbins, Christopher, Sydor, Jens, de Merbel, Nico van, Verthelyi, Daniela, Vinter, Stephen, Whale, Emma

“…The 2018 12 Workshop on Recent Issues in Bioanalysis (12th WRIB) took place in Philadelphia, PA, USA on April 9-13, 2018 with an attendance of over 900…”
Get full text

Adhesion to target cells is disrupted by the killer cell inhibitory receptor by Burshtyn, Deborah N., Shin, Jiyeon, Stebbins, Christopher, Long, Eric O.

“…Killer cell immunoglobulin-like receptors (KIR) inhibit the cytotoxic activity of natural killer (NK) cells by recruitment of the tyrosine phosphatase SHP-1 to…”
Get full text

Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules by Katz, J F, Stebbins, C, Appella, E, Sant, A J

“…We have studied the consequences of invariant chain (Ii) and DM expression on major histocompatibility complex (MHC) class II function. Ii has a number of…”
Get full text