Search Results - "Steavenson, Shirley"

A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates by Cooke, Keegan S., Hinkle, Beth, Salimi-Moosavi, Hossein, Foltz, Ian, King, Chadwick, Rathanaswami, Palaniswami, Winters, Aaron, Steavenson, Shirley, Begley, C. Glenn, Molineux, Graham, Sasu, Barbra J.

“…Iron maldistribution has been implicated in the etiology of many diseases including the anemia of inflammation (AI), atherosclerosis, diabetes, and…”
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FGF21 N- and C-termini play different roles in receptor interaction and activation by Yie, Junming, Hecht, Randy, Patel, Jennifer, Stevens, Jennitte, Wang, Wei, Hawkins, Nessa, Steavenson, Shirley, Smith, Steve, Winters, Dwight, Fisher, Seth, Cai, Ling, Belouski, Ed, Chen, Ching, Michaels, Mark L., Li, Yue-Sheng, Lindberg, Richard, Wang, Minghan, Véniant, Murielle, Xu, Jing

“…Fibroblast growth factor-21 (FGF21) signaling requires the presence of β-Klotho, a co-receptor with a very short cytoplasmic domain. Here we show that FGF21…”
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Dickkopf‐1 regulates bone formation in young growing rodents and upon traumatic injury by Li, Xiaodong, Grisanti, Mario, Fan, Wei, Asuncion, Frank J, Tan, Hong‐Lin, Dwyer, Denise, Han, Chun‐Ya, Yu, Longchuan, Lee, Jae, Lee, Edward, Barrero, Mauricio, Kurimoto, Pam, Niu, Qing‐Tian, Geng, Zhaopo, Winters, Aaron, Horan, Tom, Steavenson, Shirley, Jacobsen, Frederick, Chen, Qing, Haldankar, Raj, Lavallee, Jennifer, Tipton, Barbara, Daris, Mark, Sheng, Jackie, Lu, Hsieng S, Daris, Kristi, Deshpande, Rohini, Valente, Eliane G, Salimi‐Moosavi, Hossein, Kostenuik, Paul J, Li, Ji, Liu, Min, Li, Chaoyang, Lacey, David L, Simonet, W Scott, Ke, Hua Zhu, Babij, Philip, Stolina, Marina, Ominsky, Michael S, Richards, William G

“…The physiological role of Dickkopf‐1 (Dkk1) during postnatal bone growth in rodents and in adult rodents was examined utilizing an antibody to Dkk1 (Dkk1‐Ab)…”
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An acyl-ghrelin-specific neutralizing antibody inhibits the acute ghrelin-mediated orexigenic effects in mice by Lu, Shu-Chen, Xu, Jing, Chinookoswong, Narumol, Liu, Shuying, Steavenson, Shirley, Gegg, Colin, Brankow, David, Lindberg, Richard, Véniant, Murielle, Gu, Wei

“…Ghrelin is a 28-amino acid peptide secreted mainly by the stomach. Acyl-ghrelin, which binds to and activates the growth hormone secretagogue receptor type 1a…”
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Polyglutamine Repeat Length-Dependent Proteolysis of Huntingtin by Sun, Banghua, Fan, Wei, Balciunas, Aldona, Cooper, Jillian K., Bitan, Gal, Steavenson, Shirley, Denis, Paul E., Young, Yunjen, Adler, Beverly, Daugherty, Larry, Manoukian, Raffi, Elliott, Gary, Shen, Wenyan, Talvenheimo, Jane, Teplow, David B., Haniu, Mitsuru, Haldankar, Raj, Wypych, Jette, Ross, Christopher A., Citron, Martin, Richards, William G.

“…Amino-terminal fragments of huntingtin, which contain the expanded polyglutamine repeat, have been proposed to contribute to the pathology of Huntington's…”
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alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease by Wood, S J, Wypych, J, Steavenson, S, Louis, J C, Citron, M, Biere, A L

“…Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major…”
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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation by Narhi, L, Wood, S J, Steavenson, S, Jiang, Y, Wu, G M, Anafi, D, Kaufman, S A, Martin, F, Sitney, K, Denis, P, Louis, J C, Wypych, J, Biere, A L, Citron, M

“…Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major…”
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Parkinson's Disease-associated α-Synuclein Is More Fibrillogenic than β- and γ-Synuclein and Cannot Cross-seed Its Homologs by Biere, Anja Leona, Wood, Stephen J., Wypych, Jette, Steavenson, Shirley, Jiang, Yijia, Anafi, Dan, Jacobsen, Frederick W., Jarosinski, Mark A., Wu, Gay-May, Louis, Jean-Claude, Martin, Francis, Narhi, Linda O., Citron, Martin

“…Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies. Recently, two…”
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An antibody to IP-10 is a potent antagonist of cell migration in vitro and in vivo and does not affect disease in several animal models of inflammation by Byrne, Fergus R., Winters, Aaron, Brankow, David, Hu, Sylvia, Juan, Todd, Steavenson, Shirley, Doellgast, George, Kuchimanchi, Kamesh, Brown, Heather, Anderson, Sharon, Smelt, Sara, Sullivan, Tim, Alcorn, Dina, Tocker, Joel, Dean, Charley, Macmaster, John, Kirchner, Jacqueline, Buys, Janet, Manoukian, Raffi, Jiao, Eric, Zou, Xiaoming, Campanella, Gabriele S., Siu, Gerald

“…IP-10 secretion is induced by pro-inflammatory cytokines and mediates the migration of CXCR3+ cells. Its elevation in clinical samples has been associated with…”
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α-Synuclein Fibrillogenesis Is Nucleation-dependent by Stephen J. Wood, Jette Wypych, Shirley Steavenson, Jean-Claude Louis, Martin Citron, Anja Leona Biere

“…Parkinson’s disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major…”
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α-Synuclein Fibrillogenesis Is Nucleation-dependent by Wood, Stephen J., Wypych, Jette, Steavenson, Shirley, Louis, Jean-Claude, Citron, Martin, Biere, Anja Leona

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Parkinson's Disease-associated α-Synuclein Is More Fibrillogenic than β- and γ-Synuclein and Cannot Cross-seed Its Homologs by Anja Leona Biere, Stephen J. Wood, Jette Wypych, Shirley Steavenson, Yijia Jiang, Dan Anafi, Frederick W. Jacobsen, Mark A. Jarosinski, Gay-May Wu, Jean-Claude Louis, Francis Martin, Linda O. Narhi, Martin Citron

“…Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies. Recently, two…”
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Both Familial Parkinson’s Disease Mutations Accelerate α-Synuclein Aggregation by Linda Narhi, Stephen J. Wood, Shirley Steavenson, Yijia Jiang, Gay May Wu, Dan Anafi, Stephen A. Kaufman, Francis Martin, Karen Sitney, Paul Denis, Jean-Claude Louis, Jette Wypych, Anja Leona Biere, Martin Citron

“…Parkinson’s disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major…”
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Both familial Parkinson's disease mutations accelerate α-synuclein aggregation by Narhi, Linda, Wood, Stephen J., Steavenson, Shirley, Jiang, Yijia, Wu, Gay May, Anafi, Dan, Kaufman, Stephen A., Martin, Francis, Sitney, Karen, Denis, Paul, Louis, Jean-Claude, Wypych, Jette, Biere, Anja Leona, Citron, Martin

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The use of glucose dehydrogenase to monitor the integrity of microsomes by Bublitz, C, Steavenson, S

“…Various concentrations of Tergitol NP-10 stimulate mannose-6-phosphatase and glucose dehydrogenase to the same extent in untreated rat liver microsomes. Thus,…”
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The topology of phosphogluconate dehydrogenases in rat liver microsomes by Bublitz, C, Lawler, C A, Steavenson, S

“…Rat liver microsomes are known to contain a 6-phosphogluconate dehydrogenase which differs from the 6-phosphogluconate dehydrogenase in the soluble fraction…”
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