Search Results - "Stears, Anna"

A Double-Blind, Placebo-Controlled, Crossover Trial Comparing the Effects of Amiloride and Hydrochlorothiazide on Glucose Tolerance in Patients With Essential Hypertension by Stears, Anna J, Woods, Sarah H, Watts, Michaela M, Burton, Timothy J, Graggaber, Johann, Mir, Fraz A, Brown, Morris J

“…Hypertension guidelines advise limiting the dose of thiazide diuretics and avoiding combination with β-blockade, because of increased risk of diabetes…”
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Metabolic insights from extreme human insulin resistance phenotypes by Stears, Anna, MRCP, O’Rahilly, Stephen, FRS, FMedSci, Semple, Robert K., MRCP, PhD, Savage, David B., FRCP

“…As well as improving diagnostic and clinical outcomes for affected patients, understanding the genetic basis of rare human metabolic disorders has resulted in…”
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Premenopausal Advantages in Postprandial Lipid Metabolism Are Lost in Women With Type 2 Diabetes by Masding, Michael G, Stears, Anna J, Burdge, Graham C, Wootton, Stephen A, Sandeman, Derek D

“…Premenopausal Advantages in Postprandial Lipid Metabolism Are Lost in Women With Type 2 Diabetes Michael G. Masding , MBBS, MRCP 1 2 , Anna J. Stears , MBBS,…”
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Percentage of body fat and plasma glucose predict plasma sialic acid concentration in type 2 diabetes mellitus by Englyst, Nicola A., Crook, Martin A., Lumb, Peter, Stears, Anna J., Masding, Michael G., Wootton, Stephen A., Sandeman, Derek D., Byrne, Christopher D.

“…Circulating sialic acid is an independent risk factor for cardiovascular disease and is higher in people with type 2 diabetes mellitus. Sialic acid is…”
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Recent developments in lipodystrophy by Melvin, Audrey, Stears, Anna, Savage, David B

“…Lipodystrophy syndromes have an estimated prevalence of 1.3-4.7 cases per million and as with other rare diseases conducting research can be challenging. The…”
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“We're stuck with what we've got”: The impact of lipodystrophy on body image by Adams, Claire, Stears, Anna, Savage, David, Deaton, Christi

“…Aims and objectives To evaluate the impact of lipodystrophy on body image and how this affects patients’ daily lives. Background Lipodystrophy refers to a…”
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Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance by Lotta, Luca A, Gulati, Pawan, Day, Felix R, Payne, Felicity, Ongen, Halit, van de Bunt, Martijn, Gaulton, Kyle J, Eicher, John D, Sharp, Stephen J, Luan, Jian'an, De Lucia Rolfe, Emanuella, Stewart, Isobel D, Wheeler, Eleanor, Willems, Sara M, Adams, Claire, Yaghootkar, Hanieh, Forouhi, Nita G, Khaw, Kay-Tee, Johnson, Andrew D, Semple, Robert K, Frayling, Timothy, Perry, John R B, Dermitzakis, Emmanouil, McCarthy, Mark I, Barroso, Inês, Wareham, Nicholas J, Savage, David B, Langenberg, Claudia, O'Rahilly, Stephen, Scott, Robert A

“…Luca Lotta, Robert Scott, Stephen O’Rahilly, Claudia Langenberg, David Savage, Nicholas Wareham, Inês Barroso and colleagues identify 53 genomic regions…”
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Describing the natural history of clinical, biochemical and radiological outcomes of children with familial partial lipodystrophy type 2 (FPLD2) from the United Kingdom: A retrospective case series by Zhong, Zhu Xuan, Harris, Julie, Wilber, Ellen, Gorman, Samantha, Savage, David B., O'Rahilly, Stephen, Stears, Anna, Williams, Rachel M.

“…Context Familial partial lipodystrophy type 2 (FPLD2) results from autosomal dominant mutations in the LMNA gene, causing lack of subcutaneous fat deposition…”
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Severe insulin resistance: pathologies by Melvin, Audrey, Stears, Anna

“…In parallel with the increasing prevalence of obesity, rates of insulin resistance and its associated complications have increased; however, insulin resistance…”
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Diagnosis of insulin autoimmune syndrome using polyethylene glycol precipitation and gel filtration chromatography with ex vivo insulin exchange by Church, David, Cardoso, Luís, Bradbury, Sonia, Clarke, Catriona, Stears, Anna, Dover, Anna, Halsall, David, Semple, Robert

“…Summary Context Insulin‐binding antibodies may produce severe dysglycaemia in insulin‐naïve patients (‘insulin autoimmune syndrome’ (IAS) or Hirata disease),…”
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Bilateral macular drusen in acquired partial lipodystrophy with type 2 membranoproliferative glomerulonephritis by Tanner, Alexander, Chan, Hwei Wuen, Stears, Anna, Moosajee, Mariya

“…A 35-year-old woman with acquired partial lipodystrophy (PLD) and features of type 2 membranoproliferative glomerulonephritis (MPGN-II), presented with…”
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Ovarian Hyperandrogenism and Response to Gonadotropin-releasing Hormone Analogues in Primary Severe Insulin Resistance by Huang-Doran, Isabel, Kinzer, Alexandra B, Jimenez-Linan, Mercedes, Thackray, Kerrie, Harris, Julie, Adams, Claire L, de Kerdanet, Marc, Stears, Anna, O’Rahilly, Stephen, Savage, David B, Gorden, Phillip, Brown, Rebecca J, Semple, Robert K

“…Abstract Context Insulin resistance (IR) is associated with polycystic ovaries and hyperandrogenism, but underpinning mechanisms are poorly understood and…”
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Diagnosis and treatment of anti-insulin antibody-mediated labile glycaemia in insulin-treated diabetes by Church, David S, Barker, Peter, Burling, Keith A, Shinwari, Shah K, Kennedy, Carmel, Smith, Diarmuid, Macfarlane, David P, Kernohan, Andrew, Stears, Anna, Karamat, Muhammad A, Whyte, Karen, Narendran, Parth, Halsall, David J, Semple, Robert K

“…Anti-insulin antibodies in insulin-treated diabetes can derange glycaemia, but are under-recognised. Detection of significant antibodies is complicated by…”
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The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion by Rocha, Nuno, Payne, Felicity, Huang-Doran, Isabel, Sleigh, Alison, Fawcett, Katherine, Adams, Claire, Stears, Anna, Saudek, Vladimir, O’Rahilly, Stephen, Barroso, Inês, Semple, Robert K.

“…Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin and HDL cholesterol concentrations, obesity, and coronary…”
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Roux-en-Y Gastric Bypass Surgery in the Management of Familial Partial Lipodystrophy Type 1 by Melvin, Audrey, Adams, Claire, Flanagan, Catherine, Gaff, Lisa, Gratton, Barbara, Gribble, Fiona, Roberts, Geoffrey, Semple, Robert K, O’Rahilly, Stephen, Rubino, Francesco, Stears, Anna, Savage, David B

“…Abstract Context Familial partial lipodystrophy type 1 (FPLD1) is an extreme form of central adiposity, with peripheral lipodystrophy associated with severe…”
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Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip) Cambridge by Mosbah, Héléna, Akinci, Baris, Araújo-Vilar, David, Carrion Tudela, Juan, Ceccarini, Giovanni, Collas, Philippe, Farooqi, I. Sadaf, Fernández-Pombo, Antía, Jéru, Isabelle, Karpe, Fredrik, Krause, Kerstin, Maffei, Margherita, Miehle, Konstanze, Oral, Elif, Perez de Tudela, Naca, Prieur, Xavier, Rochford, Justin, Sanders, Rebecca, Santini, Ferruccio, Savage, David B, von Schnurbein, Julia, Semple, Robert, Stears, Anna, Sorkina, Ekaterina, Vantyghem, Marie-Christine, Vatier, Camille, Vidal-Puig, Antonio, Vigouroux, Corinne, Wabitsch, Martin

“…Lipodystrophy syndromes are rare diseases with defects in the development or maintenance of adipose tissue, frequently leading to severe metabolic…”
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Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip) Cambridge, UK, 7-8 April 2022 by Mosbah, Héléna, Akinci, Baris, Araújo-Vilar, David, Carrion Tudela, Juan, Ceccarini, Giovanni, Collas, Philippe, Farooqi, I Sadaf, Fernández-Pombo, Antía, Jéru, Isabelle, Karpe, Fredrik, Krause, Kerstin, Maffei, Margherita, Miehle, Konstanze, Oral, Elif, Perez de Tudela, Naca, Prieur, Xavier, Rochford, Justin, Sanders, Rebecca, Santini, Ferruccio, Savage, David B, von Schnurbein, Julia, Semple, Robert, Stears, Anna, Sorkina, Ekaterina, Vantyghem, Marie-Christine, Vatier, Camille, Vidal-Puig, Antonio, Vigouroux, Corinne, Wabitsch, Martin

“…Lipodystrophy syndromes are rare diseases with defects in the development or maintenance of adipose tissue, frequently leading to severe metabolic…”
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A case of type B insulin resistance presenting at a district general hospital by Ramlochansingh, Osada, Surchi, Haval, Stears, Anna, O'Rahilly, Sir Stephen, Mimmack, Michael, Jayne, David

“…Type B insulin resistance is a rare autoimmune condition with just over 100 cases described in the literature. We describe here the case of a young female who…”
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Mitochondrial Oxidative Phosphorylation Is Impaired in Patients with Congenital Lipodystrophy by Sleigh, Alison, Stears, Anna, Thackray, Kerrie, Watson, Laura, Gambineri, Alessandra, Nag, Sath, Campi, V. Irene, Schoenmakers, Nadia, Brage, Soren, Carpenter, T. Adrian, Murgatroyd, Peter R, O'Rahilly, Stephen, Kemp, Graham J, Savage, David B

“…Objective: Lipid accumulation in skeletal muscle and the liver is strongly implicated in the development of insulin resistance and type 2 diabetes, but the…”
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Regulation: The Real Threat to Clinical Research by Stewart, Paul M., Stears, Anna, Tomlinson, Jeremy W., Brown, Morris J.

“…Recent changes to research governance were intended to ensure that clinical trials are safe and effective. However, Stewart et al argue that the regulatory…”
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