Search Results - "Stearns, E. M."

Interleukin 10 (IL-10) inhibition of primary human prostate cell-induced angiogenesis : IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix metalloproteinase (MMP)-2/MMP-9 secretion by STEARNS, M. E, RHIM, J, MING WANG

“…In in vitro angiogenesis assays, aggregates of human papilloma virus (HPV)-18-immortalized primary human prostate cancer cells (HPCA-5aHPV-18 or HPCA-10aHPV-18…”
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A novel IL-10 signalling mechanism regulates TIMP-1 expression in human prostate tumour cells by WANG, M, HU, Y, STEARNS, M. E

“…We have previously reported that interleukin 10 (IL-10) signalling stimulated activation of a specific enhancer element, termed HTE-1, to promote tissue…”
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In situ hybridization studies of metalloproteinases 2 and 9 and TIMP-1 and TIMP-2 expression in human prostate cancer by Wood, M, Fudge, K, Mohler, J L, Frost, A R, Garcia, F, Wang, M, Stearns, M E

“…The expression of MMP-2, MMP-9, TIMP-1, TIMP-2, and the urokinase receptor were examined in fetal and normal prostate tissues, benign prostatic hyperplasia and…”
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Evidence for increased activated metalloproteinase 2 (MMP-2a) expression associated with human prostate cancer progression by Stearns, M, Stearns, M E

“…Immunolabeling studies have previously indicated that increased expression of the 72-kDa matrix metalloproteinase 2 (MMP-2) is associated with human prostate…”
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Taxol blocks processes essential for prostate tumor cell (PC-3 ML) invasion and metastases by STEARNS, M. E, MIN WANG

“…We have examined the antimetastatic effects of taxol on a PC-3 human prostatic tumor variant (PC-3 ML) which metastasizes to the lumbar vertebrae in severe…”
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Prostate cancer: therapeutic, diagnostic, and basic studies by Stearns, M E, McGarvey, T

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Dysplasia of human prostate CD133(hi) sub-population in NOD-SCIDS is blocked by c-myc anti-sense by Goodyear, S M, Amatangelo, M D, Stearns, M E

“…The CD133(hi) sub-population of prostate epithelial cells has been demonstrated to possess tumor-initiating capacity consistent with that of the cancer stem…”
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Growth of HPV-18 immortalized human prostatic intraepithelial neoplasia cell lines. Influence of IL-10, follistatin, activin-A, and DHT by Wang, M, Liu, A, Garcia, F U, Rhim, J S, Stearns, M E

“…Cultures from high grade prostatic intraepithelial neoplasia (HGPIN) have been established and immortalized by HPV-18 infection. The cultures were identified…”
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Platelet-derived growth factor A and B chains and the α and β receptors in prostatic intraepithelial neoplasia by Fudge, Kim, Bostwick, David G., Stearns, Mark E.

“…BACKGROUND The objective of this study was to evaluate the expression of platelet‐derived growth factor (PDGF A, PDGF B) and their receptors (PDGF α, PDGF β)…”
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Specific transcription factors prognostic for prostate cancer progression by Aoyagi, K, Shima, I, Wang, M, Hu, Y, Garcia, F U, Stearns, M E

“…We have previously identified (M. Wang et al., Oncol. Res., in press, 1998) an enhancer element [human tissue inhibitor of metalloproteinase-1 enhancer-1…”
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Alendronate blocks metalloproteinase secretion and bone collagen I release by PC-3 ML cells in SCID mice by Stearns, M E, Wang, M

“…We have previously shown that alendronate, a potent bisphosphonate compound, can prevent human PC-3 ML tumor cell metastasis to the bone (Stearns and Stearns,…”
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Isolation and characterization of PC-3 human prostatic tumor sublines which preferentially metastasize to select organs in S.C.I.D. mice by Wang, M, Stearns, M E

“…We have developed and partially characterized a mouse model system for studying human prostate tumor cell metastases in vivo. To develop this model we have…”
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Immunohistochemical studies of activated matrix metalloproteinase-2 (MMP-2a)expression in human prostate cancer by Stearns, M E, Stearns, M

“…Previous immunolabeling studies have indicated that increased expression of the matrix metalloproteinase-2 (MMP-2) zymogen is associated with an increased…”
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Liarozole and 13-cis-retinoic acid anti-prostatic tumor activity by STEARNS, M. E, WANG, M, FUDGE, K

“…Liarozole fumarate (R85,246), a novel benzimidazole derivative, reduced s.c. and bone metastasis tumor growth by the androgen-independent PC-3ML-B2 human…”
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Cytokine (IL-10, IL-6) induction of tissue inhibitor of metalloproteinase 1 in primary human prostate tumor cell lines by Stearns, M, Wang, M, Stearns, M E

“…Northern blots and scintillation counting showed that tissue inhibitor of metalloproteinase 1 (TIMP-1) mRNA was expressed by low passage, primary epithelial…”
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Estramustine Binds a MAP-1-like Protein to Inhibit Microtubule Assembly in Vitro and Disrupt Microtubule Organization in DU 145 Cells by Stearns, Mark E., Wang, Min, Tew, Kenneth D., Binder, Lester I.

“…The twofold purpose of the study was (a) to determine if a MAP-1-like protein was expressed in human prostatic DU 145 cells and (b) to demonstrate whether a…”
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Regulation of kinesin expression and type IV collagenase secretion invasive human prostate PC-3 tumor sublines by STEARNS, M. E, MIN WANG

“…PC-3 human prostatic tumor sublines have been previously isolated which exhibit striking differences in their invasive and metastatic phenotypes. This work has…”
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Type IV collagenase (M(r) 72,000) expression in human prostate: benign and malignant tissue by Stearns, M E, Wang, M

“…The expression of type IV collagenase (M(r) 72,000) has been examined in tissues from patients with benign prostatic hyperplasia (6 patients) and varying…”
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IL-10 blocks collagen IV invasion by "invasion stimulating factor" activated PC-3 ML cells: upregulation of TIMP-1 expression by Stearns, M E, Wang, M, Stearns, M

“…We have previously shown that a 78-kDa "invasion stimulating factor" (ISF) triggers collagenase IV (MMP-2) secretion and the invasive behavior of metastatic…”
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Immunohistochemistry analysis of platelet-derived growth factor A and B chains and platelet-derived growth factor alpha and beta receptor expression in benign prostatic hyperplasias and Gleason-graded human prostate adenocarcinomas by Fudge, K, Wang, C Y, Stearns, M E

“…The purpose of this study was to determine whether changes in the expression of platelet-derived growth factor (PDGF) and its receptors were associated with…”
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