Search Results - "Steadman, Victoria A."

A new antibiotic kills pathogens without detectable resistance by Ling, Losee L., Schneider, Tanja, Peoples, Aaron J., Spoering, Amy L., Engels, Ina, Conlon, Brian P., Mueller, Anna, Schäberle, Till F., Hughes, Dallas E., Epstein, Slava, Jones, Michael, Lazarides, Linos, Steadman, Victoria A., Cohen, Douglas R., Felix, Cintia R., Fetterman, K. Ashley, Millett, William P., Nitti, Anthony G., Zullo, Ashley M., Chen, Chao, Lewis, Kim

“…Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were…”
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Unprecedented Epimerization of an Azithromycin Analogue: Synthesis, Structure and Biological Activity of 2'-Dehydroxy-5″-Epi-Azithromycin by Kragol, Goran, Steadman, Victoria A, Marušić Ištuk, Zorica, Čikoš, Ana, Bosnar, Martina, Jelić, Dubravko, Ergović, Gabrijela, Trzun, Marija, Bošnjak, Berislav, Bokulić, Ana, Padovan, Jasna, Glojnarić, Ines, Eraković Haber, Vesna

“…Certain macrolide antibiotics, azithromycin included, possess anti-inflammatory properties that are considered fundamental for their efficacy in the treatment…”
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Stereocontrolled total synthesis of (+)-concanamycin F: the strategic use of boron-mediated aldol reactions of chiral ketones by Paterson, Ian, Steadman neé Doughty, Victoria A., McLeod, Malcolm D., Trieselmann, Thomas

“…A highly stereocontrolled total synthesis of the 18-membered macrolide (+)-concanamycin F, a potent inhibitor of vacuolar ATPases, is described that proceeds…”
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Structure and reactivity of bicyclic methylene aziridines prepared by intramolecular aziridination of allenes by Robertson, Jeremy, Feast, George C, White, Louise V, Steadman, Victoria A, Claridge, Timothy D W

“…Unprecedented bicyclic methylene aziridines are prepared by rhodium(II)-catalyzed allene aziridination of buta-2,3-dienyl carbamates. Aspects of their NMR and…”
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Drug Discovery: Collaborations between Contract Research Organizations and the Pharmaceutical Industry by Steadman, Victoria A.

“…Collaborations between the pharmaceutical industry and contract research organizations continue to represent an attractive alternative to internal drug…”
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Bifunctional crosslinking ligands for transthyretin by Mangione, P. Patrizia, Deroo, Stéphanie, Ellmerich, Stephan, Bellotti, Vittorio, Kolstoe, Simon, Wood, Stephen P., Robinson, Carol V., Smith, Martin D., Tennent, Glenys A., Broadbridge, Robert J., Council, Claire E., Thurston, Joanne R., Steadman, Victoria A., Vong, Antonio K., Swain, Christopher J., Pepys, Mark B., Taylor, Graham W.

“…Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing…”
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Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle by Mackman, Richard L, Steadman, Victoria A, Dean, David K, Jansa, Petr, Poullennec, Karine G, Appleby, Todd, Austin, Carol, Blakemore, Caroline A, Cai, Ruby, Cannizzaro, Carina, Chin, Gregory, Chiva, Jean-Yves C, Dunbar, Neil A, Fliri, Hans, Highton, Adrian J, Hui, Hon, Ji, Mingzhe, Jin, Haolun, Karki, Kapil, Keats, Andrew J, Lazarides, Linos, Lee, Yu-Jen, Liclican, Albert, Mish, Michael, Murray, Bernard, Pettit, Simon B, Pyun, Peter, Sangi, Michael, Santos, Rex, Sanvoisin, Jonathan, Schmitz, Uli, Schrier, Adam, Siegel, Dustin, Sperandio, David, Stepan, George, Tian, Yang, Watt, Gregory M, Yang, Hai, Schultz, Brian E

“…Cyclophilins are a family of peptidyl-prolyl isomerases that are implicated in a wide range of diseases including hepatitis C. Our aim was to discover through…”
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Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A by Steadman, Victoria A, Pettit, Simon B, Poullennec, Karine G, Lazarides, Linos, Keats, Andrew J, Dean, David K, Stanway, Steven J, Austin, Carol A, Sanvoisin, Jonathan A, Watt, Gregory M, Fliri, Hans G, Liclican, Albert C, Jin, Debi, Wong, Melanie H, Leavitt, Stephanie A, Lee, Yu-Jen, Tian, Yang, Frey, Christian R, Appleby, Todd C, Schmitz, Uli, Jansa, Petr, Mackman, Richard L, Schultz, Brian E

“…Cyclophilin inhibition has been a target for the treatment of hepatitis C and other diseases, but the generation of potent, drug-like molecules through…”
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Erratum: A new antibiotic kills pathogens without detectable resistance by Ling, Losee L., Schneider, Tanja, Peoples, Aaron J., Spoering, Amy L., Engels, Ina, Conlon, Brian P., Mueller, Anna, Schäberle, Till F., Hughes, Dallas E., Epstein, Slava, Jones, Michael, Lazarides, Linos, Steadman, Victoria A., Cohen, Douglas R., Felix, Cintia R., Fetterman, K. Ashley, Millett, William P., Nitti, Anthony G., Zullo, Ashley M., Chen, Chao, Lewis, Kim

“…Nature 517, 455–459 (2015); doi:10.1038/nature14098 In Fig. 3d of this Article, the ‘2:1’ and ‘1:1’ labels at the bottom of the panel were inadvertently…”
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