Search Results - "Stead, John D.H."

Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes by STEAD, John D. H, BUARD, Jérome, TODD, John A, JEFFREYS, Alec J

“…The insulin minisatellite or variable number of tandem repeats locus (INS VNTR) is the best candidate for the type 1 diabetes mellitus (T1DM) susceptibility…”
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Experiential and genetic contributions to depressive- and anxiety-like disorders: Clinical and experimental studies by Anisman, Hymie, Merali, Zul, Stead, John D.H.

“…Stressful events have been implicated in the precipitation of depression and anxiety. These disorders may evolve owing to one or more of an array of neuronal…”
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Global haplotype diversity in the human insulin gene region by Stead, John D H, Hurles, Matthew E, Jeffreys, Alec J

“…The insulin minisatellite (INS VNTR) has been intensively analyzed due to its associations with diseases including diabetes. We have previously used patterns…”
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Allele diversity and germline mutation at the insulin minisatellite by STEAD, J. D. H, JEFFREYS, A. J

“…Previous analysis of germline mutation at highly unstable GC-rich minisatellites with continuous allele size distributions revealed similar meiotic…”
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Empirical Characterization of False Discovery Rates of Differentially Expressed Genes and Transcriptomic Benchmark Concentrations in Zebrafish Embryos by Lee, Hyojin, Stead, John D.H., Williams, Andrew, Cortés Ramírez, Sergio A., Atlas, Ella, Mennigen, Jan A., O’Brien, Jason M., Yauk, Carole

“…High-throughput transcriptomics (HTTr) is increasingly applied to zebrafish embryos to survey the toxicological effects of environmental chemicals. Before the…”
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Genetic Liability for Internalizing Versus Externalizing Behavior Manifests in the Developing and Adult Hippocampus: Insight From a Meta-analysis of Transcriptional Profiling Studies in a Selectively Bred Rat Model by Birt, Isabelle A., Hagenauer, Megan H., Clinton, Sarah M., Aydin, Cigdem, Blandino, Peter, Stead, John D.H., Hilde, Kathryn L., Meng, Fan, Thompson, Robert C., Khalil, Huzefa, Stefanov, Alex, Maras, Pamela, Zhou, Zhifeng, Hebda-Bauer, Elaine K., Goldman, David, Watson, Stanley J., Akil, Huda

“…For more than 16 years, we have selectively bred rats for either high or low levels of exploratory activity within a novel environment. These bred…”
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Developmental underpinnings of differences in rodent novelty-seeking and emotional reactivity by Clinton, Sarah M., Stead, John D. H., Miller, Sue, Watson, Stanley J., Akil, Huda

“…Innate differences in human temperament strongly influence how individuals cope with stress and also predispose towards specific types of psychopathology. The…”
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Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus by Carlson, Erik S., Stead, John D.H., Neal, Charles R., Petryk, Anna, Georgieff, Michael K.

“…The human and rat hippocampus is highly susceptible to iron deficiency (ID) during the late fetal, early neonatal time period which is a peak time of regulated…”
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Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors by Stead, John D H, Clinton, Sarah, Neal, Charles, Schneider, Johanna, Jama, Abas, Miller, Sue, Vazquez, Delia M, Watson, Stanley J, Akil, Huda

“…Outbred Sprague-Dawley rats can be classified as high responders (HR) or low responders (LR) based on their levels of exploratory locomotion in a novel…”
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Molecular pathway reconstruction and analysis of disturbed gene expression in depressed individuals who died by suicide by Zhurov, Vladimir, Stead, John D H, Merali, Zul, Palkovits, Miklos, Faludi, Gabor, Schild-Poulter, Caroline, Anisman, Hymie, Poulter, Michael O

“…Molecular mechanisms behind the etiology and pathophysiology of major depressive disorder and suicide remain largely unknown. Recent molecular studies of…”
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On Being Attracted to the Possibility of a Win: Reward Sensitivity (via Gambling Motives) Undermines Treatment Seeking Among Pathological Gamblers by Sztainert, Travis, Wohl, Michael J. A., McManus, Justin F., Stead, John D. H.

“…Unfortunately, only a small percent of pathological gamblers seek the professional help they need. In the current study, we test the idea that individual…”
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Cross-platform analysis of global microRNA expression technologies by Yauk, Carole L, Rowan-Carroll, Andrea, Stead, John Dh, Williams, Andrew

“…Although analysis of microRNAs (miRNAs) by DNA microarrays is gaining in popularity, these new technologies have not been adequately validated. We examined…”
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Transcriptional Profiling of the Developing Rat Brain Reveals That the Most Dramatic Regional Differentiation in Gene Expression Occurs Postpartum by Stead, John D. H, Neal, Charles, Meng, Fan, Wang, Yongjia, Evans, Simon, Vazquez, Delia M, Watson, Stanley J, Akil, Huda

“…Neural development involves the expression of ensembles of regulatory genes that control the coordinate and region-specific expression of a host of other…”
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Correction: Molecular Pathway Reconstruction and Analysis of Disturbed Gene Expression in Depressed Individuals Who Died by Suicide by Zhurov, Vladimir, Stead, John D. H., Merali, Zul, Palkovits, Miklos, Faludi, Gabor, Schild-Poulter, Caroline, Anisman, Hymie, Poulter, Michael O.

“…The correct Figure 8 is available here: thumbnail Download: * PPT PowerPoint slide * PNG larger image * TIFF original image Figures Citation: Zhurov V, Stead…”
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Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birth by Petry, Clive J, Rayco-Solon, Pura, Fulford, Anthony J. C, Stead, John D. H, Wingate, Dianne L, Ong, Ken K, Sirugo, Giorgio, Prentice, Andrew M, Dunger, David B

“…The insulin variable number of tandem repeats (INS VNTR) has been variably associated with size at birth in non-African populations. Small size at birth is a…”
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Structural Analysis of Insulin Minisatellite Alleles Reveals Unusually Large Differences in Diversity between Africans and Non-Africans by Stead, John D.H., Jeffreys, Alec J.

“…The insulin minisatellite ( INS VNTR) associates with susceptibility to a variety of diseases. We have developed a high-resolution system for analyzing variant…”
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Human minisatellites, repeat DNA instability and meiotic recombination by Jeffreys, Alec J., Barber, Ruth, Bois, Philippe, Buard, Jérôme, Dubrova, Yuri E., Grant, Gemma, Hollies, Caroline R. H., May, Celia A., Neumann, Rita, Panayi, Maria, Ritchie, Alistair E., Shone, Angela C., Signer, Esther, Stead, John D. H., Tamaki, Keiji

“…Minisatellites include some of the most variable loci in the human genome and are superb for dissecting processes of tandem repeat DNA instability. Single DNA…”
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Isolation and Characterization of Mouse Minisatellites by Bois, Philippe, Stead, John D.H., Bakshi, Sharmila, Williamson, Jill, Neumann, Rita, Moghadaszadeh, Behzad, Jeffreys, Alec J.

“…Minisatellites provide the most informative system for analyzing processes of tandem repeat turnover in humans. However, little is known about minisatellites…”
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