Imaging proliferation in vivo with [F-18]FLT and positron emission tomography

Positron emission tomography (PET) is now regularly used in the diagnosis and staging of cancer. These uses and its ability to monitor treatment response would be aided by the development of imaging agents that can be used to measure tissue and tumor proliferation. We have developed and tested [F-18...

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Bibliographic Details
Published in:	Nature medicine Vol. 4; no. 11; pp. 1334 - 1336
Main Authors:	Shields, Anthony F, Grierson, John R, Dohmen, Bernhard M, Machulla, H.-Juergen, Stayanoff, Joseph C, Lawhorn-Crews, Jawana M, Obradovich, Joyce E, Muzik, Otto, Mangner, Thomas J
Format:	Journal Article
Language:	English
Published:	United States 01-11-1998
Subjects:	Animals Bone Marrow - diagnostic imaging Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - pathology Dideoxynucleosides - pharmacokinetics Dogs Fluorine Radioisotopes - pharmacokinetics Humans Lung Neoplasms - diagnostic imaging Lung Neoplasms - pathology Neoplasm Staging Pilot Projects Tissue Distribution Tomography, Emission-Computed - methods
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Summary:	Positron emission tomography (PET) is now regularly used in the diagnosis and staging of cancer. These uses and its ability to monitor treatment response would be aided by the development of imaging agents that can be used to measure tissue and tumor proliferation. We have developed and tested [F-18]FLT (3'-deoxy-3'-fluorothymidine); it is resistant to degradation, is retained in proliferating tissues by the action of thymidine kinase 1 (TK), and produces high-contrast images of normal marrow and tumors in canine and human subjects.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1078-8956 1546-170X
DOI:	10.1038/3337