Search Results - "Stawiski, Eric W"

The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer by O'Hayre, Morgan, Vázquez-Prado, José, Kufareva, Irina, Stawiski, Eric W., Handel, Tracy M., Seshagiri, Somasekar, Gutkind, J. Silvio

“…Key Points Recent cancer genome deep sequencing efforts have revealed an unanticipated high frequency of mutations in G proteins and G-protein-coupled…”
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Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations by Bueno, Raphael, Stawiski, Eric W, Goldstein, Leonard D, Durinck, Steffen, De Rienzo, Assunta, Modrusan, Zora, Gnad, Florian, Nguyen, Thong T, Jaiswal, Bijay S, Chirieac, Lucian R, Sciaranghella, Daniele, Dao, Nhien, Gustafson, Corinne E, Munir, Kiara J, Hackney, Jason A, Chaudhuri, Amitabha, Gupta, Ravi, Guillory, Joseph, Toy, Karen, Ha, Connie, Chen, Ying-Jiun, Stinson, Jeremy, Chaudhuri, Subhra, Zhang, Na, Wu, Thomas D, Sugarbaker, David J, de Sauvage, Frederic J, Richards, William G, Seshagiri, Somasekar

“…Raphael Bueno, Eric Stawiski, Somasekar Seshagiri and colleagues present a comprehensive genomic analysis of malignant pleural mesothelioma. They identify four…”
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The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins by Suryamohan, Kushal, Krishnankutty, Sajesh P., Guillory, Joseph, Jevit, Matthew, Schröder, Markus S., Wu, Meng, Kuriakose, Boney, Mathew, Oommen K., Perumal, Rajadurai C., Koludarov, Ivan, Goldstein, Leonard D., Senger, Kate, Dixon, Mandumpala Davis, Velayutham, Dinesh, Vargas, Derek, Chaudhuri, Subhra, Muraleedharan, Megha, Goel, Ridhi, Chen, Ying-Jiun J., Ratan, Aakrosh, Liu, Peter, Faherty, Brendan, de la Rosa, Guillermo, Shibata, Hiroki, Baca, Miriam, Sagolla, Meredith, Ziai, James, Wright, Gus A., Vucic, Domagoj, Mohan, Sangeetha, Antony, Aju, Stinson, Jeremy, Kirkpatrick, Donald S., Hannoush, Rami N., Durinck, Steffen, Modrusan, Zora, Stawiski, Eric W., Wiley, Kristen, Raudsepp, Terje, Kini, R. Manjunatha, Zachariah, Arun, Seshagiri, Somasekar

“…Snakebite envenoming is a serious and neglected tropical disease that kills ~100,000 people annually. High-quality, genome-enabled comprehensive…”
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Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes by Durinck, Steffen, Stawiski, Eric W, Pavía-Jiménez, Andrea, Modrusan, Zora, Kapur, Payal, Jaiswal, Bijay S, Zhang, Na, Toffessi-Tcheuyap, Vanina, Nguyen, Thong T, Pahuja, Kanika Bajaj, Chen, Ying-Jiun, Saleem, Sadia, Chaudhuri, Subhra, Heldens, Sherry, Jackson, Marlena, Peña-Llopis, Samuel, Guillory, Joseph, Toy, Karen, Ha, Connie, Harris, Corissa J, Holloman, Eboni, Hill, Haley M, Stinson, Jeremy, Rivers, Celina Sanchez, Janakiraman, Vasantharajan, Wang, Weiru, Kinch, Lisa N, Grishin, Nick V, Haverty, Peter M, Chow, Bernard, Gehring, Julian S, Reeder, Jens, Pau, Gregoire, Wu, Thomas D, Margulis, Vitaly, Lotan, Yair, Sagalowsky, Arthur, Pedrosa, Ivan, de Sauvage, Frederic J, Brugarolas, James, Seshagiri, Somasekar

“…Somasekar Seshagiri, James Brugarolas and colleagues report the mutational landscape of 167 non–clear cell renal cell carcinomas (nccRCCs) from multiple…”
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Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer by Rudin, Charles M, Durinck, Steffen, Stawiski, Eric W, Poirier, John T, Modrusan, Zora, Shames, David S, Bergbower, Emily A, Guan, Yinghui, Shin, James, Guillory, Joseph, Rivers, Celina Sanchez, Foo, Catherine K, Bhatt, Deepali, Stinson, Jeremy, Gnad, Florian, Haverty, Peter M, Gentleman, Robert, Chaudhuri, Subhra, Janakiraman, Vasantharajan, Jaiswal, Bijay S, Parikh, Chaitali, Yuan, Wenlin, Zhang, Zemin, Koeppen, Hartmut, Wu, Thomas D, Stern, Howard M, Yauch, Robert L, Huffman, Kenneth E, Paskulin, Diego D, Illei, Peter B, Varella-Garcia, Marileila, Gazdar, Adi F, de Sauvage, Frederic J, Bourgon, Richard, Minna, John D, Brock, Malcolm V, Seshagiri, Somasekar

“…Sekar Seshagiri and colleagues report exome, transcriptome and copy-number alteration data in small-cell lung cancer. The authors find SOX2 amplification in…”
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Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations by Pahuja, Kanika Bajaj, Nguyen, Thong T., Jaiswal, Bijay S., Prabhash, Kumar, Thaker, Tarjani M., Senger, Kate, Chaudhuri, Subhra, Kljavin, Noelyn M., Antony, Aju, Phalke, Sameer, Kumar, Prasanna, Mravic, Marco, Stawiski, Eric W., Vargas, Derek, Durinck, Steffen, Gupta, Ravi, Khanna-Gupta, Arati, Trabucco, Sally E., Sokol, Ethan S., Hartmaier, Ryan J., Singh, Ashish, Chougule, Anuradha, Trivedi, Vaishakhi, Dutt, Amit, Patil, Vijay, Joshi, Amit, Noronha, Vanita, Ziai, James, Banavali, Sripad D., Ramprasad, Vedam, DeGrado, William F., Bueno, Raphael, Jura, Natalia, Seshagiri, Somasekar

“…Deregulated HER2 is a target of many approved cancer drugs. We analyzed 111,176 patient tumors and identified recurrent mutations in HER2 transmembrane domain…”
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Oncogenic ERBB3 Mutations in Human Cancers by Jaiswal, Bijay S., Kljavin, Noelyn M., Stawiski, Eric W., Chan, Emily, Parikh, Chaitali, Durinck, Steffen, Chaudhuri, Subhra, Pujara, Kanan, Guillory, Joseph, Edgar, Kyle A., Janakiraman, Vasantharajan, Scholz, Rolf-Peter, Bowman, Krista K., Lorenzo, Maria, Li, Hong, Wu, Jiansheng, Yuan, Wenlin, Peters, Brock A., Kan, Zhengyan, Stinson, Jeremy, Mak, Michelle, Modrusan, Zora, Eigenbrot, Charles, Firestein, Ron, Stern, Howard M., Rajalingam, Krishnaraj, Schaefer, Gabriele, Merchant, Mark A., Sliwkowski, Mark X., de Sauvage, Frederic J., Seshagiri, Somasekar

“…The human epidermal growth factor receptor (HER) family of tyrosine kinases is deregulated in multiple cancers either through amplification, overexpression, or…”
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SCINA: A Semi-Supervised Subtyping Algorithm of Single Cells and Bulk Samples by Zhang, Ze, Luo, Danni, Zhong, Xue, Choi, Jin Huk, Ma, Yuanqing, Wang, Stacy, Mahrt, Elena, Guo, Wei, Stawiski, Eric W, Modrusan, Zora, Seshagiri, Somasekar, Kapur, Payal, Hon, Gary C, Brugarolas, James, Wang, Tao

“…Advances in single-cell RNA sequencing (scRNA-Seq) have allowed for comprehensive analyses of single cell data. However, current analyses of scRNA-Seq data…”
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Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2 by Suryamohan, Kushal, Diwanji, Devan, Stawiski, Eric W., Gupta, Ravi, Miersch, Shane, Liu, Jiang, Chen, Chao, Jiang, Ying-Ping, Fellouse, Frederic A., Sathirapongsasuti, J. Fah, Albers, Patrick K., Deepak, Tanneeru, Saberianfar, Reza, Ratan, Aakrosh, Washburn, Gavin, Mis, Monika, Santhosh, Devi, Somasekar, Sneha, Hiranjith, G. H., Vargas, Derek, Mohan, Sangeetha, Phalke, Sameer, Kuriakose, Boney, Antony, Aju, Ustav Jr, Mart, Schuster, Stephan C., Sidhu, Sachdev, Junutula, Jagath R., Jura, Natalia, Seshagiri, Somasekar

“…COVID-19 is a respiratory illness caused by a novel coronavirus called SARS-CoV-2. The viral spike (S) protein engages the human angiotensin-converting enzyme…”
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Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors by Savill, Kristin M. Zimmerman, Lee, Brian B., Oeh, Jason, Lin, Jie, Lin, Eva, Chung, Wei-Jen, Young, Amy, Chen, Wennie, Miś, Monika, Mesh, Kathryn, Eastham, Jeffrey, Gnad, Florian, Jiang, Zhaoshi, Stawiski, Eric W., Haley, Benjamin, Daemen, Anneleen, Wang, Xiaojing, Koeppen, Hartmut, Modrusan, Zora, Martin, Scott E., Sampath, Deepak, Lin, Kui

“…The AKT kinases have emerged as promising therapeutic targets in oncology and both allosteric and ATP-competitive AKT inhibitors have entered clinical…”
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Comprehensive genomic analysis identifies pathogenic variants in maturity-onset diabetes of the young (MODY) patients in South India by Mohan, Viswanathan, Radha, Venkatesan, Nguyen, Thong T, Stawiski, Eric W, Pahuja, Kanika Bajaj, Goldstein, Leonard D, Tom, Jennifer, Anjana, Ranjit Mohan, Kong-Beltran, Monica, Bhangale, Tushar, Jahnavi, Suresh, Chandni, Radhakrishnan, Gayathri, Vijay, George, Paul, Zhang, Na, Murugan, Sakthivel, Phalke, Sameer, Chaudhuri, Subhra, Gupta, Ravi, Zhang, Jingli, Santhosh, Sam, Stinson, Jeremy, Modrusan, Zora, Ramprasad, V L, Seshagiri, Somasekar, Peterson, Andrew S

“…Maturity-onset diabetes of the young (MODY) is an early-onset, autosomal dominant form of non-insulin dependent diabetes. Genetic diagnosis of MODY can…”
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Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer by Liu, Jinfeng, McCleland, Mark, Stawiski, Eric W., Gnad, Florian, Mayba, Oleg, Haverty, Peter M., Durinck, Steffen, Chen, Ying-Jiun, Klijn, Christiaan, Jhunjhunwala, Suchit, Lawrence, Michael, Liu, Hanbin, Wan, Yinan, Chopra, Vivek, Yaylaoglu, Murat B., Yuan, Wenlin, Ha, Connie, Gilbert, Houston N., Reeder, Jens, Pau, Gregoire, Stinson, Jeremy, Stern, Howard M., Manning, Gerard, Wu, Thomas D., Neve, Richard M., de Sauvage, Frederic J., Modrusan, Zora, Seshagiri, Somasekar, Firestein, Ron, Zhang, Zemin

“…Gastric cancer is the second leading cause of worldwide cancer mortality, yet the underlying genomic alterations remain poorly understood. Here we perform…”
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S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis by Yuan, Wenlin, Goldstein, Leonard D, Durinck, Steffen, Chen, Ying-Jiun, Nguyen, Thong T, Kljavin, Noelyn M, Sokol, Ethan S, Stawiski, Eric W, Haley, Benjamin, Ziai, James, Modrusan, Zora, Seshagiri, Somasekar

“…PIK3CA mutations are frequent in human breast cancer. Pik3caH1047R mutant expression in mouse mammary gland promotes tumorigenesis. TP53 mutations co-occur…”
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Annotating Nucleic Acid-Binding Function Based on Protein Structure by Stawiski, Eric W., Gregoret, Lydia M., Mandel-Gutfreund, Yael

“…Many of the targets of structural genomics will be proteins with little or no structural similarity to those currently in the database. Therefore, novel…”
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Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation by Smith, Derek K., Kates, Lance, Durinck, Steffen, Patel, Nisha, Stawiski, Eric W., Kljavin, Noelyn, Foreman, Oded, Sipos, Bence, Solloway, Mark J., Allan, Bernard B., Peterson, Andrew S.

“…The cellular origin of sporadic pancreatic neuroendocrine tumors (PNETs) is obscure. Hormone expression suggests that these tumors arise from…”
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A comprehensive transcriptional portrait of human cancer cell lines by Klijn, Christiaan, Durinck, Steffen, Stawiski, Eric W, Haverty, Peter M, Jiang, Zhaoshi, Liu, Hanbin, Degenhardt, Jeremiah, Mayba, Oleg, Gnad, Florian, Liu, Jinfeng, Pau, Gregoire, Reeder, Jens, Cao, Yi, Mukhyala, Kiran, Selvaraj, Suresh K, Yu, Mamie, Zynda, Gregory J, Brauer, Matthew J, Wu, Thomas D, Gentleman, Robert C, Manning, Gerard, Yauch, Robert L, Bourgon, Richard, Stokoe, David, Modrusan, Zora, Neve, Richard M, de Sauvage, Frederic J, Settleman, Jeffrey, Seshagiri, Somasekar, Zhang, Zemin

“…A comprehensive analysis of RNA sequencing and single-nucleotide polymorphism (SNP) array data provides new insights into the biology of 675 human cancer cell…”
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Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function by Storm, Elaine E., Durinck, Steffen, de Sousa e Melo, Felipe, Tremayne, Jarrod, Kljavin, Noelyn, Tan, Christine, Ye, Xiaofen, Chiu, Cecilia, Pham, Thinh, Hongo, Jo-Anne, Bainbridge, Travis, Firestein, Ron, Blackwood, Elizabeth, Metcalfe, Ciara, Stawiski, Eric W., Yauch, Robert L., Wu, Yan, de Sauvage, Frederic J.

“…Antibody-mediated inhibition of R-spondin-3 in colorectal tumours decreases tumour growth and promotes differentiation—these effects are associated with a…”
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Recurrent R-spondin fusions in colon cancer by Seshagiri, Somasekar, Stawiski, Eric W., Durinck, Steffen, Modrusan, Zora, Storm, Elaine E., Conboy, Caitlin B., Chaudhuri, Subhra, Guan, Yinghui, Janakiraman, Vasantharajan, Jaiswal, Bijay S., Guillory, Joseph, Ha, Connie, Dijkgraaf, Gerrit J. P., Stinson, Jeremy, Gnad, Florian, Huntley, Melanie A., Degenhardt, Jeremiah D., Haverty, Peter M., Bourgon, Richard, Wang, Weiru, Koeppen, Hartmut, Gentleman, Robert, Starr, Timothy K., Zhang, Zemin, Largaespada, David A., Wu, Thomas D., de Sauvage, Frederic J.

“…Exomes, transcriptomes and copy-number alterations in a sample of more than 70 primary human colonic tumours were analysed in an attempt to characterize the…”
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ERK mutations and amplification confer resistance to ERK-inhibitor therapy by Jaiswal, Bijay S, Durinck, Steffen, Stawiski, Eric, Yin, Jianping, Wang, Weiru, Lin, Eva, Moffat, John G, Martin, Scott, Modrusan, Zora, Seshagiri, Somasekar

“…MAPK pathway inhibitors targeting BRAF and MEK have shown clinical efficacy in patients with RAF and/or RAS mutated tumors. However, acquired resistance to…”
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Phenotypic expression and clinical outcomes in a South Asian PRKAG2 cardiomyopathy cohort by Ahamed, Hisham, Balegadde, Aniketh Vijay, Menon, Shilpa, Menon, Ramesh, Ramachandran, Aishwarya, Mathew, Navin, Natarajan, K. U., Nair, Indu Ramachandran, Kannan, Rajesh, Shankar, Meghna, Mathew, Oommen K., Nguyen, Thong T., Gupta, Ravi, Stawiski, Eric W., Ramprasad, V. L., Seshagiri, Somasekar, Phalke, Sameer

“…The PRKAG2 syndrome is a rare autosomal dominant phenocopy of sarcomeric hypertrophic cardiomyopathy (HCM), characterized by ventricular pre-excitation,…”
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