Search Results - "Stavrinides, Anna"
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A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate
Published in Nature communications (22-08-2017)“…Monoterpene indole alkaloids comprise a diverse family of over 2000 plant-produced natural products. This pathway provides an outstanding example of how nature…”
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New cup out of old coffee: contribution of parental gene expression legacy to phenotypic novelty in coffee beans of the allopolyploid Coffea arabica L
Published in Annals of botany (07-02-2023)“…Allopolyploidization is a widespread phenomenon known to generate novel phenotypes by merging evolutionarily distinct parental genomes and regulatory networks…”
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Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
Published in Nature communications (15-07-2016)“…Plants produce an enormous array of biologically active metabolites, often with stereochemical variations on the same molecular scaffold. These changes in…”
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4
Seed comparative genomics in three coffee species identify desiccation tolerance mechanisms in intermediate seeds
Published in Journal of experimental botany (19-02-2020)“…Abstract In contrast to desiccation-tolerant ‘orthodox’ seeds, so-called ‘intermediate’ seeds cannot survive complete drying and are short-lived. All species…”
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5
trade off between mlo resistance to powdery mildew and increased susceptibility of barley to a newly important disease, Ramularia leaf spot
Published in Journal of experimental botany (01-03-2014)“…Ramularia leaf spot (RLS), caused by the fungus Ramularia collo-cygni, is a serious, recently emerged disease of barley in Europe and other temperate regions…”
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Discovery of a Short‐Chain Dehydrogenase from Catharanthus roseus that Produces a New Monoterpene Indole Alkaloid
Published in Chembiochem : a European journal of chemical biology (04-05-2018)“…Plant monoterpene indole alkaloids, a large class of natural products, derive from the biosynthetic intermediate strictosidine aglycone. Strictosidine…”
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Unlocking the Diversity of Alkaloids in Catharanthus roseus: Nuclear Localization Suggests Metabolic Channeling in Secondary Metabolism
Published in Chemistry & biology (19-03-2015)“…The extraordinary chemical diversity of the plant-derived monoterpene indole alkaloids, which include vinblastine, quinine, and strychnine, originates from a…”
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Duplication of alcohol dehydrogenases unlocks the chemical diversity of the medicinal plant catharanthus roseus
Published 01-01-2016“…This thesis details the discovery and characterisation of biosynthetic enzymes implicated in the monoterpene indole alkaloid (MIA) pathway of the medicinal…”
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Dissertation