Search Results - "Stavrakov, Georgi"

Ex Vivo Antioxidant and Cholinesterase Inhibiting Effects of a Novel Galantamine-Curcumin Hybrid on Scopolamine-Induced Neurotoxicity in Mice by Simeonova, Rumyana, Atanasova, Mariyana, Stavrakov, Georgi, Philipova, Irena, Doytchinova, Irini

“…Oxidative stress is an essential factor in the development and progression of Alzheimer's disease (AD). An excessive amount of reactive oxygen species (ROS)…”
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A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders by Simeonova, Rumyana, Zheleva, Dimitrina, Valkova, Iva, Stavrakov, Georgi, Philipova, Irena, Atanasova, Mariyana, Doytchinova, Irini

“…The acetylcholinesterase (AChE) inhibitors are the main drugs for symptomatic treatment of neurodegenerative disorders like Alzheimer's disease. A recently…”
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A Galantamine-Curcumin Hybrid Decreases the Cytotoxicity of Amyloid-Beta Peptide on SH-SY5Y Cells by Mladenova, Kirilka, Stavrakov, Georgi, Philipova, Irena, Atanasova, Mariyana, Petrova, Svetla, Doumanov, Jordan, Doytchinova, Irini

“…Misfolded amyloid beta (Aβ) peptides aggregate and form neurotoxic oligomers. Membrane and mitochondrial damages, calcium dysregulation, oxidative stress, and…”
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A galantamine–curcumin hybrid lacks the depressant side effect of acetylcholinesterase inhibitors by Kostadinova, Ivanka, Atanasova, Mariyana, Stavrakov, Georgi, Philipova, Irena, Doytchinova, Irini

“…AbstractAcetylcholinesterase inhibitors (AChEIs) are drugs that enhance cholinergic neuro-transmission and are used for the treatment of Alzheimer’s disease…”
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Discovery of a Novel Acetylcholinesterase Inhibitor by Fragment-Based Design and Virtual Screening by Stavrakov, Georgi, Philipova, Irena, Lukarski, Atanas, Atanasova, Mariyana, Georgiev, Borislav, Atanasova, Teodora, Konstantinov, Spiro, Doytchinova, Irini

“…Despite extensive and intensive research efforts in recent decades, there is still no effective treatment for neurodegenerative diseases. On this background,…”
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Galantamine-Curcumin Hybrids as Dual-Site Binding Acetylcholinesterase Inhibitors by Stavrakov, Georgi, Philipova, Irena, Lukarski, Atanas, Atanasova, Mariyana, Zheleva, Dimitrina, Zhivkova, Zvetanka D, Ivanov, Stefan, Atanasova, Teodora, Konstantinov, Spiro, Doytchinova, Irini

“…Galantamine (GAL) and curcumin (CU) are alkaloids used to improve symptomatically neurodegenerative conditions like Alzheimer's disease (AD). GAL acts mainly…”
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Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database by Doytchinova, Irini, Atanasova, Mariyana, Valkova, Iva, Stavrakov, Georgi, Philipova, Irena, Zhivkova, Zvetanka, Zheleva-Dimitrova, Dimitrina, Konstantinov, Spiro, Dimitrov, Ivan

“…The inhibition of the enzyme acetylcholinesterase (AChE) increases the levels of the neurotransmitter acetylcholine and symptomatically improves the affected…”
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Camphane-based aminophosphine ligands for Pd-catalyzed asymmetric allylic alkylation by Philipova, Irena, Stavrakov, Georgi, Dimitrov, Vladimir

“…A practical synthesis of new chiral aminophosphine ligands based on the camphane scaffold bearing alkoxy groups was accomplished. The application of these…”
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From Central to Axial to Central Chirality: Enantioselective Construction of the trans-4,5,9,10-Tetrahydroxy-9,10-dihydrophenanthrene System by Stavrakov, Georgi, Keller, Manfred, Breit, Bernhard

“…Enantioselective synthesis of the core trans‐4,5,9,10‐tetrahydroxy‐9,10‐dihydrophenanthrene parent system of the antibiotics benanimicin, pradimicin and FD 594…”
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AChE inhibitory activity of N-substituted natural galanthamine derivatives by Atanasova, Mariyana, Stavrakov, Georgi, Philipova, Irena, Georgiev, Borislav, Bastida, Jaume, Doytchinova, Irini, Berkov, Strahil

“…[Display omitted] •Complete NMR data of N-acethylnorgalanthamine has been provided.•The N-substituent of galanthamine derivatives influences the binding…”
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Galantamine derivatives: Synthesis, NMR study, DFT calculations and application in asymmetric catalysis by Philipova, Irena, Stavrakov, Georgi, Dimitrov, Vladimir, Vassilev, Nikolay

“…In a search of effective ligands for asymmetric catalysis (−)-galantamine has been selected as a complex chiral framework for the synthesis of four novel…”
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Galantamine derivatives with indole moiety: Docking, design, synthesis and acetylcholinesterase inhibitory activity by Atanasova, Mariyana, Stavrakov, Georgi, Philipova, Irena, Zheleva, Dimitrina, Yordanov, Nikola, Doytchinova, Irini

“…[Display omitted] The inhibitors of acetylcholinesterase are the main therapy against Alzheimer’s disease. Among them, galantamine is the best tolerated and…”
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Ferrocene modified analogues of imatinib and nilotinib as potent anti-cancer agents by Philipova, Irena, Mihaylova, Rositsa, Momekov, Georgi, Angelova, Rostislava, Stavrakov, Georgi

“…The unique features of ferrocene and the need for development of targeted anticancer drugs inspired the design, synthesis and biological evaluation of…”
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Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents by Voynikov, Yulian, Valcheva, Violeta, Momekov, Georgi, Peikov, Plamen, Stavrakov, Georgi

“…A series of amides were synthesized by condensation of theophylline-7-acetic acid and eight commercially available amino acid methyl ester hydrochlorides…”
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Novel camphane-based anti-tuberculosis agents with nanomolar activity by Stavrakov, Georgi, Valcheva, Violeta, Philipova, Irena, Doytchinova, Irini

“…A series of new amidoalcohols and amidodiols were designed on the base of the camphor scaffold and evaluated for their in vitro activity against Mycobacterium…”
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Synthetic piperine amide analogs with antimycobacterial activity by Philipova, Irena, Valcheva, Violeta, Mihaylova, Rositsa, Mateeva, Mina, Doytchinova, Irini, Stavrakov, Georgi

“…Piperine amide analogs are synthesized by replacement of the piperidine moiety with different types of cyclic amines, including adamantyl and…”
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Synthesis and antimycobacterial activity of novel camphane-based agents by Stavrakov, Georgi, Philipova, Irena, Valcheva, Violeta, Momekov, Georgi

“…A series of six new amidoalcohols was designed and synthesized on the base of the camphor scaffold. Natural amino acids were transformed into their α-hydroxy…”
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Docking‐based design and synthesis of galantamine–camphane hybrids as inhibitors of acetylcholinesterase by Stavrakov, Georgi, Philipova, Irena, Zheleva‐Dimitrova, Dimitrina, Valkova, Iva, Salamanova, Evdokiya, Konstantinov, Spiro, Doytchinova, Irini

“…Galantamine (GAL) as an acetylcholinesterase inhibitor (AChEI) is among the main drugs approved for the treatment of Alzheimer's disease. It fits perfectly…”
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Docking-based Design of Galantamine Derivatives with Dual-site Binding to Acetylcholinesterase by Stavrakov, Georgi, Philipova, Irena, Zheleva, Dimitrina, Atanasova, Mariyana, Konstantinov, Spiro, Doytchinova, Irini

“…The enzyme acetylcholinesterase is a key target in the treatment of Alzheimer's disease because of its ability to hydrolyze acetylcholine via the catalytic…”
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Camphane-based phosphino-carboxamide ligands as P,O-chelates in Pd-catalyzed enantioselective allylic alkylation by Philipova, Irena, Stavrakov, Georgi, Dimitrov, Vladimir

“…A practical synthesis for new chiral phosphino-carboxamide ligands has been accomplished. These ligands were effectively modified both on the amide moiety and…”
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