Search Results - "Stavchansky, Salomon"

Critical research gaps in electronic cigarette devices and nicotine aerosols by Spahn, Jamie E., Stavchansky, Salomon A., Cui, Zhengrong

“…[Display omitted] Electronic cigarettes (e-cigs) are devices that aerosolize nicotine-containing liquids for delivery as an inhaled vapor. E-cigs are currently…”
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Molecular Properties of WHO Essential Drugs and Provisional Biopharmaceutical Classification by Kasim, Nehal A, Whitehouse, Marc, Ramachandran, Chandrasekharan, Bermejo, Marival, Lennernäs, Hans, Hussain, Ajaz S, Junginger, Hans E, Stavchansky, Salomon A, Midha, Kamal K, Shah, Vinod P, Amidon, Gordon L

“…The purpose of this study is to provisionally classify, based on the Biopharmaceutics Classification System (BCS), drugs in immediate-release dosage forms that…”
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The Use of BDDCS in Classifying the Permeability of Marketed Drugs by Benet, Leslie Z., Amidon, Gordon L., Barends, Dirk M., Lennernäs, Hans, Polli, James E., Shah, Vinod P., Stavchansky, Salomon A., Yu, Lawrence X.

“…We recommend that regulatory agencies add the extent of drug metabolism (i.e., ≥ 90% metabolized) as an alternate method in defining Class 1 marketed drugs…”
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Structure–activity relationships in the cytoprotective effect of caffeic acid phenethyl ester (CAPE) and fluorinated derivatives: Effects on heme oxygenase-1 induction and antioxidant activities by Wang, Xinyu, Stavchansky, Salomon, Kerwin, Sean M., Bowman, Phillip D.

“…To determine the relationship between catechol ring modifications and the activity of caffeic acid phenethyl ester (CAPE) as a cytoprotective agent, six…”
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Time Course Expression Analysis of 1[2-cyano-3,12- dioxooleana-1,9(11)-dien-28-oyl]imidazole Induction of Cytoprotection in Human Endothelial Cells by Bynum, James A, Wang, Xinyu, Stavchansky, Salomon A, Bowman, Phillip D

“…1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im), a synthetic derivative of oleanolic acid that exhibits antioxidant and anti-inflammatory…”
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Cytoprotection of human endothelial cells from oxidant stress with CDDO derivatives: network analysis of genes responsible for cytoprotection by Bynum, James A, Rastogi, Ashish, Stavchansky, Salomon A, Bowman, Phillip D

“…To identify drugs that may reduce the impact of oxidant stress on cell viability. Human umbilical vein endothelial cells were treated with 200 nmol/l CDDO-Im…”
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Drug eluting stents and beyond by Rastogi, Ashish, Stavchansky, Salomon

“…The present review discusses the mechanism of late stent thrombosis and its distinction from restenosis and summarizes the advisory note issued by FDA on the…”
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Cytoprotection of human endothelial cells from menadione cytotoxicity by caffeic acid phenethyl ester: The role of heme oxygenase-1 by Wang, Xinyu, Stavchansky, Salomon, Zhao, Baiteng, Bynum, James A., Kerwin, Sean M., Bowman, Phillip D.

“…Caffeic acid phenethyl ester (CAPE), derived from various plant sources, has been shown to ameliorate ischemia/reperfusion injury in vivo, and this has been…”
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Link between drug absorption solubility and permeability measurements in Caco-2 cells by Pade, V, Stavchansky, S

“…The objective of this investigation was to establish a relationship between drug permeability and solubility in vitro and the extent of drug absorption in…”
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Pharmacokinetics of caffeic acid phenethyl ester and its catechol-ring fluorinated derivative following intravenous administration to rats by Wang, Xinyu, Pang, Jihai, Maffucci, Jacqueline A., Pade, Devendra S., Newman, Robert A., Kerwin, Sean M., Bowman, Phillip D., Stavchansky, Salomon

“…The pharmacokinetic profiles of caffeic acid phenethyl ester (CAPE) and its catechol‐ring fluorinated derivative (FCAPE) were determined in rats after…”
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Estimation of the relative contribution of the transcellular and paracellular pathway to the transport of passively absorbed drugs in the Caco-2 cell culture model by PADE, V, STAVCHANSKY, S

“…The objective of this investigation was to determine, using the Caco-2 cell culture model, the extent to which the paracellular and transcellular routes…”
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Human endothelial cell response to gram-negative lipopolysaccharide assessed with cDNA microarrays by Zhao, B, Bowden, R A, Stavchansky, S A, Bowman, P D

“…To assess the feasibility of using cDNA microarrays to understand the response of endothelial cells to lipopolysaccharide (LPS) and to evaluate potentially…”
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Challenges and opportunities in establishing scientific and regulatory standards for determining therapeutic equivalence of modified-release products: Workshop summary report by Chen, Mei-Ling, PhD, Shah, Vinod P., PhD, Ganes, Derek, PhD, Midha, Kamal K., PhD, Caro, James, RPh, Nambiar, Prabu, PhD, Rocci, Mario L., PhD, Thombre, Avinash G., PhD, Abrahamsson, Bertil, PhD, Conner, Dale, PharmD, Davit, Barbara, PhD, JD, Fackler, Paul, PhD, Farrell, Colm, PhD, Gupta, Suneel, PhD, Katz, Russell, MD, Mehta, Mehul, PhD, Preskorn, Sheldon H., MD, Sanderink, Gerard, PhD, Stavchansky, Salomon, PhD, Temple, Robert, MD, Wang, Yaning, PhD, Winkle, Helen, Yu, Lawrence, PhD

“…Abstract Background: Modified-release (MR) products are complex dosage forms designed to release drug in a controlled manner to achieve the desired efficacy…”
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Reuse of cDNA microarrays hybridized with cRNA by stripping with RNase H by Wu, Haoxiang, Bynum, James, Stavchansky, Salomon, Bowman, Phillip

“…DNA microarrays are powerful tools for global analysis of gene transcript expression. However, their high cost and the need for replication have limited their…”
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Quantitative determination of fluorinated caffeic acid phenethyl ester derivative from rat blood plasma by liquid chromatography-electrospray ionization tandem mass spectrometry by Wang, Xinyu, Pang, Jihai, Newman, Robert A., Kerwin, Sean M., Bowman, Phillip D., Stavchansky, Salomon

“…The quantitative determination of caffeic acid phenethyl ester (CAPE) and its fluorinated derivative (FCAPE) from rat plasma using ultra-performance liquid…”
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Pharmacokinetics and biodistribution of a nucleotide-based thrombin inhibitor in rats by REYDERMAN, L, STAVCHANSKY, S

“…To characterize the pharmacokinetic and tissue distribution profiles of a nucleotide-based thrombin inhibitor (GS522, phosphodiester oligonucleotide,…”
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Scientific Perspectives on Extending the Provision for Waivers of In vivo Bioavailability and Bioequivalence Studies for Drug Products Containing High Solubility-Low Permeability Drugs (BCS-Class 3) by Stavchansky, Salomon

“…Recently, there has been increased interest in extending the provision for waivers of in vivo bioavailability and bioequivalence (BA–BE) studies that appeared…”
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Isothermal and nonisothermal decomposition of thymopentin and its analogs in aqueous solution by LEE, M.-L, STAVCHANSKY, S

“…The degradation kinetics of thymopentin (RKDVY) and its analogs (RKDVW and RPDVY) in aqueous solution was studied by isothermal and nonisothermal methods. The…”
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Dependence of cytotoxicity of menadione and cytoprotection by antioxidants in human endothelial cells on oxygen levels: Atmospheric oxygen versus physiological levels by Rastogi, Ashish, Stavchansky, Salomon, Bowman, Phillip

“…Abstract only The goal of in vitro screens of potential cytoprotective agents is to identify drugs that will be beneficial in vivo. However, in vitro screens…”
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Determination of the Minimum Exposure Time for Effecting Cytoprotection in Human Umbilical Vein Endothelial Cells (HUVEC) for Caffeic Acid Phenylethyl Ester (CAPE) and Amide (CAPA) by Yang, John, Bowman, Phillip D, Stavchansky, Salomon

“…Abstract only We have previously shown that CAPE and CAPA protect HUVEC from oxidant stress. 1 This activity was correlated with the production of heme…”
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